BGC0001019: microsclerodermin M biosynthetic gene cluster from Sorangium cellulosum
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 58,049 nt. (total: 58,049 nt).
This entry is originally from NCBI GenBank KF657738.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001019
Short description microsclerodermin M biosynthetic gene cluster from Sorangium cellulosum
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "module 1 has 3 iterations, module 3 has 2 iterations as inferred from molecule structure."
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Type I)
Loci
KF657738.1
via Knock-out studies
Compounds
  • microsclerodermin M
Species Sorangium cellulosum [taxonomy]
References
Chemical products information
microsclerodermin M Evidence:
Copy SMILES
C44H54N8O12
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AHB82049.1
  • mscK
 1 - 1248 (-) MFS transporter
  • Transport
copy AA seq
copy Nt seq
  • AHB82050.1
  • mscJ
 1473 - 2246 (+) Thioesterase II
    copy AA seq
    copy Nt seq
    • AHB82051.1
    • mscA
    		 3859 - 13686 (+) polyketide synthase
    • Scaffold biosynthesis
    copy AA seq
    copy Nt seq
    • AHB82052.1
    • mscB
    		 13709 - 16321 (+) polyketide synthase
    • Scaffold biosynthesis
    copy AA seq
    copy Nt seq
    • AHB82053.1
    • mscC
    		 16327 - 20982 (+) polyketide synthase
    • Scaffold biosynthesis
    copy AA seq
    copy Nt seq
    • AHB82054.1
    • mscD
    		 20995 - 23697 (+) polyketide synthase
    • Scaffold biosynthesis
    copy AA seq
    copy Nt seq
    • AHB82055.1
    • mscE
    		 23727 - 25067 (+) Putative Amidohydrolase
      copy AA seq
      copy Nt seq
      • AHB82056.1
      • mscF
      		 25335 - 32156 (+) non ribosomal peptide synthetase
      • Scaffold biosynthesis
      copy AA seq
      copy Nt seq
      • AHB82057.1
      • mscG
      		 32158 - 36804 (+) polyketide synthase
      • Scaffold biosynthesis
      copy AA seq
      copy Nt seq
      • AHB82058.1
      • mscH
      		 36844 - 49269 (+) non ribosomal peptide synthetase
      • Scaffold biosynthesis
      copy AA seq
      copy Nt seq
      • AHB82059.1
      • mscI
      		 49344 - 58049 (+) non ribosomal peptide synthetase/polyketide synthase
      • Scaffold biosynthesis
      copy AA seq
      copy Nt seq
      Biosynthesis information

      Biosynthetic modules

      Name
      5
      Type
      nrps-type1
      Genes
      mscF
      Substrates
      asparagine (evidence: Feeding study, Structure-based inference, Sequence-based prediction)
      Integrated Monomers
      Domains
      condensation (LCL), adenylation
      Name
      7
      Type
      nrps-type1
      Genes
      mscH
      Substrates
      glycine (evidence: Structure-based inference, Sequence-based prediction)
      Integrated Monomers
      Domains
      condensation (LCL), adenylation, methyltransferase
      Name
      8
      Type
      nrps-type1
      Genes
      mscH
      Substrates
      tryptophan (evidence: Structure-based inference, Sequence-based prediction)
      Integrated Monomers
      Domains
      condensation (LCL), adenylation, epimerase
      Name
      9
      Type
      nrps-type1
      Genes
      mscH
      Substrates
      glycine (evidence: Structure-based inference, Sequence-based prediction)
      Integrated Monomers
      Domains
      condensation (DCL), adenylation
      Name
      10
      Type
      nrps-type1
      Genes
      mscI
      Substrates
      glycine (evidence: Structure-based inference, Sequence-based prediction)
      Integrated Monomers
      Domains
      condensation (LCL), adenylation
      Name
      1
      Type
      pks-modular
      Genes
      mscA
      Substrates
      Integrated Monomers
      Domains
      acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, ligase, carrier (ACP)
      Name
      2
      Type
      pks-modular
      Genes
      mscB
      Substrates
      Integrated Monomers
      Domains
      acyltransferase, ketosynthase, acyltransferase
      Name
      3
      Type
      pks-modular
      Genes
      mscC
      Substrates
      Integrated Monomers
      Domains
      acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
      Name
      4
      Type
      pks-modular
      Genes
      mscD
      Substrates
      Integrated Monomers
      Domains
      acyltransferase, ketosynthase, acyltransferase
      Name
      5
      Type
      pks-trans-at-starter
      Genes
      mscF
      Substrates
      Integrated Monomers
      Domains
      carrier (ACP)
      Name
      6
      Type
      pks-modular
      Genes
      mscG
      Substrates
      Integrated Monomers
      Domains
      acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
      Name
      11
      Type
      pks-modular
      Genes
      mscI
      Substrates
      Integrated Monomers
      Domains
      acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
      Annotation changelog

      Entry version: 4

      Date
      Changes
      Submitters
      Reviewers
      2022-10-07
      Update chemical activity to schema version 2.11
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

      Entry version: 3

      Date
      Changes
      Submitters
      Reviewers
      2022-09-15
      Corrected NRP module activity
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      2022-09-15
      Removed ketoreductase stereochemistry annotation from modules without ketoreductases
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      2022-09-15
      Corrected NRP gene names
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      2022-09-15
      Updated NRP substrate specificities
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

      Entry version: 2

      Date
      Changes
      Submitters
      Reviewers
      2019-10-16
      Migrated from v1.4
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      2019-10-16
      Updated compound(s) information (NPAtlas curation)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

      Entry version: 1

      Date
      Changes
      Submitters
      Reviewers
      2015-06-12
      Submitted
      • (ID: RZRTXUKFH6LMF4VTOZ22YQ5Y)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      Detailed domain annotation
      Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
      A domain glossary is available here, and an explanation of the visualisation is available here.
      Selected features only
      Show module domains
      Similar known gene clusters from MIBiG 4.0
      Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
      Click on reference genes to show details of similarities to genes within the current region.
      Click on an accession to open that entry in the MiBIG database.