BGC0001029: nostophycin biosynthetic gene cluster from Nostoc sp. 152
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Location: 1 - 55,508 nt. (total: 55,508 nt).
This entry is originally from NCBI GenBank JF430079.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001029
Short description nostophycin biosynthetic gene cluster from Nostoc sp. 152
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
JF430079.1
via
Compounds
  • nostophycin
Species Nostoc sp. 152 [taxonomy]
References
Chemical products information
nostophycin Evidence:
Copy SMILES
C46H64N8O10
Chemical database entries
NPAtlas
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AEU10996.1
 2 - 1390 (+) ResB-like protein
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    • AEU10997.1
    		 1487 - 2578 (+) ABC transporter
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      • AEU10998.1
      		 2610 - 4286 (-) hypothetical protein
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        • AEU10999.1
        		 4439 - 4849 (-) GTP cyclohydrolase
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          • AEU11000.1
          		 4881 - 5279 (-) hypothetical protein
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            • AEU11001.1
            		 5432 - 5812 (-) hypothetical protein
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              • AEU11002.1
              		 6331 - 6888 (+) putative RNA ligase
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                • AEU11005.1
                • npnA
                		 7801 - 23181 (+) NpnA
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                  • AEU11006.1
                  • npnB
                  		 23208 - 37514 (+) NpnB
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                    • AEU11003.1
                    • npnC
                    		 37517 - 52732 (+) NpnC
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                      • AEU11004.1
                      		 52949 - 55249 (-) hypothetical protein
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                        Biosynthesis information

                        Biosynthetic modules

                        Name
                        0
                        Type
                        nrps-type1
                        Genes
                        npnA
                        Substrates
                        3R-amino-2S,5R-dihydroxy-8-phenyloctanoic acid (evidence: Structure-based inference)
                        Integrated Monomers
                        Domains
                        adenylation
                        Name
                        4
                        Type
                        nrps-type1
                        Genes
                        npnB
                        Substrates
                        glutamine (evidence: Sequence-based prediction)
                        Integrated Monomers
                        Domains
                        condensation (LCL), adenylation, epimerase
                        Name
                        5
                        Type
                        nrps-type1
                        Genes
                        npnB
                        Substrates
                        glycine (evidence: Sequence-based prediction)
                        Integrated Monomers
                        Domains
                        condensation (DCL), adenylation
                        Name
                        6
                        Type
                        nrps-type1
                        Genes
                        npnC
                        Substrates
                        proline (evidence: Sequence-based prediction)
                        Integrated Monomers
                        Domains
                        condensation (LCL), adenylation
                        Name
                        7
                        Type
                        nrps-type1
                        Genes
                        npnC
                        Substrates
                        phenylalanine (evidence: ATP-PPi exchange assay [1])
                        Integrated Monomers
                        Domains
                        condensation (LCL), adenylation
                        Name
                        8
                        Type
                        nrps-type1
                        Genes
                        npnC
                        Substrates
                        isoleucine (evidence: Activity assay)
                        Integrated Monomers
                        Domains
                        condensation (LCL), adenylation, epimerase
                        Name
                        9
                        Type
                        nrps-type1
                        Genes
                        npnC
                        Substrates
                        proline (evidence: Sequence-based prediction)
                        Integrated Monomers
                        Domains
                        condensation (DCL), adenylation
                        Name
                        1
                        Type
                        pks-modular
                        Genes
                        npnA
                        Substrates
                        Integrated Monomers
                        Domains
                        acyltransferase, ketosynthase, acyltransferase, dehydratase, enoylreductase, ketoreductase, carrier (ACP)
                        Name
                        2
                        Type
                        pks-modular
                        Genes
                        npnA
                        Substrates
                        Integrated Monomers
                        Domains
                        acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                        Name
                        3
                        Type
                        pks-modular
                        Genes
                        npnB
                        Substrates
                        Integrated Monomers
                        Domains
                        acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                        Annotation changelog

                        Entry version: 4

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2022-10-07
                        Update chemical activity to schema version 2.11
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                        Entry version: 3

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2022-09-15
                        Corrected NRP module activity
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        2022-09-15
                        Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        2022-09-15
                        Updated bioactivity data
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        2022-09-15
                        Updated NRP substrate specificities
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                        Entry version: 2

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2019-10-16
                        Migrated from v1.4
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        2019-10-16
                        Updated compound(s) information (NPAtlas curation)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                        Entry version: 1

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2015-06-12
                        Submitted
                        • (ID: BAJIZJS2YANDM4M7JHS5DFUK)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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