BGC0001025: myxovirescin A1 biosynthetic gene cluster from Myxococcus xanthus DK 1622
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Location: 4,726,438 - 4,809,194 nt. (total: 82,757 nt).
This entry is originally from NCBI GenBank CP000113.1.

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core biosynthetic genes
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001025
Short description myxovirescin A1 biosynthetic gene cluster from Myxococcus xanthus DK 1622
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Macrolide)
Loci NCBI GenBank: CP000113.1
Compounds
  • myxovirescin A1
Species Myxococcus xanthus DK 1622 [taxonomy]
References
Chemical products information
myxovirescin A1
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C35H61N1O8
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • MXAN_3928
  • ABF89352.1
 4726438 - 4727436 (-) radical SAM domain protein
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  • MXAN_3929
  • ABF89309.1
 4727927 - 4728967 (-) hypothetical protein
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  • MXAN_3930
  • ABF90441.1
  • lspA
 4729395 - 4729922 (+) signal peptidase II
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  • MXAN_3931
  • ABF89350.1
 4729983 - 4730855 (-) methyltransferase
  • Tailoring (Methylation)
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  • MXAN_3932
  • ABF88102.1
 4730911 - 4740024 (-) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • MXAN_3933
  • ABF92489.1
 4740017 - 4755469 (-) mixed type I polyketide synthase - peptide synthetase
  • Scaffold biosynthesis
Sequence-based prediction
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  • MXAN_3934
  • ABF87992.1
 4755331 - 4756788 (-) PfaD family protein
  • Tailoring (Dioxygenation)
Sequence-based prediction
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  • MXAN_3935
  • ABF85931.1
 4756846 - 4783794 (-) non-ribosomal peptide synthase/polyketide synthase Ta1
  • Scaffold biosynthesis
Sequence-based prediction
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  • MXAN_3936
  • ABF92824.1
 4783781 - 4790329 (-) polyketide synthase
  • Scaffold biosynthesis
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  • MXAN_3937
  • ABF90561.1
 4790333 - 4791433 (-) luciferase-like monooxygenase
  • Tailoring (Oxidation)
Sequence-based prediction
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  • MXAN_3938
  • ABF89568.1
 4791436 - 4797702 (-) polyketide synthase
  • Scaffold biosynthesis
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  • MXAN_3939
  • ABF92581.1
 4797714 - 4798457 (-) "putative enoyl-CoA-hydratase
  • Tailoring (Unknown)
Sequence-based prediction
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  • MXAN_3940
  • ABF86745.1
 4798472 - 4799260 (-) enoyl-CoA hydratase/isomerase family protein
  • Tailoring (Unknown)
Sequence-based prediction
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  • MXAN_3941
  • ABF92774.1
 4799268 - 4800521 (-) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • MXAN_3942
  • ABF91606.1
  • fabD
 4800583 - 4802556 (-) acyltranferase/malonyl CoA-acyl carrier protein transacylase
  • Activation / processing
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  • MXAN_3943
  • ABF86324.1
 4802585 - 4804048 (-) cytochrome P450
  • Tailoring (Oxidation)
Sequence-based prediction
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  • MXAN_3944
  • ABF89615.1
  • lspA
 4804061 - 4804576 (-) signal peptidase II
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  • MXAN_3945
  • ABF92623.1
  • taF
 4804604 - 4805854 (-) HMGCoA synthase
  • Tailoring (Acetylation)
Sequence-based prediction
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  • MXAN_3946
  • ABF88942.1
 4805847 - 4806098 (-) acyl carier protein
  • Scaffold biosynthesis
Sequence-based prediction
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  • MXAN_3947
  • ABF88380.1
 4806103 - 4807080 (-) conserved hypothetical protein
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  • MXAN_3948
  • ABF90176.1
  • taC
 4807103 - 4808365 (-) HMGCoA synthase
  • Tailoring (Acetylation)
Sequence-based prediction
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  • MXAN_3949
  • ABF90753.1
 4808375 - 4808614 (-) acyl-carrier protein
  • Scaffold biosynthesis
Sequence-based prediction
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  • MXAN_3950
  • ABF91060.1
  • taA
 4808688 - 4809194 (-) NusG-like protein; NusG-like protein
  • Regulation
Sequence-based prediction
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Polyketide-specific information
Subclass Macrolide
Cyclic? yes
Release type
  • Macrolactonization
Polyketide-synthases
Genes Properties Modules
MXAN_3935
+
MXAN_3933
+
fabD
+
MXAN_3932 		Synthase subclass: Trans-AT type I
Trans-acyltansferases: fabD
Module 1
Genes: MXAN_3935
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 2
Genes: MXAN_3935
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 3
Genes: MXAN_3935
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Module 4
Genes: MXAN_3935
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 5
Genes: MXAN_3935
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Module 6
Genes: MXAN_3935
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 7
Genes: MXAN_3935
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Module 8
Genes: MXAN_3933
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 9
Genes: MXAN_3933
Core domains: Ketosynthase, Dehydratase, Thiolation (ACP/PCP)
Module 10
Genes: MXAN_3933
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 11
Genes: MXAN_3933, MXAN_3932
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
Module 12
Genes: MXAN_3932
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Enoylreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: D-OH
NRP-specific information
Subclass N/A
Cyclic? no
Release type
  • Macrolactonization
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: 7SR74ARK6JXRBGJRGO2LUHE7, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Changed gene identifiers to consistently use locus tag instead of a mix of locus and protein ID
  • Merged cross-CDS PKS modules
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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