Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001038.1:
Cluster 1NRP / Polyketide141430

BGC0001038, pyralomicin biosynthetic gene cluster from Nonomuraea spiralis. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: pyralomicin 1a
PubChem ID: 3072006
SMILES string: Copy to clipboard
Molecular formula: C20H19Cl2NO7
Average molecular mass: 456.272 Da
Molecular activity: Antibacterial

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Other (linear)
Thioesterase type:
None
Release / cyclization type:
Other

Nonribosomal peptide synthetases:
prlK (AGC24265.1)
Module 0
A specificity: Proline
Evidence for specificity: Structure-based inference
C domain subtype: N/A
Polyketide subclass:
Other (cyclic)
Polyketide synthase subclass:
Modular type I
Starter unit:
Other
Thioesterase type:
Type II
Release / cyclization type:
Claisen condensation

Modular polyketide synthases:
prlP (AGC24270.1)
Module 1
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Scaffold-modifying domain: None

prlQ (AGC24271.1)
Module 2
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: Unknown
Scaffold-modifying domain: None
Module 3
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: Unknown
Scaffold-modifying domain: None

Gene cluster description

pyralomicin (BGC0001038). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank JX424761. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Enzymatic assays
MIxS-compliance:Unknown
Contact for this cluster:Taifo Mahmud (Oregon State University)

Literature references

1. Flatt PM et al. (2013) Genetic insights into pyralomicin biosynthesis in Nonomuraea spiralis IMC A-0156. J Nat Prod 76(5):939-46. doi: 10.1021/np400159a. Epub 2013 Apr 22.
2. Naganawa H et al. (2002) Biosynthesis of the cyclitol moiety of pyralomicin 1a in Nonomuraea spiralis MI178-34F18. J Antibiot (Tokyo) 55(6):578-84.