LOCUS       BGC0001039             42448 bp    DNA     linear   BCT 24-JUN-2011
DEFINITION  Streptomyces pyridomyceticus strain NRRL B-2517 pyridomycin gene
            cluster, complete sequence.
ACCESSION   BGC0001039
VERSION     BGC0001039
KEYWORDS    .
SOURCE      Streptomyces pyridomyceticus
  ORGANISM  Streptomyces pyridomyceticus
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-07 22:18:45
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 42448
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..42448
                     /db_xref="taxon:68260"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces pyridomyceticus"
                     /strain="NRRL B-2517"
     protocluster    1..42448
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[9039:27221]"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      9040..27221
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     cand_cluster    1..42448
                     /SMILES="NC(C(O)C)C(=O)NC(Cc1ccccc1)C(=O)C(C)C(=O)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /kind="interleaved"
                     /product="NRPS"
                     /product="T1PKS"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     subregion       1..42448
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001039"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..42448
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /product="T1PKS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX))"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /subregion_numbers="1"
                     /tool="antismash"
     protocluster    1..39711
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[15475:19711]"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      15476..19711
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="2"
     gene            211..360
                     /gene="pyr1"
     CDS             211..360
                     /codon_start=1
                     /gene="pyr1"
                     /product="hypothetical protein"
                     /protein_id="AEF33095.1"
                     /transl_table=11
                     /translation="MPTDRNRMMLVSFRFNGFEEISREDGLVRFAADLSSIPPDPAYLD
                     VLAG"
     misc_feature    211..42428
                     /note="pyridomycin gene cluster"
     gene            481..1221
                     /gene="pyr2"
     CDS             481..1221
                     /NRPS_PKS="Domain: PKS_KR (8-180). E-value: 3.1e-09. Score:
                     28.8. Matches aSDomain: nrpspksdomains_pyr2_PKS_KR.1"
                     /codon_start=1
                     /gene="pyr2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     198.1; E-value: 2.8e-60)"
                     /gene_kind="biosynthetic-additional"
                     /product="3-oxoacyl-[acyl-carrier protein] reductase"
                     /protein_id="AEF33074.1"
                     /sec_met_domain="adh_short (E-value: 1.3e-31, bitscore:
                     100.7, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 1.1e-36, bitscore:
                     117.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLSQKKALVTGGSRGIGRGVVERLAAEGADVAFTYREREAEAKE
                     VVAAVEAAGRTAHAIRVDLTEVAEVRRTMLEAHRLLGGLDILVNNAAAAATATRIDAVT
                     EEEFDGAMAVNARAVFFAIQEASRLMNDGGRIINLSTANTVLPVPGVSLHAGSKAAVEQ
                     YTRVAAQELGPRGITVNAISPGAVDTELLRANITQEGLELAVRMTPLGRIGEPADIAGV
                     VAFLCGPDGGFVSGQNLRVTGGMV"
     CDS_motif       505..570
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pyr2_0001"
                     /evalue="1.20E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="pyr2"
                     /protein_end="30"
                     /protein_start="8"
                     /score="14.7"
                     /tool="antismash"
                     /translation="LVTGGSRGIGRGVVERLAAEGA"
     aSDomain        505..1020
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pyr2_PKS_KR.1"
                     /evalue="3.10E-09"
                     /label="pyr2_PKS_KR.1"
                     /locus_tag="pyr2"
                     /protein_end="180"
                     /protein_start="8"
                     /score="28.8"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="LVTGGSRGIGRGVVERLAAEGADVAFTYREREAEAKEVVAAVEAA
                     GRTAHAIRVDLTEVAEVRRTMLEAHRLLGGLDILVNNAAAAATATRIDAVTEEEFDGAM
                     AVNARAVFFAIQEASRLMNDGGRIINLSTANTVLPVPGVSLHAGSKAAVEQYTRVAAQE
                     LGPRGITVN"
     gene            complement(1298..2302)
                     /gene="pyr3"
     CDS             complement(1298..2302)
                     /codon_start=1
                     /gene="pyr3"
                     /product="membrane protein"
                     /protein_id="AEF33075.1"
                     /transl_table=11
                     /translation="MDRLKNSAASALRGVSSHPKYLVGLSLCRILLGLSTTLYYVSNIP
                     YRDFLWGPHSYSGFEAFKALTGDQHIFSLYALSDGRTWFNLVYFVGLAVSLAWTVLGSR
                     SLTVVHVVFMTSIYHRNYTMWEGGDALTGIVLILMMGTTANAHFSPLAKRVRARLERRA
                     GEPHLRTSLHNTAAVLIVFQACVVYAVSALWKVAAPQWQEGTALYYISHVWQYTYSSAF
                     PQLMDSLVLTAIVTYFTIVVQLLAVPAALTSRRWFREAVVLGIAAMHIGIMAGMGLMTF
                     GLAMMAIDAVIVRDADYEALLRRVRLLRERVAARRGDRKAAAEEPAAEELSAA"
     gene            complement(2290..2922)
                     /gene="pyr4"
     CDS             complement(2290..2922)
                     /codon_start=1
                     /gene="pyr4"
                     /product="decaheme cytochrome c"
                     /protein_id="AEF33094.1"
                     /transl_table=11
                     /translation="MGLPPLLGLALVVMTLIVNAPVSPARTQAYKAVAPVADTYFRQSW
                     MLLAPYSVDYNGEVFYQVEYENATGTHTTEPASLSRKMAGTAREIRLAPNRMGAVGLYL
                     GVELGSLHEKQAAVDDARKKALSDFSGPQNELAALSEAAKTDTATVLSPLVDELHLDGR
                     VTRLRAYYTYTPVKRFDDRHSPEDPTSEVFTDLGWFDYRPGAQPWTD"
     gene            complement(3000..3218)
                     /gene="pyr5"
     CDS             complement(3000..3218)
                     /codon_start=1
                     /gene="pyr5"
                     /product="4-oxalocrotonate tautomerase"
                     /protein_id="AEF33096.1"
                     /transl_table=11
                     /translation="MPFIEVKIFEQRLTEQTERELVERLTQATVDVFGESIREQTWVVL
                     TPVPAHRWGIGGSTHPRPAAQEQEPRS"
     gene            complement(3234..4490)
                     /gene="pyrB"
     CDS             complement(3234..4490)
                     /codon_start=1
                     /gene="pyrB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056:DegT/DnrJ/EryC1/StrS aminotransferase (Score:
                     357.2; E-value: 1.8e-108)"
                     /gene_kind="biosynthetic-additional"
                     /product="L-lysin 2-aminotransferase"
                     /protein_id="AEF33097.1"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 3.1e-106,
                     bitscore: 346.4, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQQRYVVPGGRRGSVIGDRELDVLGQLVSSGAPLSAGGWREAFER
                     AFADHVGARHALSVTSGTVALDIAIRLLDLAPGDEVVVTPQTFQASIQPLLDLGVTVRF
                     CDIDPLTLNMDPAALEPLITDRTRAVILVHYGGCPADMDAIMKLTRPRAITVIEDSAHA
                     LGATYHGRRPGSLADIATFSFHSTKNITTLGEGGMITLDRDDWAERVSRYRNNAVDGVY
                     VHHGTDAAELPAALPWMMFSAEIYDRACAGIRNAGTNATMSEAAAAVGLAQLDRLDELV
                     ARRRMIARRLDEAVAAFPGVRPVSAPEGIDHAYHLYTFLVHDRDVRDALLRELDERGVE
                     VQLRYFPLHLTPEWRFRGHGPGECPVAERLWFEQHMNLPCHPGLLDSQVDHLVDALTAG
                     LTAVTGTAANLRGGTAAAV"
     gene            complement(4648..6279)
                     /gene="pyrA"
     CDS             complement(4648..6279)
                     /NRPS_PKS="Domain: AMP-binding (31-441). E-value: 4.6e-89.
                     Score: 290.6. Matches aSDomain:
                     nrpspksdomains_pyrA_AMP-binding.1"
                     /codon_start=1
                     /gene="pyrA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     464.3; E-value: 6.4e-141)"
                     /gene_kind="biosynthetic-additional"
                     /product="3-hydroxypicolinic acid:AMP ligase"
                     /protein_id="AEF33098.1"
                     /sec_met_domain="AMP-binding (E-value: 1.4e-97, bitscore:
                     317.6, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLDGCVPWPEATAAAYREAGYWRGETLGQLLRDWAAAYDGRTALV
                     GGDRRVTYTELDAWADRLAAGFAARGIRPGDRVVVQLPNTPEFVAVCFGLFRLGALPVF
                     ALPAHRHHEISHLCSHSGAVAYVVPDVHQGFDHRELATQVRASVPTVREVFVLGDPGPH
                     SSLEELSATEAPVPAPDAPADASPADPAFFLLSGGTTALPKLIPRTHEDYAYQIRAASE
                     VCELDGDTVYLAVLPIEFNFTWGCPGVLGTLSTGGTVVLARTPNPDECFALIEREKVTM
                     TSCVPTIAHMWLDAAEWTERDLSSLSVLQIGSAKLHPEVAARVTPTLGCRLQQVFGMAE
                     GLLTFTRYDDPLDRVLTTQGRPISPADEIRVVDSEDRPVAPGETGELLTRGPYTLRGYY
                     RAEEHNARAFSEDGFYRSGDLVRFTEDGDMVVQGRVKDVVIRGGDKVSATEVERHVTAA
                     HDGIQQAAVVAMPDELMGERVCVFVVPAGEPPRLPELKRLLRARGLAEYKLPDRLEVID
                     AFPLTGLGKVDKKALAVELAQRLAAA"
     aSDomain        complement(4957..6186)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pyrA_AMP-binding.1"
                     /evalue="4.60E-89"
                     /label="pyrA_AMP-binding.1"
                     /locus_tag="pyrA"
                     /protein_end="441"
                     /protein_start="31"
                     /score="290.6"
                     /specificity="consensus: pip"
                     /tool="antismash"
                     /translation="RDWAAAYDGRTALVGGDRRVTYTELDAWADRLAAGFAARGIRPGD
                     RVVVQLPNTPEFVAVCFGLFRLGALPVFALPAHRHHEISHLCSHSGAVAYVVPDVHQGF
                     DHRELATQVRASVPTVREVFVLGDPGPHSSLEELSATEAPVPAPDAPADASPADPAFFL
                     LSGGTTALPKLIPRTHEDYAYQIRAASEVCELDGDTVYLAVLPIEFNFTWGCPGVLGTL
                     STGGTVVLARTPNPDECFALIEREKVTMTSCVPTIAHMWLDAAEWTERDLSSLSVLQIG
                     SAKLHPEVAARVTPTLGCRLQQVFGMAEGLLTFTRYDDPLDRVLTTQGRPISPADEIRV
                     VDSEDRPVAPGETGELLTRGPYTLRGYYRAEEHNARAFSEDGFYRSGDLVRFTEDGDMV
                     VQGRVKDVVIR"
     CDS_motif       complement(5053..5139)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pyrA_0001"
                     /evalue="8.90E-05"
                     /label="NRPS-A_a6"
                     /locus_tag="pyrA"
                     /protein_end="409"
                     /protein_start="380"
                     /score="14.9"
                     /tool="antismash"
                     /translation="PGETGELLTRGPYTLRGYYRAEEHNARAF"
     gene            6484..6738
                     /gene="pyrU"
     CDS             6484..6738
                     /NRPS_PKS="Domain: PP-binding (17-78). E-value: 5e-11.
                     Score: 34.9. Matches aSDomain:
                     nrpspksdomains_pyrU_PP-binding.1"
                     /codon_start=1
                     /gene="pyrU"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /product="amino acid adenylation domain-containing protein"
                     /protein_id="AEF33099.1"
                     /sec_met_domain="PP-binding (E-value: 2.4e-11, bitscore:
                     34.9, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRCGKLSNQGVIPGSKSELQRVLAERLGVSISEVLDDVNLQDLGL
                     DSIGVMGIVSGWQRHGLRTEIAEFTAVPTLNDWWELISR"
     aSDomain        6535..6717
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pyrU_PP-binding.1"
                     /evalue="5.00E-11"
                     /label="pyrU_PP-binding.1"
                     /locus_tag="pyrU"
                     /protein_end="78"
                     /protein_start="17"
                     /score="34.9"
                     /tool="antismash"
                     /translation="ELQRVLAERLGVSISEVLDDVNLQDLGLDSIGVMGIVSGWQRHGL
                     RTEIAEFTAVPTLNDW"
     gene            6717..7871
                     /gene="pyrC"
     CDS             6717..7871
                     /codon_start=1
                     /gene="pyrC"
                     /gene_functions="other (smcogs) SMCOG1251:luciferase family
                     protein (Score: 275.8; E-value: 8.7e-84)"
                     /gene_kind="other"
                     /product="favin-dependent oxidoreductase"
                     /protein_id="AEF33076.1"
                     /transl_table=11
                     /translation="MGTHLPLEPGSARTAAAVIPQQAIGVTVQFGVNFFPVVDPAKKSA
                     SDYFDEALRLVSLAEELGFEHAQCVEHYFSPYGGYLPDPVTFLTAAAARTSRIRIGTGA
                     VIPAFTHPLKLAGKLAMLDNLSHGRLDVGFGRAFLPQEFEAFGIDIDESRARFAEGVEV
                     CRRLWSEQDVVWEGSFQRFGPVTMLPEPVQKPHPPIFIASAMSPDSCAAAGRAGYHLQV
                     VPSVTSREQLQSMLAGYREAWREAGHPGSPRIQIKYTCYVAEDRAKALDLAETFEVNYV
                     EHMAGAVASWGRTRSDAYRGYEQFVEKVKKYDFRQSHADNKVLAGTPDEVREQIAVLVD
                     WFGADPTLSLQFNPGHMPYEDSERAMRLFAEHVMPAFTGPEQAA"
     gene            7868..9013
                     /gene="pyrD"
     CDS             7868..9013
                     /codon_start=1
                     /gene="pyrD"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103:FAD dependent oxidoreductase (Score: 120.3;
                     E-value: 1.9e-36)"
                     /gene_kind="biosynthetic-additional"
                     /product="sarcosine oxidase"
                     /protein_id="AEF33077.1"
                     /transl_table=11
                     /translation="MTRTPDAEVAVVGLGAWGSSALWQLASRGVRVLGFERYGLGHPFG
                     ASHGGTRMFRVTCLEHPGLVPLAKRSRELWQQLETVTGRTLFDRVGAVLMGPADGHIAG
                     GSLRAAREHDLPVDTLTADELRRWLPQHAAFQDGDIGVREPEAGLIRPEEAVRAAVGAA
                     AARGARVFTDTRVTAVELTGDGAVVRTPARTFRVGQVVVTAGPWLDTLVPGLPLETVRV
                     PQTWFRPVADPAPFTLDRLPPFMRELGGRGAVWGHGSRGGPDVKLGLEDGGSAFRVTRA
                     DDCDRGVTPQDWTAVAGLLAEAVPGMGAVPSRTEVGMFSRTPDKQFLIGRPHGDPRLVI
                     GGGCNFHGFKHSTGIGEALADIVLGRPTSCPLDFTDPNRFL"
     gene            9040..15483
                     /gene="pyrE"
     CDS             9040..15483
                     /NRPS_PKS="Domain: Condensation_Starter (7-295). E-value:
                     7.2e-90. Score: 293.1. Matches aSDomain:
                     nrpspksdomains_pyrE_Condensation_Starter.1"
                     /NRPS_PKS="Domain: AMP-binding (453-867). E-value:
                     3.9e-116. Score: 379.8. Matches aSDomain:
                     nrpspksdomains_pyrE_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (979-1044). E-value: 1.8e-25. Score:
                     80.8. Matches aSDomain: nrpspksdomains_pyrE_PCP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (1058-1360). E-value:
                     1.9e-110. Score: 360.4. Matches aSDomain:
                     nrpspksdomains_pyrE_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (1530-1928). E-value:
                     1.9e-109. Score: 357.8. Matches aSDomain:
                     nrpspksdomains_pyrE_AMP-binding.2"
                     /NRPS_PKS="Domain: PCP (2037-2105). E-value: 3.2e-22.
