BGC0001023: myxochromide S1 biosynthetic gene cluster from Stigmatella aurantiaca
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Location: 1 - 29,111 nt. (total: 29,111 nt).
This entry is originally from NCBI GenBank AJ698723.2.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001023
Short description myxochromide S1 biosynthetic gene cluster from Stigmatella aurantiaca
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Other)
Loci NCBI GenBank: AJ698723.2
Compounds
  • myxochromide S1
Species Stigmatella aurantiaca [taxonomy]
References
Chemical products information
myxochromide S1
Copy SMILES
C38H54N6O8
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAG28678.1
  • mchA
1 - 6501 (+) polyketide synthase
  • Scaffold biosynthesis
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  • CAG29031.1
  • mchB
6498 - 15671 (+) nonribosomal peptide synthetase (modules 1 and 2)
  • Scaffold biosynthesis
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  • CAG29032.1
  • mchC
15705 - 29111 (+) nonribosomal peptide synthetase (modules 3 to 6)
  • Scaffold biosynthesis
Sequence-based prediction
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Polyketide-specific information
Subclass Other
Starter unit Acetyl-CoA
Cyclic? no
Release type
  • Claisen condensation
Polyketide-synthases
Genes Properties Modules
mchA Synthase subclass: Modular type I
Module 1
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: mchA
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Enoylreductase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Non-canonical activity:
  • Iterated
Evidence for non-canonical activity:
  • Structure-based inference
NRP-specific information
Subclass N/A
Cyclic? yes
Release type
  • Macrolactonization
Thioesterase genes
  • mchC (Unknown)
NRP-synthases
Gene Modules
mchB
Module 2
Specificity: threonine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Modification domains: Methylation
Module 3
Specificity: leucine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
mchC
Module 4
Specificity: alanine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: DCL
Module 5 [inactive]
Condensation domain type: LCL
Non-canonical activity:
  • Other
Evidence for non-canonical activity:
  • Structure-based inference
Module 6
Specificity: alanine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Module 7
Specificity: glutamine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: 7SR74ARK6JXRBGJRGO2LUHE7, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Updated bioactivity data
  • Updated NRP substrate specificities
Detailed domain annotation
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