BGC0001038: pyralomicin 1a biosynthetic gene cluster from Nonomuraea spiralis
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Location: 1 - 41,430 nt. (total: 41,430 nt).
This entry is originally from NCBI GenBank JX424761.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001038
Short description pyralomicin 1a biosynthetic gene cluster from Nonomuraea spiralis
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Type I)
Loci
JX424761.1
via Enzymatic assays
Compounds
  • pyralomicin 1a
Species Nonomuraea spiralis [taxonomy]
References
Chemical products information
pyralomicin 1a Evidence:
Copy SMILES
C20H19Cl2N1O7
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AGC24248.1
  • prlZ
 697 - 1515 (+) prlZ
  • Regulation
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  • AGC24249.1
  • prlY2
 1529 - 2368 (-) prlY2
  • Regulation
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  • AGC24250.1
  • prlY1
 2244 - 2486 (+) prlY1
  • Regulation
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  • AGC24251.1
  • prlX
 2536 - 3363 (-) prlX
  • Precursor biosynthesis
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  • AGC24252.1
  • prlW
 3381 - 4202 (-) prlW
  • Precursor biosynthesis
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  • AGC24253.1
  • prlV
 4192 - 5511 (-) prlV
  • Precursor biosynthesis
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  • AGC24254.1
  • prlU
 5508 - 6356 (-) prlU
  • Precursor biosynthesis
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  • AGC24255.1
  • prlA
 6768 - 8003 (+) prlA
  • Precursor biosynthesis
  • Activity assay
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  • AGC24256.1
  • prlB
 8190 - 8747 (+) prlB
  • Precursor biosynthesis
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  • AGC24257.1
  • prlC
 8811 - 9455 (-) prlC
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    • AGC24258.1
    • prlD
    		 9973 - 11370 (+) prlD
    • Transport
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    • AGC24259.1
    • prlE
    		 12108 - 12515 (+) prlE
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      • AGC24260.1
      • prlF
      		 12608 - 13444 (+) prlF
      • Tailoring
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      • AGC24261.1
      • prlG
      		 13496 - 14596 (-) prlG
      • Precursor biosynthesis
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      • AGC24262.1
      • prlH
      		 14593 - 15915 (-) prlH
      • Tailoring
      • Knock-out
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      • AGC24263.1
      • prlI
      		 16126 - 17400 (+) prlI
      • Regulation
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      • AGC24264.1
      • prlJ
      		 17413 - 18555 (+) prlJ
      • Scaffold biosynthesis
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      • AGC24265.1
      • prlK
      		 18609 - 20027 (+) prlK
      • Scaffold biosynthesis
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      • AGC24266.1
      • prlL
      		 20024 - 20614 (+) prlL
      • Activation / processing
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      • AGC24267.1
      • prlM
      		 20696 - 22330 (-) prlM
      • Tailoring
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      • AGC24268.1
      • prlN
      		 22350 - 24017 (-) prlN
      • Tailoring
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      • AGC24269.1
      • prlO
      		 24049 - 25668 (-) prlO
      • Tailoring
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      • AGC24270.1
      • prlP
      		 25707 - 30875 (-) prlP
      • Scaffold biosynthesis
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      • AGC24271.1
      • prlQ
      		 33112 - 36882 (-) prlQ
      • Scaffold biosynthesis
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      • AGC24272.1
      • prlR
      		 37552 - 37782 (+) prlR
      • Scaffold biosynthesis
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      • AGC24273.1
      • prlS
      		 37858 - 38178 (+) prlS
      • Scaffold biosynthesis
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      • AGC24274.1
      • prlT
      		 38390 - 39550 (+) prlT
      • Tailoring
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      Biosynthesis information

      Biosynthetic modules

      Name
      0
      Type
      nrps-type1
      Genes
      prlK
      Substrates
      proline (evidence: Structure-based inference)
      Integrated Monomers
      Domains
      adenylation
      Name
      1
      Type
      pks-modular
      Genes
      prlP
      Substrates
      Integrated Monomers
      Domains
      acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
      Name
      2
      Type
      pks-modular
      Genes
      prlQ
      Substrates
      Integrated Monomers
      Domains
      acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
      Name
      3
      Type
      pks-modular
      Genes
      prlQ
      Substrates
      Integrated Monomers
      Domains
      acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
      Annotation changelog

      Entry version: 4

      Date
      Changes
      Submitters
      Reviewers
      2022-10-07
      Update chemical activity to schema version 2.11
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

      Entry version: 3

      Date
      Changes
      Submitters
      Reviewers
      2022-09-15
      Corrected NRP module activity
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      2022-09-15
      Removed ketoreductase stereochemistry annotation from modules without ketoreductases
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      2022-09-15
      Corrected gene identifiers
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      2022-09-15
      Changed amino acid substrates to lower case
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

      Entry version: 2

      Date
      Changes
      Submitters
      Reviewers
      2019-10-16
      Migrated from v1.4
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      2019-10-16
      Updated compound(s) information (NPAtlas curation)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

      Entry version: 1

      Date
      Changes
      Submitters
      Reviewers
      2015-06-12
      Submitted
      • (ID: ZV4PLWZMKXHKHM6T5Z6RFAE3)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      Detailed domain annotation
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