                     Score: 70.4. Matches aSDomain: nrpspksdomains_pyrE_PCP.2"
                     /codon_start=1
                     /gene="pyrE"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127:condensation domain-containing protein (Score:
                     359.9; E-value: 4e-109)"
                     /gene_kind="biosynthetic"
                     /product="dimodular nonribosomal peptide synthetase"
                     /protein_id="AEF33078.1"
                     /sec_met_domain="Condensation (E-value: 2.9e-67, bitscore:
                     217.5, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 6.8e-127, bitscore:
                     414.1, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.6e-17, bitscore:
                     54.6, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRDREEVRRPLTGAQLGVWFAQQVDPANAAYNTAQYVEVTAPADA
                     ARLERALRRAVAETDALTVRFTVHDGQPLQQSAPLAEPLLDVVDLSAETDPTAAADRWM
                     REDAATVVDLLRGPLLRNALLVLGPDRFRWYQRCHHTLLDGYGFQLLAARTAEIYTAEA
                     AGAEPRPRWFGTLDDLVGAETGYRASERFGADRAYWAERMLGAPDAVTLARRPFDGPAV
                     DPLTVGPARVLDPRQADRATDRTALVVAALAGYLHRMTQAEDITLGVPVAGRWGAAAKT
                     PGVVVNVLPLRLSVPRGTTVAALLDHATERLGELRRHQRYRSEDILRDLGMVGRQLTGP
                     LVNIKYYDRELDFAGGRATVATVAPGPIDDLSVVVGDDPQAGGLTVAFEANPGRYGEAE
                     LAAHHRRFTGFLTALAEADPGTPLARIPVPATAPRRRARPAPAPEPRGATLHEAFEAQA
                     ARTPDRTAVTSGATRLTYRELNERANRLARLLLRRGLGPGRLAALALPRGADLVVALLA
                     VLKTGAGYLPLDPQYPADRLRFTLEDAAPALVLTDTDGADRVRGAVHPLLLDDPALAAE
                     LTGLPGTDPTAAERPAAAGPDSLAYVIYTSGSTGRPKGVAVTHHNVLRLFRQTDHWFGF
                     GADDVWTLFHSYAFDFSVWEIWGPLLHGGRLVVVPFDTSRSPADFLRLLVRERVTVLNQ
                     TPSAFYQLIAAERERPDLAGRLTLRHVVFGGEALETHRLEDWYARHGDDAPRLVNMYGI
                     TETTVHVTYAALDRETVRAARGSVIGEPIPDLDVYVLDGELRPVPEGATGELYVAGPGL
                     ARGYLGRPGLTAERFVADPFGAPGGRMYRTGDLACVLDDGSLGYLGRADSQVKIRGFRI
                     ELGEIEAALERHPGVERAAVVVREDRPGDQRLVAYAVPAAGTAPDTTGLRLHAAGVLPA
                     HMVPAAVELLDALPLTANGKLDQRALPAPAAPAPAATPAPAEGTSRAATVGALFADVLG
                     LPAVGAADDFFDLGGHSLLAAKLISRIRTELGVELAIGALFGNPTVTGIAALLGDADSA
                     VPALRPEPRPETVPLSFAQSRLWFLNQVEGLSATYNVPLAIRLSGTLDREALDRALADV
                     LARHESLRTIFPQTAGVPHQLVKPADDCRIGTTVVECRPEEQPERLRAALAQGFALETE
                     LPLRTLLFRTGPAEHTFLVVMHHIVADGWSVTPFTEDLATAYAARCEGREPGWPAQLPV
                     QYADYSLWQRRVLGDERAPGSRMARQLAYWAEQLAGLPEELPLPADRPRPLAAGYGGGT
                     VGGRMDTGLHTRLLRLGRDRGATLFMVLQAGLAALLTRLGAGEDIPLGTPVAGRGDEAL
                     DDLVGCFVNTLVLRTDTSGSPTFHELLDRVRTTDLAAYEHQDLPFDRLVEALNPPRSLA
                     RHPLFQVMLALREPAREVTGMPGLTARVESCDTDSSRFDLSFVFGEVTGADRAPGGVDC
                     SLQYSSDLFDRETAQRLLARLVLLLEAAADAPDVPVGRLEILTPREREDLLEGWQGPRR
                     ELADTTAAQLFEAQAALVPDRTAAVFEGARLTYAELNARANRLARHLVAQGVGPEQVVA
                     LAVPRSLEMVVAMLAVFKAGAAYLPVDPDYPADRIRYMLEDARPAQVLTTAEAAHVLPD
                     AVTPVLLDDPGTVARVADLPATDVTDGERLAPLVPAHPAYVIYTSGSTGRPKGVVVCHT
                     GIPSLLANQIERCAVGPDNRVLQFATASFDAAFWDVAMALFTGGTLVLAPAWRLLPGPE
                     LSELAAAHDITHVTLPPSVLAMLPVEGGLPASTTIVVAGEATPADLVARWSRGRRMVNS
                     YGPTEITVSCAISPPLDATGELPISPPSMNTRLHVLDGRLRLVPPGVPGELYVAGPGTA
                     RGYLGRPDLTAARFVADPFGPPGTRMYRTGDLARRRPDGRLEFLGRADDQVKIRGFRVE
                     LGEIEAALSSREDIAQAAVVVRAERPGDQRLVAYVTVAPGAAGPQDLRTWLASSLPDYM
                     VPSIVVTLDALPLTQSGKIDRIALTARPVSWTTDTASYVAPGEGLERRIAQAWCAVLGL
                     ERVGAQDNFFDVGGHSLTLIALQKRLVDELGRPVPVVDLFAHPTVAALAAHLAAAEGNG
                     EPAARRGNADRARQRAGLQHKAMARRAADRKGTQRNG"
     aSDomain        9061..9924
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pyrE_Condensation_Starter.1"
                     /domain_subtype="Condensation_Starter"
                     /evalue="7.20E-90"
                     /label="pyrE_Condensation_Starter.1"
                     /locus_tag="pyrE"
                     /protein_end="295"
                     /protein_start="7"
                     /score="293.1"
                     /tool="antismash"
                     /translation="RRPLTGAQLGVWFAQQVDPANAAYNTAQYVEVTAPADAARLERAL
                     RRAVAETDALTVRFTVHDGQPLQQSAPLAEPLLDVVDLSAETDPTAAADRWMREDAATV
                     VDLLRGPLLRNALLVLGPDRFRWYQRCHHTLLDGYGFQLLAARTAEIYTAEAAGAEPRP
                     RWFGTLDDLVGAETGYRASERFGADRAYWAERMLGAPDAVTLARRPFDGPAVDPLTVGP
                     ARVLDPRQADRATDRTALVVAALAGYLHRMTQAEDITLGVPVAGRWGAAAKTPGVVVNV
                     LPLRLSV"
     aSModule        9061..12171
                     /complete
                     /domains="nrpspksdomains_pyrE_Condensation_Starter.1"
                     /domains="nrpspksdomains_pyrE_AMP-binding.1"
                     /domains="nrpspksdomains_pyrE_PCP.1"
                     /locus_tags="pyrE"
                     /monomer_pairings="thr -> thr"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       9067..9105
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pyrE_0001"
                     /evalue="7.80E-03"
                     /label="C1_starter_004-017"
                     /locus_tag="pyrE"
                     /protein_end="22"
                     /protein_start="9"
                     /score="9.3"
                     /tool="antismash"
                     /translation="PLTGAQLGVWFAQ"
     CDS_motif       9124..9240
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pyrE_0002"
                     /evalue="6.60E-14"
                     /label="C2_starter_024-063"
                     /locus_tag="pyrE"
                     /protein_end="67"
                     /protein_start="28"
                     /score="44.4"
                     /tool="antismash"
                     /translation="AAYNTAQYVEVTAPADAARLERALRRAVAETDALTVRFT"
     CDS_motif       9451..9516
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pyrE_0003"
                     /evalue="9.60E-09"
                     /label="C3_starter_134-155"
                     /locus_tag="pyrE"
                     /protein_end="159"
                     /protein_start="137"
                     /score="28.0"
                     /tool="antismash"
                     /translation="CHHTLLDGYGFQLLAARTAEIY"
     CDS_motif       9829..9915
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pyrE_0004"
                     /evalue="1.10E-08"
                     /label="C5_starter_265-294"
                     /locus_tag="pyrE"
                     /protein_end="292"
                     /protein_start="263"
                     /score="27.5"
                     /tool="antismash"
                     /translation="DITLGVPVAGRWGAAAKTPGVVVNVLPLR"
     CDS_motif       9970..10071
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pyrE_0005"
                     /evalue="3.70E-13"
                     /label="C67_starter_14fromHMM"
                     /locus_tag="pyrE"
                     /protein_end="344"
                     /protein_start="310"
                     /score="41.9"
                     /tool="antismash"
                     /translation="RLGELRRHQRYRSEDILRDLGMVGRQLTGPLVNI"
     aSDomain        10399..11640
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pyrE_AMP-binding.1"
                     /evalue="3.90E-116"
                     /label="pyrE_AMP-binding.1"
                     /locus_tag="pyrE"
                     /protein_end="867"
                     /protein_start="453"
                     /score="379.8"
                     /specificity="consensus: thr"
                     /tool="antismash"
                     /translation="FEAQAARTPDRTAVTSGATRLTYRELNERANRLARLLLRRGLGPG
                     RLAALALPRGADLVVALLAVLKTGAGYLPLDPQYPADRLRFTLEDAAPALVLTDTDGAD
                     RVRGAVHPLLLDDPALAAELTGLPGTDPTAAERPAAAGPDSLAYVIYTSGSTGRPKGVA
                     VTHHNVLRLFRQTDHWFGFGADDVWTLFHSYAFDFSVWEIWGPLLHGGRLVVVPFDTSR
                     SPADFLRLLVRERVTVLNQTPSAFYQLIAAERERPDLAGRLTLRHVVFGGEALETHRLE
                     DWYARHGDDAPRLVNMYGITETTVHVTYAALDRETVRAARGSVIGEPIPDLDVYVLDGE
                     LRPVPEGATGELYVAGPGLARGYLGRPGLTAERFVADPFGAPGGRMYRTGDLACVLDDG
                     SLGYLGRADSQVKIR"
     CDS_motif       10585..10626
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pyrE_0006"
                     /evalue="3.30E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="pyrE"
                     /protein_end="529"
                     /protein_start="515"
                     /score="14.1"
                     /tool="antismash"
                     /translation="LAVLKTGAGYLPLD"
     CDS_motif       10837..10896
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pyrE_0007"
                     /evalue="1.30E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="pyrE"
                     /protein_end="619"
                     /protein_start="599"
                     /score="33.1"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGRPKGVAVTH"
     CDS_motif       11290..11313
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pyrE_0008"
                     /evalue="2.00E+00"
                     /label="NRPS-A_a5"
                     /locus_tag="pyrE"
                     /protein_end="758"
                     /protein_start="750"
                     /score="2.3"
                     /tool="antismash"
                     /translation="YGITETTV"
     CDS_motif       11431..11520
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pyrE_0009"
                     /evalue="9.30E-17"
                     /label="NRPS-A_a6"
                     /locus_tag="pyrE"
                     /protein_end="827"
                     /protein_start="797"
                     /score="53.1"
                     /tool="antismash"
                     /translation="PEGATGELYVAGPGLARGYLGRPGLTAERF"
     CDS_motif       11605..11670
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pyrE_0010"
                     /evalue="1.70E-12"
                     /label="NRPS-A_a8"
                     /locus_tag="pyrE"
                     /protein_end="877"
                     /protein_start="855"
                     /score="39.1"
                     /tool="antismash"
                     /translation="YLGRADSQVKIRGFRIELGEIE"
     aSDomain        11977..12171
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pyrE_PCP.1"
                     /evalue="1.80E-25"
                     /label="pyrE_PCP.1"
                     /locus_tag="pyrE"
                     /protein_end="1044"
                     /protein_start="979"
                     /score="80.8"
                     /tool="antismash"
                     /translation="VGALFADVLGLPAVGAADDFFDLGGHSLLAAKLISRIRTELGVEL
                     AIGALFGNPTVTGIAALLGD"
     aSDomain        12214..13119
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pyrE_Condensation_LCL.1"
                     /domain_subtype="Condensation_LCL"
                     /evalue="1.90E-110"
                     /label="pyrE_Condensation_LCL.1"
                     /locus_tag="pyrE"
                     /protein_end="1360"
                     /protein_start="1058"
                     /score="360.4"
                     /tool="antismash"
                     /translation="ETVPLSFAQSRLWFLNQVEGLSATYNVPLAIRLSGTLDREALDRA
                     LADVLARHESLRTIFPQTAGVPHQLVKPADDCRIGTTVVECRPEEQPERLRAALAQGFA
                     LETELPLRTLLFRTGPAEHTFLVVMHHIVADGWSVTPFTEDLATAYAARCEGREPGWPA
                     QLPVQYADYSLWQRRVLGDERAPGSRMARQLAYWAEQLAGLPEELPLPADRPRPLAAGY
                     GGGTVGGRMDTGLHTRLLRLGRDRGATLFMVLQAGLAALLTRLGAGEDIPLGTPVAGRG
                     DEALDDLVGCFVNTLVLRTDT"
     aSModule        12214..15354
                     /complete
                     /domains="nrpspksdomains_pyrE_Condensation_LCL.1"
                     /domains="nrpspksdomains_pyrE_AMP-binding.2"
                     /domains="nrpspksdomains_pyrE_PCP.2"
                     /locus_tags="pyrE"
                     /monomer_pairings="phe -> phe"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       12223..12255
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pyrE_0011"
                     /evalue="6.00E-01"
                     /label="C1_starter_004-017"
                     /locus_tag="pyrE"
                     /protein_end="1072"
                     /protein_start="1061"
                     /score="3.8"
                     /tool="antismash"
                     /translation="PLSFAQSRLWF"
     CDS_motif       12280..12396
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pyrE_0012"
                     /evalue="8.90E-18"
                     /label="C2_LCL_024-062"
                     /locus_tag="pyrE"
                     /protein_end="1119"
                     /protein_start="1080"
                     /score="56.7"
                     /tool="antismash"
                     /translation="ATYNVPLAIRLSGTLDREALDRALADVLARHESLRTIFP"
     CDS_motif       12598..12663
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pyrE_0013"
                     /evalue="8.40E-10"
                     /label="C3_LCL_132-143"
                     /locus_tag="pyrE"
                     /protein_end="1208"
                     /protein_start="1186"
                     /score="31.1"
                     /tool="antismash"
                     /translation="MHHIVADGWSVTPFTEDLATAY"
     CDS_motif       12715..12753
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pyrE_0014"
                     /evalue="2.90E-05"
                     /label="C4_LCL_164-176"
                     /locus_tag="pyrE"
                     /protein_end="1238"
                     /protein_start="1225"
                     /score="16.6"
                     /tool="antismash"
                     /translation="QYADYSLWQRRVL"
     CDS_motif       13021..13110
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pyrE_0015"
                     /evalue="3.00E-14"
                     /label="C5_LCL_267-296"
                     /locus_tag="pyrE"
                     /protein_end="1357"
                     /protein_start="1327"
                     /score="45.3"
                     /tool="antismash"
                     /translation="DIPLGTPVAGRGDEALDDLVGCFVNTLVLR"
     CDS_motif       13159..13278
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pyrE_0016"
                     /evalue="1.70E-23"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="pyrE"
                     /protein_end="1413"
                     /protein_start="1373"
                     /score="75.1"
                     /tool="antismash"
                     /translation="RTTDLAAYEHQDLPFDRLVEALNPPRSLARHPLFQVMLAL"
     aSDomain        13630..14823
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pyrE_AMP-binding.2"
                     /evalue="1.90E-109"
                     /label="pyrE_AMP-binding.2"
                     /locus_tag="pyrE"
                     /protein_end="1928"
                     /protein_start="1530"
                     /score="357.8"
                     /specificity="consensus: phe"
                     /tool="antismash"
                     /translation="FEAQAALVPDRTAAVFEGARLTYAELNARANRLARHLVAQGVGPE
                     QVVALAVPRSLEMVVAMLAVFKAGAAYLPVDPDYPADRIRYMLEDARPAQVLTTAEAAH
                     VLPDAVTPVLLDDPGTVARVADLPATDVTDGERLAPLVPAHPAYVIYTSGSTGRPKGVV
                     VCHTGIPSLLANQIERCAVGPDNRVLQFATASFDAAFWDVAMALFTGGTLVLAPAWRLL
                     PGPELSELAAAHDITHVTLPPSVLAMLPVEGGLPASTTIVVAGEATPADLVARWSRGRR
                     MVNSYGPTEITVSCAISPPLDATGELPISPPSMNTRLHVLDGRLRLVPPGVPGELYVAG
                     PGTARGYLGRPDLTAARFVADPFGPPGTRMYRTGDLARRRPDGRLEFLGRADDQVKIR"
     CDS_motif       13816..13857
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pyrE_0017"
                     /evalue="8.10E-05"
                     /label="NRPS-A_a2"
                     /locus_tag="pyrE"
                     /protein_end="1606"
                     /protein_start="1592"
                     /score="15.9"
                     /tool="antismash"
                     /translation="LAVFKAGAAYLPVD"
     CDS_motif       14068..14127
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pyrE_0018"
                     /evalue="3.40E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="pyrE"
                     /protein_end="1696"
                     /protein_start="1676"
                     /score="31.8"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGRPKGVVVCH"
     CDS_motif       14482..14514
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pyrE_0019"
                     /evalue="5.70E-02"
                     /label="NRPS-A_a5"
                     /locus_tag="pyrE"
                     /protein_end="1825"
                     /protein_start="1814"
                     /score="6.6"
                     /tool="antismash"
                     /translation="SYGPTEITVSC"
     CDS_motif       14614..14703
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pyrE_0020"
                     /evalue="1.10E-16"
                     /label="NRPS-A_a6"
                     /locus_tag="pyrE"
                     /protein_end="1888"
                     /protein_start="1858"
                     /score="52.8"
                     /tool="antismash"
                     /translation="PPGVPGELYVAGPGTARGYLGRPDLTAARF"
     CDS_motif       14788..14853
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pyrE_0021"
                     /evalue="7.10E-13"
                     /label="NRPS-A_a8"
                     /locus_tag="pyrE"
                     /protein_end="1938"
                     /protein_start="1916"
                     /score="40.3"
                     /tool="antismash"
                     /translation="FLGRADDQVKIRGFRVELGEIE"
     aSDomain        15151..15354
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pyrE_PCP.2"
                     /evalue="3.20E-22"
                     /label="pyrE_PCP.2"
                     /locus_tag="pyrE"
                     /protein_end="2105"
                     /protein_start="2037"
                     /score="70.4"
                     /tool="antismash"
                     /translation="ERRIAQAWCAVLGLERVGAQDNFFDVGGHSLTLIALQKRLVDELG
                     RPVPVVDLFAHPTVAALAAHLAA"
     gene            15476..19711
                     /gene="pyrF"
     CDS             15476..19711
                     /NRPS_PKS="Domain: PKS_KS(Hybrid-KS) (12-439). E-value:
                     1e-152. Score: 500.8. Matches aSDomain:
                     nrpspksdomains_pyrF_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (535-811). E-value: 2.2e-82.
                     Score: 268.6. Matches aSDomain:
                     nrpspksdomains_pyrF_PKS_AT.1"
                     /NRPS_PKS="Domain: cMT (1074-1258). E-value: 1.1e-49.
                     Score: 160.4. Matches aSDomain: nrpspksdomains_pyrF_cMT.1"
                     /NRPS_PKS="Domain: PCP (1321-1387). E-value: 2.2e-21.
