BGC0001015: microcystin biosynthetic gene cluster from Planktothrix agardhii NIVA-CYA 126/8
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 55,575 nt. (total: 55,575 nt).
This entry is originally from NCBI GenBank AJ441056.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001015
Short description microcystin biosynthetic gene cluster from Planktothrix agardhii NIVA-CYA 126/8
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
AJ441056.1
via
Compounds
  • microcystin
Species Planktothrix agardhii NIVA-CYA 126/8 [taxonomy]
References
Chemical products information
microcystin Evidence:
Copy SMILES
C49H74N10O12
Chemical database entries
PubCHEM
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAD29792.1
  • mcyT
 449 - 1240 (-) microcystin synthetase associated thioesterase
    copy AA seq
    copy Nt seq
    • CAD29793.1
    • mcyD
    		 1400 - 13120 (+) polyketide synthase type I
      copy AA seq
      copy Nt seq
      • CAD29794.1
      • mcyE
      		 13178 - 23644 (+) peptide synthetase
        copy AA seq
        copy Nt seq
        • CAD29795.1
        • mcyG
        		 23901 - 31823 (+) peptide synthetase
          copy AA seq
          copy Nt seq
          • CAD29796.1
          • mcyH
          		 31924 - 33678 (+) ABC transporter
            copy AA seq
            copy Nt seq
            • CAD29797.1
            • mcyA
            		 33731 - 42181 (+) peptide synthetase
              copy AA seq
              copy Nt seq
              • CAD29798.1
              • mcyB
              		 42195 - 48629 (+) peptide synthetase
                copy AA seq
                copy Nt seq
                • CAD29799.1
                • mcyC
                		 48704 - 52600 (+) microcystin synthetase
                  copy AA seq
                  copy Nt seq
                  • CAD29800.2
                  • mcyJ
                  		 52795 - 53625 (+) O-methyltransferase
                    copy AA seq
                    copy Nt seq
                    Biosynthesis information

                    Biosynthetic modules

                    Name
                    Unk01
                    Type
                    nrps-type1
                    Genes
                    mcyE
                    Substrates
                    D-glutamic acid branched (evidence: )
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk02
                    Type
                    nrps-type1
                    Genes
                    mcyG
                    Substrates
                    cinnamic acid, hydrocinnamic acid, D-phenylalanine (evidence: Structure-based inference, Homology)
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk03
                    Type
                    nrps-type1
                    Genes
                    mcyA
                    Substrates
                    serine (evidence: Structure-based inference, Homology)
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk04
                    Type
                    nrps-type1
                    Genes
                    mcyA
                    Substrates
                    alanine (evidence: Structure-based inference [1])
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk05
                    Type
                    nrps-type1
                    Genes
                    mcyB
                    Substrates
                    arginine, leucine (evidence: Structure-based inference [2], [3])
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk06
                    Type
                    nrps-type1
                    Genes
                    mcyB
                    Substrates
                    D-aspartic acid branched (evidence: Structure-based inference [2], [3])
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk07
                    Type
                    nrps-type1
                    Genes
                    mcyC
                    Substrates
                    arginine (evidence: Structure-based inference [1])
                    Integrated Monomers
                    Domains
                    adenylation
                    Annotation changelog

                    Entry version: 4

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2022-10-07
                    Update chemical activity to schema version 2.11
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                    Entry version: 3

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2022-09-15
                    Linked new NPAtlas id for microcystin (npatlas:NPA02920)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    2022-09-15
                    Updated bioactivity data
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    2022-09-15
                    Added NRP substrate specificities
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                    Entry version: 2

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2019-10-16
                    Migrated from v1.4
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                    Entry version: 1

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2015-06-12
                    Submitted
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    Detailed domain annotation
                    Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                    A domain glossary is available here, and an explanation of the visualisation is available here.
                    Selected features only
                    Show module domains
                    Similar known gene clusters from MIBiG 4.0
                    Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                    Click on reference genes to show details of similarities to genes within the current region.
                    Click on an accession to open that entry in the MiBIG database.