BGC0001039: pyridomycin biosynthetic gene cluster from Streptomyces pyridomyceticus
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Location: 1 - 42,448 nt. (total: 42,448 nt).
This entry is originally from NCBI GenBank HM436809.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001039
Short description pyridomycin biosynthetic gene cluster from Streptomyces pyridomyceticus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide
Loci NCBI GenBank: HM436809.1
Compounds
  • pyridomycin
Species Streptomyces pyridomyceticus [taxonomy]
References
Chemical products information
pyridomycin
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C27H32N4O8
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AEF33095.1
  • pyr1
 211 - 360 (+) hypothetical protein
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  • AEF33074.1
  • pyr2
 481 - 1221 (+) 3-oxoacyl-[acyl-carrier protein] reductase
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  • AEF33075.1
  • pyr3
 1298 - 2302 (-) membrane protein
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  • AEF33094.1
  • pyr4
 2290 - 2922 (-) decaheme cytochrome c
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  • AEF33096.1
  • pyr5
 3000 - 3218 (-) 4-oxalocrotonate tautomerase
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  • AEF33097.1
  • pyrB
 3234 - 4490 (-) L-lysin 2-aminotransferase
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  • AEF33098.1
  • pyrA
 4648 - 6279 (-) 3-hydroxypicolinic acid:AMP ligase
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  • AEF33099.1
  • pyrU
 6484 - 6738 (+) amino acid adenylation domain-containing protein
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  • AEF33076.1
  • pyrC
 6717 - 7871 (+) favin-dependent oxidoreductase
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  • AEF33077.1
  • pyrD
 7868 - 9013 (+) sarcosine oxidase
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  • AEF33078.1
  • pyrE
 9040 - 15483 (+) dimodular nonribosomal peptide synthetase
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  • AEF33079.1
  • pyrF
 15476 - 19711 (+) polyketide synthase
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  • AEF33080.1
  • pyrG
 19866 - 27221 (+) putative peptide synthetase
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  • AEF33081.1
  • pyrH
 27251 - 27466 (+) putative MbtH-like protein
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  • AEF33082.1
  • pyrI
 27463 - 28671 (+) cytochrome P450
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  • AEF33083.1
  • pyrJ
 28697 - 29815 (+) putative aminotransferase
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  • AEF33084.1
  • pyrK
 29818 - 30339 (+) putative oxidoreductase
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  • AEF33085.1
  • pyrL
 30336 - 31544 (+) dehydrogenase
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  • AEF33087.1
  • pyrM
 31544 - 33010 (+) putative dehydrogenase
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  • AEF33086.1
  • pyrN
 33007 - 33726 (+) esterase
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  • AEF33088.1
  • pyrO
 33780 - 34418 (-) TetR family transcriptional regulator
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  • AEF33089.1
  • pyrP
 35412 - 36524 (+) 3-dehydroquinate synthase
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  • AEF33090.1
  • pyrQ
 36631 - 37995 (+) aspartate kinase
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  • AEF33091.1
  • pyrR
 38118 - 39344 (+) cytochrome P450 family protein
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  • AEF33092.1
  • pyrS
 39341 - 40882 (+) choline dehydrogenase
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  • AEF33093.1
  • pyrT
 40935 - 42428 (+) putative aldehyde dehydrogenase
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
pyrE
Module ?
Specificity: threonine
Evidence for specificity:
Module ?
Specificity: 3-(3-pyridyl)-alanine
Evidence for specificity:
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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