BGC0001013 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001013 (Streptomyces sp)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS,T1PKS	1	116,856	meridamycin	NRPS:Type I+PKS	95%

BGC0001013 - Region 1 - NRPS,T1PKS

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Location: 1 - 116,856 nt. (total: 116,856 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 116,857
Label		BGC0001013

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001013	1.19	NRP, Polyketide	meridamycin	Streptomyces sp.
BGC0001012	0.72	NRP, Polyketide	meridamycin	Streptomyces violaceusniger
BGC0002171	0.56	NRP, Polyketide	pyrophen, campyrone B	Aspergillus niger ATCC 1015
BGC0002275	0.56	NRP, Polyketide	pyrophen, campyrone B	Aspergillus niger CBS 101883
BGC0000342	0.55	NRP	enniatin	Fusarium equiseti
BGC0002135	0.51	NRP	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000996	0.50	NRP, Polyketide	frontalamide B, frontalamide A	Streptomyces sp. SPB78
BGC0002437	0.50	NRP	thermoactinoamide A	Thermoactinomyces sp. AS95
BGC0001132	0.50	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002518	0.50	NRP	syringafactin A, syringafactin C	Pseudomonas sp. SZ57

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001013	0.97	NRP, Polyketide	meridamycin	Streptomyces sp.
BGC0001012	0.81	NRP, Polyketide	meridamycin	Streptomyces violaceusniger
BGC0001163	0.66	Polyketide	1-heptadecene	Moorea producens 3L
BGC0002631	0.66	RiPP	myxarylin	Pyxidicoccus fallax
BGC0000067	0.66	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001164	0.64	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000844	0.63	Other	clavulanic acid	Streptomyces clavuligerus
BGC0002171	0.63	NRP, Polyketide	pyrophen, campyrone B	Aspergillus niger ATCC 1015
BGC0002275	0.63	NRP, Polyketide	pyrophen, campyrone B	Aspergillus niger CBS 101883
BGC0000996	0.63	NRP, Polyketide	frontalamide B, frontalamide A	Streptomyces sp. SPB78

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 1637 - 116856:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Hpr) + (mal - pk - Me-ccmal - ohmal) + (pk - pk - pk - pk) + (ohmal - ohmal - pk - ohmal - ohmal) + (pk - ccmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 1637 - 46311:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Hpr) + (mal - pk - Me-ccmal - ohmal) + (pk - pk - pk - pk)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 6334 - 116856:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Hpr) + (mal - pk - Me-ccmal - ohmal) + (pk - pk - pk - pk) + (ohmal - ohmal - pk - ohmal - ohmal) + (pk - ccmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg1_orf19

Search NORINE for peptide: strict or relaxed

AMP-binding (487..903): Hpr

nrpys: Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: pro (Pro)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: DIQFSAHVVK
Nearest Stachelhaus code(s):: Hpr DIQFSAHVVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

ctg1_orf20

PKS_AT (565..863): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 190.8
inactive: 94.4
Methoxymalonyl-CoA: 69.9
Methylmalonyl-CoA: 51.4
Propionyl-CoA: 26.6
Isobutyryl-CoA: 25.4
Ethylmalonyl-CoA: 21.5
Acetyl-CoA: 20.3
fatty_acid: 16.1
2-Methylbutyryl-CoA: 13.8
Benzoyl-CoA: 10.0
CHC-CoA: 9.4
trans-1,2-CPDA: 5.1
3-Methylbutyryl-CoA: 0.0

PKS_AT (1574..1859): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 220.0
Methylmalonyl-CoA: 213.8
Methoxymalonyl-CoA: 171.9
2-Methylbutyryl-CoA: 144.0
trans-1,2-CPDA: 139.9
CHC-CoA: 128.0
Propionyl-CoA: 113.7
Malonyl-CoA: 91.7
Isobutyryl-CoA: 79.3
Benzoyl-CoA: 73.8
Acetyl-CoA: 51.7
fatty_acid: 40.7
inactive: 23.2
3-Methylbutyryl-CoA: 19.9

