BGC0001027: nocobactin NA biosynthetic gene cluster from Nocardia farcinica IFM 10152
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Location: 820,180 - 840,689 nt. (total: 20,510 nt).
This entry is originally from NCBI GenBank AP006618.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001027
Short description nocobactin NA biosynthetic gene cluster from Nocardia farcinica IFM 10152
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
AP006618.1
820180 - 840689
via
Compounds
  • nocobactin NA
  • nocobactin NA 10152B
Species Nocardia farcinica IFM 10152 [taxonomy]
References
Chemical products information
nocobactin NA Evidence:
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C36H53N5O10
Chemical database entries
PubCHEM
nocobactin NA 10152B Evidence:
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C38H57N5O10
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • NFA_7610
  • BAD55606.1
  • nbtG
 820180 - 821469 (+) putative lysine-N-oxygenase
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    • NFA_7620
    • BAD55607.1
    • nbtH
    		 821524 - 822204 (-) putative N6-hydroxylysine acetyltransferase
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      • NFA_7630
      • BAD55608.1
      • nbtA
      		 822348 - 823103 (+) thioesterase
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        • NFA_7640
        • BAD55609.1
        • nbtB
        		 823100 - 824410 (+) putative polyketide synthase
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          • NFA_7650
          • BAD55610.1
          • nbtC
          		 824403 - 827489 (+) putative polyketide synthase
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            • NFA_7660
            • BAD55611.1
            • nbtD
            		 827508 - 832613 (+) putative non-ribosomal peptide synthetase
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              • NFA_7670
              • BAD55612.1
              • nbtE
              		 832610 - 837178 (+) non-ribosomal peptide synthetase
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                • NFA_7680
                • BAD55613.1
                • nbtF
                		 837186 - 840689 (+) putative non-ribosomal peptide synthetase
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                  Biosynthesis information

                  Biosynthetic modules

                  Name
                  Unk01
                  Type
                  nrps-type1
                  Genes
                  nbtD
                  Substrates
                  N6-hydroxylysine (evidence: Structure-based inference, X-ray crystallography)
                  Integrated Monomers
                  Domains
                  adenylation
                  Name
                  Unk02
                  Type
                  nrps-type1
                  Genes
                  nbtE
                  Substrates
                  N6-hydroxylysine (evidence: Structure-based inference, X-ray crystallography)
                  Integrated Monomers
                  Domains
                  adenylation
                  Name
                  Unk03
                  Type
                  nrps-type1
                  Genes
                  nbtF
                  Substrates
                  threonine (evidence: )
                  Integrated Monomers
                  Domains
                  adenylation
                  Annotation changelog

                  Entry version: 4

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2022-10-07
                  Update chemical activity to schema version 2.11
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                  Entry version: 3

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2022-09-15
                  Update compound structure (SMILES) for nocobactin NA
                  • (ID: 5UL74VURKJ25VSPPPO3H2NYB)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  2022-09-15
                  Add new compound: nocobactin NA 10152B
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  2022-09-15
                  Updated bioactivity data
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  2022-09-15
                  Added NRP substrate specificities
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                  Entry version: 2

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2019-10-16
                  Migrated from v1.4
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  2019-10-16
                  Updated compound(s) information (NPAtlas curation)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                  Entry version: 1

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2015-06-12
                  Submitted
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  Detailed domain annotation
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