                     Score: 67.7. Matches aSDomain: nrpspksdomains_pyrF_PCP.1"
                     /codon_start=1
                     /gene="pyrF"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 247.4; E-value:
                     4.5e-75)"
                     /gene_kind="biosynthetic"
                     /product="polyketide synthase"
                     /protein_id="AEF33079.1"
                     /sec_met_domain="PP-binding (E-value: 9.3e-16, bitscore:
                     49.0, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_KS (E-value: 4.8e-153, bitscore:
                     500.8, seeds: 2284, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 1e-82, bitscore: 268.6,
                     seeds: 1682, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADDSQTVRDLDIAIVAMEGRFPGARDVAQFWANLVAGEESVRPV
                     GDEEYLAAGGDPAALGDRYAVKAAAAMDDADLFDADFFGLRADEAETMDPQQRVFLEVC
                     HHALEQSGHDPDRFDGVIGVYGGASQSRYYLSHVRPRLDESAEPLRAWTASMGNDPGVF
                     ATRVAYALNLTGPALTVQTACSTSLAAIHLACQDLLSYRCDVALAGGSSINPAAKRGYR
                     HTPDGPFSPDGHVRAFDARAEGMVPGDATAVVVLKRLTDAVADGDRIRAVIKGTAVNND
                     GSRKVGFTAPSPLGQAEVVLAAHAAAEVDADTIGYVEAHGTGTPVGDPIEFAALTQAFA
                     ETTTRTGFCALGSVKTNIGHTDAAAGVVGLIKAALVVEHGTIPPTLHYTSPNPLIDLDS
                     SPFHVNDRLTEWPAGPTPRRAGVSSFGIGGTNAHAVLEEPPAAPARGTGEGWVLLPWSA
                     RSAEAADRLGALLGDHLARTPDLALGDVAHTLRSGRRTFAHRRFAVCRDRDGAVAQLVA
                     PGHAAPPADGPTERPVAFLFPGGGAQYDGMGRGLYETEPVFRETLDRCAAILEPVLGFD
                     VRAALHRGEEGPRSSLLPGLVSTEYALATLLMSRGVRPQSLIGHSAGEYTAACLAGVMS
                     LEDMLPLVAKRQWLLERAGGVAVSVRLGERDLDAYLTERLSLATVNAPALCTVSGPEED
                     VRELEARWDAEGVEYQRVHFPSAVHSWLLDSVLDDYAAALAEVTLRPPAIPFVSNVSGT
                     WITDAEATSPDYWLRHTRRTVRFADGLTALRAGGEPVLVEVGPGRILTRCAQLQFGDAV
                     PTVETMRHPRADQHDQQVLLTALGRLWQLGARLTWDGENRADEEEGQGGRRVPLPGYPF
                     ERKRYWLDEVRPAATASATASAAAAGRGAVRDLAEAERELRRSTDVSTVPARLREDFDR
                     LAALRAAAFLRTAGVDTTAGRTYTPEDLVGRLRPAGPYRKLLDALLHMLRESGVLAREG
                     DLLRFTGSGADAAEEARLTRSVTERHPSLAKDLELLDTCLAGCADVLRGDTDGTAVLTP
                     DGRTDLTAGVLETHMDEGDFALYRTLLAEHVAELARAAGGRPFRILEAGAGRGRLTWTV
                     AEALRGIPGVRYHVTDLGRSFVLEAEREAARRGIDFMSFGVLDIGQAVDPVALGGAFDV
                     VLAFNVLHIPADLRECTRHVRRLLAPGGLLCALETVRMPWASELSVGLLPQWWAFADDL
                     RRNSPILPADRWRELLVSEGFDEVRVLSDDRADQPLIPHALIVGRRPAASAAEPATAEP
                     ATARPTAGSARTPEETGTGRQPRPALGVAHRAPSTDTERVVARHWEELLRVDGIGADDN
                     FFDLGGESLLALQLVTRLRDELGVELRVKKLMEKLTVAAMATEADALRGNADTAPRITP
                     SARRGRRAG"
     aSDomain        15512..16792
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pyrF_PKS_KS.1"
                     /domain_subtype="Hybrid-KS"
                     /evalue="1.00E-152"
                     /label="pyrF_PKS_KS.1"
                     /locus_tag="pyrF"
                     /protein_end="439"
                     /protein_start="12"
                     /score="500.8"
                     /tool="antismash"
                     /translation="IAIVAMEGRFPGARDVAQFWANLVAGEESVRPVGDEEYLAAGGDP
                     AALGDRYAVKAAAAMDDADLFDADFFGLRADEAETMDPQQRVFLEVCHHALEQSGHDPD
                     RFDGVIGVYGGASQSRYYLSHVRPRLDESAEPLRAWTASMGNDPGVFATRVAYALNLTG
                     PALTVQTACSTSLAAIHLACQDLLSYRCDVALAGGSSINPAAKRGYRHTPDGPFSPDGH
                     VRAFDARAEGMVPGDATAVVVLKRLTDAVADGDRIRAVIKGTAVNNDGSRKVGFTAPSP
                     LGQAEVVLAAHAAAEVDADTIGYVEAHGTGTPVGDPIEFAALTQAFAETTTRTGFCALG
                     SVKTNIGHTDAAAGVVGLIKAALVVEHGTIPPTLHYTSPNPLIDLDSSPFHVNDRLTEW
                     PAGPTPRRAGVSSFGIGGTNAHAVLEEP"
     aSModule        15512..19636
                     /complete
                     /domains="nrpspksdomains_pyrF_PKS_KS.1"
                     /domains="nrpspksdomains_pyrF_PKS_AT.1"
                     /domains="nrpspksdomains_pyrF_cMT.1"
                     /domains="nrpspksdomains_pyrF_PCP.1"
                     /locus_tags="pyrF"
                     /monomer_pairings="mal -> Me-mal"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       15872..15892
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pyrF_0001"
                     /evalue="9.90E+01"
                     /label="PKSI-AT-M_m8"
                     /locus_tag="pyrF"
                     /protein_end="139"
                     /protein_start="132"
                     /score="-2.8"
                     /tool="antismash"
                     /translation="YYLSHVR"
     CDS_motif       15998..16045
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pyrF_0002"
                     /evalue="2.60E-05"
                     /label="PKSI-KS_m3"
                     /locus_tag="pyrF"
                     /protein_end="190"
                     /protein_start="174"
                     /score="16.4"
                     /tool="antismash"
                     /translation="GPALTVQTACSTSLAA"
     CDS_motif       16421..16468
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pyrF_0003"
                     /evalue="7.50E-05"
                     /label="PKSI-KS_m5"
                     /locus_tag="pyrF"
                     /protein_end="331"
                     /protein_start="315"
                     /score="14.5"
                     /tool="antismash"
                     /translation="YVEAHGTGTPVGDPIE"
     CDS_motif       16529..16573
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pyrF_0004"
                     /evalue="6.30E-04"
                     /label="PKSI-KS_m6"
                     /locus_tag="pyrF"
                     /protein_end="366"
                     /protein_start="351"
                     /score="12.2"
                     /tool="antismash"
                     /translation="GSVKTNIGHTDAAAG"
     CDS_motif       17078..17131
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pyrF_0005"
                     /evalue="4.10E-05"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="pyrF"
                     /protein_end="552"
                     /protein_start="534"
                     /score="16.1"
                     /tool="antismash"
                     /translation="FLFPGGGAQYDGMGRGLY"
     aSDomain        17081..17908
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pyrF_PKS_AT.1"
                     /evalue="2.20E-82"
                     /label="pyrF_PKS_AT.1"
                     /locus_tag="pyrF"
                     /protein_end="811"
                     /protein_start="535"
                     /score="268.6"
                     /specificity="consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="LFPGGGAQYDGMGRGLYETEPVFRETLDRCAAILEPVLGFDVRAA
                     LHRGEEGPRSSLLPGLVSTEYALATLLMSRGVRPQSLIGHSAGEYTAACLAGVMSLEDM
                     LPLVAKRQWLLERAGGVAVSVRLGERDLDAYLTERLSLATVNAPALCTVSGPEEDVREL
                     EARWDAEGVEYQRVHFPSAVHSWLLDSVLDDYAAALAEVTLRPPAIPFVSNVSGTWITD
                     AEATSPDYWLRHTRRTVRFADGLTALRAGGEPVLVEVGPGRILTRCAQLQFGDA"
     CDS_motif       17306..17413
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pyrF_0006"
                     /evalue="1.10E-19"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="pyrF"
                     /protein_end="646"
                     /protein_start="610"
                     /score="62.6"
                     /tool="antismash"
                     /translation="GVRPQSLIGHSAGEYTAACLAGVMSLEDMLPLVAKR"
     CDS_motif       17768..17803
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pyrF_0007"
                     /evalue="3.40E-04"
                     /label="PKSI-AT-M_m8"
                     /locus_tag="pyrF"
                     /protein_end="776"
                     /protein_start="764"
                     /score="14.0"
                     /tool="antismash"
                     /translation="YWLRHTRRTVRF"
     CDS_motif       18455..18487
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pyrF_0008"
                     /evalue="7.70E+01"
                     /label="PKSI-AT-M_m1"
                     /locus_tag="pyrF"
                     /protein_end="1004"
                     /protein_start="993"
                     /score="-2.4"
                     /tool="antismash"
                     /translation="FTGSGADAAEE"
     aSDomain        18698..19249
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pyrF_cMT.1"
                     /domain_subtype="cMT"
                     /evalue="1.10E-49"
                     /label="pyrF_cMT.1"
                     /locus_tag="pyrF"
                     /protein_end="1258"
                     /protein_start="1074"
                     /score="160.4"
                     /tool="antismash"
                     /translation="LAEHVAELARAAGGRPFRILEAGAGRGRLTWTVAEALRGIPGVRY
                     HVTDLGRSFVLEAEREAARRGIDFMSFGVLDIGQAVDPVALGGAFDVVLAFNVLHIPAD
                     LRECTRHVRRLLAPGGLLCALETVRMPWASELSVGLLPQWWAFADDLRRNSPILPADRW
                     RELLVSEGFDEVRVLSDDRAD"
     aSDomain        19439..19636
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pyrF_PCP.1"
                     /evalue="2.20E-21"
                     /label="pyrF_PCP.1"
                     /locus_tag="pyrF"
                     /protein_end="1387"
                     /protein_start="1321"
                     /score="67.7"
                     /tool="antismash"
                     /translation="ERVVARHWEELLRVDGIGADDNFFDLGGESLLALQLVTRLRDELG
                     VELRVKKLMEKLTVAAMATEA"
     gene            19866..27221
                     /gene="pyrG"
     CDS             19866..27221
                     /NRPS_PKS="Domain: Condensation_LCL (28-331). E-value:
                     8.3e-110. Score: 358.3. Matches aSDomain:
                     nrpspksdomains_pyrG_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (495-846). E-value: 1.8e-17.
                     Score: 54.8. Matches aSDomain:
                     nrpspksdomains_pyrG_AMP-binding.1"
                     /NRPS_PKS="Domain: CAL_domain (1054-1468). E-value: 4e-77.
                     Score: 251.0. Matches aSDomain:
                     nrpspksdomains_pyrG_CAL_domain.1"
                     /NRPS_PKS="Domain: PKS_KR (1787-1981). E-value: 1.4e-36.
                     Score: 117.9. Matches aSDomain:
                     nrpspksdomains_pyrG_PKS_KR.1"
                     /NRPS_PKS="Domain: PCP (2116-2183). E-value: 1.3e-24.
                     Score: 78.0. Matches aSDomain: nrpspksdomains_pyrG_PCP.1"
                     /NRPS_PKS="Domain: Thioesterase (2204-2433). E-value:
                     1.6e-39. Score: 128.4. Matches aSDomain:
                     nrpspksdomains_pyrG_Thioesterase.1"
                     /codon_start=1
                     /gene="pyrG"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1209:polyketide synthase associated protein papA3
                     (Score: 68.7; E-value: 5.1e-21)"
                     /gene_kind="biosynthetic"
                     /product="putative peptide synthetase"
                     /protein_id="AEF33080.1"
                     /sec_met_domain="Condensation (E-value: 3.9e-87, bitscore:
                     282.8, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 9.8e-82, bitscore:
                     265.4, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 3.8e-18, bitscore:
                     56.6, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 7.1e-34, bitscore:
                     108.1, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 6.9e-09, bitscore: 26.4,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPSASTSETQEPATDVRTAPEEAADVLEFPATYAQQGLWFFYRLN
                     PHSAFYNVSMMHRLTGELDTAVLRSALNDVVQRHEALRTTFREHDGELRQVVADAVDIA
                     LPVHEAAGSAADRTAPHEVPAVREQLTGLIQAPFDLENGPLLRAALVRTAPADHLLVLS
                     MHHIVVDGWSLGIFLRELAEAYRARRAGQAPQLPELAIQYGDYAEWQAEQLHGPALQDG
                     LDYWRARLGGDLPELRLATDRPRPEARSFVGARFDFTFDEELTAGLREMCRAEGVTLYM
                     VLFAGVSALLHRYTGQDDFILGTPMAGRDDAQTQPLIGSFVNTLPMRADLSGDPSFTRV
                     LGRVREMSQGAYAHDDIPFEKIVQEVAPQRGIGANPLFQVTFALQNYELGGFELDGVHA
                     ERIAVEEGTARFDLEVHCWDDPDRLRGSFVYSTDLFDRATLERMAAHLTKVFEGALADP
                     SRTIGELSLLTEDDHLVLDAVAGPDAGFDADATVPRLFAAQVTARPGATAVRAPGATLS
                     YAELAAGVSALAARLRAAGLTPGARAGLHLDGPVDELVGTLAVLEAGGVCVPLNPSDDP
                     ALLRRSTRRTGLALLLTRGAAGDWADGLTAVDLDTAAPAGVGPDAAPAPVRPAGSAPAL
                     LLDVPGGPLVLDHAGLADRLARLAAAAALTTGDVVARHAPWGQERAVWEALLPVCHGAS
                     LAAVGGAGVPGDATVVIAADSDLSGILAADAPTLSPRALLCLASVPSPALVRRCHDRFG
                     PAARWVYATSHAGPTGVAESAPTDAALLFAPLRAVRMLDARGATTPVGVPAEVYVGGSG
                     LARPALGSGPVTWAAAGDTGRITADGKLEILARRPGTAVVSGVPVDLAEVTAAILAEQA
                     VAEVTVVERRATAGHTELVGYAVRCGQVTSQRLVQAARAALPGGAALAAVVFVTALPRT
                     PGGGVDTAALSELPVLDDELIGAWEQALSERGVPAVVVVAESDPAPAAEDFVDPRALGR
                     DTAAESTPTGGAGTAGDSDVPAISSGGPALDPGAANLAEVLRRVAADPASGDLVYVSAQ
                     GEEDHQSYGELRDEASRVLGGLRALGTRPGDQVILQLADNRDFVTGLWACVLGGFVAVP
                     LAVSPTYAEDTAATNKLAGAWTLLSGPLLLTDRTLAGPLRGLGERLGWQEPRLAVLDDL
                     RDGPQATDWHDSRGDDLVLLLLTSGSTGRPKAVELRHRNVLARTAAARHVYELTQRDVS
                     FNWMPLDHVGGIVMSHIRDVFVGCRQIQAPTQWVLADPLRWTAKMAEHRVTTTWAPNFA
                     FGLIAERAAQLAGQDWDLGALRLIINGGEAIVPRVTRRFMAALAPLGLPATAMRPAWGM
                     SETSSGEVDDRFDPATATDDDQFVCVGAPFPGFTMRIVDGDDAVVHEGVPGRLQVKGPA
                     VTSGYHLNPEQNAESFTEDGWFETGDLAVLRDGKLTITGRAKDAIIINGHNFHSHELEE
                     CVEELDEVERSFTAACAVRTADSSTDELALFFCLKDGVADAEAISLIRAKLQREAGVHA
                     SYLVPVTRERIPKTEIGKIQRTLLRTQFEAGEFAAELRRTGAGTDDDTALPNWFHRPVW
                     RRAADGPRPVAPAAGHTLLVADGHGLADALAELLRDRGERCTVLPAGAAHAAQAHGAVD
                     RVVHLASCAPYQELPTGTQELAAAYREGPPALAELVGAVVRANPEGRPVALTVVATHSQ
                     WVREGDRVAPARGASTGVVKSVGQEYDWLRATHLDVEPQEPAELAQRILELLDAAGNEP
                     EQALRGGERWVRRIERLPAAPSGTTGLRRGELVVVSGGLGGLAAETAAHLLSVHGVRLL
                     LLGRTVLPPEEAWDEELASGGATAERIAVLRRLRALGEVHYAAADVTDAAAVRAAVRHA
                     EERCSTQAATVIHLAGHFHEAPVTEAGEEDWAEVTRAKVLGAAVLHHLVKDRPGARFLS
                     YSSVNGYFGGANVAGYAAANAFLDALAVHQSTGHGMRAQSLGWTMWDELGLSRGYALKA
                     LTEARGYRVLAPGQGVASVDVALRHGTPQVLIGLDHTAPWVAGRLQAPTAPLHRLVGYR
                     TAGSADGRGDLGLPDRYGTRTDCEFAVVAELPVTESGEVDRRRLAEAGGAGAATAAADD
                     RPHSAAEQAIAAIWCDLLGLAEVGVHDNFFDIGGHSLRAAMLLSRLRAELGVDLTIASL
                     FENPTIAGLARQLDPMTAQDPLAVVLPLRREGAAAPLFCLHPGGGISWCYSGLLGGLPD
                     RHPVYGIQARGLNGEEPLPATLDEMVDDYLGQVREIQPAGPYHFLGWSFGGVIAHAMAT
                     RLTAEGHRVGVLAMIDAWPADPELDPEFGDDLNVEKEMLGALLADAGYEGPVDEELTRA
                     EALRILRSEGSPLGNLTEESITSLVAIATNNIKLRACELPPYDGDLLLFHADGDDRDAD
                     AVTRSWRRFSTGRIDNRPMPYGHNSIIHPKPLAEIGALVGERMADG"
     aSDomain        19950..20858
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pyrG_Condensation_LCL.1"
                     /domain_subtype="Condensation_LCL"
                     /evalue="8.30E-110"
                     /label="pyrG_Condensation_LCL.1"
                     /locus_tag="pyrG"
                     /protein_end="331"
                     /protein_start="28"
                     /score="358.3"
                     /tool="antismash"
                     /translation="FPATYAQQGLWFFYRLNPHSAFYNVSMMHRLTGELDTAVLRSALN
