LOCUS       BGC0001037             18799 bp    DNA     linear   CON 23-MAR-2015
DEFINITION  Aspergillus fumigatus Af293 chromosome 8, whole genome shotgun
            sequence.
ACCESSION   BGC0001037
VERSION     BGC0001037
KEYWORDS    .
SOURCE      Aspergillus fumigatus Af293
  ORGANISM  Aspergillus fumigatus Af293
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Aspergillus; Aspergillus subgen. Fumigati.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 14:43:36
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 18799
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..1338)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="AFUA_8G00530"
                     /note="encoded by transcript AFUA_8G00530A"
                     /old_locus_tag="Afu8g00530"
                     /product="alpha/beta hydrolase, putative"
                     /protein_id="EAL85114.1"
                     /sec_met_domain="PF00561 (E-value: 6.3e-08, bitscore: 20.9,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.4e-09, bitscore:
                     27.3, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATIHKLFKSPFFDFEFLRLLAMAPYEGAEIGEVLEAAAKIKDQD
                     PESWYSTLLETGGKAEAIAKQAEASGDRVGARRAYLRSSNYLRAAQFMLNEGPIGHDER
                     VLPTLERAIANFRKGVQYRDGKTIFLEIPYEGGKTLPGYLYLPPAARRIPGRKIPILLN
                     SGGGDSTQEEIYFVNPAYGPDLGYAVLTFEGPGQGIVLRRDKLPMRPDWESVTGPVLDH
                     LFDLATRHPELELDLDHIAVTGASMGGYFALRAAADPRIKACVSVDGFYSLSSFVGGRM
                     PGPLFNGFMSGWLSDWMFNGILGVLKKLAFQARWEFNHLRWATGSTTDADVMRSFGAYT
                     LQKADGTEYLADVKCPTLVTGAGASFYFDPATTTDKIYDCLTSLQDGVDKEKWIATDVA
                     YGGLQAKIGAFGYSAQKTFEWLDQRFGIQREPLAASSRLEDLVSRL"
     protocluster    1..18799
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[1800:14106]"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1801..14106
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     protocluster    1..18799
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[1800:14106]"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      1801..14106
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="2"
     cand_cluster    1..18799
                     /SMILES="C([*])C(-O)NC(Cc1ccccc1)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /kind="chemical_hybrid"
                     /product="NRPS"
                     /product="T1PKS"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     subregion       1..18799
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001037"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..18799
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /product="T1PKS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX))"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(<1..>1338)
                     /locus_tag="AFUA_8G00530"
                     /old_locus_tag="Afu8g00530"
     mRNA            complement(<1..>1338)
                     /locus_tag="AFUA_8G00530"
                     /note="transcript AFUA_8G00530A"
                     /old_locus_tag="Afu8g00530"
                     /product="alpha/beta hydrolase, putative"
     gene            <1801..>14106
                     /locus_tag="AFUA_8G00540"
                     /old_locus_tag="Afu8g00540"
     mRNA            join(<1801..2764,2820..2957,3022..8404,8462..8819,
                     8880..9344,9391..>14106)
                     /locus_tag="AFUA_8G00540"
                     /note="transcript AFUA_8G00540A; non-consensus splice site"
                     /old_locus_tag="Afu8g00540"
                     /product="hybrid PKS-NRPS enzyme, putative"
     CDS             join(1801..2764,2820..2957,3022..8404,8462..8819,
                     8880..9344,9391..14106)
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (10-445). E-value:
                     5.3e-162. Score: 531.4. Matches aSDomain:
                     nrpspksdomains_AFUA_8G00540_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (574-891). E-value: 1.8e-81.
                     Score: 265.6. Matches aSDomain:
                     nrpspksdomains_AFUA_8G00540_PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_DH (968-1146). E-value: 3.9e-26.
                     Score: 84.3. Matches aSDomain:
                     nrpspksdomains_AFUA_8G00540_PKS_DH.1"
                     /NRPS_PKS="Domain: PKS_KR (2129-2304). E-value: 5.8e-49.
                     Score: 158.3. Matches aSDomain:
                     nrpspksdomains_AFUA_8G00540_PKS_KR.1"
                     /NRPS_PKS="Domain: PKS_PP (2415-2493). E-value: 4.9e-12.
                     Score: 37.9. Matches aSDomain:
                     nrpspksdomains_AFUA_8G00540_PKS_PP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (2588-2884). E-value:
                     7.5e-65. Score: 210.7. Matches aSDomain:
                     nrpspksdomains_AFUA_8G00540_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (3053-3463). E-value:
                     3.4e-82. Score: 268.0. Matches aSDomain:
                     nrpspksdomains_AFUA_8G00540_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (3578-3651). E-value: 2.3e-13.
                     Score: 42.0. Matches aSDomain:
                     nrpspksdomains_AFUA_8G00540_PCP.1"
                     /NRPS_PKS="Domain: TD (3693-3921). E-value: 6.6e-71. Score:
                     230.2. Matches aSDomain: nrpspksdomains_AFUA_8G00540_TD.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     itr_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 209; E-value:
                     2e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="AFUA_8G00540"
                     /note="encoded by transcript AFUA_8G00540A; non-consensus
                     splice site; GO_function: GO:0016218 - polyketide synthase
                     activity"
                     /old_locus_tag="Afu8g00540"
                     /product="hybrid PKS-NRPS enzyme, putative"
                     /protein_id="EAL85113.2"
                     /sec_met_domain="itr_KS (E-value: 1.2e-166, bitscore:
                     543.0, seeds: 96, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 1.6e-82, bitscore: 265.6,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 3.7e-43, bitscore:
                     136.0, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="Condensation (E-value: 1.1e-49, bitscore:
                     157.5, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 3.9e-87, bitscore:
                     280.8, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 5.1e-14, bitscore:
                     41.1, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 4.4e-40, bitscore:
                     125.7, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVYTHSPKEPIAIIGTGCRFPGGSTSPSKLWDLLYSPRDLTREVP
                     AESRFNPKGFYNVDGEHHGASNATNAYFIEEDPRYFDAGFFSIAPREAESIDPQQRLLL
                     ETVYEAMENAGLTLNGMRGSATSAYMGAMSADYTDTQLRDIENVSKYMITGTSRALLAN
                     RLSYFFDWKGPSISVDTACSSSLAAVHLGVQALRAGECTISCVGGSNIILNPDCYLAAT
                     SLHLLSPTGRSQMWDQAADGYARGEGVCVFFMKTLSQALRDGDRIDALLRETCVNSDGR
                     TQGIALPSAEAQVSLMRTAYKNAGLDLSKAEDRPQYIEAHGTGTQAGDPREAYAIATTF
