Gene cluster description
pellasoren (BGC0001034). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank HE616533, positions 708-61485. Click on genes for more information.
Homologous known gene clusters
General MIBiG information on this cluster
|Complete gene cluster sequence?||complete|
|Evidence for cluster-compound connection:||Knock-out studies|
|Comments:||DH of module 7 is inactive as inferred from the structure of pellasoren. Active site alignment showed two aa being different to the other active DHs within the cluster. I don't know how to mark this DH as inactive.|
|Contact for this cluster:||Thomas Hoffmann (Helmholtz Institute for Pharmaceutical Research Saarland (HIPS))|
1. Jahns C et al. (2012) Pellasoren: structure elucidation, biosynthesis, and total synthesis of a cytotoxic secondary metabolite from Sorangium cellulosum. Angew Chem Int Ed Engl 51(21):5239-43. doi: 10.1002/anie.201200327.