Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001025.1:
Cluster 1NRP / Polyketide182757

BGC0001025, myxovirescin biosynthetic gene cluster from Myxococcus xanthus. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Myxovirescin A
SMILES string: Copy to clipboard
Molecular formula: C35H61N1O8
Exact molecular mass: 624.447 Da ([M+H]+)
Molecular activity: Antibacterial

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Other (linear)
Thioesterase type:
None
Release / cyclization type:
Macrolactonization

Polyketide subclass:
Macrolide (cyclic)
Polyketide synthase subclass:
Trans-AT type I
Starter unit:
Other
Polyketide synthase / ketosynthase-encoding genes:
ABF91606.1
Thioesterase type:
Type I
Release / cyclization type:
Macrolactonization

Modular polyketide synthases:
Ta1 (ABF85931.1)
Module 1
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Module 2
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: B-group
Module 3
AT specificity: None
Evidence for specificity: Unknown
Module 4
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Module 5
AT specificity: None
Evidence for specificity: Unknown
Module 6
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Module 7
AT specificity: None
Evidence for specificity: Unknown

taO (MXAN_3933)
Module 8
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Module 9
AT specificity: None
Evidence for specificity: Unknown
Module 10
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Module 11
AT specificity: None
Evidence for specificity: Unknown
Scaffold-modifying domain: Methylation

taP (ABF88102.1)
Module 11
AT specificity: None
Evidence for specificity: Unknown
Module 12
AT specificity: None
Evidence for specificity: Unknown
KR stereochemistry: A-group
Scaffold-modifying domain: Methylation

Gene cluster description

myxovirescin (BGC0001025). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank CP000113, positions 18728-128324. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
MIxS-compliance:No
Contact for this cluster:Daniel Krug (HIPS)

Literature references

1. Simunovic V et al. (2006) Myxovirescin A biosynthesis is directed by hybrid polyketide synthases/nonribosomal peptide synthetase, 3-hydroxy-3-methylglutaryl-CoA synthases, and trans-acting acyltransferases. Chembiochem 7(8):1206-20. doi: 10.1002/cbic.200600075.