                     FPPGEDHSHRPKLVVGSVKTIIGHTEGCAGIAGILKAVLAMRHKTIPPNQHFHNLNPSV
                     KPSFKHLSIATSPQPWPVVPPDTPLRASVNGFGSGGTNCHAIVESYVPEIHDNGPWGKP
                     KEMTQVPNGVAAPETDFSPIPLIFSASSGTALRAMLERYQEYLERTEVSLLRLAMTLNS
                     HRSTLPVRVSIPGTSKADVLAAIRTQLAKVGSNPGAEIGTRSSVPEFDHVRRPKILGVF
                     TGQGAQWAGMGQGLMAKSALFRQVIEVMEEAMAQLPDGPEWSLKEEIMKPPKTSRLGEA
                     EISLPVCAALQVGLVKVLRSAGITFSMVVGHSGGEIGSAYAAGKISEVDAIKIAYYRGV
                     YTKLAIGKDGKKGGMIAVGFGYEDGLNFCAMEQFADRLTVAASNSPKSVTLSGDLDAVH
                     EAKELLDAEGVFNRVLRLDTAYHSPHMYPCAAPYLAAIERCGLVAGKSNGTAWASSVYD
                     DNRMMTSAQDKDLEAAYWKDNLIGRVLFSQAVERALDEGNGDFDLALEIGPHPSLKGPT
                     LETIRHKIGSEIPYSGVLDRKADDILALSTALGFSWLTLGSGVVDFAGYVSGFDPSNAS
                     ILNAPALPDLPTYPWDHKKVLYRESRLNKNVRHRVDPPHPLLGSRTPDDTDYEPRWRNF
                     LIMEELPWLRDHCVQGQIIVPAATYSVMALEAAKVLCRGKHVQSIELSDVAILRPIVLD
                     EASDGTETLFSVRSDLDSNKKHEDEIHAQFTLSAGAMDDRHLRTAATGHIRITLAAEAP
                     SSFPNGPRPTELDLLPTSVDRFYASMDEIGLSYSGPFRAMTSMKRRLNVASATVAVDRD
                     LAGTIPVHPTWLDACFQTFLAAFAAPRDGSLWTAFMPTAIGRMVFSPSSTSQVPGRSVT
                     VDAHITDFAPGYQVSLPTLTGDMSIFNSETNQLQIQIEDFVMSSFLPASEKDDRRFYLQ
                     NVWGQEMLSGALCAAAERCVAPTESESKIIDTCEKAVHYYLSKLKAAGLLDQWADKNPG
                     LRSLMNEIEARVTSIPEQSDLVSMLGEVGEHIDLVLVRTIGESLLNSPSEGLGPITPSP
                     MGALISRWHHEGLGFAQLQRHFVSAAKQISHQHANLRILQVGPSSPGLVRSVCQELGRS
                     LERYTLVDDSEQTIEEMKSALAADQLRVDFTTASVENGIDAVNHLTSAGGFDLVIVHKA
                     FTKQVTALKTVRNLLRPGGFMLMMAATGAQLRFPFMLMSTLPSLDDERLAQTKFINATR
                     AETHDLLRQIGFSGVDSIALDNVPDKHTFSVVVSQALDDHIAFLRSPLTSPSPVPLSGN
                     LLVVGGFSADIAKLATAIQSLVSTVWHGDIINVRTLAELDDEASTVEAVLSLTDLDRPV
                     LEDVRAPTFRGLQRLFSEAKTVLWITHRAKADNPYHNATIGLGRSFQSENPQKVLQFLD
                     VDTLDGVESAIAETFLKLIGGVNMRNSNPADPTRLWTIEPEVSLENGKYLVPRLFPDTE
                     RNDRLNALRRKVQTQVSVETQPISLSRSAQSDQVAYTAEAVHFHRDLADGATDPVTIQV
                     ELCSTEPVIPNIDNEDLFCFVGRTSEGARLVGLSTSNSSVVKVPREWTIPVDKHTSHDQ
                     GAFVLELRNEIQSLVIAKSIPPGSTTLIYEPDPHLAASLQRPGRPATSSVSFRARSTWS
                     IPGSHILIDPHASRKDIQAKVPPKTRMLIHMEQGPETCEFLALRQALPPYATVVAFNDL
                     AADDVNPRELLAEALSIIRGDSQSTKVPFDPSSVVKASALVAGGTREHANAAVVDWTGA
                     QSITLSPRPVDTRNLFSPNKTYLLVGLTGHIGQSICRWMVQGGARHIVVTSRHPEKQGQ
                     LWREELLRQGVNIVIEAADVTKEHDLLDLRARIVSSMPPVGGIANGAMVLDDKLFIDMP
                     FESFQAAMKPKVQGSIYLEEVFSADNLDFFLFFSSISVMTGQRTQANYVAANNFMVAMA
                     ERRRARGLPASVIDIGMVVGIGVIQRSQNDKGVSAMENSIRQMDYMPVSETDLHHLLAE
                     AILVGQRDESPELITGLETYKPVEGEAPFWHHNVRFSHLITDPDAAQAGADSAGSAQKS
                     LKEMLLSSGGPEEARKVMENALLQYLASSLKLSRETIYTDVPIIDLGIDSLVAVQIRNW
                     TWAEAGYDLPVLKILGGSSVTQICDEVVASLSFDKSSIAAAKVDSQAAPAHKLRPWDKP
                     SADTKRTDSIAPVPRSQIAANGPNGLPNGALKKASKLAVKVRPLWTTQAGGKDTKKGPR
                     PAPIRIQPLSLGQSRLYFLSQYMDDDRVLNCTISYALSGKLDVSKLEQSLIQVVQRHEA
                     LRTSFYTDEKDGKPMQGLLEKSPFRLRVVPGVSASSDVETEFNLIRYRPYDLEQADTFA
                     ATLLSHSPDSHTLICGYHHIIMDGVSWQIFQKDLAMFYNNSGIADSAKHLPAQYSEFTR
                     KQQEDLSCGAYAERLRFFQDQFREPVESLPLFPFAKVGTRKVVKQYAVQEATTHLNAKV
                     VSAIKQASQTSRTTPFHFYLSAFQVLLHRLLETDKMCIGVVDANRSDQNFVNTIGFFLE
                     TIPLWFKVNSEQRFVELLKETRTKAYAALAQTGVPTEEILRACGVASSTTETPLFQVCF
                     NYRMGAGRTAALQGVEMKFLDYVDAQNPFDLVATVDDLDDGTAMITLYLQDYLYDQEGA
                     QLLATMYANVLQVLAENPERLVGSVSISNATLEDEGVKLGTGPILDLVAPSTPTLSKIF
                     HTWVDKDPHALAVKDTTGKSKTYVQLAERANAIAASLLNAGAAPSIPIGVLLDPGVDTI
                     ATILAILRIGAAYVPLDTRSSDAVLSDILQESQPGIVIHHSATAPRSQILLKASAKTKL
                     VTLNAVPQKTIRKIQDVSVPEGLAMILYTSGSTGSPKGIPLTNANIRTPILGVSERVPL
                     GREVVLQQSGQGFDAAVYQIFIALANGGTLIMVDNRDDPAKVAALMAQESVTCTTHIVS
                     EMQALLKYGYDELRNCSSWRIAMVAGEAFTVHLLDQFRALNRPDLKVINAYGPTEASIC
                     SSLGEVSFNRISSSETSIPIGKAIPNYGTYIVDQHCKPVPLGWPGEVAIAGPGVASGYL
                     NLGELTQAKFRSAATLGEVFGSDCLYLTGDRGRMLSDGSIVLSGRVDGDDQVKIRGHRV
                     QLGDVARALVQASRGVFADAAVILKGDDTSNPQLVAYVVFSRTSNIQDQQTYLRQLNQD
                     LPVPAYMRPAITIPLDTLPVTDRGKLDSKKLASLPLPSISVDYEEDEQLTPTEARLRDV
                     WKNVLGDIASSIPIRRSSDFFSVGGNSLILLALKAEIAQVFGVGLSVSELFQASTLELL
                     AARLDGTSLLAQINWEEETAPDETQFTLPPPINGINGHGSSNGHAQGISVLLTGATGFL
                     GGHILRQLVQLPSVEHVHCVAIRPNKVDVRRQLSVESPKIIRYSGDLALPNMGMSESEF
                     SDLFKSIDVIVHNGAEVSHMKNYRSLRAANFLSTVGLARAAVSRGIPIHYISTGGVARL
                     SVADEQPEASLAAFHPPIDGSDGYVASKWASEVFLEKVQRRFQGQVWIHRPSSITGDDV
                     PDNDIAHSLLKFSRELGAVPELTGSGFFDFINVETVSNNIAASVVRSSEKSGGGLIYLH
                     QSGEQVIPVGDLQKYVEELEGRPLQVLPLKEWVDLSIRKGLDEVLGSYMLASKGVIRAP
                     LLQRGPHVE"
     aSDomain        join(1831..2764,2820..2957,3022..3254)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AFUA_8G00540_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="5.30E-162"
                     /label="AFUA_8G00540_PKS_KS.1"
                     /locus_tag="AFUA_8G00540"
                     /protein_end="445"
                     /protein_start="10"
                     /score="531.4"
                     /tool="antismash"
                     /translation="IAIIGTGCRFPGGSTSPSKLWDLLYSPRDLTREVPAESRFNPKGF
                     YNVDGEHHGASNATNAYFIEEDPRYFDAGFFSIAPREAESIDPQQRLLLETVYEAMENA
                     GLTLNGMRGSATSAYMGAMSADYTDTQLRDIENVSKYMITGTSRALLANRLSYFFDWKG
                     PSISVDTACSSSLAAVHLGVQALRAGECTISCVGGSNIILNPDCYLAATSLHLLSPTGR
                     SQMWDQAADGYARGEGVCVFFMKTLSQALRDGDRIDALLRETCVNSDGRTQGIALPSAE
                     AQVSLMRTAYKNAGLDLSKAEDRPQYIEAHGTGTQAGDPREAYAIATTFFPPGEDHSHR
                     PKLVVGSVKTIIGHTEGCAGIAGILKAVLAMRHKTIPPNQHFHNLNPSVKPSFKHLSIA
                     TSPQPWPVVPPDTPLRASVNGFGSGGTNCHAIVESY"
     aSModule        1831..9561
                     /complete
                     /domains="nrpspksdomains_AFUA_8G00540_PKS_KS.1"
                     /domains="nrpspksdomains_AFUA_8G00540_PKS_AT.1"
                     /domains="nrpspksdomains_AFUA_8G00540_PKS_DH.1"
                     /domains="nrpspksdomains_AFUA_8G00540_PKS_KR.1"
                     /domains="nrpspksdomains_AFUA_8G00540_PKS_PP.1"
                     /iterative
                     /locus_tags="AFUA_8G00540"
                     /monomer_pairings="pk -> pk"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       2317..2364
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AFUA_8G00540_0001"
                     /evalue="8.20E-06"
                     /label="PKSI-KS_m3"
                     /locus_tag="AFUA_8G00540"
                     /protein_end="188"
                     /protein_start="172"
                     /score="17.9"
                     /tool="antismash"
                     /translation="GPSISVDTACSSSLAA"
     CDS_motif       2506..2544
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AFUA_8G00540_0002"
