Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001028.1:
Cluster 1NRP140989

BGC0001028, nostopeptolide biosynthetic gene cluster from Nostoc sp. GSV224. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: nostopeptolide A
SMILES string: Copy to clipboard
Molecular formula: C52H78N10O14
Exact molecular mass: 1067.2343 Da (None)
Molecular activity: Unknown

Class-specific details

Biosynthetic class(es):
NRP
Cyclic depsipeptide (cyclic)
Thioesterase type:
Type I
Release / cyclization type:
Macrolactonization

Nonribosomal peptide synthetases:
nosA (AAF15891.2)
Module 1
A specificity: Isoleucine
Evidence for specificity: Activity assay
C domain subtype: LCL
Module 2
A specificity: Serine
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Module 3
A specificity: Proline
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Module 4
A specificity: Leucine
Evidence for specificity: Structure-based inference
C domain subtype: LCL
nosC (AAF17280.1)
Module 6
A specificity: Leucine
Evidence for specificity: Activity assay
C domain subtype: LCL
Module 7
A specificity: Glycine
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Module 8
A specificity: Asparigine
Evidence for specificity: Structure-based inference
C domain subtype: LCL
nosD (AAF17281.1)
Module 10
A specificity: Proline
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Module 9
A specificity: Tyrosine
Evidence for specificity: Activity assay
C domain subtype: LCL

Gene cluster description

nostopeptolide (BGC0001028). Gene Cluster 1. Biosynthetic class = NRP. GenBank AF204805, positions 1-40989. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Enzymatic assays
MIxS-compliance:Unknown
Contact for this cluster:Bradley S Moore (Scripps Institution of Oceanography)

Literature references

1. Hoffmann D et al. (2003) Sequence analysis and biochemical characterization of the nostopeptolide A biosynthetic gene cluster from Nostoc sp. GSV224. Gene 311:171-80.