BGC0001036: polyoxypeptin biosynthetic gene cluster from Streptomyces sp. MK498-98F14
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Location: 1 - 73,445 nt. (total: 73,445 nt).
This entry is originally from NCBI GenBank KF386858.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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resistance
TTA codons
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Gene details
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General
Compounds
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NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001036
Short description polyoxypeptin biosynthetic gene cluster from Streptomyces sp. MK498-98F14
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide
Loci NCBI GenBank: KF386858.1
Compounds
  • polyoxypeptin
Species Streptomyces sp. MK498-98F14 [taxonomy]
References
Chemical products information
polyoxypeptin
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C45H76N8O15
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AGZ15443.1
 1 - 1269 (-) 3-dehydroquinate synthase
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  • AGZ15444.1
 1379 - 1765 (-) MarR family transcriptional regulator
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  • AGZ15445.1
 1860 - 2300 (+) hypothetical protein
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  • AGZ15446.1
 2334 - 4034 (+) putative polyketide oxygenase/hydroxylase
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  • AGZ15447.1
 4206 - 5339 (-) alcohol dehydrogenase BadC
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  • AGZ15448.1
 5423 - 6361 (-) 3-oxoacyl-[acyl-carrier-protein] synthase III
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  • AGZ15449.1
 6358 - 6606 (-) hypothetical protein
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  • AGZ15450.1
 6658 - 6906 (-) dihydrolipoamide succinyltransferase
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  • AGZ15451.1
 6903 - 7883 (-) 2-oxoisovalerate dehydrogenase
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  • AGZ15452.1
 7883 - 8794 (-) pyruvate dehydrogenase
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  • AGZ15453.1
 9465 - 9680 (+) MbtH-like protein
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  • AGZ15454.1
 9770 - 10447 (+) putative regulator
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  • AGZ15455.1
 10526 - 12112 (+) non-ribosomal peptide synthetase
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  • AGZ15456.1
 12144 - 12377 (+) putative peptide synthetase
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  • AGZ15457.1
 12463 - 13650 (+) putative hydroxylase
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  • AGZ15458.1
 13694 - 21445 (+) putative non-ribosomal peptide synthetase
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  • AGZ15459.1
 20806 - 29235 (+) putative non-ribosomal peptide synthetase
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  • AGZ15460.1
 29232 - 34220 (+) putative non-ribosomal peptide synthetase
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  • AGZ15461.1
 34267 - 35010 (+) putative thioesterase
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  • AGZ15462.1
 35178 - 36116 (+) daunorubicin resistance ABC transporter
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  • AGZ15463.1
 36113 - 36874 (+) ABC transporter system
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  • AGZ15464.1
 36858 - 39989 (-) transcriptional regulator
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  • AGZ15465.1
 40381 - 41619 (+) cytochrome P450 monooxygenase
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  • AGZ15466.1
 41691 - 43043 (-) aminotransferase class I and II
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  • AGZ15467.1
 44033 - 44959 (+) polyketide fumonisin
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  • AGZ15468.1
 45638 - 46450 (-) L-proline 3-hydroxylase type II
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  • AGZ15469.1
 46983 - 47249 (+) non-ribosomal peptide synthetase
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  • AGZ15470.1
 47246 - 48493 (+) cytochrome P450 monooxygenase
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  • AGZ15471.1
 48490 - 49227 (+) thioesterase II
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  • AGZ15472.1
 49280 - 52375 (+) putative modular polyketide synthase
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  • AGZ15473.1
 52415 - 58033 (+) putative type I polyketide synthase
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  • AGZ15474.1
 58043 - 64642 (+) putative type I polyketide synthase
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  • AGZ15475.1
 64639 - 67764 (+) putative type 1 modular polyketide synthase
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  • AGZ15476.1
 67952 - 71194 (+) putative non ribosomal peptide synthetase
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  • AGZ15477.1
 71245 - 72006 (+) putative thioesterase
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  • AGZ15478.1
 72270 - 72509 (+) LysR family transcriptional regulator
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  • AGZ15479.1
 72582 - 73445 (+) hypothetical protein
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
AGZ15455.1
Module ?
Specificity: alanine / leucine / valine
Evidence for specificity:
AGZ15458.1
Module ?
Specificity: piperazic acid
Evidence for specificity:
Module ?
Specificity: alanine
Evidence for specificity:
AGZ15459.1
Module ?
Specificity: piperazic acid
Evidence for specificity:
Module ?
Specificity: isoleucine
Evidence for specificity:
AGZ15460.1
Module ?
Specificity: valine
Evidence for specificity:
AGZ15476.1
Module ?
Specificity: proline
Evidence for specificity:
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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