                     /evalue="2.80E-03"
                     /label="PKSI-KS_m4"
                     /locus_tag="AFUA_8G00540"
                     /protein_end="248"
                     /protein_start="235"
                     /score="11.0"
                     /tool="antismash"
                     /translation="WDQAADGYARGEG"
     CDS_motif       join(2749..2764,2820..2851)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AFUA_8G00540_0003"
                     /evalue="9.00E-04"
                     /label="PKSI-KS_m5"
                     /locus_tag="AFUA_8G00540"
                     /protein_end="332"
                     /protein_start="316"
                     /score="11.7"
                     /tool="antismash"
                     /translation="YIEAHGTGTQAGDPRE"
     CDS_motif       join(2933..2957,3022..3053)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AFUA_8G00540_0004"
                     /evalue="1.00E+01"
                     /label="PKSI-AT-mM_m3"
                     /locus_tag="AFUA_8G00540"
                     /protein_end="378"
                     /protein_start="359"
                     /score="-0.6"
                     /tool="antismash"
                     /translation="TIIGHTEGCAGIAGILKAV"
     CDS_motif       3642..3692
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AFUA_8G00540_0005"
                     /evalue="4.00E-05"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="AFUA_8G00540"
                     /protein_end="591"
                     /protein_start="574"
                     /score="16.1"
                     /tool="antismash"
                     /translation="VFTGQGAQWAGMGQGLM"
     aSDomain        3642..4592
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AFUA_8G00540_PKS_AT.1"
                     /evalue="1.80E-81"
                     /label="AFUA_8G00540_PKS_AT.1"
                     /locus_tag="AFUA_8G00540"
                     /protein_end="891"
                     /protein_start="574"
                     /score="265.6"
                     /specificity="substrate consensus: pk"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mmal"
                     /tool="antismash"
                     /translation="VFTGQGAQWAGMGQGLMAKSALFRQVIEVMEEAMAQLPDGPEWSL
                     KEEIMKPPKTSRLGEAEISLPVCAALQVGLVKVLRSAGITFSMVVGHSGGEIGSAYAAG
                     KISEVDAIKIAYYRGVYTKLAIGKDGKKGGMIAVGFGYEDGLNFCAMEQFADRLTVAAS
                     NSPKSVTLSGDLDAVHEAKELLDAEGVFNRVLRLDTAYHSPHMYPCAAPYLAAIERCGL
                     VAGKSNGTAWASSVYDDNRMMTSAQDKDLEAAYWKDNLIGRVLFSQAVERALDEGNGDF
                     DLALEIGPHPSLKGPTLETIRHKIGSEIPYSGVLDR"
     CDS_motif       3888..3992
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AFUA_8G00540_0006"
                     /evalue="8.20E-07"
                     /label="PKSI-AT-mM_m3"
                     /locus_tag="AFUA_8G00540"
                     /protein_end="691"
                     /protein_start="656"
                     /score="21.7"
                     /tool="antismash"
                     /translation="GITFSMVVGHSGGEIGSAYAAGKISEVDAIKIAYY"
     aSDomain        4824..5357
                     /aSDomain="PKS_DH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AFUA_8G00540_PKS_DH.1"
                     /evalue="3.90E-26"
                     /label="AFUA_8G00540_PKS_DH.1"
                     /locus_tag="AFUA_8G00540"
                     /protein_end="1146"
                     /protein_start="968"
                     /score="84.3"
                     /tool="antismash"
                     /translation="HPLLGSRTPDDTDYEPRWRNFLIMEELPWLRDHCVQGQIIVPAAT
                     YSVMALEAAKVLCRGKHVQSIELSDVAILRPIVLDEASDGTETLFSVRSDLDSNKKHED
                     EIHAQFTLSAGAMDDRHLRTAATGHIRITLAAEAPSSFPNGPRPTELDLLPTSVDRFYA
                     SMDEIGLSYSGPFRA"
     CDS_motif       4908..4985
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AFUA_8G00540_0007"
                     /evalue="6.50E-12"
                     /label="PKSI-DH_m2"
                     /locus_tag="AFUA_8G00540"
                     /protein_end="1022"
                     /protein_start="996"
                     /score="37.8"
                     /tool="antismash"
                     /translation="WLRDHCVQGQIIVPAATYSVMALEAA"
     aSDomain        join(8307..8404,8462..8819,8880..8948)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AFUA_8G00540_PKS_KR.1"
                     /evalue="5.80E-49"
                     /label="AFUA_8G00540_PKS_KR.1"
                     /locus_tag="AFUA_8G00540"
                     /protein_end="2304"
                     /protein_start="2129"
                     /score="158.3"
                     /specificity="KR activity: active"
                     /specificity="KR stereochemistry: B1"
                     /tool="antismash"
                     /translation="KTYLLVGLTGHIGQSICRWMVQGGARHIVVTSRHPEKQGQLWREE
                     LLRQGVNIVIEAADVTKEHDLLDLRARIVSSMPPVGGIANGAMVLDDKLFIDMPFESFQ
                     AAMKPKVQGSIYLEEVFSADNLDFFLFFSSISVMTGQRTQANYVAANNFMVAMAERRRA
                     RGLPASVIDIGM"
     CDS_motif       join(8310..8404,8462)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AFUA_8G00540_0008"
                     /evalue="3.90E-15"
                     /label="PKSI-KR_m1"
                     /locus_tag="AFUA_8G00540"
                     /protein_end="2162"
                     /protein_start="2130"
                     /score="48.3"
                     /tool="antismash"
                     /translation="TYLLVGLTGHIGQSICRWMVQGGARHIVVTSR"
     CDS_motif       join(8739..8819,8880..8909)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AFUA_8G00540_0009"
                     /evalue="2.00E-16"
                     /label="PKSI-KR_m4"
                     /locus_tag="AFUA_8G00540"
                     /protein_end="2291"
                     /protein_start="2254"
                     /score="52.5"
                     /tool="antismash"
                     /translation="LDFFLFFSSISVMTGQRTQANYVAANNFMVAMAERRR"
     aSDomain        join(9282..9344,9391..9561)
                     /aSDomain="PKS_PP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AFUA_8G00540_PKS_PP.1"
                     /evalue="4.90E-12"
                     /label="AFUA_8G00540_PKS_PP.1"
                     /locus_tag="AFUA_8G00540"
                     /protein_end="2493"
                     /protein_start="2415"
                     /score="37.9"
                     /tool="antismash"
                     /translation="PEEARKVMENALLQYLASSLKLSRETIYTDVPIIDLGIDSLVAVQ
                     IRNWTWAEAGYDLPVLKILGGSSVTQICDEVVA"
     aSDomain        9847..10734
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AFUA_8G00540_Condensation_LCL.1"
                     /domain_subtypes="Condensation_LCL"
                     /evalue="7.50E-65"
                     /label="AFUA_8G00540_Condensation_LCL.1"
                     /locus_tag="AFUA_8G00540"
                     /protein_end="2884"
                     /protein_start="2588"
                     /score="210.7"
                     /tool="antismash"
                     /translation="QPLSLGQSRLYFLSQYMDDDRVLNCTISYALSGKLDVSKLEQSLI
