BGC0001018 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001018 (Microcystis aeruginosa K-139)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	33,711	micropeptin K139	NRPS:Type I	100%

BGC0001018 - Region 1 - NRPS

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Location: 1 - 33,711 nt. (total: 33,711 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 33,712
Label		BGC0001018

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001018	1.00	NRP	micropeptin K139	Microcystis aeruginosa K-139
BGC0000331	0.54	NRP	cyanopeptolin	Planktothrix agardhii NIVA-CYA 116
BGC0000332	0.46	NRP	cyanopeptolin	Microcystis sp. NIVA-CYA 172/5
BGC0000465	0.41	NRP	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061
BGC0001844	0.38	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001050	0.37	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0001434	0.37	NRP	nematophin	Xenorhabdus budapestensis
BGC0001131	0.36	NRP	ambactin	Xenorhabdus miraniensis
BGC0002135	0.36	NRP	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001758	0.35	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001018	1.00	NRP	micropeptin K139	Microcystis aeruginosa K-139
BGC0000331	0.81	NRP	cyanopeptolin	Planktothrix agardhii NIVA-CYA 116
BGC0000332	0.76	NRP	cyanopeptolin	Microcystis sp. NIVA-CYA 172/5
BGC0000465	0.73	NRP	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061
BGC0001844	0.70	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001050	0.70	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0001434	0.70	NRP	nematophin	Xenorhabdus budapestensis
BGC0001131	0.69	NRP	ambactin	Xenorhabdus miraniensis
BGC0002135	0.69	NRP	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001758	0.68	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 33711:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Asp) + (Thr) + (Arg - X - Ile - NMe-Tyr) + (Ile)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

mcnA

Search NORINE for peptide: strict or relaxed

AMP-binding (482..891): Asp

nrpys: Asp

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asp (Asp)

Stachelhaus prediction details:

Stachelhaus sequence:: DLTKIGHVGK
Nearest Stachelhaus code(s):: Asp DLTKIGHVGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

mcnB

Search NORINE for peptide: strict or relaxed

AMP-binding (476..909): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: DFWNIGMVHK
Nearest Stachelhaus code(s):: Thr DFWNIGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

mcnC

Search NORINE for peptide: strict or relaxed

AMP-binding (469..889): Arg

nrpys: Arg

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAEGVGAIAK
Nearest Stachelhaus code(s):: Arg DAEGVGAIAK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1555..1962): X

nrpys: Ahp

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVENAGVVTK
Nearest Stachelhaus code(s):: Ahp DVENAGVVTK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2623..3036): Ile

nrpys: Ile

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: ile (Ile)

Stachelhaus prediction details:

Stachelhaus sequence:: DAFFLGVTFK
Nearest Stachelhaus code(s):: Ile DAFFLGVTFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3695..4098): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DASTIAGVCK
Nearest Stachelhaus code(s):: Tyr DASTIAGVCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

mcnE

Search NORINE for peptide: strict or relaxed

AMP-binding (507..920): Ile

nrpys: Ile

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: ile (Ile)

Stachelhaus prediction details:

Stachelhaus sequence:: DAFFLGVTFK
Nearest Stachelhaus code(s):: Ile DAFFLGVTFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)