Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001023.1:
Cluster 1NRP / Polyketide129111

BGC0001023, myxochromide biosynthetic gene cluster from Stigmatella aurantiaca. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Myxochromide S1
SMILES string: Copy to clipboard
Molecular formula: C38H54N6O8
Exact molecular mass: 723.4076 Da ([M+H]+)
Molecular activity: Unknown

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Other (cyclic)
Thioesterase type:
None
Release / cyclization type:
Macrolactonization

Nonribosomal peptide synthetases:
mchB (CAG29031.1)
Module 2
A specificity: Threonine
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Scaffold-modifying domain: Methylation
Module 3
A specificity: Leucine
Evidence for specificity: Structure-based inference
AA is epimerized
C domain subtype: LCL
mchC (CAG29032.1)
Module 4
A specificity: Alanine
Evidence for specificity: Structure-based inference
C domain subtype: DCL
Module 5
A specificity: None
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Module is skipped
Evidence for skipping: Unknown
Module 6
A specificity: Alanine
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Module 7
A specificity: Glutamine
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Polyketide subclass:
Other (linear)
Polyketide synthase subclass:
Modular type I
Starter unit:
Acetyl-CoA
Thioesterase type:
None
Release / cyclization type:
Claisen condensation

Modular polyketide synthases:
mchA (CAG28678.1)
Module 1
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: Unknown
Scaffold-modifying domain: None
Module is iterated
Evidence for iteration: Unknown

Gene cluster description

myxochromide (BGC0001023). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank AJ698723, positions 1-29111. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Heterologous expression
MIxS-compliance:Unknown
Contact for this cluster:Daniel Krug (Helmholtz Institute for Pharmaceutical Research Saarland)

Literature references

1. Wenzel SC et al. (2005) Structure and biosynthesis of myxochromides S1-3 in Stigmatella aurantiaca: evidence for an iterative bacterial type I polyketide synthase and for module skipping in nonribosomal peptide biosynthesis. Chembiochem 6(2):375-85. doi: 10.1002/cbic.200400282.