                     QVVQRHEALRTSFYTDEKDGKPMQGLLEKSPFRLRVVPGVSASSDVETEFNLIRYRPYD
                     LEQADTFAATLLSHSPDSHTLICGYHHIIMDGVSWQIFQKDLAMFYNNSGIADSAKHLP
                     AQYSEFTRKQQEDLSCGAYAERLRFFQDQFREPVESLPLFPFAKVGTRKVVKQYAVQEA
                     TTHLNAKVVSAIKQASQTSRTTPFHFYLSAFQVLLHRLLETDKMCIGVVDANRSDQNFV
                     NTIGFFLETIPLWFK"
     aSModule        9847..13845
                     /complete
                     /domains="nrpspksdomains_AFUA_8G00540_Condensation_LCL.1"
                     /domains="nrpspksdomains_AFUA_8G00540_AMP-binding.1"
                     /domains="nrpspksdomains_AFUA_8G00540_PCP.1"
                     /domains="nrpspksdomains_AFUA_8G00540_TD.1"
                     /final_module
                     /locus_tags="AFUA_8G00540"
                     /monomer_pairings="Phe -> Phe"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       9916..10020
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AFUA_8G00540_0010"
                     /evalue="3.50E-12"
                     /label="C2_LCL_024-062"
                     /locus_tag="AFUA_8G00540"
                     /protein_end="2646"
                     /protein_start="2611"
                     /score="38.7"
                     /tool="antismash"
                     /translation="NCTISYALSGKLDVSKLEQSLIQVVQRHEALRTSF"
     CDS_motif       10231..10296
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AFUA_8G00540_0011"
                     /evalue="1.60E-07"
                     /label="C3_LCL_132-143"
                     /locus_tag="AFUA_8G00540"
                     /protein_end="2738"
                     /protein_start="2716"
                     /score="23.9"
                     /tool="antismash"
                     /translation="YHHIIMDGVSWQIFQKDLAMFY"
     CDS_motif       10645..10725
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AFUA_8G00540_0012"
                     /evalue="4.00E-04"
                     /label="C5_LCL_267-296"
                     /locus_tag="AFUA_8G00540"
                     /protein_end="2881"
                     /protein_start="2854"
                     /score="12.9"
                     /tool="antismash"
                     /translation="CIGVVDANRSDQNFVNTIGFFLETIPL"
     aSDomain        11242..12471
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AFUA_8G00540_AMP-binding.1"
                     /evalue="3.40E-82"
                     /label="AFUA_8G00540_AMP-binding.1"
                     /locus_tag="AFUA_8G00540"
                     /protein_end="3463"
                     /protein_start="3053"
                     /score="268.0"
                     /specificity="substrate consensus: Phe"
                     /tool="antismash"
                     /translation="FHTWVDKDPHALAVKDTTGKSKTYVQLAERANAIAASLLNAGAAP
                     SIPIGVLLDPGVDTIATILAILRIGAAYVPLDTRSSDAVLSDILQESQPGIVIHHSATA
                     PRSQILLKASAKTKLVTLNAVPQKTIRKIQDVSVPEGLAMILYTSGSTGSPKGIPLTNA
                     NIRTPILGVSERVPLGREVVLQQSGQGFDAAVYQIFIALANGGTLIMVDNRDDPAKVAA
                     LMAQESVTCTTHIVSEMQALLKYGYDELRNCSSWRIAMVAGEAFTVHLLDQFRALNRPD
                     LKVINAYGPTEASICSSLGEVSFNRISSSETSIPIGKAIPNYGTYIVDQHCKPVPLGWP
                     GEVAIAGPGVASGYLNLGELTQAKFRSAATLGEVFGSDCLYLTGDRGRMLSDGSIVLSG
                     RVDGDDQVKIR"
     CDS_motif       11431..11472
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AFUA_8G00540_0013"
                     /evalue="2.60E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="AFUA_8G00540"
                     /protein_end="3130"
                     /protein_start="3116"
                     /score="14.4"
                     /tool="antismash"
                     /translation="LAILRIGAAYVPLD"
     CDS_motif       11668..11724
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AFUA_8G00540_0014"
                     /evalue="4.10E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="AFUA_8G00540"
                     /protein_end="3214"
                     /protein_start="3195"
                     /score="19.4"
                     /tool="antismash"
                     /translation="AMILYTSGSTGSPKGIPLT"
     CDS_motif       12247..12336
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AFUA_8G00540_0015"
                     /evalue="8.90E-11"
                     /label="NRPS-A_a6"
                     /locus_tag="AFUA_8G00540"
                     /protein_end="3418"
                     /protein_start="3388"
                     /score="34.0"
                     /tool="antismash"
                     /translation="PLGWPGEVAIAGPGVASGYLNLGELTQAKF"
     CDS_motif       12451..12498
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AFUA_8G00540_0016"
                     /evalue="1.40E-06"
                     /label="NRPS-A_a8"
                     /locus_tag="AFUA_8G00540"
                     /protein_end="3472"
                     /protein_start="3456"
                     /score="20.8"
                     /tool="antismash"
                     /translation="DDQVKIRGHRVQLGDV"
     aSDomain        12817..13035
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AFUA_8G00540_PCP.1"
                     /evalue="2.30E-13"
                     /label="AFUA_8G00540_PCP.1"
                     /locus_tag="AFUA_8G00540"
                     /protein_end="3651"
                     /protein_start="3578"
                     /score="42.0"
                     /tool="antismash"
                     /translation="EARLRDVWKNVLGDIASSIPIRRSSDFFSVGGNSLILLALKAEIA
                     QVFGVGLSVSELFQASTLELLAARLDGT"
     CDS_motif       13159..13221
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AFUA_8G00540_0017"
                     /evalue="6.20E-02"
                     /label="PKSI-KR_m1"
                     /locus_tag="AFUA_8G00540"
                     /protein_end="3713"
                     /protein_start="3692"
                     /score="6.0"
                     /tool="antismash"
                     /translation="SVLLTGATGFLGGHILRQLVQ"
     aSDomain        13162..13845
                     /aSDomain="TD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AFUA_8G00540_TD.1"
                     /evalue="6.60E-71"
                     /label="AFUA_8G00540_TD.1"
                     /locus_tag="AFUA_8G00540"
                     /protein_end="3921"
                     /protein_start="3693"
                     /score="230.2"
                     /tool="antismash"
                     /translation="VLLTGATGFLGGHILRQLVQLPSVEHVHCVAIRPNKVDVRRQLSV
                     ESPKIIRYSGDLALPNMGMSESEFSDLFKSIDVIVHNGAEVSHMKNYRSLRAANFLSTV
                     GLARAAVSRGIPIHYISTGGVARLSVADEQPEASLAAFHPPIDGSDGYVASKWASEVFL
                     EKVQRRFQGQVWIHRPSSITGDDVPDNDIAHSLLKFSRELGAVPELTGSGFFDFINVET
                     VSNNIA"
     gene            complement(<14341..>15210)
                     /locus_tag="AFUA_8G00550"
                     /old_locus_tag="Afu8g00550"
     mRNA            complement(join(<14341..14987,15042..>15210))
                     /locus_tag="AFUA_8G00550"
                     /note="transcript AFUA_8G00550A"
                     /old_locus_tag="Afu8g00550"