PKS_AT (3027..3312): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 209.8
Ethylmalonyl-CoA: 209.1
Methoxymalonyl-CoA: 166.8
2-Methylbutyryl-CoA: 145.0
trans-1,2-CPDA: 143.6
Propionyl-CoA: 121.2
CHC-CoA: 118.7
Malonyl-CoA: 87.8
Isobutyryl-CoA: 73.0
Benzoyl-CoA: 67.4
Acetyl-CoA: 53.4
fatty_acid: 41.2
inactive: 22.6
3-Methylbutyryl-CoA: 10.9

PKS_AT (4702..4975): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 212.4
inactive: 116.1
Methoxymalonyl-CoA: 61.2
Methylmalonyl-CoA: 49.5
Isobutyryl-CoA: 37.6
Propionyl-CoA: 33.5
Ethylmalonyl-CoA: 28.5
Benzoyl-CoA: 28.3
Acetyl-CoA: 18.1
2-Methylbutyryl-CoA: 15.5
fatty_acid: 14.7
CHC-CoA: 11.7
trans-1,2-CPDA: 10.9
3-Methylbutyryl-CoA: 0.0

ctg1_orf21

PKS_AT (558..856): pk

ATSignature: Methoxymalonyl-CoA

Top 3 matches:: Methoxymalonyl-CoA: 87.5%; Ethylmalonyl-CoA: 83.3%; Methylmalonyl-CoA: 79.2%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 186.1
Methylmalonyl-CoA: 179.0
Methoxymalonyl-CoA: 152.5
2-Methylbutyryl-CoA: 119.3
trans-1,2-CPDA: 115.7
Propionyl-CoA: 95.4
CHC-CoA: 89.3
Malonyl-CoA: 81.7
Isobutyryl-CoA: 59.3
fatty_acid: 40.2
Benzoyl-CoA: 33.8
Acetyl-CoA: 29.6
inactive: 20.4
3-Methylbutyryl-CoA: 16.0

PKS_AT (2268..2554): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 214.2
Methylmalonyl-CoA: 208.4
Methoxymalonyl-CoA: 168.0
2-Methylbutyryl-CoA: 148.0
trans-1,2-CPDA: 140.9
CHC-CoA: 114.4
Propionyl-CoA: 113.2
Malonyl-CoA: 88.2
Isobutyryl-CoA: 63.8
Benzoyl-CoA: 55.2
Acetyl-CoA: 40.4
fatty_acid: 40.2
3-Methylbutyryl-CoA: 31.1
inactive: 21.9

PKS_AT (3808..4093): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 211.5
Methylmalonyl-CoA: 210.3
Methoxymalonyl-CoA: 167.2
2-Methylbutyryl-CoA: 148.1
trans-1,2-CPDA: 144.0
CHC-CoA: 121.1
Propionyl-CoA: 120.3
Malonyl-CoA: 89.1
Isobutyryl-CoA: 76.7
Benzoyl-CoA: 70.2
Acetyl-CoA: 56.1
fatty_acid: 41.1
inactive: 25.4
3-Methylbutyryl-CoA: 10.9

PKS_AT (5843..6128): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 214.1
Methylmalonyl-CoA: 209.3
Methoxymalonyl-CoA: 167.0
trans-1,2-CPDA: 142.1
2-Methylbutyryl-CoA: 136.4
CHC-CoA: 124.0
Propionyl-CoA: 117.0
Malonyl-CoA: 89.0
Isobutyryl-CoA: 72.4
Benzoyl-CoA: 62.3
Acetyl-CoA: 46.7
fatty_acid: 33.3
inactive: 21.2
3-Methylbutyryl-CoA: 11.6

ctg1_orf22

PKS_AT (571..844): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 211.4
inactive: 114.8
Methoxymalonyl-CoA: 58.0
Methylmalonyl-CoA: 49.7
Isobutyryl-CoA: 36.1
Propionyl-CoA: 32.8
Ethylmalonyl-CoA: 30.7
Benzoyl-CoA: 25.9
Acetyl-CoA: 19.4
fatty_acid: 18.9
2-Methylbutyryl-CoA: 14.0
trans-1,2-CPDA: 10.2
CHC-CoA: 8.9
3-Methylbutyryl-CoA: 0.0