                     DVVQRHEALRTTFREHDGELRQVVADAVDIALPVHEAAGSAADRTAPHEVPAVREQLTG
                     LIQAPFDLENGPLLRAALVRTAPADHLLVLSMHHIVVDGWSLGIFLRELAEAYRARRAG
                     QAPQLPELAIQYGDYAEWQAEQLHGPALQDGLDYWRARLGGDLPELRLATDRPRPEARS
                     FVGARFDFTFDEELTAGLREMCRAEGVTLYMVLFAGVSALLHRYTGQDDFILGTPMAGR
                     DDAQTQPLIGSFVNTLPMRADL"
     aSModule        19950..22403
                     /domains="nrpspksdomains_pyrG_Condensation_LCL.1"
                     /domains="nrpspksdomains_pyrG_AMP-binding.1"
                     /incomplete
                     /locus_tags="pyrG"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       20010..20126
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pyrG_0001"
                     /evalue="8.60E-18"
                     /label="C2_LCL_024-062"
                     /locus_tag="pyrG"
                     /protein_end="87"
                     /protein_start="48"
                     /score="56.7"
                     /tool="antismash"
                     /translation="AFYNVSMMHRLTGELDTAVLRSALNDVVQRHEALRTTFR"
     CDS_motif       20355..20420
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pyrG_0002"
                     /evalue="3.30E-12"
                     /label="C3_LCL_132-143"
                     /locus_tag="pyrG"
                     /protein_end="185"
                     /protein_start="163"
                     /score="38.7"
                     /tool="antismash"
                     /translation="MHHIVVDGWSLGIFLRELAEAY"
     CDS_motif       20469..20507
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pyrG_0003"
                     /evalue="6.60E-04"
                     /label="C4_LCL_164-176"
                     /locus_tag="pyrG"
                     /protein_end="214"
                     /protein_start="201"
                     /score="12.4"
                     /tool="antismash"
                     /translation="QYGDYAEWQAEQL"
     CDS_motif       20760..20849
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pyrG_0004"
                     /evalue="1.20E-13"
                     /label="C5_LCL_267-296"
                     /locus_tag="pyrG"
                     /protein_end="328"
                     /protein_start="298"
                     /score="43.4"
                     /tool="antismash"
                     /translation="DFILGTPMAGRDDAQTQPLIGSFVNTLPMR"
     CDS_motif       20898..21017
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pyrG_0005"
                     /evalue="1.00E-15"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="pyrG"
                     /protein_end="384"
                     /protein_start="344"
                     /score="50.0"
                     /tool="antismash"
                     /translation="REMSQGAYAHDDIPFEKIVQEVAPQRGIGANPLFQVTFAL"
     aSDomain        21351..22403
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pyrG_AMP-binding.1"
                     /evalue="1.80E-17"
                     /label="pyrG_AMP-binding.1"
                     /locus_tag="pyrG"
                     /protein_end="846"
                     /protein_start="495"
                     /score="54.8"
                     /specificity="consensus: X"
                     /tool="antismash"
                     /translation="FAAQVTARPGATAVRAPGATLSYAELAAGVSALAARLRAAGLTPG
                     ARAGLHLDGPVDELVGTLAVLEAGGVCVPLNPSDDPALLRRSTRRTGLALLLTRGAAGD
                     WADGLTAVDLDTAAPAGVGPDAAPAPVRPAGSAPALLLDVPGGPLVLDHAGLADRLARL
                     AAAAALTTGDVVARHAPWGQERAVWEALLPVCHGASLAAVGGAGVPGDATVVIAADSDL
                     SGILAADAPTLSPRALLCLASVPSPALVRRCHDRFGPAARWVYATSHAGPTGVAESAPT
                     DAALLFAPLRAVRMLDARGATTPVGVPAEVYVGGSGLARPALGSGPVTWAAAGDTGRIT
                     ADGKLEILARR"
     CDS_motif       21537..21578
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pyrG_0006"
                     /evalue="9.00E-03"
                     /label="NRPS-A_a2"
                     /locus_tag="pyrG"
                     /protein_end="571"
                     /protein_start="557"
                     /score="9.8"
                     /tool="antismash"
                     /translation="LAVLEAGGVCVPLN"
     CDS_motif       21816..21884
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pyrG_0007"
                     /evalue="2.80E+01"
                     /label="C2_dual_024-063"
                     /locus_tag="pyrG"
                     /protein_end="673"
                     /protein_start="650"
                     /score="-2.6"
                     /tool="antismash"
                     /translation="LADRLARLAAAAALTTGDVVARH"
     CDS_motif       22260..22310
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pyrG_0008"
                     /evalue="1.30E-04"
                     /label="NRPS-A_a6"
                     /locus_tag="pyrG"
                     /protein_end="815"
                     /protein_start="798"
                     /score="14.4"
                     /tool="antismash"
                     /translation="PVGVPAEVYVGGSGLAR"
     aSDomain        23028..24269
                     /aSDomain="CAL_domain"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pyrG_CAL_domain.1"
                     /evalue="4.00E-77"
                     /label="pyrG_CAL_domain.1"
                     /locus_tag="pyrG"
                     /protein_end="1468"
                     /protein_start="1054"
                     /score="251.0"
                     /specificity="Minowa: fatty_acid"
                     /tool="antismash"
                     /translation="SYGELRDEASRVLGGLRALGTRPGDQVILQLADNRDFVTGLWACV
                     LGGFVAVPLAVSPTYAEDTAATNKLAGAWTLLSGPLLLTDRTLAGPLRGLGERLGWQEP
                     RLAVLDDLRDGPQATDWHDSRGDDLVLLLLTSGSTGRPKAVELRHRNVLARTAAARHVY
                     ELTQRDVSFNWMPLDHVGGIVMSHIRDVFVGCRQIQAPTQWVLADPLRWTAKMAEHRVT
                     TTWAPNFAFGLIAERAAQLAGQDWDLGALRLIINGGEAIVPRVTRRFMAALAPLGLPAT
                     AMRPAWGMSETSSGEVDDRFDPATATDDDQFVCVGAPFPGFTMRIVDGDDAVVHEGVPG
                     RLQVKGPAVTSGYHLNPEQNAESFTEDGWFETGDLAVLRDGKLTITGRAKDAIIINGHN
                     FHSHELEECVEELDE"
     aSModule        23028..27164
                     /domains="nrpspksdomains_pyrG_CAL_domain.1"
                     /domains="nrpspksdomains_pyrG_PKS_KR.1"
                     /domains="nrpspksdomains_pyrG_PCP.1"
                     /domains="nrpspksdomains_pyrG_Thioesterase.1"
                     /final_module
                     /incomplete
                     /locus_tags="pyrG"
                     /starter_module
                     /tool="antismash"
                     /type="pks"
     CDS_motif       23151..23189
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pyrG_0009"
                     /evalue="3.10E+01"
                     /label="NRPS-A_a2"
                     /locus_tag="pyrG"
                     /protein_end="1108"
                     /protein_start="1095"
                     /score="-0.8"
                     /tool="antismash"
                     /translation="WACVLGGFVAVPL"
     CDS_motif       23421..23474
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pyrG_0010"
                     /evalue="6.40E-05"
                     /label="NRPS-A_a3"
                     /locus_tag="pyrG"
                     /protein_end="1203"
                     /protein_start="1185"
                     /score="15.8"
                     /tool="antismash"
                     /translation="LLLTSGSTGRPKAVELRH"
     CDS_motif       23712..23750
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pyrG_0011"
                     /evalue="3.10E+01"
                     /label="C3_starter_134-155"
                     /locus_tag="pyrG"
                     /protein_end="1295"
                     /protein_start="1282"
                     /score="-2.0"
                     /tool="antismash"
                     /translation="FAFGLIAERAAQL"
     CDS_motif       24036..24119
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pyrG_0012"
                     /evalue="3.00E-08"
                     /label="NRPS-A_a6"
                     /locus_tag="pyrG"
                     /protein_end="1418"
                     /protein_start="1390"
                     /score="26.0"
                     /tool="antismash"
                     /translation="GVPGRLQVKGPAVTSGYHLNPEQNAESF"
     aSDomain        25227..25808
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pyrG_PKS_KR.1"
                     /evalue="1.40E-36"
                     /label="pyrG_PKS_KR.1"
                     /locus_tag="pyrG"
                     /protein_end="1981"
                     /protein_start="1787"
                     /score="117.9"
                     /specificity="KR activity: active"
                     /specificity="KR stereochemistry: (unknown)"
                     /tool="antismash"
                     /translation="LVVVSGGLGGLAAETAAHLLSVHGVRLLLLGRTVLPPEEAWDEEL
                     ASGGATAERIAVLRRLRALGEVHYAAADVTDAAAVRAAVRHAEERCSTQAATVIHLAGH
                     FHEAPVTEAGEEDWAEVTRAKVLGAAVLHHLVKDRPGARFLSYSSVNGYFGGANVAGYA
                     AANAFLDALAVHQSTGHGMRAQSLGWTMWDE"
     CDS_motif       25233..25325
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pyrG_0013"
                     /evalue="2.40E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="pyrG"
                     /protein_end="1820"
                     /protein_start="1789"
                     /score="17.0"
                     /tool="antismash"
                     /translation="VVSGGLGGLAAETAAHLLSVHGVRLLLLGRT"
     CDS_motif       25656..25754
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pyrG_0014"
                     /evalue="6.80E-10"
                     /label="PKSI-KR_m4"
                     /locus_tag="pyrG"
                     /protein_end="1963"
                     /protein_start="1930"
                     /score="31.5"
                     /tool="antismash"
                     /translation="FLSYSSVNGYFGGANVAGYAAANAFLDALAVHQ"
     aSDomain        26214..26414
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pyrG_PCP.1"
                     /evalue="1.30E-24"
                     /label="pyrG_PCP.1"
                     /locus_tag="pyrG"
                     /protein_end="2183"
                     /protein_start="2116"
                     /score="78.0"
                     /tool="antismash"
                     /translation="EQAIAAIWCDLLGLAEVGVHDNFFDIGGHSLRAAMLLSRLRAELG
                     VDLTIASLFENPTIAGLARQLD"
     CDS_motif       26478..26507
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pyrG_0015"
                     /evalue="6.40E-03"
                     /label="NRPS-beforete1"
                     /locus_tag="pyrG"
                     /protein_end="2214"
                     /protein_start="2204"
                     /score="9.6"
                     /tool="antismash"
                     /translation="PLFCLHPGGG"
     aSDomain        26478..27164
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pyrG_Thioesterase.1"
                     /evalue="1.60E-39"
                     /label="pyrG_Thioesterase.1"
                     /locus_tag="pyrG"
                     /protein_end="2433"
                     /protein_start="2204"
                     /score="128.4"
                     /tool="antismash"
                     /translation="PLFCLHPGGGISWCYSGLLGGLPDRHPVYGIQARGLNGEEPLPAT
                     LDEMVDDYLGQVREIQPAGPYHFLGWSFGGVIAHAMATRLTAEGHRVGVLAMIDAWPAD
                     PELDPEFGDDLNVEKEMLGALLADAGYEGPVDEELTRAEALRILRSEGSPLGNLTEESI
                     TSLVAIATNNIKLRACELPPYDGDLLLFHADGDDRDADAVTRSWRRFSTGRIDNRPMPY
                     GHNSIIH"
     CDS_motif       26658..26732
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pyrG_0016"
                     /evalue="1.00E-14"
                     /label="NRPS-te1"
                     /locus_tag="pyrG"
                     /protein_end="2289"
                     /protein_start="2264"
                     /score="46.7"
                     /tool="antismash"
                     /translation="QPAGPYHFLGWSFGGVIAHAMATRL"
     gene            27251..27466
                     /gene="pyrH"
     CDS             27251..27466
                     /codon_start=1
                     /gene="pyrH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1009:mbtH-like protein (Score: 89.6; E-value:
                     1.4e-27)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative MbtH-like protein"
                     /protein_id="AEF33081.1"
                     /transl_table=11
                     /translation="MTNPFDDPDGTYRVLANDEGQHCLWPDALDVPQGWHTLRGAGTRQ
                     ESLDFIAGNWTDLRPASLAAGEDGAR"
     gene            27463..28671
                     /gene="pyrI"
     CDS             27463..28671
                     /codon_start=1
                     /gene="pyrI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007:cytochrome P450 (Score: 400; E-value: 1.8e-121)"
                     /gene_kind="biosynthetic-additional"
                     /product="cytochrome P450"
                     /protein_id="AEF33082.1"
                     /sec_met_domain="p450 (E-value: 3.6e-23, bitscore: 72.7,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDARTPVGVDLLNPDVYAVDNQPRLWRRLQDECPVGWHEPTPGV
                     PGFWVLSRYADIMEVFKDTTTFSSARGNILGTLLAGGDPAGGQMLAVTDPPRHRDLRRI
                     LQGGFSARSMRRIADSVRTVARRLVAEAVERGGCDFVADIAARIPLEAICELLAVPVED
                     RARMLELTSTALDADSTPMEAARAQSDIMNYYAKLLPERRANPQDDAVSMLAAGAIDGR
                     PLSEVEVFLNCYNLIIGGDETTRFSGAGGLLALIEHPDQWRLLKERPDVIDSAVEEIVR
                     WTSPALHIARVATVDTTVRGTRIAAGDIVTLWIGAANRDEEVFEDPYAFDLARTPNKHM
                     AYGFGPHFCLGGALARIEMQILFEELRDQVGSVSLAGEVEYSRSNFLTGVSRLPVALTP
                     STR"
     gene            28697..29815
                     /gene="pyrJ"
     CDS             28697..29815
                     /NRPS_PKS="Domain: Aminotran_1_2 (31-329). E-value:
                     4.1e-54. Score: 175.9. Matches aSDomain:
                     nrpspksdomains_pyrJ_Aminotran_1_2.1"
                     /codon_start=1
                     /gene="pyrJ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019:aminotransferase (Score: 161.3; E-value:
                     5.6e-49)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative aminotransferase"
                     /protein_id="AEF33083.1"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 7.7e-10,
                     bitscore: 29.2, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPSTTSPRMRPALDAVPGYTPARVPDGTAPVHRLAANESPYPPLP
                     GVLERLAVTAQDANRYPDFGCRELTAELAARLDVPAAHIAVGTGSVALAQQLIQITADP
                     GDEVLFAWRSFEAYPVMTRLAGAVPVQVPLTADERHDLRAMARAVTERTRLVIVCNPNN
                     PTGTVVGRAELEAFLDQVPADVLVVLDEAYVEFADDPDHPDGVELYRDRPNVCVLRTFS
                     KAHGLAGLRVGYAVAHEPVAAALRTAAVPFGVSQLAQDAAVASLRAESAMRERVAALTA
                     ERARVVRELAAQGWTVAPTRANFVWLRLGDRTAEFADACAAAGVSVMAFPGDGARVSIG
                     DAAANDAFLRCTSRFRTGGAAAQEQASRQAGE"
     aSDomain        28790..29683
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pyrJ_Aminotran_1_2.1"
                     /evalue="4.10E-54"
                     /label="pyrJ_Aminotran_1_2.1"
                     /locus_tag="pyrJ"
                     /protein_end="329"
                     /protein_start="31"
                     /score="175.9"