                     /product="methyltransferase SirN-like, putative"
     CDS             complement(join(14341..14987,15042..15210))
                     /codon_start=1
                     /locus_tag="AFUA_8G00550"
                     /note="encoded by transcript AFUA_8G00550A; similar to
                     methyltransferase GliN (GI:56609351) [Aspergillus
                     fumigatus] PMID: 15979823 similar to ubiE/COQ5 family
                     methyltransferase UmtA that negatively regulates sexual
                     development [Emericella nidulans] similar to
                     methyltransferase SirN (GI:46578134) [Leptosphaeria
                     maculans] PMID: 15387811"
                     /old_locus_tag="Afu8g00550"
                     /product="methyltransferase SirN-like, putative"
                     /protein_id="EAL85112.1"
                     /transl_table=11
                     /translation="MDNFMEMTKKLGHQPELLRLRALDATYDDALEGKLVVAPLDMSEP
                     GKKILDSGTADGTWLRNVRSKQSVPHDYYGSDVEGELFPKDPDGITYFAHSFKDPWPQQ
                     YLGFFDLVHIRGSLAGSAPEGPAPVIQNLTTLLKPGGWVQLMEMNAFSPPPNGPAMTDF
                     AKMASEMFTGIGVGDFANNNKSMLEDAGLKNVQEKRVIVNLGKKAKPELHDQSIHGVTG
                     PIVPLTSVARTVKSSFTGEQLDALPARVKEELETEGGQVEMIIAFGQKA"
     gene            <15749..>17497
                     /locus_tag="AFUA_8G00560"
                     /old_locus_tag="Afu8g00560"
     mRNA            join(<15749..15774,15845..16185,16247..17051,17113..>17497)
                     /locus_tag="AFUA_8G00560"
                     /note="transcript AFUA_8G00560A"
                     /old_locus_tag="Afu8g00560"
                     /product="cytochrome P450 oxidoreductase, putative"
     CDS             join(15749..15774,15845..16185,16247..17051,17113..17497)
                     /EC_number="1.14.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 145.1; E-value: 5.3e-44)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="AFUA_8G00560"
                     /note="encoded by transcript AFUA_8G00560A; similar to
                     GB:BAC21103.1: cytochrome P450 2 Le.CYP2 [Lentinula edodes]
                     similar to SP:P79084: O-methylsterigmatocystin
                     oxidoreductase [Aspergillus flavus]; GO_function:
                     GO:0016491 - oxidoreductase activity; GO_process:
                     GO:0008152 - metabolic process"
                     /old_locus_tag="Afu8g00560"
                     /product="cytochrome P450 oxidoreductase, putative"
                     /protein_id="EAL85111.2"
                     /sec_met_domain="p450 (E-value: 3e-55, bitscore: 176.1,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIISSYHLLAPRCRRDQKVYNKSIHVLNTVAKGIKGWPFLGSAPA
                     LAAVDTNGIIGIFKSWAEQYGSITQFSAMGDKQVILTEDKDARELFVRRGIKYSDRGAP
                     HAVEYISMKQNPGFRPKDDGWRRQRSMIQSAINITSINKYQSLMDDEATFTVNALLQSP
                     DSFHGEFLRYSYSVLTSSLLGFSVRSPSDPFIHHNETFTAELMNSFRPDCFPSNVFPVL
                     RKLPMWLLPSLRTMERLRKEYVGEMWAFRRKIEKLVKEGSATECIYKHFLLHRDQYNVT
                     EEESVHTFQAMIDGGTRSPHNNLLTFLFLMMEFPEWQKKLQEEVDRVVGRDRMPSYRDI
                     PNLPTVRAIVKETVRYRSIVAEMGIGHCLQTDDIYKGYFFEKGTVFNAIFASILMDKDT
                     YPDGKLFNPARWLEPSYPTYKEPLTTYPNCQGFPAFGYGRRACPGVDFAERTLVIMFAK
                     LGWTMNIRWPRDEDGNELREELQYEPVPAPRPLKFGCRLEARDADRAKIVEEAAKHLKL
                     Q"
     gene            complement(<17586..>18799)
                     /locus_tag="AFUA_8G00570"
                     /old_locus_tag="Afu8g00570"
     mRNA            complement(join(<17586..18379,18436..>18799))
                     /locus_tag="AFUA_8G00570"
                     /note="transcript AFUA_8G00570A"
                     /old_locus_tag="Afu8g00570"
                     /product="alpha/beta hydrolase, putative"
     CDS             complement(join(17586..18379,18436..18799))
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="AFUA_8G00570"
                     /note="encoded by transcript AFUA_8G00570A; similar to
                     GB:AAN70113.1: hydrolase, alpha/beta fold family
                     [Pseudomonas putida KT2440]"
                     /old_locus_tag="Afu8g00570"
                     /product="alpha/beta hydrolase, putative"
                     /protein_id="EAL85110.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 6.7e-13, bitscore:
                     38.2, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 3.1e-14, bitscore: 41.6,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLGLALVITLLSAPLSVYLYRQIRASLEDIQHTPEELTFTPARS
                     GPAAPGAQTFPKPVYPIDAFPGSRQFKTVYGTIHVFEWGPEDGEKVLLVHGLGTPCIAL
                     GDMAKELVRRGYRVMMYDLFGRGYSDAPNDLVFDARLYTTQVLLVLASSPLSWTGASAF
                     HMIGFSLGGSIAVAFAAYHATMLRSVTLVCPGGLIRTSHMKPLDKMLYSSARVIPEWLR
                     LRLFRESLEPRNGAACADVPGEMEDEDDVAFDDVPIAQDRPQVTVGDVIRWQLAANAGF
                     VRSYLSTLRSALVYRRHDRTWRVLADELARRRVADALPGLPGGKVCLIVAERDVIVVGD
                     ECASDAAEILGAEAVETHVLGGGHEIAISRARDVISIAVRFWNRR"
ORIGIN
        1 ctacaaacgg ctcaccagat cttccaacct cgagctggct gccaaaggct ctcgctgaat
       61 cccaaacctt tggtcgagcc attcgaatgt tttctgcgcc gagtatccaa acgcaccaat
      121 cttggcctgg agccctccgt acgcgacatc cgtagcaatc catttctcct tatccacgcc
      181 atcttggaga ctcgtcaagc agtcgtagat cttgtcggtc gtggtggcgg ggtcgaagta
      241 gaagcttgcc ccggctcccg tcaccagggt cgggcacttc acatcagcca agtattccgt
      301 gccgtctgcc ttctgcagag tgtaggcgcc aaagctacgc atgacatccg catccgtcgt
      361 ggagccggtg gcccacctca agtggttaaa ctcccaccgg gcctgaaacg caagtttctt
      421 gagaacgccg aggatcccgt tgaacatcca gtcggagagc cagccgctca tgaagccgtt
      481 gaagagcggg cccggcatcc ggccgcccac aaagctcgac aggctgtaga atccatccac
      541 gctcacgcat gccttgatcc gggggtcggc agccgcgcgg agggcaaagt agccccccat
      601 cgaggcaccc gtcacggcaa tgtggtccag gtccagctcc agttcgggat ggcgcgtagc
      661 caggtcgaag aggtgatcca gaacgggacc cgtgacggat tcccagtccg ggcgcattgg
      721 cagcttgtcg cgacggagga cgattccttg gccgggcccc tcaaacgtca ggactgcgta
      781 gcccaagtcc ggcccgtacg ccggattgac aaagtagatc tcttcctggg tcgaatcgcc
      841 cccgcccgag ttgagcagga tcgggatctt gcgaccaggg atgcgccggg cggcaggcgg
      901 caagtacaga tatccaggca gcgttttgcc gccctcgtat gggatctcca ggaagatcgt
      961 cttgccatca cgatactgga cgccctttcg gaaattggca atggctcgtt ccaaggtggg
     1021 aaggactctt tcgtcatgtc cgatggggcc ttcgttgagc atgaactgcg cggcccggag
     1081 gtagttggag gagcgcaggt acgcgcgccg tgcaccgaca cgatctccag aggcctcggc
     1141 ttgctttgcg atggcttctg ccttgccacc ggtttcgaga agagtgctgt accatgactc
     1201 tggatcctgg tccttgatct tggctgctgc ttctaggact tctccgatct cggccccttc
     1261 gtatggcgcc atggccagca gacgaaggaa ctcgaaatcg aagaagggcg acttgaacag
     1321 cttgtgtatc gttgccatgt tgccttgtta gggattttca gcatcgagat gtctggcgcg
     1381 cgggaacgat gtctccttga gagtcgtgtg ctccatcgat cggtgctcaa tcgattctta
     1441 cccattgcag atccttagcc cagtgatgca gctcataacc gcgggaaagt gaattgcaga
     1501 ccaacggcgt tgttcgattg ggatttggat tcggagcttg agttgatagc cgcattccga
     1561 attcggtggt tgtgatgcca ccaatcgtat cgggtgtcgg aaggccgaag attggggaga
     1621 acgctgagag taaggctcct gaggtctagg ggatttgacc taagagaagg gtgaatatgc
