BGC0001034: pellasoren biosynthetic gene cluster from Sorangium cellulosum
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Location: 1 - 61,485 nt. (total: 61,485 nt).
This entry is originally from NCBI GenBank HE616533.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0001034
Short description pellasoren biosynthetic gene cluster from Sorangium cellulosum
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "DH of module 7 is inactive as inferred from the structure of pellasoren. Active site alignment showed two aa being different to the other active DHs within the cluster. I don't know how to mark this DH as inactive."
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Type I)
Loci
HE616533.1
via Knock-out studies
Compounds
  • pellasoren
  • pellasoren B
Species Sorangium cellulosum [taxonomy]
References
Chemical products information
pellasoren Evidence:
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C26H41N1O4
Chemical database entries
PubCHEM
pellasoren B Evidence:
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C26H41N1O4
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CCE88383.1
  • pelT
 1478 - 3736 (+) ABC transporter protein
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    • CCE88382.1
    • pelG
    		 4808 - 7192 (+) polyketide synthase
    • Precursor biosynthesis
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    • CCE88386.1
    • pelH
    		 7189 - 8040 (+) hydroxyacyl-CoA dehydrogenase
    • Precursor biosynthesis
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    • CCE88387.1
    • pelI
    		 8044 - 8325 (+) Ppant binding-site containing protein
    • Precursor biosynthesis
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    • CCE88384.1
    • pelJ
    		 8375 - 9529 (+) acyl-CoA dehydrogenase
    • Precursor biosynthesis
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    • CCE88385.1
    • pelK
    		 9581 - 10711 (+) HAD superfamily phosphatase
    • Precursor biosynthesis
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    • CCE88377.1
    • pelA
    		 10735 - 22728 (+) non-ribosomal peptide synthetase/polyketide synthase
    • Scaffold biosynthesis
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    • CCE88381.1
    • pelB
    		 22730 - 28303 (+) polyketide synthase
    • Scaffold biosynthesis
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    • CCE88380.1
    • pelC
    		 28317 - 33929 (+) polyketide synthase
    • Scaffold biosynthesis
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    • CCE88376.1
    • pelD
    		 33926 - 45976 (+) polyketide synthase
    • Scaffold biosynthesis
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    • CCE88379.1
    • pelE
    		 45973 - 51621 (+) polyketide synthase
    • Scaffold biosynthesis
    • Knock-out
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    • CCE88378.1
    • pelF
    		 51618 - 58979 (+) polyketide synthase
    • Scaffold biosynthesis
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    Biosynthesis information

    Biosynthetic modules

    Name
    2
    Type
    nrps-type1
    Genes
    pelA
    Substrates
    alanine (evidence: Structure-based inference)
    Integrated Monomers
    Domains
    condensation (LCL), adenylation
    Name
    1
    Type
    pks-modular
    Genes
    pelA
    Substrates
    Integrated Monomers
    Domains
    acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, enoylreductase, carrier (ACP)
    Name
    2
    Type
    pks-trans-at-starter
    Genes
    pelA
    Substrates
    Integrated Monomers
    Domains
    ketoreductase
    Name
    3
    Type
    pks-modular
    Genes
    pelB
    Substrates
    Integrated Monomers
    Domains
    acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
    Name
    4
    Type
    pks-modular
    Genes
    pelC
    Substrates
    Integrated Monomers
    Domains
    acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
    Name
    5
    Type
    pks-modular
    Genes
    pelD
    Substrates
    Integrated Monomers
    Domains
    acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
    Name
    6
    Type
    pks-modular
    Genes
    pelD
    Substrates
    Integrated Monomers
    Domains
    acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, enoylreductase, carrier (ACP)
    Name
    7
    Type
    pks-modular
    Genes
    pelE
    Substrates
    Integrated Monomers
    Domains
    acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
    Name
    8
    Type
    pks-modular
    Genes
    pelF
    Substrates
    Integrated Monomers
    Domains
    acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, enoylreductase, carrier (ACP)
    Annotation changelog

    Entry version: 4

    Date
    Changes
    Submitters
    Reviewers
    2022-10-07
    Update chemical activity to schema version 2.11
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

    Entry version: 3

    Date
    Changes
    Submitters
    Reviewers
    2022-09-15
    Update compound structure (SMILES) for pellasoren
    • (ID: 5UL74VURKJ25VSPPPO3H2NYB)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    2022-09-15
    Linked new PubChem id for pellasoren (pubchem:60145150)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    2022-09-15
    Add new compound: pellasoren B
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    2022-09-15
    Corrected NRP module activity
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    2022-09-15
    Corrected gene identifiers
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    2022-09-15
    Changed amino acid substrates to lower case
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

    Entry version: 2

    Date
    Changes
    Submitters
    Reviewers
    2019-10-16
    Migrated from v1.4
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

    Entry version: 1

    Date
    Changes
    Submitters
    Reviewers
    2015-06-12
    Submitted
    • (ID: RZRTXUKFH6LMF4VTOZ22YQ5Y)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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