Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001035.1:
Cluster 1Other1115835

BGC0001035, pneumocandin biosynthetic gene cluster from Glarea lozoyensis. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: pneumocandin B0
PubChem ID: 5742645
SMILES string: Copy to clipboard
Molecular formula: C50H80N8O17
Average molecular mass: 1065.229 Da
Molecular activity: Antifungal
Molecular target: Glucan synthase

Class-specific details

Biosynthetic class(es):
Other
Other biosynthetic class:
Aminocoumarin

Gene cluster description

pneumocandin (BGC0001035). Gene Cluster 1. Biosynthetic class = Other. GenBank KE145356, positions 213690-279400. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Li Chen (university of Texas Health Science Center at Houston)

Literature references

1. Chen L et al. (2013) Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in the fungus Glarea lozoyensis. BMC Genomics 14:339. doi: 10.1186/1471-2164-14-339.
2. Li Y et al. (2015) Genetic Manipulation of the Pneumocandin Biosynthetic Pathway for Generation of Analogues and Evaluation of Their Antifungal Activity. ACS Chem Biol 10(7):1702-10. doi: 10.1021/acschembio.5b00013. Epub
3. Chen L et al. (2015) Engineering of Glarea lozoyensis for exclusive production of the pneumocandin B0 precursor of the antifungal drug caspofungin acetate. Appl Environ Microbiol 81(5):1550-8. doi: 10.1128/AEM.03256-14. Epub
4. Houwaart S et al. (2014) Pneumocandin biosynthesis: involvement of a trans-selective proline hydroxylase. Chembiochem 15(16):2365-9. doi: 10.1002/cbic.201402175. Epub 2014 Oct
5. Chen L et al. (2016) Engineering of New Pneumocandin Side-Chain Analogues from Glarea lozoyensis by Mutasynthesis and Evaluation of Their Antifungal Activity. ACS Chem Biol 11(10):2724-2733. doi: 10.1021/acschembio.6b00604.