Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001029.1:
Cluster 1NRP155508

BGC0001029, nostophycin biosynthetic gene cluster from Nostoc sp. 152. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Nostophycin
ChemSpider ID: 8899707
SMILES string: Copy to clipboard
Molecular formula:
Average molecular mass: Da
Molecular activity: Unknown

Class-specific details

Biosynthetic class(es):
NRP
Other (cyclic)
Thioesterase type:
None
Release / cyclization type:
Hydrolysis

Nonribosomal peptide synthetases:
npnA (AEU11005.1)
Module 0
A specificity: VGVWVAASGK
Evidence for specificity: Activity assay
C domain subtype: N/A
npnB (AEU11006.1)
Module 4
A specificity: DAWLFGLIDK
Evidence for specificity: Sequence-based prediction
AA is epimerized
C domain subtype: LCL
Module 5
A specificity: DILALGLIWK
Evidence for specificity: Sequence-based prediction
C domain subtype: DCL
npnC (AEU11003.1)
Module 6
A specificity: DVQFIAHVVK
Evidence for specificity: Sequence-based prediction
C domain subtype: LCL
Module 7
A specificity: DAWTIAAVCK
Evidence for specificity: Activity assay
C domain subtype: LCL
Module 8
A specificity: DAFFLGVTFK
Evidence for specificity: Activity assay
AA is epimerized
C domain subtype: LCL
Module 9
A specificity: DVQFIAHVVK
Evidence for specificity: Sequence-based prediction
C domain subtype: DCL

Gene cluster description

nostophycin (BGC0001029). Gene Cluster 1. Biosynthetic class = NRP. GenBank JF430079. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:David Fewer (University of Helsinki)

Literature references

1. Fewer DP et al. (2011) Nostophycin biosynthesis is directed by a hybrid polyketide synthase-nonribosomal peptide synthetase in the toxic cyanobacterium Nostoc sp. strain 152. Appl Environ Microbiol 77(22):8034-40. doi: 10.1128/AEM.05993-11. Epub