                     /tool="antismash"
                     /translation="HRLAANESPYPPLPGVLERLAVTAQDANRYPDFGCRELTAELAAR
                     LDVPAAHIAVGTGSVALAQQLIQITADPGDEVLFAWRSFEAYPVMTRLAGAVPVQVPLT
                     ADERHDLRAMARAVTERTRLVIVCNPNNPTGTVVGRAELEAFLDQVPADVLVVLDEAYV
                     EFADDPDHPDGVELYRDRPNVCVLRTFSKAHGLAGLRVGYAVAHEPVAAALRTAAVPFG
                     VSQLAQDAAVASLRAESAMRERVAALTAERARVVRELAAQGWTVAPTRANFVWLRLGDR
                     TAEFADACAAAGVSVMA"
     gene            29818..30339
                     /gene="pyrK"
     CDS             29818..30339
                     /codon_start=1
                     /gene="pyrK"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1160:flavin reductase domain protein FMN-binding
                     (Score: 120.8; E-value: 7e-37)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative oxidoreductase"
                     /protein_id="AEF33084.1"
                     /transl_table=11
                     /translation="MTTAVAQDRFKDVMAGVGGPVTVVTAFDEGEPHGTTVTAFASLSL
                     DPPMVTVALSENSSLLPRIIRSGRFGVNLLCASQEEPAARFARRDVDRFAGAHWYADNG
                     LPRLAGCLGWVACDVAQAVRGGDHTLLLGAVTDAQQGTPEHPLIYVNRAFGMLLPGPGI
                     MPAVTSRTVS"
     gene            30336..31544
                     /gene="pyrL"
     CDS             30336..31544
                     /codon_start=1
                     /gene="pyrL"
                     /product="dehydrogenase"
                     /protein_id="AEF33085.1"
                     /transl_table=11
                     /translation="MSERTITPRNRGFLFLDAHPAGCTRLVNDMWRSVAAGPAEALGED
                     APVALVIGSSAGYGLAAAVTGLARVGIRGIGVSFEKAPTERRTGTAGWYRTAATAELAR
                     EAGREMLFLNGDAFSDGMKEQVADLIEQRFGRLDHLIYSVAAPRRTDPETGVTYASALK
                     PIGGTARTRTLVFDEDGKPDVREVTTDPADEDEIAQTIAVMGGTDWERWVSHLAGRRLL
                     ADGFTTAALTYIGSPLTADIYRQGTIGAAKTHLEQTARALDARLGELCGGRAVTSVNGA
                     AVTQSSTAIPGIALYTGLLRGVLGGRMVSPADQLSQLWDQLTGVRPLVTDDEGRVRLDT
                     WELTAEVQAAVADRWRTATTDTITDLADLDWFRDSVRQLYGFSVPGIDYSAPVETDVPW
                     PAG"
     gene            31544..33010
                     /gene="pyrM"
     CDS             31544..33010
                     /codon_start=1
                     /gene="pyrM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222:dehydrogenase (Score: 108.3; E-value: 8.7e-33)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative dehydrogenase"
                     /protein_id="AEF33087.1"
                     /transl_table=11
                     /translation="MSGPDVAVVGTGPNGLAAGVTLARAGLSVVLHEAADRFGGGLRTT
                     PLFDDDVVHDICSAVHPMAAASRFFREFDLAARGVELLQPEIGYAHPLDGGRAALAHRD
                     LDVTCDLLGPDGKRWRRLMEPLVAHSTGIVDLVLSGGRALPDDWAAPFLLAGRTLAHGT
                     ALARGRFATEEADALLAGVAAHAIGRLPSLASGAIAVLLGHLAHASGWPVPRGGSARIA
                     EAMAADITAHGGTFHLGRTITDLRELAGARAVLLDTGVKGLLRIAGDRLPRRYARRLAR
                     FRYGPAAAKVDFLVSDAIPWSHPELGRAGTVHLGGTRAEVFRAESLTAAGVAVDDPFVL
                     LVDPGAVDGTRVRPGRRPVYAYAHVPNGDDRDPVELVSGRIERYAPGFRDTVLAARGIS
                     GRQFEAYNPNYVGGDISSGAATLVQSILRPTAQLDPYRTPLPGVYLCSAATPPGPGVHG
                     MSGHLAALSVLRREFGVTTPPRLGPDASNA"
     gene            33007..33726
                     /gene="pyrN"
     CDS             33007..33726
                     /NRPS_PKS="Domain: Thioesterase (3-107). E-value: 1.2e-10.
                     Score: 34.0. Matches aSDomain:
                     nrpspksdomains_pyrN_Thioesterase.1"
                     /codon_start=1
                     /gene="pyrN"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /product="esterase"
                     /protein_id="AEF33086.1"
                     /sec_met_domain="PF00561 (E-value: 1.3e-09, bitscore: 28.7,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKFVMVPGGWHGGWVFDAVAAELRRAGHQVEAVTLAGLEPDGPAD
                     ADRPPNLDTHIDQVAAIVDGSAAGPLALCGHSYGGMVIAGVADRLGHRLDQLVFIDAYV
                     PEDGDSCWSLTSDHFRELFVAGSRADGRWVAVPDRFDPRARAHPLASFLQSVRLGGGPG
                     HGFGRTYISGGAWLGNPFVALTERLREDSDWRVHEIPVGHDIARRDPSGLAAVLDALPA
                     AGGRRSVGRAARALDTD"
     aSDomain        33016..33327
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pyrN_Thioesterase.1"
                     /evalue="1.20E-10"
                     /label="pyrN_Thioesterase.1"
                     /locus_tag="pyrN"
                     /protein_end="107"
                     /protein_start="3"
                     /score="34.0"
                     /tool="antismash"
                     /translation="VMVPGGWHGGWVFDAVAAELRRAGHQVEAVTLAGLEPDGPADADR
                     PPNLDTHIDQVAAIVDGSAAGPLALCGHSYGGMVIAGVADRLGHRLDQLVFIDAYVPED
                     "
     CDS_motif       33208..33252
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pyrN_0001"
                     /evalue="3.20E-04"
                     /label="NRPS-te1"
                     /locus_tag="pyrN"
                     /protein_end="82"
                     /protein_start="67"
                     /score="13.3"
                     /tool="antismash"
                     /translation="AGPLALCGHSYGGMV"
     gene            complement(33780..34418)
                     /gene="pyrO"
     CDS             complement(33780..34418)
                     /codon_start=1
                     /gene="pyrO"
                     /gene_functions="regulatory (smcogs) SMCOG1057:TetR family
                     transcriptional regulator (Score: 109; E-value: 6.3e-33)"
                     /gene_kind="regulatory"
                     /product="TetR family transcriptional regulator"
                     /protein_id="AEF33088.1"
                     /transl_table=11
                     /translation="MNSRNSDLWTAVGTKAALRELKQERAGHTRRQLLDAAARAFAEKG
                     FPAVTLQDIADRAEVTKGAVYFHFKNKEAVAVAVTEEFYTQLPAVAEAVMDKQLPPLDT
                     VTEFLLQTAVFLRDNPVAQAGARLQIERNLVNADMPTPFSGFTQLITELLARAQHENAW
                     QPTADAAIIARVVVAAFFGSQHISWVERDRKDLTDRVREILDVVLPCHA"
     gene            35412..36524
                     /gene="pyrP"
     CDS             35412..36524
                     /codon_start=1
                     /gene="pyrP"
                     /product="3-dehydroquinate synthase"
                     /protein_id="AEF33089.1"
                     /transl_table=11
                     /translation="MKSAWIDLRGFAGELAAAVIEESAHLGVEAVVFDDPDLAAKIPPN
                     LTKTAVVNGETPTTLIDRLVEVVDLLVVDHAIAEKFEGIRPGLRTGVLVRVLDEQTLDV
                     ACKVANRAEVTLVEFRQDPSKIPLEILLAAADQAKGSIVTVVEDIEDAKITIGVLERGS
                     DGVLFTPKRVGEVTELVEATHGQASSLDLEPLEIVQLQHLGLGDRVCVDTCSHLRPNEG
                     ILLGSYSSGLMLVSSETHPLPYMPTRPFRVNAAALSTYTLTPGNRTQYLSELHCGSEIL
                     AVSTDGSVRTVIVGRIKMESRPMLRIEARTASGQLVDMVGQDDWHVRALGPGGSVHNFT
                     ELRKGDVILGHTMTDQRHVGYAIREFLHEQ"
     gene            36631..37995
                     /gene="pyrQ"
     CDS             36631..37995
                     /codon_start=1
                     /gene="pyrQ"
                     /product="aspartate kinase"
                     /protein_id="AEF33090.1"
                     /transl_table=11
                     /translation="MALIVQKYGGTSVATPEKVIEAARQVRAAREEGHQVVVVVSAMGG
                     ATDGLLRLASAVTDLPVPRELDGLLSTGEAASAALLSLALNHQGVASRSFSGAQAGIRT
                     DHRHGKATIVQVDPRRLREDLGRGMVPVVAGFQGESVLTGACTTLGRGGSDTTGVALAA
                     ALGADHCEIVTDVAGVYTADPRTVVGARRHTGLSYEEMAELAVSGAKVLAADSVDYART
                     HGVELKVRANSTATGPKTWVGHGRSAGGPTPGDSRTADGQGCPIAGVAGRSGLVRCVLR
                     RISPDHVLRLLRELAEREIEVELRRYGNLGTEDAGDIALTLPEESAEELRELLADTDRG
                     IHLDEAHWTSNLARLSVVGLGIGRRPYAPLHLLEALRSVDAARADVHVTSNRVSVLTGR
                     SDLAEATQIVHDTFVSGPEMPAIHPVDPDDADTTWSLTAERGHLDVELPALAAAE"
     gene            38118..39344
                     /gene="pyrR"
     CDS             38118..39344
                     /codon_start=1
                     /gene="pyrR"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007:cytochrome P450 (Score: 360.5; E-value:
                     1.7e-109)"
                     /gene_kind="biosynthetic-additional"
                     /product="cytochrome P450 family protein"
                     /protein_id="AEF33091.1"
                     /sec_met_domain="p450 (E-value: 1.5e-16, bitscore: 50.8,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTPHFDPTSDGQLADPYPMYARLRGSCPVVHDPKLDVWVVSRH
                     EDVARVLHDPGVFSSESAVRVAVGPEADEVKQVMAEGWSLTPNLTESDGEVHTRLRVAV
                     NRVFTPRRVAELEPFVRATAEELIGRFAAAGEVDVIEGYAWPLPLMVMAQILGVPAGDV
                     PRLRRWSHNWLRLSVGTGPAEERVEWARDVVEMQHYVMALLQEPGRVAQGGLIASLAAD
                     GDEHGLDTVELMRIVMNLIIAGHVTVTRAIGNGVVTLLEHPGQLAALRAGEASVEAMVE
                     ETLRYESPVQGLFRTVTEGTELGGRRLVPGERVMVHFGSANRDEHVITDADAFTLQNRP
                     GRHQMAFGRGIHACLGASLARLQLRIAIPLLFDRLPGLRLGPADARVRERLVIARGFEE
                     LRLHWDVPQ"
     gene            39341..40882
                     /gene="pyrS"
     CDS             39341..40882
                     /codon_start=1
                     /gene="pyrS"
                     /product="choline dehydrogenase"
                     /protein_id="AEF33092.1"
                     /transl_table=11
                     /translation="MTYDVIVIGGGSAGCVLAARLSADPALSVLLLEAGPDFATLEDLP
                     PEVADASYAPFTHDWGYRSVADEFGNEVPVPRGRLIGGSSAVNVCVAMRARPSDHQAWA
                     EAAGPAWGYEQMLPLYQEMEHYPYGEPKYHGLGGPYRMTMPVAEDLGPHAAAVRQASAD
                     LGHPLVDDFNAPGAPGFAYTPLSAADGVRLSTAVGYLNPVRHRPNLEVRGETLVDRVLF
                     DGTRATGVRLATGEEIPARHVVLSAGAYNSPAIALRSGIGDGADLAALGIDVVADLPGV
                     GRNLTDHPAYWNIHVAKPPQDLAKSMFGSVLSVAVGEGEPDYDVQILPSAAVPTAGLPA
                     AFVSPTENHPTGWDMVFFVSCVQPRSRGSVRLASRDPEDAPVIDLGLYTDADDAELVAG
                     GVRLARRLARTEPLADLLVAERVPGPDVSDEDLAEAIRRAPAHYNHGSSTMRMGGPDDP
                     AAVVDADGAVHGVQGLTVADASVFPAMPRVATNVPAIVVAERIAGVLRERLTTDN"
     gene            40935..42428
                     /gene="pyrT"
     CDS             40935..42428
                     /codon_start=1
                     /gene="pyrT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017:aldehyde dehydrogenase (Score: 453.6; E-value:
                     1e-137)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative aldehyde dehydrogenase"
                     /protein_id="AEF33093.1"
                     /transl_table=11
                     /translation="MSTTEENVEVLHTRWSSKDDADRFTVENPATGKPLVVIQGAGADQ
                     VDQAVEAAYDAHFAWKARTPRERGKYLWKVAQVIREHADEIAALESSDNGKPVTQARQF
                     DLEGAATVFELFASLCEVMPGQVRDSGSMLDVTVREPFGVIGAIVPFNWPPLHTAGKIA
                     PALAAGNAVVIKPPEQAPLSVLRTVELIQSVLPDDVVHAVPGPGAVGARLAGHKLVGKV
                     SFTGAPTTGQAIIRTASENLTPTLLELGGKNALVIFDDADLDSALRWAVEGGYFNQGEA
                     CTASSRVLVHADLHDEVARRLAAAVSRLKVGNGADAGTHVGPLVTEAQRRRVLDYLEIG
                     VGEGATIAAQAPLPTDPELADGYYVPPTLFTGVTPDMRIAKEEIFGPVVCLIPFRDEEE
                     AVRIANGTDFGLVAGVFTRDSERALRFSRELRAGVVFVNHYNRSFTGSPFGGVGASGYG
                     REHALETLQEYSFSRTLRLTSGRGEVPRWAPSLEVVDAE"
ORIGIN
        1 gtacatatgc tagcatcgat gtacctcgcc gccaacccgt accacggcct ctgacggctc
       61 ccggccaggc cgcggaaagc gggggccggg cgccggtctc cagggcggcc gggtccctcc
      121 gaccgcacgg aggccgcttc cggagtggtc cggaagcggc ctgcggagcg ccctgcgggg
      181 cggctctaga gatatcggat cgcggacttc gtgccgaccg accgcaaccg gatgatgctc
      241 gtctccttca ggttcaacgg cttcgaggag atctcccgcg aggacggcct ggtgcggttc
      301 gccgcggacc tgtcgtccat cccgcccgac ccggcctacc tcgacgtcct ggccggctga
      361 ccggccgaca ggcccaaggg ggccggccgc ccggccggcc cccgctccac atccgcttcg
      421 tcacatccgc ttcgtcacat ccgcttcgtc gcatccgctt cgtcacaacg aggacacatc
      481 atgactcttt cgcagaagaa ggcgctggtc accggaggct cgcgcggcat cggccgcggg
      541 gtcgtcgagc gactcgccgc cgagggcgcc gacgtggcct tcacctaccg cgagcgcgag
      601 gcggaggcca aggaggtcgt ggcggcggtc gaggccgcgg gccgcaccgc gcacgccatc
      661 cgggtggacc tcaccgaggt cgccgaggtg cgccgcacga tgctagaggc gcaccgcctg
      721 ctgggcggcc tggacatcct ggtgaacaac gccgccgccg cggccaccgc gacgcgcatc
      781 gacgccgtga cggaggagga gttcgacggg gcgatggcgg tcaacgcccg ggccgtcttc
      841 ttcgccatcc aggaggcgtc gcggctgatg aacgacggcg gccgcatcat caacctctcg
      901 accgccaaca ccgtgctgcc ggtgcccggc gtgtcgctgc acgccggcag caaggcggcc
      961 gtcgagcagt acacgcgcgt ggcggcccag gagctcggcc cgcgcggcat caccgtcaac
     1021 gcgatctcgc cgggcgcggt cgacaccgag ctgctgcggg ccaacatcac ccaggagggc
     1081 ctggagctgg ccgttcggat gacgccgctg ggccggatcg gtgagcccgc ggacatcgcc
     1141 ggcgtggtgg ccttcctctg cggcccggac ggcggcttcg tcagcggcca gaacctgcgc
     1201 gtgaccggcg gcatggtctg accgcagcgt cacggcacgg cgagagcccg accggtcggc
     1261 cgaccggtcg ggctcttcgt cgtccggggg cgcgggctca ggccgcgctc agctcctcgg
     1321 ccgcgggttc ctcggcggcc gccttccggt cgccgcgccg ggccgccacg cgttcccgca
     1381 gcagccgcac gcgcctcaag agcgcctcgt agtcggcgtc gcggacgatg acggcgtcga
     1441 tggccatcat ggcgaggccg aaggtcatca ggcccatgcc ggccatgatg ccgatgtgca
     1501 tcgcggcgat gcccaggacg accgcctcgc ggaaccaccg ccgcgaggtg agcgccgccg
     1561 ggacggcgag cagctgcacg acgatggtga agtaggtgac gatcgcggtc aggaccaggc
     1621 tgtccatcag ctgggggaag gcggagctgt aggtgtactg ccacacgtgg ctgatgtagt
     1681 agagcgcggt gccctcctgc cactgcggtg cggccacctt ccacagggcg gagacggcgt
     1741 agacgacgca cgcctggaag acgatcagca cggccgccgt gttgtgcagc gaggttcgca
     1801 ggtgcggttc gccggcgcgc cgctccagcc gcgcgcggac gcgcttggcc agcgggctga
     1861 agtgggcgtt cgccgtggtg cccatcatga ggatcagcac gatgccggtg agcgcgtcgc
     1921 cgccctccca catcgtgtag ttgcggtggt agatggaggt catgaacacc acgtgcacca
     1981 cggtcaggct gcgcgagccg agcaccgtcc aggcgaggga gaccgccagg ccgacgaagt
     2041 acacgaggtt gaaccaggtc ctgccgtcgc tgagcgcgta cagcgagaag atgtgctggt
     2101 ccccggtcag ggccttgaag gcctcgaagc cggagtagct gtgcggcccc cagaggaagt
     2161 cgcggtaggg gatgttggag acgtagtaga gcgtggtgct caggcccagc aggatgcggc
     2221 agagcgagag gccgacgagg tacttcgggt ggctggacac accgcgcagc gcgctcgcgg
     2281 cggagttctt cagtctgtcc atggctgggc tccaggccgg tagtcgaacc agccgaggtc
     2341 ggtgaacacc tcggaggtgg ggtcctcggg cgagtggcgg tcgtcgaagc gcttgacggg
     2401 cgtgtacgtg tagtaggcgc gcagccgggt gaccctgccg tccaggtgga gctcgtccac
     2461 cagcggcgac agcaccgtgg cggtgtccgt cttcgccgcc tccgacaggg ccgccagttc
     2521 gttctgcggg ccggagaagt cggagagcgc cttcttgcgc gcgtcgtcga cggccgcctg
     2581 cttctcgtgc aggctgccga gctcgacgcc gaggtagagg ccgaccgcgc ccatgcggtt
     2641 cggggcgagg cggatctcac gggcggtgcc ggccatcttg cgggacagcg acgccggttc
     2701 ggtggtgtgc gtgccggtcg cgttctcgta ctcgacctgg tagaagacct cgccgttgta
     2761 gtccaccgag tacggcgcga ggagcatcca gctctgccgg aagtaggtgt cggcgacggg
     2821 ggcgaccgcc ttgtacgcct gggtccgcgc gggggagacc ggcgcgttga cgatgagcgt
     2881 catgacgacc aaggccaggc cgagcagcgg cggcaggccc atgctcagca gccgccaccg
     2941 gctggtcccg gctcgtggcg ccgtcccggc tcgcggtgcg gtcccggctc gtggtgccgt
     3001 catgaccggg gctcctgctc ctgcgcggcg ggccgggggt gggtgctgcc gccgatgccc
     3061 cagcggtggg ccgggaccgg ggtgaggacc acccaggtct gctcccggat ggactcgccg
     3121 aacacgtcga ccgtggcctg ggtgagccgt tcgaccagtt cccgctcggt ctgctcggtc
     3181 aggcgctgtt cgaagatctt gacttcgatg aaaggcatgg ttgctcctgt tgttcagacg
     3241 gcggcggccg tgccgccgcg gaggttcgcg gccgtgccgg tgacggcggt gaggccggcg
     3301 gtcagggcgt cgacgaggtg gtcgacctgg gagtcgagca gccccgggtg gcatggcagg
     3361 ttcatgtgct gctcgaacca gagccgttcc gcgaccgggc actcgccggg gccgtgtccg