PKS_AT (2024..2297): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 210.7
inactive: 113.5
Methoxymalonyl-CoA: 63.3
Methylmalonyl-CoA: 52.5
Isobutyryl-CoA: 38.9
Propionyl-CoA: 35.5
Ethylmalonyl-CoA: 29.4
Benzoyl-CoA: 26.4
Acetyl-CoA: 19.5
2-Methylbutyryl-CoA: 16.2
fatty_acid: 14.7
trans-1,2-CPDA: 12.5
CHC-CoA: 12.4
3-Methylbutyryl-CoA: 0.0

PKS_AT (3477..3764): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 220.4
Methylmalonyl-CoA: 215.2
Methoxymalonyl-CoA: 171.6
2-Methylbutyryl-CoA: 146.9
trans-1,2-CPDA: 145.4
CHC-CoA: 124.6
Propionyl-CoA: 117.3
Malonyl-CoA: 89.4
Isobutyryl-CoA: 72.8
Benzoyl-CoA: 63.4
Acetyl-CoA: 48.4
fatty_acid: 40.7
inactive: 17.5
3-Methylbutyryl-CoA: 15.6

PKS_AT (5004..5277): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 210.5
inactive: 112.2
Methoxymalonyl-CoA: 60.5
Methylmalonyl-CoA: 52.8
Propionyl-CoA: 36.1
Isobutyryl-CoA: 35.1
Ethylmalonyl-CoA: 32.6
Acetyl-CoA: 23.4
Benzoyl-CoA: 20.5
2-Methylbutyryl-CoA: 18.5
fatty_acid: 15.2
trans-1,2-CPDA: 12.1
CHC-CoA: 11.9
3-Methylbutyryl-CoA: 0.0

PKS_AT (6458..6731): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 209.9
inactive: 109.3
Methoxymalonyl-CoA: 62.3
Methylmalonyl-CoA: 47.6
Propionyl-CoA: 30.7
Isobutyryl-CoA: 26.2
Benzoyl-CoA: 26.0
Ethylmalonyl-CoA: 25.1
Acetyl-CoA: 20.1
2-Methylbutyryl-CoA: 14.0
fatty_acid: 11.6
CHC-CoA: 10.6
trans-1,2-CPDA: 9.9
3-Methylbutyryl-CoA: 0.0

ctg1_orf23

PKS_AT (10..229): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 75.0%; Methoxymalonyl-CoA: 70.8%; Malonyl-CoA: 70.8%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 174.5
Methylmalonyl-CoA: 169.4
Methoxymalonyl-CoA: 133.6
2-Methylbutyryl-CoA: 113.2
trans-1,2-CPDA: 103.2
CHC-CoA: 91.0
Propionyl-CoA: 83.1
Malonyl-CoA: 67.5
Isobutyryl-CoA: 48.4
Benzoyl-CoA: 48.0
Acetyl-CoA: 47.1
fatty_acid: 35.4
3-Methylbutyryl-CoA: 14.2
inactive: 13.0

PKS_AT (2086..2375): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; inactive: 70.8%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 192.5
inactive: 94.1
Methoxymalonyl-CoA: 66.1
Methylmalonyl-CoA: 60.2
Propionyl-CoA: 38.4
Ethylmalonyl-CoA: 29.8
Isobutyryl-CoA: 27.4
Acetyl-CoA: 22.7
CHC-CoA: 16.4
fatty_acid: 13.8
2-Methylbutyryl-CoA: 12.6
trans-1,2-CPDA: 10.8
Benzoyl-CoA: 10.5
3-Methylbutyryl-CoA: 0.0