BGC0001025: myxovirescin A1 biosynthetic gene cluster from Myxococcus xanthus DK 1622
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Location: 4,726,438 - 4,809,194 nt. (total: 82,757 nt).
This entry is originally from NCBI GenBank CP000113.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001025
Short description myxovirescin A1 biosynthetic gene cluster from Myxococcus xanthus DK 1622
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Trans-AT type I)
Loci
CP000113.1
4726438 - 4809194
via Knock-out studies
Compounds
  • myxovirescin A1
Species Myxococcus xanthus DK 1622 [taxonomy]
References
Chemical products information
myxovirescin A1 Evidence:
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C35H61N1O8
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • MXAN_3928
  • ABF89352.1
 4726438 - 4727436 (-) radical SAM domain protein
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    • MXAN_3929
    • ABF89309.1
    		 4727927 - 4728967 (-) hypothetical protein
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      • MXAN_3930
      • ABF90441.1
      • lspA
      		 4729395 - 4729922 (+) signal peptidase II
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        • MXAN_3931
        • ABF89350.1
        		 4729983 - 4730855 (-) methyltransferase
        • Tailoring
        • Knock-out
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        • MXAN_3932
        • ABF88102.1
        		 4730911 - 4740024 (-) polyketide synthase
        • Scaffold biosynthesis
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        • MXAN_3933
        • ABF92489.1
        		 4740017 - 4755469 (-) mixed type I polyketide synthase - peptide synthetase
        • Scaffold biosynthesis
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        • MXAN_3934
        • ABF87992.1
        		 4755331 - 4756788 (-) PfaD family protein
        • Tailoring
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        • MXAN_3935
        • ABF85931.1
        		 4756846 - 4783794 (-) non-ribosomal peptide synthase/polyketide synthase Ta1
        • Scaffold biosynthesis
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        • MXAN_3936
        • ABF92824.1
        		 4783781 - 4790329 (-) polyketide synthase
        • Scaffold biosynthesis
        • Knock-out
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        • MXAN_3937
        • ABF90561.1
        		 4790333 - 4791433 (-) luciferase-like monooxygenase
        • Tailoring
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        • MXAN_3938
        • ABF89568.1
        		 4791436 - 4797702 (-) polyketide synthase
        • Scaffold biosynthesis
        • Knock-out
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        • MXAN_3939
        • ABF92581.1
        		 4797714 - 4798457 (-) "putative enoyl-CoA-hydratase
        • Tailoring
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        • MXAN_3940
        • ABF86745.1
        		 4798472 - 4799260 (-) enoyl-CoA hydratase/isomerase family protein
        • Tailoring
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        • MXAN_3941
        • ABF92774.1
        		 4799268 - 4800521 (-) polyketide synthase
        • Scaffold biosynthesis
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        • MXAN_3942
        • ABF91606.1
        • fabD
        		 4800583 - 4802556 (-) acyltranferase/malonyl CoA-acyl carrier protein transacylase
        • Activation / processing
        • Knock-out
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        • MXAN_3943
        • ABF86324.1
        		 4802585 - 4804048 (-) cytochrome P450
        • Tailoring
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        • MXAN_3944
        • ABF89615.1
        • lspA
        		 4804061 - 4804576 (-) signal peptidase II
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          • MXAN_3945
          • ABF92623.1
          • taF
          		 4804604 - 4805854 (-) HMGCoA synthase
          • Tailoring
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          • MXAN_3946
          • ABF88942.1
          		 4805847 - 4806098 (-) acyl carier protein
          • Scaffold biosynthesis
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          • MXAN_3947
          • ABF88380.1
          		 4806103 - 4807080 (-) conserved hypothetical protein
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            • MXAN_3948
            • ABF90176.1
            • taC
            		 4807103 - 4808365 (-) HMGCoA synthase
            • Tailoring
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            • MXAN_3949
            • ABF90753.1
            		 4808375 - 4808614 (-) acyl-carrier protein
            • Scaffold biosynthesis
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            • MXAN_3950
            • ABF91060.1
            • taA
            		 4808688 - 4809194 (-) NusG-like protein; NusG-like protein
            • Regulation
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            Biosynthesis information

            Biosynthetic modules

            Name
            1
            Type
            pks-trans-at
            Genes
            MXAN_3935
            Substrates
            Integrated Monomers
            Domains
            ketosynthase, ketoreductase, dehydratase, carrier (ACP)
            Name
            2
            Type
            pks-trans-at
            Genes
            MXAN_3935
            Substrates
            Integrated Monomers
            Domains
            ketosynthase, ketoreductase, carrier (ACP)
            Name
            3
            Type
            pks-trans-at
            Genes
            MXAN_3935
            Substrates
            Integrated Monomers
            Domains
            ketosynthase, carrier (ACP)
            Name
            4
            Type
            pks-trans-at
            Genes
            MXAN_3935
            Substrates
            Integrated Monomers
            Domains
            ketosynthase, ketoreductase, dehydratase, carrier (ACP)
            Name
            5
            Type
            pks-trans-at
            Genes
            MXAN_3935
            Substrates
            Integrated Monomers
            Domains
            ketosynthase, carrier (ACP)
            Name
            6
            Type
            pks-trans-at
            Genes
            MXAN_3935
            Substrates
            Integrated Monomers
            Domains
            ketosynthase, ketoreductase, dehydratase, carrier (ACP)
            Name
            7
            Type
            pks-trans-at
            Genes
            MXAN_3935
            Substrates
            Integrated Monomers
            Domains
            ketosynthase, carrier (ACP)
            Name
            8
            Type
            pks-trans-at
            Genes
            MXAN_3933
            Substrates
            Integrated Monomers
            Domains
            ketosynthase, ketoreductase, dehydratase, carrier (ACP)
            Name
            9
            Type
            pks-trans-at
            Genes
            MXAN_3933
            Substrates
            Integrated Monomers
            Domains
            ketosynthase, dehydratase, carrier (ACP)
            Name
            10
            Type
            pks-trans-at
            Genes
            MXAN_3933
            Substrates
            Integrated Monomers
            Domains
            ketosynthase, ketoreductase, dehydratase, carrier (ACP)
            Name
            11
            Type
            pks-trans-at
            Genes
            MXAN_3933 MXAN_3932
            Substrates
            Integrated Monomers
            Domains
            ketosynthase, methyltransferase, carrier (ACP)
            Name
            12
            Type
            pks-trans-at
            Genes
            MXAN_3932
            Substrates
            Integrated Monomers
            Domains
            ketosynthase, ketoreductase, dehydratase, enoylreductase, methyltransferase, carrier (ACP)
            Annotation changelog

            Entry version: 4

            Date
            Changes
            Submitters
            Reviewers
            2022-10-07
            Update chemical activity to schema version 2.11
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

            Entry version: 3

            Date
            Changes
            Submitters
            Reviewers
            2022-09-15
            Removed ketoreductase stereochemistry annotation from modules without ketoreductases
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            2022-09-15
            Changed gene identifiers to consistently use locus tag instead of a mix of locus and protein ID
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            2022-09-15
            Merged cross-CDS PKS modules
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            2022-09-15
            Updated bioactivity data
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

            Entry version: 2

            Date
            Changes
            Submitters
            Reviewers
            2019-10-16
            Migrated from v1.4
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            2019-10-16
            Updated compound(s) information (NPAtlas curation)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

            Entry version: 1

            Date
            Changes
            Submitters
            Reviewers
            2015-06-12
            Submitted
            • (ID: 7SR74ARK6JXRBGJRGO2LUHE7)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            Detailed domain annotation
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