     1681 agcctattcc aatctctgtg tgtagctcaa ggtctagaac aataacaaaa cacgttccat
     1741 gcccgacctg acacacatct cccctgttca gtgatacgat tccactctag cctcaacgtc
     1801 atggtctaca cacactcacc aaaggagccc attgccatca ttggcaccgg gtgtcgcttc
     1861 cccggcggtt cgacgtctcc gtcgaagttg tgggatctac tctactcgcc gcgggatctc
     1921 acgagagaag ttcccgcgga atcacggttc aaccccaagg gtttctacaa tgtcgacggg
     1981 gaacatcatg gggcaagcaa cgcaaccaat gcgtacttca ttgaggagga tccgcggtat
     2041 ttcgatgcgg gattcttcag catcgccccg cgcgaggccg aatcgatcga cccgcaacaa
     2101 aggctcctgc tggagacagt gtacgaagcg atggaaaatg cagggcttac cctgaatgga
     2161 atgcgaggca gcgcgacttc agcctacatg ggcgccatgt cggccgatta caccgatacc
     2221 cagctgagag atatcgagaa cgtctccaaa tacatgatca ccggaacctc gcgcgcactc
     2281 ttggcgaacc gtctctccta cttttttgac tggaaaggcc cgtcgatcag tgtcgacacg
     2341 gcctgctcgt cgagtctggc ggccgtgcat cttggggtcc aggccttgcg cgctggcgag
     2401 tgtaccatct cctgcgtggg cggctccaat atcattttga accccgattg ctaccttgcc
     2461 gcgaccagtc tgcatttgct ttcaccgacg ggtcgctcac agatgtggga tcaagccgcc
     2521 gacggatacg cccgaggcga gggcgtgtgt gtcttcttca tgaagacctt gtctcaggcg
     2581 ctgcgagatg gagatcggat cgacgcactc ctgcgagaga catgcgtcaa ctcggatggt
     2641 cgcacccagg gaatcgcctt accgagtgct gaggcccaag tgtcgttgat gcgcactgca
     2701 tataagaacg ctggacttga cctctcaaag gccgaggatc gcccccagta cattgaagcg
     2761 catggtgagc ccctggttat cgacaagttt ttcgtgacta acccttttgt gtctctcagg
     2821 aaccggtact caagcgggag atcccagaga agcatacgcc attgccacca cgtttttccc
     2881 gcctggagaa gaccacagtc atcgacctaa actggtcgtt gggtcagtca agaccattat
     2941 tggtcacacc gaaggatgta agcagtcttt gaatctacgt ctgctgtatt gactccgcga
     3001 aactgaccat atgtgacaca ggtgctggta tcgcaggaat tctgaaggct gttctggcca
     3061 tgcggcataa gaccattccc ccgaaccaac atttccacaa cctcaacccc agcgtaaagc
     3121 cttctttcaa gcacctttca atagcgactt caccccagcc ctggcccgtt gtgcctcctg
     3181 acacaccgct acgggcaagt gttaacggat ttggctcggg tggtactaat tgccatgcaa
     3241 ttgtggaaag ctacgtgccc gaaattcatg acaatggccc ttggggaaag ccaaaagaga
     3301 tgacacaggt ccccaacggt gtcgccgcac cggagactga cttctcccct atacccctga
     3361 ttttttcagc tagctccgga acagccctcc gtgccatgct agagaggtat caagagtatc
     3421 tggagaggac cgaggtgtcc cttctacgcc tggcaatgac gctcaactct catcgttcga
     3481 ctctgccagt ccgggtctcg attcctggga cctcgaaagc tgatgttctc gcagcgatcc
     3541 ggacgcaact tgccaaagtc ggttcaaatc ccggtgccga gattggtacc agatcttccg
     3601 ttccagagtt tgatcacgtc agacgcccca agatattggg tgtgttcact ggtcaaggag
     3661 ctcaatgggc cggcatgggc caaggtctga tggcgaagag tgcgctgttc agacaagtca
     3721 tcgaggtgat ggaagaggca atggcacaac tccccgatgg accagagtgg tctctgaaag
     3781 aggagatcat gaagcctcca aaaacctcgc gcttgggcga agccgagatt tccctacccg
     3841 tatgtgcggc ccttcaggtt ggcctggtca aggtgctccg gagcgcagga atcactttca
     3901 gcatggtcgt cggtcactct ggcggcgaga ttggttctgc ctatgccgcg ggcaaaatca
     3961 gcgaggtcga tgccatcaag attgcctact atcgcggggt gtacaccaaa ctcgccattg
     4021 ggaaggatgg aaagaagggc ggtatgattg ccgttggatt tggctacgaa gacggtctca
     4081 acttttgcgc gatggagcaa ttcgccgatc gcctcacggt tgctgccagc aactcgccca
     4141 agagcgtcac actttcggga gacctggacg ctgttcatga ggcaaaggaa ttgctggacg
     4201 ctgaaggcgt gttcaaccgt gtcttacggc tcgacacggc gtaccactcg ccccacatgt
     4261 atccttgcgc ggcgccgtat ctggctgcta tcgagcgctg cggtctggtg gctggcaaat
     4321 ccaatggaac ggcttgggca tccagtgtct acgacgataa ccggatgatg acctccgccc
     4381 aagacaaaga cctggaagcg gcatactgga aagacaatct gatcgggagg gttctgttct
     4441 cgcaagccgt ggaacgtgcc ctggacgagg ggaatggcga ctttgacctc gcccttgaga
     4501 ttggcccgca tccttcactc aaagggccta ctctggagac aatcagacac aagattggct
     4561 cggagattcc ttactctggc gtcttggatc gcaaggccga cgacatcttg gccctgagta
     4621 ccgctcttgg gttctcatgg ctgacattgg ggtcgggggt ggtcgacttt gccgggtacg
     4681 tgtctggatt tgacccgagc aatgcttcca tcctaaacgc cccggcgttg cctgacctgc
     4741 cgacctatcc gtgggatcat aagaaggtct tgtatcgcga gtcccgtctc aacaagaatg
     4801 tccgccacag ggttgatccg cctcacccgc tgctgggcag tagaacgccc gatgatacag
     4861 attacgagcc ccgatggcga aacttcctta tcatggagga gctgccctgg ctgcgggacc
     4921 attgtgtcca aggccagatc atcgttccgg cggctaccta ctccgtgatg gctctggagg
     4981 ccgccaaggt cctttgcagg ggcaagcatg tgcagagtat tgagctgtcc gatgtggcca
     5041 tattacgccc gattgttctc gacgaggcat cagatggcac cgagaccttg ttttcggtgc
     5101 gcagcgatct tgattccaac aagaagcacg aggacgaaat tcatgctcaa tttaccctca
     5161 gcgctggtgc tatggatgac aggcacttga gaactgctgc caccggccac attcgaatca
     5221 cccttgcagc ggaagcaccc agctcgttcc ccaacggacc tcgaccgaca gagttggatc
     5281 tgttgcccac cagtgtcgat cgattctatg cgtcgatgga cgagattggg ctgagctaca
     5341 gtggaccgtt cagggccatg acgtccatga agaggcgtct gaacgttgca tctgcaacag
     5401 tcgctgtgga tcgagacctg gcggggacga ttcccgttca tcccacctgg cttgacgcct
     5461 gcttccagac cttcctcgca gcttttgctg cccctcgcga cggctcgtta tggacagcct
     5521 tcatgcccac cgcgatcggt cgaatggtgt tctccccatc gagcacgtcc caagttccag
     5581 gccgttccgt aactgtggac gcgcacatca ccgactttgc gcctggttat caggtatcgc
     5641 tcccgacact gactggtgac atgagcatct tcaactctga aaccaaccaa ctgcaaattc
     5701 agattgaaga ctttgtgatg agctcattcc tccctgcttc ggagaaggac gacaggaggt
     5761 tttacctgca gaacgtgtgg ggacaggaga tgctttctgg agccctgtgt gcagcagctg
     5821 aacgctgcgt cgcacccaca gagagcgagt cgaagatcat tgatacgtgt gaaaaggctg
     5881 tgcactatta cctgtcaaaa ctcaaggcgg ccggactcct cgaccagtgg gctgacaaga
     5941 accccgggct ccgctctctg atgaacgaga tagaggctcg tgttactagc atcccggagc
     6001 aatcggatct ggtctcaatg ctgggagaag tcggcgagca catcgatctt gtccttgtgc
     6061 gcactattgg cgagagtctc ctcaactctc cgagtgaggg ccttggccca atcacacctt
     6121 caccgatggg ggctctgata tctcgttggc accatgaagg cctgggtttc gcgcaacttc
     6181 agcgccattt cgtgagcgca gctaaacaaa tctcccacca gcacgcgaat ttgcgaatcc
     6241 ttcaagtcgg cccatcttcg ccagggctcg tccgttcagt ttgccaggag ctgggtcgca
     6301 gcttggagag gtatacgcta gtcgatgatt cagagcaaac catcgaggag atgaagagtg
     6361 ctcttgctgc agaccagtta cgagtagact ttaccacagc cagtgttgaa aatgggattg
     6421 atgcggtcaa ccatctgact agtgccggcg gtttcgactt ggtgatcgtc cacaaggcct
     6481 ttaccaagca agttacggcg ctgaagactg tccgaaatct gctgcgcccg ggaggtttca
     6541 tgctcatgat ggcggcaact ggtgcccagc tccgtttccc cttcatgttg atgtccaccc
     6601 tcccttcgct cgacgacgaa agattggcac agaccaaatt catcaacgct acacgcgcgg
     6661 agacccacga cctactccga cagattggat tctctggagt tgactcgatt gctctagaca
     6721 atgtgcctga caagcatacg ttctcggtcg tcgtgtccca agcccttgat gatcacatcg
     6781 ctttcttacg cagcccattg acgtctccgt cacctgttcc actcagcgga aatctcctcg
     6841 tggtaggcgg cttctcggcg gatatagcca agctggctac agctatacaa tcactcgtat
     6901 cgactgtgtg gcacggcgac attatcaatg tgcggactct cgcggagctc gacgacgaag
     6961 cgagcaccgt tgaggctgtt ctgagcttga ctgacctgga tcgcccagtc ctggaggatg
     7021 tgagagcccc aacgttcagg ggtttgcaga gactcttctc cgaggcgaaa acggtcctct
     7081 ggattaccca ccgggcgaaa gctgacaatc cttaccacaa tgccaccatc ggccttggcc
     7141 ggtcgttcca gtctgagaac ccgcagaagg tactccagtt tcttgatgtg gacacgctgg
     7201 atggagttga gtcagccatt gccgagacct tcctcaaact catcgggggc gtgaacatga
     7261 ggaatagcaa tcccgcggac cctactcgtc tctggacgat tgagccagaa gtctccctgg
     7321 agaacgggaa atacctcgtt ccaagacttt tcccagatac ggagcgcaac gaccgactca
