BGC0001029: nostophycin biosynthetic gene cluster from Nostoc sp. 152
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Location: 1 - 55,508 nt. (total: 55,508 nt).
This entry is originally from NCBI GenBank JF430079.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001029
Short description nostophycin biosynthetic gene cluster from Nostoc sp. 152
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide
Loci NCBI GenBank: JF430079.1
Compounds
  • nostophycin
Species Nostoc sp. 152 [taxonomy]
References
Chemical products information
nostophycin
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C46H64N8O10
Chemical database entries
NPAtlas
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AEU10996.1
 2 - 1390 (+) ResB-like protein
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  • AEU10997.1
 1487 - 2578 (+) ABC transporter
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  • AEU10998.1
 2610 - 4286 (-) hypothetical protein
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  • AEU10999.1
 4439 - 4849 (-) GTP cyclohydrolase
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  • AEU11000.1
 4881 - 5279 (-) hypothetical protein
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  • AEU11001.1
 5432 - 5812 (-) hypothetical protein
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  • AEU11002.1
 6331 - 6888 (+) putative RNA ligase
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  • AEU11005.1
  • npnA
 7801 - 23181 (+) NpnA
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  • AEU11006.1
  • npnB
 23208 - 37514 (+) NpnB
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  • AEU11003.1
  • npnC
 37517 - 52732 (+) NpnC
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  • AEU11004.1
 52949 - 55249 (-) hypothetical protein
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Polyketide-specific information
Subclass Unknown
Cyclic? no
Polyketide-synthases
Genes Properties Modules
npnA
+
npnB 		Synthase subclass:
Module 1
Specificity: Malonyl-CoA
Genes: npnA
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Enoylreductase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 2
Specificity: Malonyl-CoA
Genes: npnA
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 3
Specificity: Malonyl-CoA
Genes: npnB
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
NRP-specific information
Subclass N/A
Cyclic? yes
Release type
  • Hydrolysis
NRP-synthases
Gene Modules
npnA
Module 0
Specificity: 3R-amino-2S,5R-dihydroxy-8-phenyloctanoic acid
Evidence for specificity:
  • Structure-based inference
npnB
Module 4
Specificity: glutamine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
Module 5
Specificity: glycine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: DCL
npnC
Module 6
Specificity: proline
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
Module 7
Specificity: phenylalanine
Evidence for specificity:
  • ATP-PPi exchange assay
Condensation domain type: LCL
Module 8
Specificity: isoleucine
Evidence for specificity:
  • Activity assay
Condensation domain type: LCL
Module 9
Specificity: proline
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: DCL
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: BAJIZJS2YANDM4M7JHS5DFUK, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Updated bioactivity data
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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