BGC0001015: microcystin biosynthetic gene cluster from Planktothrix agardhii NIVA-CYA 126/8
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Location: 1 - 55,575 nt. (total: 55,575 nt).
This entry is originally from NCBI GenBank AJ441056.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001015
Short description microcystin biosynthetic gene cluster from Planktothrix agardhii NIVA-CYA 126/8
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide
Loci NCBI GenBank: AJ441056.1
Compounds
  • microcystin
Species Planktothrix agardhii NIVA-CYA 126/8 [taxonomy]
References
Chemical products information
microcystin
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C49H74N10O12
Chemical database entries
PubCHEM
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAD29792.1
  • mcyT
 449 - 1240 (-) microcystin synthetase associated thioesterase
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  • CAD29793.1
  • mcyD
 1400 - 13120 (+) polyketide synthase type I
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  • CAD29794.1
  • mcyE
 13178 - 23644 (+) peptide synthetase
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  • CAD29795.1
  • mcyG
 23901 - 31823 (+) peptide synthetase
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  • CAD29796.1
  • mcyH
 31924 - 33678 (+) ABC transporter
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  • CAD29797.1
  • mcyA
 33731 - 42181 (+) peptide synthetase
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  • CAD29798.1
  • mcyB
 42195 - 48629 (+) peptide synthetase
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  • CAD29799.1
  • mcyC
 48704 - 52600 (+) microcystin synthetase
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  • CAD29800.2
  • mcyJ
 52795 - 53625 (+) O-methyltransferase
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
mcyE
Module ?
Specificity: D-glutamic acid branched
Evidence for specificity:
mcyG
Module ?
Specificity: cinnamic acid / hydrocinnamic acid / D-phenylalanine
Evidence for specificity:
  • Structure-based inference
  • Homology
mcyA
Module ?
Specificity: serine
Evidence for specificity:
  • Structure-based inference
  • Homology
Module ?
Specificity: alanine
Evidence for specificity:
  • Structure-based inference
mcyB
Module ?
Specificity: arginine / leucine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: D-aspartic acid branched
Evidence for specificity:
  • Structure-based inference
mcyC
Module ?
Specificity: arginine
Evidence for specificity:
  • Structure-based inference
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Linked new NPAtlas id for microcystin (npatlas:NPA02920)
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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