     3421 cggaagcgcc actccggcgt caggtgcagc gggaagtagc gcagttggac ctcgacgccg
     3481 cgctcgtcga gttcgcgcag cagggcgtcg cggacgtccc ggtcgtgcac gaggaaggtg
     3541 tagaggtggt aggcgtggtc gatgccctcc ggcgcggaga ccggccggac gccggggaac
     3601 gcggcgacgg cctcgtccag tctgcgggcg atcatccgac ggcgcgccac cagctcgtcc
     3661 agccggtcga gttgggccag gcccaccgcg gcggccgcct cggacatcgt ggcgttcgtg
     3721 ccggcgttgc ggatgccggc gcaggcgcgg tcgtagatct cggcggagaa catcatccag
     3781 ggcagtgcgg cgggcagctc cgccgcgtcc gtcccgtggt ggacgtagac gccgtccacc
     3841 gcgttgttcc ggtagcggct cacccgctcc gcccagtcgt cgcggtcgag ggtgatcatg
     3901 ccgccctcgc cgagggtggt gatgttcttg gtggagtgga agctgaaggt cgcgatgtcg
     3961 gccagcgaac cgggccggcg gccgtggtag gtggcgccga gcgcgtgggc gctgtcctcg
     4021 atcaccgtga tggcgcgggg ccgggtgagc ttcatgatgg cgtccatgtc cgccgggcag
     4081 ccgccgtagt ggaccaggat cacggccctg gtccggtcgg tgatcagcgg ctccagcgcg
     4141 gccgggtcca tgttcagggt gagcgggtcg atgtcgcaga accggaccgt gacgcccagg
     4201 tcgagcagcg gttggatgct ggcctggaag gtctgcggcg tcaccacgac ctcgtcgccc
     4261 ggggccaggt cgagcagccg gatggcgatg tccagggcca cggtcccgct cgtcaccgac
     4321 agggcgtgcc gggcgccgac gtggtcggcg aaggcccgct cgaacgcctc ccgccacccc
     4381 ccggcggaga gcggggcgcc cgaggagacg agctgcccca ggacgtccag ttcgcgatcg
     4441 ccgatgacac tgcctcgacg gccgcccggt acgacgtagc gttgctgcat acggaggtac
     4501 ccccatgacg gaaagacgtc ccgcgccgtg cgggacgtgg gctgatgggt gcccgcgtgc
     4561 cggggccggc ggagcggggc acgcgggcgc gccccgccgg gagggccgcc ttccggtggc
     4621 ggtccctccc ggcgggggcg tacgcggtca ggcggcggcc aggcgctgcg cgagttccac
     4681 ggcgagcgcc ttcttgtcga ccttgccgag cccggtcagc gggaaggcgt cgatcacttc
     4741 gaggcggtcc ggcagcttgt actcggccag cccgcgggcg cgcagcaggc gcttgagctc
     4801 ggggaggcgg ggaggctcgc cggccgggac gacgaagacg cagacccgtt cgcccatgag
     4861 ctcgtcgggc atcgccacca cggcggcctg ctggatcccg tcgtgcgcgg cggtgacgtg
     4921 ccgctccacc tcggtggccg agaccttgtc gccgccgcgg atgacgacgt ccttgacccg
     4981 gccctggacg accatgtccc cgtcctcggt gaagcgcacg aggtcaccgc tgcggtagaa
     5041 gccgtcctcg ctgaacgcgc gggcgttgtg ctcctcggcg cggtagtagc cgcgcagggt
     5101 gtaggggccg cgcgtcagca gctcgccggt ctcgcccggg gccacgggcc ggtcctcgga
     5161 gtccaccacg cggatctcgt cggcggggga gatgggccgg ccctgggtgg tgagcacccg
     5221 gtcgaggggg tcgtcgtagc gggtgaaggt gagcaggccc tcggccatgc cgaacacctg
     5281 ctggagccgg cagccgaggg tcggggtgac ccgggcggcc acctcggggt ggagcttggc
     5341 gctgccgatc tggaggaccg agaggctgct caggtcccgc tcggtccact cggcggcgtc
     5401 cagccacatg tgggcgatgg tcggcacgca ggaggtcatg gtgaccttct cccgctcgat
     5461 gagcgcgaag cactcgtcgg ggttcggcgt cctggccagc acgaccgtgc cgcccgtgct
     5521 cagggtgccg agcacgcccg ggcagcccca ggtgaagttg aactcgatgg gcaggacggc
     5581 gaggtagacg gtgtcgccgt ccagttcgca gacctccgag gcggcgcgga tctggtaggc
     5641 gtagtcctcg tgggtccgcg ggatgagctt gggaagcgcg gtcgtgccgc cggacaggag
     5701 gaagaacgcg gggtccgccg gggacgcgtc ggccggcgcg tccggggccg ggacgggcgc
     5761 ctcggtcgcc gagagttcct ccagcgagct gtgcgggccg gggtcgccga ggacgaacac
     5821 ctcgcgcacg gtcgggaccg aggcgcggac ctgggtggcc agttcgcggt ggtcgaagcc
     5881 ctggtggacg tcgggcacca cgtaggcgac ggcgccggag tgcgagcaga ggtggctgat
     5941 ctcgtggtgc cggtgcgccg ggagcgcgaa gacgggcagc gcgccgagcc ggaagagtcc
     6001 gaagcagacg gcgacgaact ccggggtgtt ggggagctgg accacgaccc ggtcgccggg
     6061 ccggatgccg cgcgcggcga agcccgccgc cagccggtcc gcccacgcgt cgagctcggt
     6121 gtacgtgacg cgccggtcgc cgccgacgag ggcggtccgg ccgtcgtacg cggcggccca
     6181 gtcgcgcagc agctgcccga gcgtctcccc ccgccagtat ccggcctccc ggtatgccgc
     6241 cgcggtggct tccggccagg gaacgcatcc gtccagcatt tccagtcctt ttctccagcc
     6301 atcacaatcg atggtttccg gggctgatat cttggcgata ctagccgagc cgtcgggatt
     6361 tggataccgt taatatccgg cgctttaggg tgcggcacaa cgcatcaata gcccctttta
     6421 agggggcttt taggggtggc ggctagggtt gattccagtt gagtcatcag gcggatccga
     6481 acggtgcggt gtggcaaatt gagtaaccag ggtgtaattc cggggagcaa gtcggagctg
     6541 cagcgcgtgc tcgccgagcg gctcggtgtc agcatctccg aggtgctgga cgacgtgaat
     6601 ctccaggatc tcggcctcga ctcgatcggt gtgatgggca tcgtgtcggg ctggcagcgg
     6661 cacggcctcc ggaccgaaat cgctgaattc accgcagtgc ccaccctcaa cgactggtgg
     6721 gaactcatct cccgctagaa cccgggtcgg cccgcacggc ggcggccgtc atccctcaac
     6781 aagccattgg agtcacggtg caattcggcg tgaatttctt tcccgttgtc gacccggcga
     6841 agaagagcgc gagcgactac ttcgacgagg ccctgcggct ggtgagcctg gccgaggagc
     6901 tcggcttcga gcacgcgcag tgcgtggagc actacttctc cccgtacggc ggctacctgc
     6961 ccgacccggt caccttcctc accgcggccg ccgcccgcac gagccggatc cggatcggca
     7021 ccggagcggt catccccgcc ttcacccacc cgctgaagct cgccggcaag ctcgcgatgc
     7081 tggacaacct ctcccacggg cggctcgacg tcggcttcgg ccgcgccttc ctgccgcagg
     7141 agttcgaggc cttcggcatc gacatcgacg agagccgggc gcgcttcgcc gagggcgtcg
     7201 aggtctgccg gcggctgtgg tccgagcagg acgtggtctg ggagggctcc ttccagcggt
     7261 tcggccccgt cacgatgctc ccggagcccg tccagaagcc gcacccgccc atcttcatcg
     7321 cctccgcgat gagcccggac tcgtgcgccg ccgccggccg cgccggctac cacctccagg
     7381 tggtgccgtc ggtgacctcc cgcgagcagc tccagtcgat gctggccggc taccgcgagg
     7441 cctggcgcga ggccggccac ccgggcagcc cgcgcatcca gatcaagtac acctgctacg
     7501 tggccgagga ccgcgcgaag gcgctcgacc tcgccgagac cttcgaggtc aactacgtcg
     7561 agcacatggc cggggccgtg gcgagctggg gccggacgcg cagcgacgcg taccgcggct
     7621 acgagcagtt cgtggagaag gtcaagaagt acgacttccg gcagtcgcac gccgacaaca
     7681 aggtgctggc cggcaccccg gacgaggtgc gcgagcagat cgccgtgctc gtcgactggt
     7741 tcggcgcgga ccccacgctc agcctccagt tcaaccccgg ccacatgccc tacgaggact
     7801 ccgagcgcgc catgaggctc ttcgccgagc acgtgatgcc cgcgttcacc ggcccggagc
     7861 aggcggcatg acccggaccc ccgacgccga ggtcgcggtg gtggggctcg gcgcctgggg
     7921 ttcctcggcc ctgtggcagc tcgcctcgcg cggcgtccgg gtgctgggct tcgagcggta
     7981 cggcctgggc caccccttcg gcgcctcgca cggcggcacc cggatgttcc gcgtcacctg
     8041 cctcgaacac cccggtctcg tgccgctggc caagcgctcc cgggagctgt ggcagcagct
     8101 ggagaccgtc accggccgta ccctcttcga ccgggtgggc gccgtcctga tgggccccgc
     8161 ggacggacac atcgcgggcg gttcgctgcg cgccgcccgc gagcacgacc tgcccgtgga
     8221 caccctgacc gccgacgagc tgcgccggtg gctgccacag cacgcggcgt tccaggacgg
     8281 cgacatcggc gtccgcgagc cggaggccgg gctgatccgg ccggaggagg ccgtccgcgc
     8341 cgccgtcggc gcggcggcgg cgcgcggcgc ccgggtcttc accgacaccc gcgtcaccgc
     8401 cgtcgaactg accggggacg gggcggtcgt ccgcaccccc gcccgcacct tccgggtcgg
     8461 tcaggtcgtg gtcacggcgg gcccctggct cgacacgctg gtgcccggcc tgcccctgga
     8521 gaccgtgcgc gtcccccaga cctggttccg gccggtcgca gaccccgcgc cgttcaccct
     8581 cgaccggctg ccgcccttca tgcgggagct cggcggccgc ggcgccgtct ggggccacgg
     8641 ctcccgcggc ggcccggacg tcaagctcgg cctggaggac ggcggaagcg ccttccgggt
     8701 cacccgcgcc gacgactgcg accgcggcgt caccccgcag gactggaccg cggtcgccgg
     8761 cctgctggcc gaggcggtgc ccgggatggg cgccgtgccg tcccggacgg aggtcggcat
     8821 gttcagccgc acccccgaca agcagttcct catcggccgc ccgcacggcg acccgcgact
     8881 ggtcatcggc ggcggctgca acttccacgg cttcaagcac tccaccggga tcggggaggc
     8941 gctggccgac atcgtcctcg gccggccgac cagctgtccg ctggacttca ccgatcccaa
     9001 ccgattcctg taagtcctcg ccgggagaaa gtctcaagca tgcgcgatcg ggaagaggtg
     9061 cgccggccgc tcaccggggc ccagctcggg gtgtggttcg cccagcaggt cgaccctgcc
     9121 aacgcggcct acaacaccgc ccagtacgtc gaggtgacgg cgcccgccga cgcggcccgc
     9181 ctggagcggg cgctgcggcg cgcagtggcc gaaaccgacg ccctcaccgt gcggttcacc
     9241 gtgcacgacg ggcagcccct gcaacagtcg gcaccgctcg ccgagccgct cctcgacgtg
     9301 gtggacctga gcgccgagac ggacccgacg gccgcggccg accggtggat gcgcgaggac
     9361 gccgccaccg tcgtcgacct gctgcgcgga ccgctcctgc gcaacgccct gctcgtgctc
     9421 ggaccggacc ggttccgctg gtaccagcgc tgccaccaca ccctcctgga cgggtacggc
     9481 ttccagctgc tggccgcgcg caccgccgag atctacaccg ccgaggcggc cggcgcggag
     9541 ccccgcccgc gctggttcgg caccctcgac gacctcgtcg gcgccgagac cggctaccgg
     9601 gcctccgagc gtttcggggc cgatcgcgcc tactgggccg agcgcatgct cggcgccccg
     9661 gacgccgtca ccctcgcccg ccggcccttc gacggcccgg ccgtcgaccc cctcaccgtc
     9721 ggccccgccc gcgtcctcga cccgcggcag gccgaccggg ccaccgaccg gaccgcactc
     9781 gtggtcgccg cactcgctgg ctacctgcac cgcatgacgc aggccgagga catcacgctg
     9841 ggcgtccccg tggccggccg ctggggcgcc gccgccaaga cccccggcgt cgtcgtcaac
     9901 gtgctgcccc tgcggctgtc ggtgccgcgg ggcaccaccg tcgccgccct gctggaccac
     9961 gccaccgagc ggctgggcga gctccgccgt caccagcgct accgcagcga ggacatcctg
    10021 cgcgacctcg gcatggtcgg acggcagctc accggcccgc tggtcaacat caagtactac
    10081 gaccgggagc tggacttcgc cggcggccgg gcgaccgtcg ccaccgtcgc ccccgggccc
    10141 atcgacgacc tctccgtcgt cgtcggcgac gacccgcagg ccggcggcct caccgtcgcc
    10201 ttcgaggcca accccggccg ctacggtgag gccgaactgg ccgcccacca ccggcggttc
    10261 accggcttcc tcaccgccct cgccgaggcc gacccgggca ccccgctcgc ccggataccg
    10321 gtgcccgcca cggccccgcg ccgccgcgcc cgccccgccc cggcccccga gccgcgcggc
    10381 gccaccctgc acgaggcgtt cgaggcccag gcggcacgca cccccgaccg caccgcggtg
    10441 accagcggcg cgacgcggct cacctaccgg gagctcaacg agcgcgccaa ccgcctcgcc
    10501 cgactgctcc tgcgccgggg cctgggcccc ggccggctgg ccgccctcgc cctgccgcgc
    10561 ggcgccgacc tggtggtcgc cctgctcgcc gtcctcaaga cgggcgccgg ctacctgccg
    10621 ctcgaccccc agtaccccgc ggaccgcctg cggttcaccc tggaggacgc cgccccggcc
    10681 ctggtgctca ccgacaccga cggcgccgac cgcgtccgcg gcgccgtgca cccgctgctc
    10741 ctggacgacc ccgcgctcgc cgccgagctg accgggctcc ccggcaccga cccgaccgcc
    10801 gccgagcgcc cggccgcagc cggcccggac agtctggcct acgtcatcta cacctccggt
    10861 tccaccggcc ggcccaaggg cgtggcggtc acccaccaca acgtcctgcg cctcttccgg
    10921 cagacggacc actggttcgg cttcggcgcc gacgacgtgt ggacgctctt ccactcctac
    10981 gcgttcgact tctcggtgtg ggagatctgg gggccgctgc tgcacggcgg ccggctcgtc
    11041 gtggtgccct tcgacaccag ccgctccccg gccgacttcc tgcggctgct cgtccgggaa
    11101 cgggtgaccg tcctcaacca gaccccctcg gccttctacc agctcatcgc cgccgagcgg
    11161 gaacgccccg acctcgccgg acggctgacg ctgcgccacg tcgtcttcgg cggcgaggcg
    11221 ctggagacgc accggctgga ggactggtac gcacgccacg gcgacgacgc gccgcgcctg
    11281 gtcaacatgt acggcatcac cgagacgacc gtgcacgtca cctacgccgc cctcgaccgc
    11341 gagacggtgc gcgccgcccg gggcagcgtg atcggcgagc cgatccccga cctcgacgtg
    11401 tacgtcctgg acggcgagct gcggccggtg ccggaaggcg ccaccggcga gctctacgtg
    11461 gccggcccgg gcctggccag gggctacctc gggcggcccg gcctgaccgc cgaacgcttc
    11521 gtggccgacc ccttcggcgc ccccggcggc cgcatgtacc gcaccggcga cctggcctgc
    11581 gtgctcgacg acgggagcct cggctacctc gggcgcgcgg acagccaggt gaagatccgc
    11641 ggcttccgca tcgaactcgg cgagatcgag gccgcgctcg aacgccaccc gggcgtcgag
    11701 cgggccgcgg tggtcgtccg cgaggaccgg ccgggcgacc agcgcctggt ggcgtacgcc
    11761 gtgccggccg ccggtacggc gccggacacc accggcctgc gcctgcacgc cgcgggagtc
    11821 ctgcccgccc acatggtccc cgccgccgtc gaactgctcg acgcgctgcc gctgaccgcg
    11881 aacggcaagc tcgaccagcg ggccctgccc gcgcccgccg ccccggcgcc ggccgcgacc
    11941 ccggcgccgg ccgagggtac ctcgcgggcg gcgaccgtcg gcgcgctgtt cgccgacgtc
    12001 ctcggcctgc ccgccgtcgg cgccgcggac gacttcttcg acctgggcgg tcactcgctg
    12061 ctcgccgcca agctgatcag ccgcatccgc accgagctgg gcgtcgaact cgccatcggc
    12121 gcgctgttcg gcaacccgac ggtcacgggg atcgccgccc tcctcggcga cgccgactcg
    12181 gccgtgcccg ccctgcggcc ggaaccccgc ccggagacgg tgccactgtc cttcgcgcag
    12241 agcaggctgt ggttcctcaa ccaggtcgag ggcctgtccg ccacgtacaa cgtcccgctg
    12301 gcgatccggc tgtccggcac cctcgaccgg gaagcgctcg accgtgcgct ggcagacgtg
    12361 ctcgcccggc acgagagcct gcgcacgatc ttcccgcaga ccgcgggcgt cccgcaccag
    12421 ctggtcaagc ccgccgacga ctgccgcatc gggacgaccg tcgtcgagtg ccggcccgag
    12481 gagcagccgg agcggctgcg cgcggccctg gcccagggct tcgcgctgga gaccgaactc
    12541 ccgctgcgga ccctcctgtt ccgcaccggg cccgccgaac acaccttcct ggtggtgatg
    12601 caccacatcg tcgcggacgg ctggtccgtc acaccgttca ccgaggacct ggccaccgcc
    12661 tacgcggccc ggtgcgaggg ccgcgagccc ggctggcctg cccaactgcc cgtccagtac
    12721 gccgactaca gcctctggca gcgccgggtg ctgggcgacg aaagggcccc cggcagccgg
    12781 atggcccggc aactcgccta ctgggccgag cagttggcag gcctgccgga ggagctgccg
    12841 ctgcctgccg accggccccg cccgctcgcg gccgggtacg gaggcggcac cgtcggcggc
    12901 cggatggaca ccggactcca cacccggctg ctacgcctgg gccgggaccg cggagccacc
    12961 ctcttcatgg tcctccaggc cggtctcgcc gccctgctca cccgtctggg cgcgggggag
    13021 gacatccccc tcggcacccc cgtcgcgggc cgcggcgacg aggcgctgga cgacctcgtc
    13081 ggctgcttcg tcaacaccct cgtgctgcgc acggacacct ccggctcccc gaccttccac
    13141 gagctgctcg accgcgtccg caccaccgac ctggccgcct acgagcacca ggacctgccc
    13201 ttcgaccggc tggtggaggc cctcaacccg ccccggtcgc tggcccggca cccgctcttc
    13261 caggtcatgc tggcgctgcg cgaaccggcc cgggaggtca ccggcatgcc cggcctcacc
    13321 gcccgggtcg agtcctgtga caccgacagc tcgcgcttcg acctgtcctt cgtgttcggc
    13381 gaggtgacgg gggcggaccg ggcgcccggc ggcgtcgact gctcgctgca gtacagcagc
    13441 gacctcttcg accgggagac ggcgcagcgg ctgctggccc gcctcgtgct gctgctggag
    13501 gcggcggccg acgcccccga cgtccccgtc ggccggctgg agatcctcac cccccgggag
    13561 cgcgaggacc tgctggaggg ctggcagggg ccgcggcgcg agctcgcgga cacgaccgcc
    13621 gcccagctct tcgaggccca ggcggcgctc gtcccggaca ggaccgccgc cgtcttcgag
    13681 ggcgcccggc tgacctacgc cgagctcaac gcccgggcca accggctcgc ccggcacctc
    13741 gtcgcccagg gcgtcggccc ggagcaggtg gtcgcgctgg cggtgccgcg ctccctggag
    13801 atggtggtcg ccatgctcgc cgtcttcaag gcgggagcgg cctacctccc ggtggacccc
    13861 gactaccccg ccgaccgcat ccgctacatg ctggaggacg cgcggccggc ccaagtactg
    13921 accacggccg aggccgccca cgtgctcccc gacgcggtca cccccgtcct cctggacgac
    13981 ccggggacgg tggcccgcgt cgccgacctg cccgccaccg acgtgacgga cggcgagcgc
    14041 ctcgccccgc tggttcccgc gcaccccgcg tacgtcatct acacctcggg gtccaccggg
    14101 cggcccaagg gcgtggtggt ctgccacacc gggatcccca gcctgctcgc gaaccagatc
    14161 gagcgctgcg ccgtcggacc ggacaaccgg gtgctgcagt tcgccaccgc gagcttcgac
    14221 gcggccttct gggacgtcgc catggcgctg ttcacgggcg gcacgctcgt cctggccccc
    14281 gcctggcgcc tgctgcccgg ccccgagctc tccgagctcg ccgccgccca cgacatcacc
    14341 catgtgacgc tgccgccgtc ggtgctggcg atgctgcccg tggagggcgg cctgccggcg
    14401 tccaccacga tcgtcgtggc cggtgaggcc accccggccg acctggtcgc gcggtggtcc
    14461 cgcggccggc ggatggtcaa ctcctacggc cccacggaga tcacggtctc ctgcgcgatc
    14521 agccccccgc tggacgccac cggagagctg ccgatcagcc cgccctcgat gaacacccgc
    14581 ctccacgtcc tggacggccg cctgcggctg gtcccgccgg gcgtgccggg cgagctgtac
    14641 gtggcgggcc ccggcacggc ccgcggctac ctgggccgcc ccgacctcac cgcggcccgc
    14701 ttcgtggccg acccgttcgg cccgcccggc acccggatgt accgcaccgg cgacctcgcc
    14761 cgccggcgcc ccgacgggcg gctggagttc ctcggccggg ccgacgacca ggtcaagatc
    14821 cgcggcttcc gggtggaact cggcgagatc gaggccgcgt tgagctcccg cgaggacatc
    14881 gcccaggcgg ccgtcgtggt ccgcgcggag cggccgggcg accagcggct ggtggcctac
    14941 gtgacggtcg cgcccggcgc cgccggacca caggacctgc ggacgtggct ggcctcctcg
    15001 ctgcccgact acatggtgcc gtccatcgtc gtcacgctgg acgcgctgcc gctcacccag
    15061 tccgggaaga tcgaccggat cgcgctcacc gcgcgcccgg tgtcctggac gacggacacg
    15121 gcgtcgtacg tcgcccccgg cgaagggctg gagcgccgca tcgcccaggc gtggtgcgcg
    15181 gtactgggcc tggaacgggt gggcgcccag gacaacttct tcgacgtcgg cggtcactcg
    15241 ctgaccctga tcgccctgca gaagcggctc gtcgacgaac tcgggcgccc cgtcccggtc
    15301 gtcgacctgt tcgcccaccc gaccgtggcc gcgctcgccg cgcacctggc cgccgcggag
    15361 gggaacggcg aacccgcggc ccggcgcggc aacgccgacc gcgcccggca gcgcgccgga
    15421 ctccagcaca aggccatggc ccgccgggcc gcagacagga agggaacgca gcgcaatggc
    15481 tgacgactcg cagacggtgc gggacctgga catcgccatc gtcgccatgg agggccgctt
    15541 cccgggggcc cgcgacgtgg cgcagttctg ggccaacctg gtggccggcg aggagtccgt
    15601 ccggccggtc ggcgacgagg agtacctcgc cgcgggcggc gacccggccg cgctcggcga
    15661 ccgctacgcc gtcaaggccg ccgcagccat ggacgacgcc gacctcttcg acgcggactt