     7381 atgctctgag gcgcaaagtc cagacacaag tttctgtcga aacgcagcct atctcgctca
     7441 gcagatctgc gcagagtgac caagtcgcct atactgcgga agcagtccac ttccacagag
     7501 atctcgcaga tggggcaact gatcccgtta ctattcaagt ggagctctgc tcgacggagc
     7561 ctgtcattcc gaacattgac aacgaggatc ttttctgctt tgttggacgc acgtcagaag
     7621 gtgcacggct tgtgggccta tcaacatcca attcctcggt ggtcaaagtg ccacgcgaat
     7681 ggacgatacc cgtcgacaag catacatcac acgatcaagg tgcatttgtt ttggagctgc
     7741 ggaacgaaat ccaatccctt gtcattgcca agtccattcc cccgggatct actacattga
     7801 tatacgagcc cgatcctcat cttgcagcct ccttgcagcg gccagggcga ccagctactt
     7861 cgtcggtcag tttcagagcc cgttcgacat ggtcaatccc cgggagccat attttgatcg
     7921 atccgcatgc ctctagaaag gatatacaag caaaggtacc ccccaaaact aggatgctaa
     7981 ttcacatgga acaaggaccc gagacgtgcg agttcttggc tctcagacaa gctctcccgc
     8041 cgtacgctac agtcgtcgcg ttcaatgacc ttgcagctga tgatgtcaat ccacgcgaat
     8101 tgcttgcgga ggctttgtcc attattcggg gcgattccca gtccacgaag gttccattcg
     8161 accctagcag tgtggtaaaa gcctctgcct tggtcgctgg gggaacgagg gaacatgcca
     8221 atgctgctgt cgttgactgg acaggcgctc agagcattac cctgagcccg agaccggtgg
     8281 acactcgcaa cctattttct cccaataaga catatcttct tgtcggcctt accgggcata
     8341 ttggtcagtc aatttgtcgc tggatggtcc aaggcggcgc tcggcatatc gtcgtcacca
     8401 gtcggtacgt aatgagttga tctgactgct gttggatgac tttactaacc atgatgtaca
     8461 gacaccccga gaagcaagga cagctctgga gagaggagtt actgagacag ggagtcaaca
     8521 ttgtcattga agccgctgac gtgaccaaag agcatgatct cctggacctc cgcgctcgca
     8581 ttgtcagctc catgcctcca gtgggtggca ttgctaatgg cgccatggtg ttggacgaca
     8641 aattgttcat cgacatgcct tttgagagtt tccaagctgc catgaagcct aaagtacaag
     8701 gctccatcta cctcgaggag gttttctcgg ctgataacct tgactttttc ctgttcttct
     8761 cgtccatttc cgtaatgacg ggccagcgaa cacaggcgaa ctatgttgct gccaacaatg
     8821 caagtctaac ccccttttca cccctgtcca ggcgtttcta accagctgat tgcttttagt
     8881 tcatggtcgc tatggctgaa cgaagaaggg cccgtggtct gccagcttct gtcattgata
     8941 tcggcatggt cgtcggcatc ggtgttattc agagatcgca gaatgacaaa ggcgtcagcg
     9001 cgatggagaa ctcgatccga cagatggact acatgcctgt gtccgaaact gacctacatc
     9061 atctcctcgc tgaggccatc ctcgtgggcc agcgagatga gtccccggaa ctaatcacag
     9121 ggttggagac atacaagcca gttgagggag aggctccctt ctggcaccat aacgtgcgct
     9181 tttcccacct catcactgac cctgatgctg cgcaagcggg tgcggactct gctggtagcg
     9241 ctcagaaatc gttgaaggag atgctgctca gctctggtgg gcccgaggaa gcgaggaagg
     9301 tcatggagaa tgccctcttg caatatctag cgtcctcact caaggtaagt actgccctat
     9361 tcaaaccttc gtgatgctga caacccgtag ctgtcacgcg agaccattta caccgatgtg
     9421 ccgatcattg acctcggtat cgattccctt gtcgccgtcc agattcggaa ctggacctgg
     9481 gccgaagctg gatatgacct tccagtcttg aagatcctgg gcggatcttc ggtaacacag
     9541 atttgcgatg aggtagtcgc atctctgtcc tttgacaaga gttcgattgc ggccgccaag
     9601 gtcgacagtc aagcagcacc ggctcacaaa cttcgcccgt gggataaacc atccgcagat
     9661 acaaagcgaa cggactctat agcacccgtg cctaggtcac agatcgctgc aaatggaccc
     9721 aacggcttgc cgaatggggc tttgaagaaa gcctccaagc ttgccgtaaa ggtcaggcct
     9781 ctctggacga ctcaagctgg cggtaaagat accaagaaag gtcctcggcc agccccgatc
     9841 aggatacagc cattgtcctt gggtcaatct cggctctact tcctctctca atacatggac
     9901 gatgatagag tcctgaactg caccatctcc tacgccctct ccgggaagct ggatgtgtcc
     9961 aaattggagc agtcactcat tcaggtggtg cagcgtcacg aggccttgcg cacctcgttc
    10021 tatacagatg agaaggatgg gaagcccatg cagggtttgt tggaaaagtc accgtttcgc
    10081 ctcagggtcg ttcccggtgt cagtgcctcc tctgatgtcg agactgaatt taacttgatc
    10141 cgctatcgtc cctatgatct cgagcaagcg gacacctttg ccgccaccct gctctcacat
    10201 agtccagatt ctcacactct gatatgcgga taccatcaca tcatcatgga cggcgtcagc
    10261 tggcaaatat tccagaagga cttggccatg ttctacaaca attcgggaat cgcggactcg
    10321 gccaaacatc tgccagcgca atactccgag tttactcgaa agcaacaaga agacctgtcc
    10381 tgtggagctt acgccgaaag gctccgcttc ttccaagacc aattccgaga gcctgtcgag
    10441 tctttacctc tgtttccttt tgccaaagtt ggcacacgga aggtcgtgaa gcagtacgcg
    10501 gtgcaggagg ccaccaccca tctcaatgcc aaggtagtca gcgcgatcaa gcaggcgagc
    10561 cagacgtctc gtaccacccc tttccatttc tacctctcgg catttcaggt tctactacac
    10621 cgactcctag aaacagacaa gatgtgcatt ggagtggtag acgccaaccg gtctgaccag
    10681 aacttcgtga acactatcgg gttcttcctg gaaaccatcc ccttgtggtt caaggtcaat
    10741 agcgagcaac ggttcgtgga actgttaaag gagacacgaa ccaaggcata tgctgccttg
    10801 gcacagaccg gggtccctac cgaggagatt ctgagagcat gcggtgtcgc atcatcgaca
    10861 accgaaacgc cgctcttcca agtttgcttc aattaccgca tgggagctgg ccgcaccgca
    10921 gcgctgcaag gagtcgagat gaaattcttg gactatgttg acgctcagaa cccatttgat
    10981 ctcgttgcga ctgtcgatga cttagacgac ggaactgcca tgattaccct ctatctacaa
    11041 gattacttgt acgaccagga gggtgctcaa ctactcgcca ccatgtacgc gaacgtgctg
    11101 caagtactgg cagagaaccc agagagatta gttggctctg tgtcgatttc caacgctacg
    11161 ttggaggacg agggtgtcaa actaggcacc gggcccatct tggaccttgt agctccgtct
    11221 actcccactt tgtcaaagat tttccacaca tgggtagaca aggaccccca cgctctcgct
    11281 gtcaaggaca ctaccggcaa gtcgaagaca tacgtgcagc tcgcagaaag ggcgaacgcc
    11341 attgccgcgt cgctgctgaa cgccggcgcg gcgccttcca ttcccatcgg tgtcctgctt
    11401 gatcccggcg tagacacaat tgccacgatc ctcgccatac ttcgcattgg tgccgcctat
    11461 gtaccgctcg atacacggag ctccgatgca gttctatctg atattctaca agaatcccag
    11521 ccaggcattg ttatccacca cagcgccacc gccccacgca gccagatcct tctcaaagcc
    11581 tccgccaaaa ccaagctggt cactttgaac gccgtccctc agaagaccat cagaaagatc
    11641 caagacgttt cagttcccga gggccttgca atgatccttt acacaagcgg ttctactggt
    11701 agtccaaaag ggatcccgct gaccaacgcc aatatccgaa ccccgatcct cggcgtttca
    11761 gagagagtac cacttgggcg agaggtggtt ctccaacaga gtggacaagg gttcgatgcc
    11821 gcagtctacc agatcttcat tgcccttgca aacggcggca ccttgatcat ggttgacaat
    11881 agagatgatc ctgcaaaagt tgccgcgcta atggcccagg aatccgtaac ttgcaccacc
    11941 cacattgtct ctgagatgca agctttgttg aagtatgggt acgatgagct tcgcaactgc
    12001 tcctcctggc gcattgcaat ggttgctggc gaggcgttca ctgtccacct cttggaccag
    12061 ttccgcgctc tcaaccggcc tgacttgaag gtaatcaacg cgtatggtcc gactgaagcg
    12121 tccatctgct cttccctggg cgaagtgtca ttcaacagaa tcagctccag tgaaactagc
    12181 attcccatcg ggaaggctat tcccaactac ggcacctata tcgtggatca gcattgcaaa
    12241 cctgtgccac ttggctggcc cggtgaggtc gcaattgctg ggcctggtgt tgccagtggc
    12301 tatctcaacc tcggtgagct gacccaggct aaatttaggt ctgcggccac cctgggagaa
    12361 gtgtttggat cggattgcct ttatctcact ggcgataggg gtcgaatgct gtctgacggc
    12421 tccattgtcc tctctggtcg tgtagatgga gacgatcagg tcaagattcg aggtcatcga
    12481 gtgcagctcg gcgatgttgc cagagctctt gtccaagcct cccgaggcgt ctttgcggat
    12541 gcggctgtta tcctgaaggg agacgataca tcaaatccgc agctcgtggc ttacgtcgtc
    12601 ttctcccgaa ccagcaatat tcaggaccag cagacatatc tgcgtcaact gaaccaagat
    12661 ctcccagttc cagcgtacat gcgtccggca atcaccattc ctctggatac tctgccggtg
    12721 acagaccgtg gcaagctgga ctccaagaag ctggcgtcgt tgcctctacc cagcatttct
    12781 gttgactacg aagaggacga gcagcttaca ccaacagagg cgcgattgcg agatgtttgg
    12841 aagaatgtct taggtgacat cgcttcatcc attccaatcc gccgtagctc cgacttcttt
    12901 tccgttggcg gcaactccct gatcctgctg gctctgaagg ctgagatcgc tcaagtcttt
    12961 ggggtgggac tttcagtctc cgaacttttc caagccagca cacttgagct tctcgctgca
    13021 agactcgacg gaacttcttt gttagcacag atcaactggg aggaggaaac agccccggat
