BGC0001021: mycobactin biosynthetic gene cluster from Mycobacterium tuberculosis H37Rv
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Location: 2,656,200 - 2,680,020 nt. (total: 23,821 nt).
This entry is originally from NCBI GenBank AL123456.3.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001021
Short description mycobactin biosynthetic gene cluster from Mycobacterium tuberculosis H37Rv
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
AL123456.3
2656200 - 2680020
via
Compounds
  • mycobactin
Species Mycobacterium tuberculosis H37Rv [taxonomy]
References
Chemical products information
mycobactin Evidence:
Copy SMILES
C46H76Fe1N5O10
Chemical database entries
PubCHEM
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • Rv2377c
  • CCP45165.1
  • mbtH
 2656215 - 2656430 (-) Putative conserved protein MbtH
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    • Rv2378c
    • CCP45166.1
    • mbtG
    		 2656408 - 2657703 (-) Lysine-N-oxygenase MbtG (L-lysine 6-monooxygenase) (lysine N6-hydroxylase)
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      • Rv2379c
      • CCP45167.1
      • mbtF
      		 2657700 - 2662085 (-) Peptide synthetase MbtF (peptide synthase)
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        • Rv2380c
        • CCP45168.1
        • mbtE
        		 2662067 - 2667115 (-) Peptide synthetase MbtE (peptide synthase)
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          • Rv2381c
          • CCP45169.1
          • mbtD
          		 2667255 - 2670269 (-) Polyketide synthetase MbtD (polyketide synthase)
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            • Rv2382c
            • CCP45170.1
            • mbtC
            		 2670269 - 2671603 (-) Polyketide synthetase MbtC (polyketide synthase)
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              • Rv2383c
              • CCP45171.1
              • mbtB
              		 2671593 - 2675837 (-) Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)
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                • Rv2384
                • CCP45172.1
                • mbtA
                		 2675936 - 2677633 (+) Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase
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                  • Rv2385
                  • CCP45173.1
                  • mbtJ
                  		 2677729 - 2678649 (+) Putative acetyl hydrolase MbtJ
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                    • Rv2386c
                    • CCP45174.1
                    • mbtI
                    		 2678653 - 2680005 (-) Isochorismate synthase MbtI
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                      Biosynthesis information

                      Biosynthetic modules

                      Name
                      Unk01
                      Type
                      nrps-type1
                      Genes
                      mbtF
                      Substrates
                      lysine (evidence: )
                      Integrated Monomers
                      Domains
                      adenylation
                      Annotation changelog

                      Entry version: 4

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2022-10-07
                      Update chemical activity to schema version 2.11
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 3

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2022-09-15
                      Update compound structure (SMILES) for mycobactin
                      • (ID: 5UL74VURKJ25VSPPPO3H2NYB)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2022-09-15
                      Linked new PubChem id for mycobactin (pubchem:136041711)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2022-09-15
                      Updated bioactivity data
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2022-09-15
                      Added NRP substrate specificities
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 2

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2019-10-16
                      Migrated from v1.4
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 1

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2015-06-12
                      Submitted
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      Detailed domain annotation
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