    15721 cttcggcctg cgggcagacg aggccgagac gatggatccg cagcagcgcg tcttcctgga
    15781 ggtctgccac cacgcgctgg agcagtcggg ccacgacccc gaccgcttcg acggggtgat
    15841 cggcgtctac ggcggggcca gccagagcag gtactacctg tcccacgtgc gcccccgcct
    15901 cgacgagtcg gccgagccgc tgcgggcctg gacggcgtcc atgggcaacg accccggcgt
    15961 cttcgccacc cgcgtcgcct acgcgctcaa cctgaccggg cccgcgctga ccgtccagac
    16021 ggcctgttcc acctcgctcg ccgcgatcca cctcgcctgc caggacctgc tgtcctaccg
    16081 ctgcgacgtg gcgctcgccg gcggctcgtc gatcaacccg gccgccaagc ggggctaccg
    16141 ccacacgccc gacggcccgt tctcgcccga cggccacgtc cgggccttcg acgcgcgggc
    16201 cgagggcatg gtgcccggag acgccacggc ggtggtcgtg ctcaagcggc tgaccgacgc
    16261 ggtggccgac ggcgaccgca tccgggccgt catcaagggc accgcggtca acaacgacgg
    16321 cagccgcaag gtcggattca ccgcgcccag cccgctgggc caggccgagg tcgtcctcgc
    16381 cgcccacgcg gccgccgagg tcgacgccga caccatcggc tacgtggagg cccacggcac
    16441 cggcaccccg gtcggcgacc cgatcgaatt cgccgcgctc acccaggcgt tcgcggagac
    16501 cacgacgcgc accgggttct gcgccctcgg atcggtcaag accaacatcg ggcacaccga
    16561 cgccgcggcc ggcgtggtcg gcctgatcaa ggccgccctg gtggtggagc acggcacgat
    16621 cccgcccacg ctccactaca cctccccgaa cccgctcatc gacctcgact cctccccctt
    16681 ccacgtcaac gaccggctca ccgagtggcc ggccggcccg acgccgcgcc gagccggcgt
    16741 gagctccttc ggcatcggcg ggacgaacgc ccacgccgtc ctggaggagc cccccgcggc
    16801 cccggcgcgc ggaaccggcg agggctgggt gctgctgccc tggtcggcca ggtccgccga
    16861 ggccgccgac cggctcggcg ccctgttggg cgaccacctc gcccgcaccc cggacctcgc
    16921 cctcggcgac gtggcgcaca ccctgcgctc gggccgccgg accttcgcgc accgccgctt
    16981 cgccgtctgc cgcgaccggg acggggcggt ggcgcagctc gtcgcccccg gccacgccgc
    17041 accgcccgcc gacggcccga ccgagcggcc cgtcgccttc ctgttcccgg gcggcggcgc
    17101 gcagtacgac ggcatgggtc gcggcctgta cgagaccgag ccggtcttcc gggagacgct
    17161 ggaccgctgc gccgccatcc tggaacccgt cctgggcttc gatgtgcgcg ccgccctgca
    17221 ccgcggggag gagggccccc ggtcgagcct gctgcccggg ctggtctcga ccgagtacgc
    17281 cctcgccacc ctgctgatgt cccggggagt caggccgcag tcgctcatcg ggcactcggc
    17341 cggcgagtac accgccgcct gcctggccgg ggtgatgtcc ctggaggaca tgctgcccct
    17401 ggtcgccaag cggcagtggc tcctggagcg ggccggcgga gtcgcggtga gcgtccggct
    17461 cggcgagcgg gacctcgacg cctacctcac cgagcgactc tccctggcca ccgtcaacgc
    17521 ccccgccctg tgcaccgtgt cggggccgga ggaggacgtc cgggagctgg aggcacgctg
    17581 ggacgccgaa ggcgtcgagt accagcgggt ccacttcccc agcgccgtgc actcctggct
    17641 gctggactcc gtcctggacg actacgcggc ggcactcgcc gaggtcacgc tccgtccgcc
    17701 ggccatcccc ttcgtctcca acgtctccgg cacctggatc accgacgcgg aggcgaccag
    17761 ccccgactac tggctgcggc acacccgccg gaccgtgcgc ttcgccgacg ggttgacggc
    17821 actgcgcgcg ggcggggagc ccgtgctggt ggaggtcgga ccgggtcgga tcctcacccg
    17881 gtgcgcgcag ctgcagttcg gcgacgccgt gcccacggtg gagaccatgc gccacccccg
    17941 cgccgaccag cacgaccagc aggtgctgct caccgcgctc ggccggctct ggcagctcgg
    18001 cgcccggctg acgtgggacg gggagaaccg cgcggacgag gaggaggggc agggcggccg
    18061 ccgcgtgccg ctgcccggct accccttcga gcgcaagcgg tactggctgg acgaggtccg
    18121 ccccgccgcc accgcctctg ccaccgcttc tgctgccgcc gccggccgcg gggcggtgcg
    18181 cgacctcgcc gaggccgaac gcgagctgcg gcgcagcacc gacgtgtcca cggtgccggc
    18241 gcggctgcgc gaggacttcg accggctcgc cgctctgcgg gccgccgcgt tcctgcgcac
    18301 ggcgggcgtg gacaccacgg ccggccgcac ctacaccccc gaggacctcg tcggccgact
    18361 ccggcccgcg gggccctacc gcaagctgct cgacgccctg ctgcacatgc tccgggagtc
    18421 gggagtgctg gcccgcgagg gcgacctgct gcggttcacc ggcagcggcg ccgacgccgc
    18481 ggaggaggca cggctcaccc ggtccgtcac cgagcggcac ccttcgctcg ccaaggacct
    18541 ggagctgctc gacacctgcc tggccggctg cgcggacgtg ctgcggggcg acacggacgg
    18601 caccgcggtg ctgacccccg acggccgtac ggacctcacc gccggcgtgc tcgaaacgca
    18661 catggacgag ggcgacttcg ccctgtaccg cacgctcctg gccgagcacg tcgcggagct
    18721 ggcgcgcgcg gcgggcggtc gcccgttccg gatcctggag gcgggcgccg ggcggggacg
    18781 gctcacctgg accgtcgccg aggccctgcg gggcatcccc ggagtgcggt accacgtcac
    18841 cgacctgggc cggtccttcg tcctggaggc cgagcgcgag gccgcgcggc gcgggatcga
    18901 cttcatgtcc ttcggcgtgc tggacatcgg gcaggccgtg gaccccgtcg cgctcggcgg
    18961 cgccttcgac gtggtgctgg ccttcaacgt gctgcacatc cccgccgacc tgcgggagtg
    19021 cacccgccac gtccggcggc tgctggcccc cggcggcctg ctgtgcgcgc tggagaccgt
    19081 acggatgccg tgggcgtccg agctgtccgt ggggctgctc ccgcagtggt gggcgttcgc
    19141 ggacgacctg cgccggaact cgccgatcct gcccgccgac cggtggcgcg agctgctggt
    19201 ctcggagggc ttcgacgagg tgcgggtcct cagcgacgac cgggcggacc agccgctgat
    19261 cccgcacgcc ctcatcgtcg gccgccgtcc cgccgcgagc gccgccgagc ccgccaccgc
    19321 cgagcccgcc accgcccggc ccaccgccgg gtcggcgcgg acgccggagg agaccggtac
    19381 gggacggcag ccgcgcccgg ccctcggcgt cgcccaccgc gccccgtcga ccgacaccga
    19441 acgcgtcgtc gcccggcact gggaggagct cctgcgcgtc gacggcatcg gggccgacga
    19501 caacttcttc gacctcggcg gcgagtccct gctcgcgttg cagctcgtca cgcggctgcg
    19561 cgacgaactg ggcgtggaac tgcgggtgaa gaagctcatg gagaagctca ccgtcgcggc
    19621 gatggccacc gaggccgacg cgctgcgggg caacgcggac accgcccccc ggatcacccc
    19681 cagcgcccgc cgggggcggc gcgccggcta gggcctgtcc ggcggatctt gccgggcgcc
    19741 cgacgccgcg cgctgatccg ccaagatcca ccggacaggc cccaatcgcc cgcccccgct
    19801 gaagtcccgt ccgagtcccg aaccaccggc gcagagccgg gtgctagccg ccaaggagta
    19861 caccgatgcc gtcagcttcg acgagcgaga cgcaggagcc cgccaccgac gtgcggacgg
    19921 cccccgagga ggcggccgac gtcctggagt tcccggccac ctacgcccag cagggactgt
    19981 ggttcttcta ccgcctgaac ccgcacagcg ccttctacaa cgtgtcgatg atgcaccggc
    20041 tcaccggtga actggacacc gccgtgctcc ggtcggccct gaacgacgtc gtgcagcgcc
    20101 acgaggcgct gcgcacgacg ttccgcgagc acgacggcga gctgcgccag gtcgtcgccg
    20161 acgccgtgga catcgcgctt cccgtgcacg aggccgccgg ctccgcggcc gaccggacgg
    20221 ccccgcacga ggtgcccgcg gtgcgcgagc agctgaccgg gctcatccag gcccccttcg
    20281 acctggagaa cggcccgctg ctgcgcgccg ccctggtgcg caccgcgccc gccgaccacc
    20341 tcctcgtcct gtcgatgcac cacatcgtcg tggacggctg gtccctgggc atcttcctcc
    20401 gggaactcgc cgaggcctac cgggcccgcc gggcgggcca ggccccgcag ctgccggaac
    20461 tggccatcca gtacggcgac tacgcggaat ggcaggccga gcagctgcac gggccggcgc
    20521 tgcaggacgg actggactac tggcgtgcgc ggctgggcgg cgatctgccc gagctgcggc
    20581 tggcgaccga ccggccgcgc cccgaggccc gctccttcgt cggcgcccgc ttcgacttca
    20641 ccttcgacga ggagctcacc gcgggcctga gggagatgtg ccgggcggag ggcgtcaccc
    20701 tgtacatggt gctgttcgcc ggggtctccg ccctcctgca ccgctacacc ggccaggacg
    20761 acttcatcct cggcaccccg atggccgggc gcgacgacgc ccagacccag ccgctcatcg
    20821 gctcgttcgt caacaccctg ccgatgcgcg cggacctctc gggcgacccc tccttcaccc
    20881 gcgtcctggg ccgggtgcgg gagatgagcc agggcgccta cgcgcacgac gacatcccgt
    20941 tcgagaagat cgtgcaggag gtcgcaccgc agcgcggcat cggcgccaac ccgctgttcc
    21001 aggtcacctt cgcgctccag aactacgagc tcggcggatt cgagctcgac ggcgtgcacg
    21061 cggagcggat cgccgtcgag gagggcaccg cccgcttcga cctggaggtg cactgctggg
    21121 acgacccgga ccggctgcgc ggctccttcg tctacagcac cgacctgttc gaccgcgcca
    21181 ccctggaacg catggcggcg cacctcacca aggtgttcga gggcgcgctg gcggacccct
    21241 cccggaccat cggcgagctg tccctcctca ccgaggacga ccacctggtc ctggacgcgg
    21301 ttgccggccc ggacgccgga ttcgacgccg acgccaccgt gccgcggctg ttcgccgccc
    21361 aggtgacggc ccgccccggg gcgacggccg tgcgggcccc cggcgcgacc ctgtcctacg
    21421 cggaactcgc cgcgggcgtg agcgcgctcg cggcccggct gcgcgcggcc gggctcaccc
    21481 cgggcgcccg ggccggcctg cacctcgacg gcccggtcga cgaactggtg ggcaccctcg
    21541 ccgtcctgga ggcgggcggc gtgtgcgtgc cgctgaaccc gtccgacgac ccggcgctgc
    21601 tgcgccgctc gacccgccgc accgggctcg ccctgctgct cacccgaggc gcggccggtg
    21661 actgggcgga cggcctcacc gcggtggacc tggacaccgc cgccccggcc ggcgtcggcc
    21721 cggacgcggc gccggcaccc gtacggcccg ccggttccgc gccggccctc ctgctggacg
    21781 tgccgggcgg cccgctcgtc ctcgaccacg cgggactcgc cgaccggctg gcccggctgg
    21841 ccgcagcggc cgcgctgacc accggtgacg tcgtcgcccg gcacgcgccc tggggccagg
    21901 agcgcgccgt gtgggaggca ctgctcccgg tctgccacgg ggcgagcctg gcggccgtcg
    21961 gcggggccgg tgtccccggg gacgccaccg tggtgatcgc cgcggactcc gacctgtccg
    22021 gcatcctcgc cgcggacgcg ccgacactct ccccgcgggc cctgctgtgc ctggcctccg
    22081 tgccgtcgcc cgccctcgtc cggcgctgcc acgaccgctt cgggcccgcg gcgcgctggg
    22141 tgtacgccac ctcgcacgcg ggtccgaccg gtgtcgccga gtcggccccg acggacgcgg
    22201 ccctgctgtt cgcacccctg cgcgcggtcc ggatgctgga cgcgcgcggc gccaccaccc
    22261 cggtcggcgt ccccgccgag gtgtacgtcg gcggctccgg cctggcccgc cccgccctcg
    22321 ggagcggccc ggtgacgtgg gccgccgccg gcgacaccgg ccggatcacc gcggacggga
    22381 agctggagat cctcgcccgc cgccccggca ccgccgtcgt ctccggcgtg cccgtcgacc
    22441 tcgccgaggt caccgcggcg atcctggccg agcaggccgt cgccgaggtc acggtcgtgg
    22501 agcgccgtgc caccgcaggc cacaccgagc tggtcggcta tgccgtccgc tgcggccagg
    22561 tgacctcgca gcgcctcgtg caggccgcgc gcgccgcgct gcccggcggc gccgccctgg
    22621 cggcggtggt gttcgtcacc gccctgccgc gcacccccgg cggcggtgtg gacaccgccg
    22681 cgctgagcga gctgcccgtc ctcgacgacg agctgatcgg cgcgtgggag caggcgctgt
    22741 ccgagcgggg cgttcccgcg gtcgtggtgg tagcggagag cgacccggcg ccggccgccg
    22801 aggacttcgt cgatccgcgg gccctcggcc gcgacaccgc cgccgagagc accccgaccg
    22861 gcggtgccgg gacggccggg gactcggacg tgccggcgat cagcagcggc gggcccgcgc
    22921 tggaccccgg cgcggcgaac ctcgccgagg tgctccgccg ggtcgccgcc gacccggcct
    22981 ccggtgacct cgtctacgtc tccgcccagg gggaggagga ccaccagtcg tacggcgagc
    23041 tgcgcgacga ggcgtcccgg gtactgggcg ggctccgcgc gctgggcacg cgtcccggcg
    23101 accaggtgat cctccaactc gcggacaacc gcgacttcgt gaccggcctg tgggcctgcg
    23161 tgctgggcgg gttcgtcgcc gtcccgctcg ccgtgtcgcc cacctacgcg gaggacacgg
    23221 ccgccaccaa caagctcgcc ggcgcgtgga cgctgctgtc ggggcccctg ctgctcacgg
    23281 accgcacgct cgcgggcccg ctgcgcgggc tgggggagcg gctcggctgg caggagcccc
    23341 ggctcgcggt gctcgacgac ctgcgcgacg gtccgcaggc caccgactgg cacgactccc
    23401 ggggcgacga cctggtcctg ctgctgctga cctccggcag caccggccgc cccaaggcgg
    23461 tcgagctgcg ccaccgcaac gtcctggccc gcacggcggc cgcccggcac gtctacgaac
    23521 tcacccagcg ggacgtctcg ttcaactgga tgccgctgga ccacgtcggc ggcatcgtga
    23581 tgtcccacat ccgtgacgtc ttcgtcggct gccggcagat ccaggccccc acccagtggg
    23641 tgctcgccga tccgctgcgc tggacggcca agatggccga gcaccgggtg acgaccacct
    23701 gggccccgaa cttcgccttc ggcctgatcg ccgagcgcgc cgcccagctc gccgggcagg
    23761 actgggacct cggcgcgctg cgcctgatca tcaacggcgg cgaggccatc gtcccccggg
    23821 tcacccggcg cttcatggcg gcgctggccc cgctcgggct gcccgccacc gccatgcgtc
    23881 ccgcctgggg catgtccgag acgtcctcgg gcgaggtcga cgaccgcttc gacccggcga
    23941 ccgccaccga cgacgaccag ttcgtctgcg tcggcgcccc cttcccgggg ttcaccatgc
    24001 ggatcgtgga cggcgacgac gccgtcgtcc acgaaggggt gcccggccga ctccaggtca
    24061 agggcccggc ggtcacctcc ggataccacc tgaaccccga gcagaacgcc gagtccttca
    24121 ccgaggacgg ctggttcgag accggcgacc tcgccgtgct gcgcgacggc aagctgacga
    24181 tcaccgggcg cgccaaggac gccatcatca tcaacggcca caacttccac agccacgagc
    24241 tggaggagtg cgtcgaggag ctcgacgagg tcgaacggtc cttcaccgcg gcctgcgcgg
    24301 tgcgcaccgc cgacagctcc acggacgaac tggcgctgtt cttctgcctc aaggacggcg
    24361 tggccgacgc cgaggcgatc tccctgatcc gcgccaagct ccagcgcgag gccggtgtcc
    24421 acgcctccta cctggtgccc gtcacccggg agcgcatccc caagacggag atcggcaaga
    24481 tccagcgcac cctgctgcgc acgcagttcg aggccggcga gttcgcggcc gaactgcggc
    24541 gcaccggagc cggaacggac gacgacacgg cgctgcccaa ctggttccac cggcctgtgt
    24601 ggcggcgggc cgcggacggc ccacggcccg tcgcgccggc cgccggccac accctgctcg
    24661 tcgccgacgg ccacggactg gcggacgccc tggccgagct gttgcgcgac cgcggcgagc
    24721 gctgcaccgt ccttccggcc ggcgccgccc acgccgcgca ggcgcacggc gccgtcgacc
    24781 gcgtcgtcca cctcgccagc tgcgccccgt accaggagct gccgacgggc acgcaggagc
    24841 tcgccgcggc ctaccgcgag gggccgccgg ccctcgcgga gctcgtcggc gccgtggtcc
    24901 gggccaaccc ggagggccgg ccggtggccc tgaccgtggt cgccacccac agccagtggg
    24961 tgcgcgaggg cgaccgggtg gcgcccgcgc gcggcgcctc gaccggtgtg gtgaagtccg
    25021 tcggccagga gtacgactgg ctgcgcgcca cccacctcga cgtggagccg caggagcccg
    25081 cggagctggc gcagcggatc ctggagctcc tcgacgccgc cggcaacgag cccgagcagg
    25141 cgctgcgcgg cggggaacgc tgggtgcgcc gcatcgagcg gctgcccgcc gccccgtccg
    25201 ggaccaccgg gctgcgccgc ggcgaactcg tcgtcgtcag cggcggtctg ggcggcctcg
    25261 ccgcggagac cgcggcccac ctgctgtccg tccacggcgt gcgactgctg ctgctgggcc
    25321 gcaccgtcct gccgcccgag gaggcctggg acgaggagct cgcctccggc ggagcgaccg
    25381 ccgagcggat cgccgtcctg cgccggctgc gcgccctggg cgaggtccac tacgcggccg
    25441 ccgacgtcac cgacgcggca gccgtacggg cggccgtccg gcacgccgag gagcgctgct
    25501 cgacgcaggc ggccaccgtc atccacctcg ccggccactt ccacgaggct ccggtgaccg
    25561 aggcgggcga ggaggactgg gcggaggtca cccgggccaa ggtgctcggc gccgccgtcc
    25621 tgcaccacct ggtgaaggac cgcccggggg cccgcttcct gtcctactcc tcggtcaacg
    25681 gctacttcgg cggcgccaac gtcgcgggct acgccgcggc caacgccttc ctggacgcgc
    25741 tggcggtcca ccagtccacc gggcacggca tgcgggccca gagcctgggc tggaccatgt
    25801 gggacgagct gggcctcagc cgcggctacg ccctgaaggc cctgaccgag gcccgcggat
    25861 accgcgtgct cgcccccgga cagggcgtcg cctccgtcga cgtcgccctg cggcacggca
    25921 ccccgcaggt gctgatcggc ctggaccaca ccgctccgtg ggtggccggc cggctccagg
    25981 cccccaccgc gccactgcac cggctggtcg gctaccgcac cgccgggtcc gccgacgggc
    26041 gcggcgacct cggcctgccg gaccgctacg ggacccgcac ggactgcgag ttcgccgtgg
    26101 tggccgagct gcccgtcacc gagagcgggg aggtcgaccg ccggcgcctg gccgaggcgg
    26161 gcggcgccgg tgccgcgacc gccgcggccg acgaccgtcc gcacagcgcg gccgagcagg
    26221 ccatcgccgc catctggtgc gatctgctgg gcctggcgga ggtcggtgtc cacgacaact
    26281 tcttcgacat cggcgggcac tcgctgcgcg cggccatgct gctcagccgg ctccgcgccg
    26341 agctgggcgt ggacctcacc atcgcctcgc tcttcgagaa cccgacgatc gccggcctgg
    26401 cccgccagct cgacccgatg acggcccagg acccgctggc cgtggtgctg ccgctgcgcc
    26461 gcgagggcgc cgccgccccg ctgttctgcc tgcaccccgg cggcggcatc agctggtgct
    26521 actccggcct gctcggcggc ctgccggacc ggcacccggt ctacggcatc caggcccgcg
    26581 ggttgaacgg cgaggagccg ctgcccgcga cgctggacga gatggtcgac gactacctgg
    26641 ggcaggtgcg cgagatccag ccggccggcc cctaccactt cctcggctgg tcgttcggcg
    26701 gtgtgatcgc ccacgccatg gcgaccaggc tgaccgccga gggccaccgg gtcggggtgc
    26761 tggccatgat cgacgcctgg cctgcggacc cggagctcga cccggagttc ggcgacgacc
    26821 tgaacgtcga gaaggagatg ctcggcgccc tgctcgccga cgcgggctac gagggccccg
    26881 tcgacgagga gctcacccgc gccgaggcgc tgcggatcct gcgcagcgag ggcagcccgc
    26941 tcggcaacct cacggaggag agcatcacct cgctcgtcgc catcgcgacg aacaacatca
    27001 agctgcgcgc ctgcgagctc ccgccgtacg acggcgacct gctcctcttc cacgcggacg
    27061 gggacgaccg cgacgcggac gccgtgacgc gcagctggcg gaggttcagc accggccgga
    27121 tcgacaaccg cccgatgccc tacggccaca acagcatcat ccaccccaag ccgctggccg
    27181 agatcggcgc gctcgtcggg gagcggatgg cggacggatg acccggcccg cagcaccaca
    27241 ggagaagacc atgaccaatc cgttcgacga cccggacggc acctaccgcg tgctggccaa
    27301 cgacgagggc cagcactgcc tctggccgga cgcgctggac gtcccgcagg gctggcacac
    27361 cctgcggggc gcgggcaccc ggcaggagag cctcgacttc atcgccggga actggaccga
    27421 cctgcgtccg gcgagcctgg cggccggaga ggacggcgcc cggtgagcga cgcgaggacg
    27481 cccgtcggcg tcgacctgct gaaccccgac gtctacgcgg tggacaacca gccccggctg
    27541 tggcggcggt tgcaggacga gtgcccggtc ggctggcacg aacccacgcc cggcgtcccc
    27601 gggttctggg tgctgtcccg ctacgcggac atcatggagg tgttcaagga caccaccacc
    27661 ttcagctcgg cccgcggcaa catcctgggc accctgctgg ccggtggcga cccggccggc
    27721 gggcagatgc tggccgtcac cgacccgccg cgccaccgcg acctgcgccg catcctccag
    27781 ggcggcttct cggcacggtc gatgcggcgc atcgccgaca gcgtccgcac ggtggcgcgc
    27841 cggctggtcg ccgaggcggt cgaacgcggc ggctgtgact tcgtggcgga catcgcggcg
    27901 cgcatccccc tggaggcgat ctgcgaactg ctcgccgtcc cggtcgagga ccgggcgcgg
    27961 atgctggagc tcacctcgac ggcgctcgac gcggacagca cgccgatgga ggcggccagg