    13081 gagacgcagt tcacactacc cccgcctatc aacggaatca acggacatgg atcatcgaat
    13141 ggccatgcac aagggatatc tgttctcctt actggcgcca caggcttttt aggtggtcat
    13201 atccttcgcc aattggtgca actgcccagt gtcgagcatg tacactgcgt ggccatccgt
    13261 cccaataagg ttgatgtacg ccgacaactg agtgtggaat cacccaaaat cattcgttac
    13321 tctggtgatc tggccctccc gaacatgggc atgagcgagt ccgagttctc cgatctattc
    13381 aagagtatcg atgtcattgt tcacaacggc gctgaagtct cgcacatgaa gaactatcgc
    13441 agtctgcggg ccgccaactt tctgtcgaca gtcgggctgg cgcgggctgc tgtcagccgt
    13501 gggatcccga ttcattacat ttccacaggg ggagtcgcgc gcctgagtgt cgctgacgag
    13561 caacccgagg catcgctggc agcgtttcac cctcccatcg acggatcaga cggatacgtg
    13621 gcttccaaat gggccagcga ggtctttctt gagaaggttc aaagacgctt ccaaggccag
    13681 gtttggatcc accggcccag cagcatcacc ggtgacgatg tcccggacaa tgatattgcg
    13741 catagcctgc tcaagttctc gagggagctc ggggctgtgc ctgagctaac cggaagtggg
    13801 ttcttcgact ttatcaatgt cgaaactgta tcaaacaaca ttgctgctag cgtggtcaga
    13861 agcagcgaaa agagtggtgg cggcctgatc taccttcacc aaagtggtga acaagtcatc
    13921 cctgtcggag acttgcagaa gtatgttgaa gaactggaag ggcgaccatt gcaagttctg
    13981 ccattgaagg agtgggtgga tttgtcgatc cgcaagggct tggacgaggt tctggggtcc
    14041 tacatgttag cgtccaaggg agtgattcgg gcacctctgt tgcagagagg tcctcatgtc
    14101 gagtagacac gtggatgttg tagtagacaa tatctcgcta gggaagggta atcaaagtat
    14161 tggaaggtcc aatttctgtc caccaccggt catagacaag aggaatctct acataaaggc
    14221 gctatccctg ctattaaatg acgggcatgg gattggtagt tcgtagacaa ttgctcacaa
    14281 gaatttccat tcattgtatt catttgacaa atcctacctg atacatacaa ctggtagatc
    14341 tcaagccttc tggccaaagg caataatcat ctcaacttga cccccttcgg tctccagctc
    14401 ttccttgaca cgcgcgggaa gcgcatcaag ctgttcaccg gtaaacgaag acttcacggt
    14461 cctggccacg ctcgtcaacg gcacaatggg cccagtgact ccatgaatac tctggtcgtg
    14521 gagctcgggc tttgctttct ttcccaggtt gacaatgacg cgcttctcct gcacgttctt
    14581 caagccggcg tcttccagca tggacttgtt gttgttggca aagtcaccca caccgatgcc
    14641 tgtgaacatt tccgaggcca tcttggcaaa gtccgtcatg gcagggccat tcggtggcgg
    14701 gctgaaggca ttcatttcca tgagctgaac ccaaccgcca ggcttcaaca gagtagtcag
    14761 gttctgaatc accggagccg gtccctcggg cgcggagccc gccagactgc ctcggatgtg
    14821 gaccaggtcg aaaaagccca agtactgctg gggccatggg tccttgaagg aatgggcgaa
    14881 ataggtgatg ccatctggat ccttagggaa caactcgcct tcaacgtcgc tgccgtagta
    14941 gtcatgcggg accgattgtt tgctccgcac attgcgaagc caggtgcctt ttcaacggtg
    15001 tcaacgagag taatcaacca ggtgaaagtg aaccacctta ccatccgcgg tgccagagtc
    15061 cagaatcttc ttgcccggct cgctcatatc gaggggggcc accacaagtt tcccctccaa
    15121 ggcatcgtca taagtggcat ccaatgctct caggcgcagc aactcgggct gatgcccgag
    15181 cttcttggtc atctccataa agttatccat attgagtatt atccctttgt atcactactt
    15241 ttgtgcgtaa tgagcaatgc aatgggaaag caaggtcgac aaggctagtt aaaccacata
    15301 cttttcccaa gactgtgccg attctacgtg tgagcatgta caatcgggca aggtggtgct
    15361 acccacttta ctctgatggt gctcgctgga acccggttag gcctgtgacg ttgtccagca
    15421 ccgaaatgcg aacagagtgc atactgcata gggattgcct gggcgaacgg catcattacc
    15481 gtacatggac aacctaccga atcggatgct gccgccgaat ggtcgtggcc gagtctaatg
    15541 atccgcagtg gagagagaca tgaacaattt cttcttgcct tgtggggcaa ttcatagcga
    15601 atctaccgca ttccgttgcc tattgcatgc acggcgtggc cggcctccat atcccacaat
    15661 cagtaaacct tgtgcagtgg acgatcaata ttgaagagcc actttgtgac atctcactga
    15721 gccatagcag agacgcacaa gcgtgaccat gataatttcg tcgtaccacc tgttgtggtt
    15781 ggctttggtg gccttcattt tgcagtatgt tgctgggata gtgtcaacgc gtcaacggag
    15841 acagggcgcc aaggtgccgc cgggaccaaa aggtatacaa caagtcaatc cacgtcttga
    15901 acacagtggc taaaggaatc aaaggatggc cattccttgg aagcgcgcca gctctggctg
    15961 ccgttgacac caatgggata atcggtatct tcaagagctg ggccgagcaa tatggctcca
    16021 tcactcagtt cagcgccatg ggcgacaagc aagtcattct taccgaggat aaggacgcaa
    16081 gagagctctt tgtcagacgg gggatcaagt attctgatcg tggagctcct catgccgtcg
    16141 aatacatttc gatgaaacag aatcccggtt tcaggcccaa ggatggtaag catctcgacc
    16201 cagtcacgac gagagcaggg ctctgagtgg gtactgacac cttcagatgg atggcgccgc
    16261 caaagaagca tgatccaaag cgcgatcaac atcacctcca tcaataaata ccagagtctg
    16321 atggacgatg aagccacgtt caccgtgaac gcactgctgc agtccccgga ctcgtttcat
    16381 ggcgagttct tgcgatattc ctactccgtg ttgacgagct cgttgctcgg cttctcagtc
    16441 cgcagtccat cggacccttt catccaccac aatgaaacct tcacggccga actcatgaac
    16501 tctttccgtc ctgactgctt cccgagcaac gtgttccctg tgctccggaa actgcccatg
    16561 tggcttctgc ccagcttgag aacgatggaa aggctccgga aagagtatgt gggcgagatg
    16621 tgggcgttca ggaggaagat cgagaagctc gtcaaggagg gctcggcgac agagtgcatc
    16681 tataaacatt ttctcctcca ccgggatcag tataacgtca ccgaggaaga gtcggttcac
    16741 acatttcagg ccatgattga cggtgggacc cgctcgcccc acaacaacct gctaacattc
    16801 ctcttcctga tgatggagtt tcccgagtgg cagaagaagc tgcaagagga ggtcgacaga
    16861 gtcgttggca gggatcgaat gccgagctat agggacattc ctaacctgcc tactgtgaga
    16921 gctattgtca aggaaacagt ccgatacaga agtattgtcg cagaaatggg cattggccat
    16981 tgcctgcaaa cggacgacat ttacaagggc tacttctttg aaaaaggcac tgtattcaac
    17041 gctatatttg cgtaagtcat tgacttcctc gctctctaga tatccgcagg ttctgtgatt
    17101 aatatctatc aggtctatcc ttatggacaa agacacctac ccagacggca aacttttcaa
    17161 tcctgcgcgc tggctggagc ctagttaccc gacttacaag gaacccctga ccacgtaccc
    17221 aaactgtcag ggctttcctg cattcggcta tggtaggcgg gcatgcccgg gggttgactt
    17281 tgcggagaga accctggtca taatgtttgc gaagctggga tggacgatga atattcgatg
    17341 gccgagggat gaggacggta acgaacttcg ggaggaatta cagtatgaac cagtgccagc
    17401 gccgaggccg ttgaagtttg gttgcaggct tgaggctcga gatgctgacc gcgccaagat
    17461 agtggaggaa gcagcgaagc atttgaagtt gcaatgatat gaatgacttt gccattagat
    17521 agcacgagca actcaagttc acctaactgc agagtctgaa tctatatcta tctatgcaca
    17581 ctccgtcatc gtctattcca aaatctcacg gctattgaaa tcacgtctct tgctctcgag
    17641 atggcaatct cgtgccctcc acccaggacg tgagtctcca cggcttctgc ccccagtatc
    17701 tccgccgcgt ccgaggcaca ttcatctccc acaacgataa cgtccctctc ggccacgatc
    17761 agacaaacct tgccccctgg caacccaggg agagcatctg ctactcgtct tctggccagc
    17821 tcgtcggcca agaccctcca cgtccggtcg tgtcgtcgat agaccagggc gctgcggagg
    17881 gtactcaggt aggaccgcac aaaccctgca ttggctgcta gctgccaccg gatcacatct
    17941 ccgacggtga cctggggccg gtcctgtgca attggcacat catcaaaagc cacgtcgtcc
    18001 tcgtcctcca tttccccggg aacatccgca caggccgcgc cgttcctggg ctccaaactc
    18061 tcccgaaaaa gcctgaggcg tagccactcg ggtataacac gagcagaaga gtataacatt
    18121 ttgtctagag gcttcatgtg cgacgtgcgg atgaggccac ctggacatac cagagtcacg
    18181 gagcggagca tcgtcgcgtg gtaggcagcg aaagcgacgg cgatggagcc gccgagagaa
    18241 aagccgatca tatggaaggc agaggcgccc gtccaggata gcggggacga agcgagcaca
    18301 agcaacactt gtgtggtgta gagtcttgcg tcaaagacga ggtcattcgg cgcatcggag
    18361 taaccgcgac caaacagatc tccagtcgtg tctcagccgg tcactgccaa agggcgcaga
    18421 acagatagaa cttaccgtac atcataaccc tgtagcctct gcgaaccaac tctttagcca
    18481 tatcacccaa tgctatacag ggtgtaccaa ggccgtgcac cagtaacacc ttttccccat
    18541 cctcagggcc ccattcgaac acgtggattg ttccgtatac agtcttgaac tgcctgctgc
    18601 cggggaatgc gtcgatcggg tacactggtt tcgggaatgt ttgtgctcct ggcgccgccg
    18661 gtcccgatcg cgcaggagta aaggtcagtt cttctggcgt gtgttgtata tcctcgagcg
    18721 atgcgcggat ctgtctgtac aagtaaaccg ataatggtgc ggaaaggaga gtgatgacta
    18781 gtgcgagtcc gaggtccat
//
