BGC0001023: myxochromide S1 biosynthetic gene cluster from Stigmatella aurantiaca
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Location: 1 - 29,111 nt. (total: 29,111 nt).
This entry is originally from NCBI GenBank AJ698723.2.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001023
Short description myxochromide S1 biosynthetic gene cluster from Stigmatella aurantiaca
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Type I)
Loci
AJ698723.2
via Knock-out studies, Heterologous expression
Compounds
  • myxochromide S1
Species Stigmatella aurantiaca [taxonomy]
References
Chemical products information
myxochromide S1 Evidence:
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C38H54N6O8
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAG28678.1
  • mchA
 1 - 6501 (+) polyketide synthase
  • Scaffold biosynthesis
  • Knock-out
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  • CAG29031.1
  • mchB
 6498 - 15671 (+) nonribosomal peptide synthetase (modules 1 and 2)
  • Scaffold biosynthesis
  • Knock-out
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  • CAG29032.1
  • mchC
 15705 - 29111 (+) nonribosomal peptide synthetase (modules 3 to 6)
  • Scaffold biosynthesis
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Biosynthesis information

Biosynthetic modules

Name
2
Type
nrps-type1
Genes
mchB
Substrates
threonine (evidence: Structure-based inference [1])
Integrated Monomers
Domains
condensation (LCL), adenylation, methyltransferase
Name
3
Type
nrps-type1
Genes
mchB
Substrates
leucine (evidence: Structure-based inference [1])
Integrated Monomers
Domains
condensation (LCL), adenylation, epimerase
Name
4
Type
nrps-type1
Genes
mchC
Substrates
alanine (evidence: Structure-based inference [1])
Integrated Monomers
Domains
condensation (DCL), adenylation
Name
6
Type
nrps-type1
Genes
mchC
Substrates
alanine (evidence: Structure-based inference [1])
Integrated Monomers
Domains
condensation (LCL), adenylation
Name
7
Type
nrps-type1
Genes
mchC
Substrates
glutamine (evidence: Structure-based inference [1])
Integrated Monomers
Domains
condensation (LCL), adenylation
Name
1
Type
pks-modular
Genes
mchA
Substrates
Integrated Monomers
Domains
acyltransferase, ketosynthase, acyltransferase, dehydratase, enoylreductase, ketoreductase, carrier (ACP)
Annotation changelog

Entry version: 4

Date
Changes
Submitters
Reviewers
2022-10-07
Update chemical activity to schema version 2.11
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Entry version: 3

Date
Changes
Submitters
Reviewers
2022-09-15
Corrected NRP module activity
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2022-09-15
Updated bioactivity data
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2022-09-15
Updated NRP substrate specificities
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Entry version: 2

Date
Changes
Submitters
Reviewers
2019-10-16
Migrated from v1.4
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2019-10-16
Updated compound(s) information (NPAtlas curation)
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Entry version: 1

Date
Changes
Submitters
Reviewers
2015-06-12
Submitted
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Detailed domain annotation
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