BGC0001037: pseurotin biosynthetic gene cluster from Aspergillus fumigatus Af293
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Location: 115,218 - 134,016 nt. (total: 18,799 nt).
This entry is originally from NCBI GenBank CM000176.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001037
Short description pseurotin biosynthetic gene cluster from Aspergillus fumigatus Af293
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Polyene)
Loci NCBI GenBank: CM000176.1
Compounds
  • pseurotin
  • azaspirene
Species Aspergillus fumigatus Af293 [taxonomy]
References
Chemical products information
pseurotin [synonyms: pseurotin a]
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C22H25N1O8
Chemical database entries
NPAtlas
PubCHEM
azaspirene
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C21H23N1O5
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AFUA_8G00530
  • EAL85114.1
 115218 - 116555 (-) alpha/beta hydrolase
  • Tailoring (Heterocyclization)
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  • AFUA_8G00540
  • EAL85113.2
 117018 - 129323 (+) hybrid PKS-NRPS enzyme
  • Scaffold biosynthesis
Activity assay
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  • AFUA_8G00550
  • EAL85112.1
 129558 - 130427 (-) methyltransferase
  • Unknown
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  • AFUA_8G00560
  • EAL85111.2
 130966 - 132714 (+) cytochrome P450 oxidoreductase
  • Unknown
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  • AFUA_8G00570
  • EAL85110.1
 132803 - 134016 (-) alpha/beta hydrolase, putative
  • Unknown
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Polyketide-specific information
Subclass Polyene
Starter unit Propionyl-CoA
Cyclic? no
Polyketide-synthases
Genes Properties Modules
AFUA_8G00540 Synthase subclass: Iterative type I
Iterative PKS type: Partially reducing, Unknown
Iteration counts: 4
Module 1
Specificity: Malonyl-CoA
Evidence for specificity: Activity assay
Genes: AFUA_8G00540
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Non-canonical activity:
  • Iterated
Evidence for non-canonical activity:
  • Activity assay
NRP-specific information
Subclass N/A
Cyclic? no
Release type
  • Reductive release
NRP-synthases
Gene Modules
AFUA_8G00540
Module 2
Specificity: phenylalanine
Evidence for specificity:
  • Structure-based inference
  • Homology
Condensation domain type: Unknown
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: J4R6BDENZAM7XVDGVEEHZB2Y, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Removed gene names of 'No gene ID'
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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