BGC0001038: pyralomicin 1a biosynthetic gene cluster from Nonomuraea spiralis
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Location: 1 - 41,430 nt. (total: 41,430 nt).
This entry is originally from NCBI GenBank JX424761.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001038
Short description pyralomicin 1a biosynthetic gene cluster from Nonomuraea spiralis
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Other)
Loci NCBI GenBank: JX424761.1
Compounds
  • pyralomicin 1a
Species Nonomuraea spiralis [taxonomy]
References
Chemical products information
pyralomicin 1a
Copy SMILES
C20H19Cl2N1O7
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AGC24248.1
  • prlZ
 697 - 1515 (+) prlZ
  • Regulation
Sequence-based prediction
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  • AGC24249.1
  • prlY2
 1529 - 2368 (-) prlY2
  • Regulation
Sequence-based prediction
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  • AGC24250.1
  • prlY1
 2244 - 2486 (+) prlY1
  • Regulation
Sequence-based prediction
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  • AGC24251.1
  • prlX
 2536 - 3363 (-) prlX
  • Precursor biosynthesis
Sequence-based prediction
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  • AGC24252.1
  • prlW
 3381 - 4202 (-) prlW
  • Precursor biosynthesis
Sequence-based prediction
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  • AGC24253.1
  • prlV
 4192 - 5511 (-) prlV
  • Precursor biosynthesis
Sequence-based prediction
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  • AGC24254.1
  • prlU
 5508 - 6356 (-) prlU
  • Precursor biosynthesis
Sequence-based prediction
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  • AGC24255.1
  • prlA
 6768 - 8003 (+) prlA
  • Precursor biosynthesis
Activity assay
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  • AGC24256.1
  • prlB
 8190 - 8747 (+) prlB
  • Precursor biosynthesis
Sequence-based prediction
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  • AGC24257.1
  • prlC
 8811 - 9455 (-) prlC
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  • AGC24258.1
  • prlD
 9973 - 11370 (+) prlD
  • Transport
Sequence-based prediction
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  • AGC24259.1
  • prlE
 12108 - 12515 (+) prlE
  • Unknown
Sequence-based prediction
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  • AGC24260.1
  • prlF
 12608 - 13444 (+) prlF
  • Tailoring (Methylation)
Sequence-based prediction
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  • AGC24261.1
  • prlG
 13496 - 14596 (-) prlG
  • Precursor biosynthesis
Sequence-based prediction
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  • AGC24262.1
  • prlH
 14593 - 15915 (-) prlH
  • Tailoring (Glycosylation)
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  • AGC24263.1
  • prlI
 16126 - 17400 (+) prlI
  • Regulation
Sequence-based prediction
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  • AGC24264.1
  • prlJ
 17413 - 18555 (+) prlJ
  • Scaffold biosynthesis
Sequence-based prediction
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  • AGC24265.1
  • prlK
 18609 - 20027 (+) prlK
  • Scaffold biosynthesis
Sequence-based prediction
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  • AGC24266.1
  • prlL
 20024 - 20614 (+) prlL
  • Activation / processing
Sequence-based prediction
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  • AGC24267.1
  • prlM
 20696 - 22330 (-) prlM
  • Tailoring (Halogenation)
Sequence-based prediction
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  • AGC24268.1
  • prlN
 22350 - 24017 (-) prlN
  • Tailoring (Halogenation)
Sequence-based prediction
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  • AGC24269.1
  • prlO
 24049 - 25668 (-) prlO
  • Tailoring (Halogenation)
Sequence-based prediction
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  • AGC24270.1
  • prlP
 25707 - 30875 (-) prlP
  • Scaffold biosynthesis
Sequence-based prediction
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  • AGC24271.1
  • prlQ
 33112 - 36882 (-) prlQ
  • Scaffold biosynthesis
Sequence-based prediction
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  • AGC24272.1
  • prlR
 37552 - 37782 (+) prlR
  • Scaffold biosynthesis
Sequence-based prediction
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  • AGC24273.1
  • prlS
 37858 - 38178 (+) prlS
  • Scaffold biosynthesis
Sequence-based prediction
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  • AGC24274.1
  • prlT
 38390 - 39550 (+) prlT
  • Tailoring (Halogenation)
Sequence-based prediction
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Polyketide-specific information
Subclass Other
Cyclic? yes
Release type
  • Claisen condensation
Polyketide-synthases
Genes Properties Modules
prlQ
+
prlP
+
prlR 		Synthase subclass: Modular type I
Thioesterases:
  • prlR (Type II)
Module 1
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: prlP
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
Module 2
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: prlQ
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 3
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: prlQ
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
prlK
Module 0
Specificity: proline
Evidence for specificity:
  • Structure-based inference
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: ZV4PLWZMKXHKHM6T5Z6RFAE3, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Corrected gene identifiers
  • Changed amino acid substrates to lower case
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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