BGC0001024: myxothiazol biosynthetic gene cluster from Stigmatella aurantiaca DW4/3-1
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Location: 1 - 42,603 nt. (total: 42,603 nt).
This entry is originally from NCBI GenBank AF188287.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001024
Short description myxothiazol biosynthetic gene cluster from Stigmatella aurantiaca DW4/3-1
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Other)
Loci NCBI GenBank: AF188287.1
Compounds
  • myxothiazol
Species Stigmatella aurantiaca DW4/3-1 [taxonomy]
References
Chemical products information
myxothiazol
Copy SMILES
C25H33N3O3S2
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAF19809.1
  • mtaA
 1 - 834 (+) MtaA
  • Activation / processing
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  • AAF19810.1
  • mtaB
 1388 - 13399 (+) MtaB
  • Scaffold biosynthesis
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  • AAF19811.1
  • mtaC
 13537 - 17409 (+) mtaC
  • Scaffold biosynthesis
Sequence-based prediction
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  • AAF19812.1
  • mtaD
 17406 - 27281 (+) MtaD
  • Scaffold biosynthesis
Sequence-based prediction
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  • AAF19813.1
  • mtaE
 27340 - 33183 (+) MtaE
  • Scaffold biosynthesis
Sequence-based prediction
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  • AAF19814.1
  • mtaF
 33188 - 37270 (+) MtaF
  • Scaffold biosynthesis
Sequence-based prediction
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  • AAF19815.1
  • mtaG
 37285 - 42537 (+) mtaG
  • Scaffold biosynthesis
Sequence-based prediction
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Polyketide-specific information
Subclass Other
Starter unit 3-Methylbutyryl-CoA
Cyclic? no
Polyketide-synthases
Genes Properties Modules
mtaB
+
mtaD
+
mtaF
+
mtaE 		Synthase subclass: Modular type I
Module 1
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: mtaB
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Enoylreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 2
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: mtaB
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 5
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: mtaD
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 6
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: mtaE
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 7
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: mtaF
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
mtaC
Module 3
Specificity: cysteine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Heterocyclization
Modification domains: Oxidation
mtaD
Module 4
Specificity: cysteine
Evidence for specificity:
Condensation domain type: Heterocyclization
Modification domains: Oxidation
mtaG
Module 8
Specificity: glycine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: 7SR74ARK6JXRBGJRGO2LUHE7, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Remove leading/trailing whitespace in gene identifiers
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Changed amino acid substrates to lower case
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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