BGC0001035: pneumocandin B0 biosynthetic gene cluster from Glarea lozoyensis ATCC 20868
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Location: 180,393 - 296,227 nt. (total: 115,835 nt).
This entry is originally from NCBI GenBank KE145356.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001035
Short description pneumocandin B0 biosynthetic gene cluster from Glarea lozoyensis ATCC 20868
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide
  • NRP
Loci NCBI GenBank: KE145356.1
Compounds
  • pneumocandin B0
  • pneumocandin A0
Species Glarea lozoyensis ATCC 20868 [taxonomy]
References
Chemical products information
pneumocandin B0
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C50H80N8O17
Chemical database entries
NPAtlas
PubCHEM
pneumocandin A0
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C51H82N8O17
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • GLAREA_10020
  • EPE34326.1
 180393 - 181353 (-) heterokaryon incompatibility protein
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  • GLAREA_10021
  • EPE34327.1
 182554 - 184500 (+) alpha/beta-Hydrolase
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  • GLAREA_10022
  • EPE34328.1
 185467 - 186512 (-) hypothetical protein
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  • GLAREA_10023
  • EPE34329.1
 188198 - 192242 (-) hypothetical protein
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  • GLAREA_10024
  • EPE34330.1
 192814 - 196319 (+) vWA-like protein
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  • GLAREA_10025
  • EPE34331.1
 197590 - 198369 (+) hypothetical protein
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  • GLAREA_10026
  • EPE34332.1
 199366 - 201280 (-) hypothetical protein
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  • GLAREA_10027
  • EPE34333.1
 203148 - 204811 (-) hypothetical protein
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  • GLAREA_10028
  • EPE34334.1
 205415 - 206770 (+) hypothetical protein
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  • GLAREA_10029
  • EPE34335.1
 208475 - 210659 (-) Winged helix DNA-binding protein
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  • GLAREA_10030
  • EPE34336.1
 213690 - 215442 (-) Cytochrome P450
  • Tailoring (Hydroxylation)
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  • GLAREA_10031
  • EPE34337.1
 215868 - 217547 (+) Cytochrome P450
  • Tailoring (Hydroxylation)
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  • GLAREA_10032
  • EPE34338.1
 217962 - 218919 (+) alpha/beta-Hydrolase
  • Unknown
Sequence-based prediction
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  • GLAREA_10033
  • EPE34339.1
 219395 - 220466 (-) nonheme mononuclear iron oxygenase
  • Tailoring (Hydroxylation)
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  • GLAREA_10034
  • EPE34340.1
 220862 - 228891 (-) polyketide synthase
  • Scaffold biosynthesis
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  • GLAREA_10035
  • EPE34341.1
 230546 - 252235 (+) non-ribosomal peptide synthetase
  • Scaffold biosynthesis
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  • GLAREA_10036
  • EPE34342.1
 253841 - 258579 (+) ABC-transporter
  • Unknown
Sequence-based prediction
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  • GLAREA_10037
  • EPE34343.1
 258935 - 261970 (-) Aconitase
  • Precursor biosynthesis
Sequence-based prediction
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  • GLAREA_10038
  • EPE34344.1
 262418 - 263855 (+) Isopropylmalate dehydrogenase
  • Precursor biosynthesis
Sequence-based prediction
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  • GLAREA_10039
  • EPE34345.1
 264293 - 266317 (-) isopropyl malate synthase
  • Precursor biosynthesis
Sequence-based prediction
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  • GLAREA_10040
  • EPE34346.1
 267099 - 268369 (-) D-aminoacid aminotransferase
  • Precursor biosynthesis
Sequence-based prediction
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  • GLAREA_10041
  • EPE34347.1
 268608 - 269705 (-) nonheme mononuclear iron oxygenase
  • Tailoring (Hydroxylation)
Activity assay
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  • GLAREA_10042
  • EPE34348.1
 270159 - 271199 (+) nonheme mononuclear iron oxygenase
  • Tailoring (Hydroxylation)
Sequence-based prediction
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  • GLAREA_10043
  • EPE34349.1
 271791 - 273838 (-) acyl-AMP ligase
  • Transport
Sequence-based prediction
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  • GLAREA_10044
  • EPE34350.1
 275478 - 276584 (+) nonheme mononuclear iron oxygenase
  • Tailoring (Hydroxylation)
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  • GLAREA_10045
  • EPE34351.1
 277253 - 279400 (-) hypothetical protein
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  • GLAREA_10046
  • EPE34352.1
 284860 - 285558 (+) hypothetical protein
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  • GLAREA_10047
  • EPE34353.1
 286919 - 288178 (+) hypothetical protein
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  • GLAREA_10048
  • EPE34354.1
 288504 - 289227 (+) hypothetical protein
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  • GLAREA_10049
  • EPE34355.1
 290531 - 291572 (-) hypothetical protein
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  • GLAREA_10050
  • EPE34356.1
 293985 - 296227 (-) C2H2 and C2HC zinc finger
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Polyketide-specific information
Subclass Unknown
Cyclic? no
Polyketide-synthases
Genes Properties Modules
GLAREA_10034 Synthase subclass:
Module 1
Specificity: Malonyl-CoA
Genes: GLAREA_10034
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Enoylreductase, Ketoreductase
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: Unknown
Non-canonical activity:
  • Iterated
Evidence for non-canonical activity:
  • Sequence-based prediction
NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
GLAREA_10035
Module 1
Condensation domain type: Starter
Module 2
Specificity: 4,5-dihydroxyornithine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Module 3
Specificity: threonine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Module 4
Specificity: 4R-hydroxyproline
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Module 5
Specificity: 3S,4S-dihydroxyhomotyrosine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Module 6
Specificity: 3-hydroxyglutamine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Module 7
Specificity: 3S-hydroxy-4S-methylproline / 3S-hydroxyproline
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Unknown
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: HLWXAJASFSPJVZTT5243VTF5, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: 3UOU7PODQJXIM6BEPUHHRRA5, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Remove aminocoumarin BGC type
  • Cleaned up synonym list
  • Corrected NRP module activity
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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