    28021 gcgcagagcg acatcatgaa ctactacgcg aagctgctgc ccgagcgccg ggcgaaccct
    28081 caggacgacg ccgtcagcat gctcgcggcc ggtgcgatcg acgggcggcc gctgagcgag
    28141 gtcgaggtct tcctcaactg ctacaacctc atcatcggcg gcgacgagac cacccggttc
    28201 tcaggcgccg gcggcctgct cgcgctgatc gagcatccgg accagtggcg tctgctcaag
    28261 gagcggcccg acgtcatcga cagcgccgtg gaggagatcg tccgctggac ctcgcccgcg
    28321 ttgcacatcg cgcgggtggc gacggtcgac accaccgtcc ggggaacccg gatcgccgcg
    28381 ggcgacatcg tcaccctgtg gatcggtgcg gccaaccggg acgaggaggt gttcgaggac
    28441 ccgtacgcct tcgacctggc ccgcacgccc aacaagcaca tggcgtacgg cttcgggccg
    28501 cacttctgcc tgggcggagc gctcgcccgg atcgagatgc agatcctctt cgaggagctc
    28561 cgggaccagg tgggttccgt cagcctggcc ggcgaggtcg agtactcgcg gtccaacttc
    28621 ctcaccggcg tcagcaggct gcccgtcgcc ctcaccccga gcacccgctg acgtccccga
    28681 ccacggaaga ggcatgatgc cgagcaccac cagcccccga atgcgccccg cgctggacgc
    28741 cgttcccggc tacacgccgg cccgagtccc ggacggcacc gcaccggtcc accggctggc
    28801 cgccaacgag agcccctacc cgccgctgcc cggcgtcctg gagcggctcg cggtcaccgc
    28861 ccaggacgcc aaccgctacc ccgacttcgg gtgccgcgag ctcaccgccg aactcgccgc
    28921 ccggctggac gtcccggccg cgcacatcgc ggtgggcacc ggctcggtcg ccctcgccca
    28981 gcagctgatc cagatcaccg ccgacccggg ggacgaagtc ctcttcgcct ggcgctcctt
    29041 cgaggcgtac ccggtgatga cccggctcgc cggcgccgta ccggtccagg tgccgctcac
    29101 cgccgacgaa cggcacgacc tgcgggccat ggcccgggcc gtgaccgagc ggaccaggct
    29161 ggtcatcgtc tgcaatccca acaacccgac cggcaccgtc gtggggcgcg ccgagctgga
    29221 ggccttcctg gaccaggtgc cggcggacgt cctggtggtc ctggacgagg cctacgtcga
    29281 gttcgccgac gacccggacc acccggacgg ggtcgagctc taccgcgacc gccccaacgt
    29341 ctgcgtgctg cgcacgttct ccaaggcgca cggactggcc ggcctgcggg tcggctacgc
    29401 cgtcgcgcac gagccggtgg ccgcggccct gcgcacggcc gcggtcccct tcggcgtgag
    29461 ccagctggcc caggacgcgg cggtcgcctc gttgcgcgcc gagtccgcga tgcgcgaacg
    29521 cgtcgcggcg ctgacggccg aacgcgcccg ggtcgtccgg gagttggccg cacagggctg
    29581 gaccgtcgcg ccgacgcggg cgaacttcgt gtggctgcga ctcggcgacc gcaccgcgga
    29641 gttcgccgac gcgtgcgccg cggcgggcgt gtccgtgatg gccttcccgg gcgacggcgc
    29701 gcgggtcagc atcggggacg ccgcggccaa cgacgctttc ctgcgctgta cttcgcgatt
    29761 ccggaccggg ggcgcggcgg cgcaggagca ggcgtcccgg caggcggggg agtgagcatg
    29821 accaccgccg tggcgcagga ccggttcaag gacgtgatgg cgggcgtggg cggcccggtg
    29881 accgtcgtga ccgccttcga cgagggcgag ccgcacggga ccacggtcac cgcgttcgcc
    29941 tccctctccc tcgacccgcc gatggtcacc gtcgcgctga gtgagaactc ctccctgctc
    30001 cccaggatca tccggtcggg acggttcggg gtgaacctgc tctgcgcctc ccaggaggag
    30061 ccggccgccc gcttcgcccg gcgtgacgtg gaccgcttcg ccggcgcgca ctggtacgcc
    30121 gacaacgggc tgccgcggct ggcgggttgc ctcggatggg tggcctgcga cgtcgcgcag
    30181 gccgtccggg gcggcgacca cacactgctc ctcggggcgg tgacggatgc tcaacaaggc
    30241 accccggagc atccgttgat ctacgtcaac cgggccttcg gtatgctcct tccgggccct
    30301 gggatcatgc ccgccgtcac gtcaaggact gtttcatgag cgaacgcacc atcactccgc
    30361 gcaaccgagg attcctcttc ctggacgcgc acccggccgg ctgcacccgg ctggtgaacg
    30421 acatgtggcg ttcggtcgcg gccgggcccg ccgaggccct cggcgaggac gcgcccgtgg
    30481 ccctcgtcat cggctcctcc gccggctacg gactggccgc cgccgtcacc gggctcgccc
    30541 gcgtggggat ccgcggcatc ggcgtctcct tcgagaaggc gccgaccgag cgcaggaccg
    30601 gcaccgcggg ctggtaccgc accgcggcca ccgccgaact ggcccgggag gccgggcggg
    30661 agatgctctt cctcaacggc gacgcgttct ccgacggcat gaaggagcag gtggccgacc
    30721 tgatcgagca gcgcttcggc cggctcgacc acctgatcta ctccgtggcg gccccccgcc
    30781 gcaccgatcc cgagacgggc gtcacctacg cctcggccct caagccgatc ggcggcacgg
    30841 cccgcaccag gaccctcgtc ttcgacgagg acgggaagcc ggacgtccgg gaggtgacca
    30901 ccgacccggc cgacgaggac gagatcgcgc agacgatcgc cgtgatgggc ggcaccgact
    30961 gggagcggtg ggtgtcccac ctggccggcc gacggctgct ggccgacggc ttcaccacgg
    31021 cggccctcac gtacatcggc tctccgctga cggccgacat ctaccggcag ggcaccatcg
    31081 gcgccgccaa gacccacctg gagcagaccg cccgggcgct cgacgcacgg ctgggcgagc
    31141 tctgcggagg gcgcgcggtg acctcggtca acggggccgc cgtcacccag tcgtcgacgg
    31201 ccatccccgg gatcgccctg tacacgggcc tgctgcgggg cgtcctcggc ggccgcatgg
    31261 tgtccccggc ggaccagctg tcgcagctgt gggaccagct caccggcgtg cgcccgctcg
    31321 tgacggacga cgagggacgg gtgcggctcg acacctggga gctcacggcc gaggtgcagg
    31381 ccgccgtcgc cgaccgctgg cggaccgcca ccaccgacac catcacggac ctcgccgacc
    31441 tggactggtt ccgtgacagc gtccggcagc tgtacggctt cagcgtcccc ggcatcgact
    31501 actccgctcc cgtcgagacc gacgtgccct ggcccgccgg ctgatgagcg ggcccgacgt
    31561 cgcggtcgtg gggaccggcc ccaacggtct ggcggcagga gtgacgctgg cccgcgccgg
    31621 gctgagcgtc gtcctccacg aggccgccga ccggttcggc ggcggcctgc gcacgacgcc
    31681 gctgttcgac gacgacgtcg tgcacgacat ctgctcggcg gtccacccca tggccgcggc
    31741 ctcccggttc ttccgcgagt tcgacctggc cgcgcggggc gtggagctcc tccagcccga
    31801 gatcggctac gcgcacccgc tggacggcgg ccgggccgcg ctggcccacc gcgacctcga
    31861 cgtcacctgt gacctcctcg gcccggacgg gaagaggtgg cgccgcctca tggaacccct
    31921 cgtggcccac agcacgggca tcgtggatct ggtgctgtcc ggcgggcgcg ccctgccgga
    31981 cgactgggcg gccccgttcc tgctcgccgg ccggaccctc gcgcacggca ccgcgctcgc
    32041 ccgcgggcgc ttcgccaccg aggaggccga cgccctgctg gccggcgtcg ccgcgcacgc
    32101 catcggcagg ctgcccagcc tcgcctccgg cgcgatcgcc gtgctgctgg gccatctcgc
    32161 ccatgcctcg ggctggccgg tcccccgggg cggcagcgcc cggatcgccg aggccatggc
    32221 cgccgacatc accgcccacg gcggcacctt ccacctggga cggaccatca ccgacctgcg
    32281 cgagctggcc ggcgcgaggg ccgtgctcct ggacacgggg gtgaagggac tgctgcggat
    32341 cgccggcgac cgcctgccgc gccgctacgc gcgccgcctg gcccggttcc gctacggccc
    32401 cgccgccgcc aaggtcgatt tcctcgtgtc ggacgccatc ccctggtccc acccggagct
    32461 gggcagagcg ggcacggtgc acctcggcgg cacccgggcg gaggtcttcc gcgcggagtc
    32521 gctgaccgcc gcgggcgtcg ccgtcgacga tcccttcgtc ctcctcgtcg acccgggtgc
    32581 cgtcgacggc acccgggtcc gcccgggcag gcgcccggtg tacgcctacg cccacgtgcc
    32641 caacggcgac gaccgcgacc cggtggaact cgtgagcggg cgcatcgagc gctacgcacc
    32701 cggcttccgc gacaccgtgc tcgcggcccg cggcatcagc ggccggcagt tcgaggcgta
    32761 caaccccaac tacgtcggcg gcgacatcag cagcggggcg gcgacgctcg tccagagcat
    32821 cctgcgcccc accgcgcagc tggacccgta ccgcaccccg ctccccgggg tgtacctctg
    32881 ctcggccgcc accccgcccg ggccgggtgt gcacggcatg tccggacacc tcgcggccct
    32941 gtccgtactg cgccgcgagt tcggcgtcac cacgccgccc cggctggggc cggacgcgag
    33001 caacgcgtga agttcgtgat ggtgccgggt ggttggcacg gcgggtgggt gttcgacgcg
    33061 gtggcggccg agctgcgccg ggccggtcac caggtcgagg cggtgaccct ggcggggttg
    33121 gagccggacg gccccgccga tgcggaccgt ccgccgaacc tcgacaccca catcgaccag
    33181 gtggccgcga tcgtcgacgg cagcgccgca ggacccctcg cgctgtgcgg gcacagctac
    33241 ggcgggatgg tgatcgccgg tgtcgcggac cggctcggcc accgcctcga ccagctcgtc
    33301 ttcatcgacg cctacgtccc ggaggacggg gactcctgct ggtccctgac cagcgaccac
    33361 ttccgggagc tgttcgtggc cggctcccgc gccgacggtc gctgggtcgc ggtccccgac
    33421 cggttcgacc cccgcgcgcg agcgcacccg ctggcgagct tcctccagtc ggtcaggctg
    33481 ggaggcggcc ccgggcacgg gttcggccgg acgtacatca gtggtggcgc gtggctgggc
    33541 aacccgttcg tggcgctgac cgaacggctg cgcgaggact cggactggcg ggtgcacgag
    33601 attcccgtcg ggcacgacat cgcccgccgc gacccgtccg gcctcgcggc cgttctcgac
    33661 gcactgccag cggccggtgg gcggcgatca gtcgggcgcg cggcccgggc cctggacacc
    33721 gactgacggg ccgctggtgt ccaggggact gccgggggga cggccggggg tgcgaggtgt
    33781 cacgcgtggc aggggaggac gacgtcgagg atctcccgta cgcggtcggt gaggtccttg
    33841 cggtcgcgtt cgacccagga gatgtgctgg ctgccgaaga acgcggcgac gacgacgcgg
    33901 gcgatgatgg cggcgtcggc ggtgggctgc caggcgttct cgtgctgggc ccgggccagc
    33961 agctcggtga tgagctgggt gaacccgctg aacggcgtcg gcatgtcggc gttgaccagg
    34021 ttccgctcga tctgcagccg ggcaccggcc tgcgccaccg ggttgtcccg caggaagacc
    34081 gcggtctgca ggaggaactc ggtgaccgtg tcgagcggcg ggagctgctt gtccatcacc
    34141 gcttcggcga cggcgggcag ttgcgtgtag aactcctcgg tgacggcgac ggccaccgcc
    34201 tccttgttct tgaagtggaa gtagacggcg cccttggtca cctccgcgcg gtcggcgatg
    34261 tcctggagcg tgacggcggg gaaccccttc tcggcgaagg ccctggcagc ggcgtccaag
    34321 agctgcctgc gggtgtggcc ggcccgttcc tgcttgagtt cccgcagggc ggccttggtc
    34381 ccgacggctg tccacagatc gctgttgcgg ctgttcatgg tccctctccc gtgccggtct
    34441 ctggcgcaag cccgagcctt gctagatacc tctgcgaagg tatatttttg tttcgcaccc
    34501 gattttaata cgccgggagg ccgtgggcca gctgcttgag ccgccggtca agatcccggc
    34561 cgcttcgagc gccgtctcca gccggtccgt ggcggaggcg aagtcgccgt cggatgcggg
    34621 ccgcgcccgt ccggagcggt cgggcggatc ctggtggaat gcgccgaccg gcccgcgccc
    34681 ggccggcggg atccggctcg gcccggaata tcccggcgat ccgccgcccc cgatttcccc
    34741 ccggtggagc gcggcggccc gcccgcctgc gggttggtgc acgaatcatc agggaatcgc
    34801 cgtgggccgg gcctgccggt gcgcggctcc cgtcgcggta cggcaggggc cgggctacgc
    34861 tgcgaccaga agggccgccg cacggccaca cccccgaggg ccgtgcggcg gcccttcttc
    34921 gttcccgccg ccctgcccgc cgccggcctc ctccccgccg gcgcccggcc gcccggtccg
    34981 cccgtgcggg cacccggtgt gcaaccgggg atttccccgg ttgcacaccg tgcacaccgt
    35041 gcacaccgtg tgcagcccgt gcggcgcagg ggttggaaaa aaataccttg gcaaaggtat
    35101 ccttacgtca ggtcgatcgg agccgcgtac agggctccgt ggcgcccggc cgtgagcgtc
    35161 gggtgcggca ggggagtggt cgagcgcggc cggcggtggg gcggtgcccc gtcgtccggg
    35221 cgttcgaatc cgttgcggcg cccggaggag ttcgcggtga actccggaaa gcggggaatc
    35281 cgcggtcctt gacgggccat cgaattcctt ggtttgctca tgaaagcgaa attcgaaaca
    35341 ccacaagaaa tgccgcagaa agagtgcggg aacaatccga cgggcaagca tccacaacca
    35401 aaggtgcgaa aatgaaatcc gcatggatcg atctccgtgg tttcgccggt gagctcgcgg
    35461 ctgccgtcat cgaggagagt gctcacctcg gtgtcgaggc cgtcgtgttc gacgacccgg
    35521 acctggcggc gaagatcccg ccgaacctga cgaagaccgc cgtggtgaac ggggagaccc
    35581 cgaccacgct gatcgaccgg ctggtcgagg tggtggacct gctggtcgtg gaccacgcga
    35641 tcgccgagaa gttcgagggg atccggccgg gtctgcgcac cggtgtgctg gtgcgggtgc
    35701 tggacgagca gaccctggac gtcgcctgca aggtggcgaa ccgggccgag gtgacgctgg
    35761 tggagttccg gcaggacccg agcaagatcc cgctggagat cctgctggcc gcggcggacc
    35821 aggccaaggg ctcgatcgtg acggtggtcg aggacatcga ggacgcgaag atcaccatcg
    35881 gggtgctgga gcgcggttcg gacggtgtgc tgttcacccc gaagcgggtg ggcgaggtga
    35941 ccgagctggt cgaggccacc cacgggcagg cgtcgtcgct ggacctggag ccgctggaga
    36001 tcgtccagct gcagcacctg ggcctgggcg accgggtctg cgtggacacc tgctcgcacc
    36061 tgcgccccaa cgaggggatc ctgctgggct cgtactccag tggtctgatg ctggtcagca
    36121 gtgagaccca cccgctgccg tacatgccga cccgcccgtt ccgggtcaac gcggccgcgc
    36181 tgtccacgta cacgctgact ccgggcaacc gcacccagta cctgtccgag ctgcactgcg
    36241 gctcggagat cctggccgtc tccactgacg gcagcgtgcg caccgtgatc gtcgggcgga
    36301 tcaagatgga gtcccgtccg atgctgcgga tcgaggcccg taccgcgagc ggtcagctgg
    36361 tggacatggt cgggcaggac gactggcacg tgcgggcgct gggcccgggc ggcagcgtcc
    36421 acaacttcac cgagctgcgc aagggcgacg tcatcctggg ccacaccatg accgaccagc
    36481 gccacgtcgg ctacgcgatc cgcgagttcc tccacgagca gtaaagaccc ctgcgtcgct
    36541 cacgcggtca accggggaaa cggccggtcg gcgcggcgct ccaccaacgt cctccacgtc
    36601 ccaaggatct gaaggaagag agtgcgtgag atggcgctca ttgtgcaaaa gtacggcgga
    36661 acctcggtcg ccacaccgga gaaggtcatc gaagcggccc ggcaggtccg ggccgcacgc
    36721 gaggaagggc accaggtcgt ggtggtggtg tccgccatgg gcggtgccac cgacgggctg
    36781 ctgcgcctgg cgtccgcggt gaccgacctc cccgttccgc gtgagctcga cggcctgctc
    36841 tccacgggcg aggccgcctc cgccgcgctg ctgtcgctgg cgctcaacca ccagggcgtc
    36901 gccagccggt cgttcagcgg tgcgcaggcc ggcatccgca ccgaccaccg ccacggcaag
    36961 gcgacgatcg tgcaggtgga cccgcggcgg ctgcgggagg acctcggcag aggaatggtc
    37021 cccgtcgtcg cgggtttcca gggcgagtcg gtcctcaccg gggcctgcac gaccctgggc
    37081 cgcggcggct cggacaccac cggggtcgcc ctggccgccg cgctcggcgc ggaccactgc
    37141 gagatcgtca ccgatgtcgc cggcgtctac accgccgacc cccgcacggt cgtcggtgcc
    37201 cggcgccaca ccggcctctc ctacgaggag atggccgaac tcgcggtcag cggcgccaag
    37261 gtgctcgccg cggactccgt ggactacgcc cgcacccacg gcgtcgagtt gaaggtgcgg
    37321 gccaacagca ccgcgaccgg cccgaagacc tgggtcggcc acggccggag cgccggcggg
    37381 ccgacgcccg gggactcccg gacggccgac ggacagggct gtccgatcgc cggcgtggcc
    37441 gggcgctccg gcctggtccg ctgcgtactg cggcggatca gcccggacca cgtcctgcgc
    37501 ctgctcaggg agttggccga gcgcgagatc gaggtcgaac tgcgccgcta cggcaacctc
    37561 ggcaccgagg acgccggcga catcgcgctc acccttcccg aggagagcgc cgaggagctg
    37621 cgggagctgc tggccgacac cgaccgcggg atccacctcg acgaggcgca ctggacgtcg
    37681 aacctggcca ggctctccgt cgtcggcctc ggcatcggcc gacggccgta cgctccgctg
    37741 cacctgctcg aagccctgcg ctcggtcgac gccgcgcgcg ccgacgtcca cgtcacctcc
    37801 aaccgggtca gcgtgctgac cgggcggagc gacctggccg aggcgaccca gatcgtccac
    37861 gacaccttcg tgtccgggcc ggagatgccc gcgatccacc cggtggaccc ggacgacgcc
    37921 gacacgacct ggtcgctgac cgccgagcgc gggcacctcg acgtcgagct gcccgccctg
    37981 gccgccgccg agtgaccccc ccgccacccc acgccccaag ggagaacacc gatgtccgcc
    38041 atccgactcg accccggccg ccggggcggg ccgacaccgc tccggcccgc cgagcggccg
    38101 cgttcggagc gtccccgatg accacgacgc cgcacttcga tccgacgtcc gacggccagt
    38161 tggccgatcc ctatccgatg tatgcgcggt tgcgtggttc gtgtccggtg gtgcatgacc
    38221 cgaagctgga tgtgtgggtg gtgtcccggc atgaggatgt ggcccgggtg ttgcacgatc
    38281 cgggggtgtt ctcctcggag agtgcggtgc gggtggcggt cgggccggag gctgatgagg
    38341 tcaagcaggt gatggccgag ggctggtcgt tgacgccgaa cctgacggag agcgacggtg
    38401 aggtgcacac ccggctgcgg gtggcggtca accgggtctt cacgccgcgg cgggtggccg
    38461 agttggagcc gttcgtgcgg gcgactgcgg aggagttgat cggccggttc gccgcggccg
    38521 gtgaggtcga cgtcatcgag ggttatgcgt ggccgctgcc gttgatggtg atggcgcaga
    38581 tcctgggggt gccggcgggg gatgtgccgc ggcttcggcg gtggagccac aactggctgc
    38641 ggctgtcggt ggggacgggc ccggccgagg agcgggtgga gtgggcgcgt gacgtggtgg
    38701 agatgcagca ctacgtgatg gcgctgctcc aggagcccgg ccgggtcgcg cagggcgggc
    38761 tgatcgcctc cctggcggcg gatggggacg agcacgggtt ggacacggtg gagctgatgc
    38821 gcatcgtgat gaacctgatc atcgcggggc acgtgacggt gacccgggcg atcggcaacg
    38881 gcgtggtcac cctgctggaa caccccggcc agctcgcggc gctgcgggcc ggggaggcga
    38941 gtgtggaggc gatggtggag gagaccctgc gctacgagtc ccccgtccag ggcctgttcc
    39001 gcaccgtcac cgagggcacc gagctcggcg gccgcaggct ggtacccggc gagcgggtga
    39061 tggtgcactt cggctccgcc aaccgcgacg aacacgtcat caccgacgct gacgcgttca
    39121 ccctccagaa caggccgggc cgccaccaga tggccttcgg ccgcggcatc cacgcctgcc
    39181 tcggcgcctc cctggcccgc ctccaactgc gtatcgccat accgctgctc ttcgaccgac
    39241 tccccggact gcgcctgggg cccgccgacg cgcgtgttcg tgaacggctg gtcatcgccc
    39301 gcggattcga ggaactccga ctccactggg acgtcccaca atgacctacg acgtgatcgt
    39361 gatcggcggc ggctccgcgg ggtgcgtcct cgccgcccgg ctgagcgccg acccggcgct
    39421 gtcggtcctc ctgctggagg ccgggcccga cttcgccacc ctggaggacc tgcccccgga
    39481 ggtcgccgac gcgagctacg cgccgttcac ccacgactgg ggctaccgct cggtcgcgga
    39541 cgagttcggg aacgaggtgc ccgtcccccg gggccgcctc atcggcggct cctccgcggt
    39601 caacgtctgc gtcgcgatgc gggcccggcc ctccgaccac caggcgtggg ccgaagcggc
    39661 cggccccgca tggggctacg agcagatgct gccgctctac caggagatgg agcactaccc
    39721 gtacggcgag cccaagtacc acggtctggg cggcccctac cggatgacca tgccggtggc
    39781 ggaggacctg gggccgcacg cggccgcggt acgacaggcc agcgccgacc tcgggcaccc
    39841 gctcgtcgac gacttcaacg cgccgggcgc accgggcttc gcgtacaccc cgctcagcgc
    39901 ggccgacggc gtccggctga gcaccgcggt cggctacctc aaccccgtcc gccaccggcc
    39961 caacctggag gtgcgcggcg agacgctggt cgaccgggtg ctgttcgacg gcacccgggc
    40021 gaccggagta cggctcgcca ccggggagga gatccccgcc cggcacgtgg tgctcagcgc
    40081 cggcgcctac aactcgcccg cgatcgcgct gcgttcgggc atcggcgacg gtgccgacct
    40141 ggccgcgctc ggcatcgacg tggtggccga cctgcccggg gtggggcgca acctcaccga
    40201 ccaccccgcc tactggaaca tccacgtcgc caagccgccg caggacctgg ccaagtcgat
    40261 gttcggcagc gtgctgagcg tcgcggtggg ggagggcgag cccgactacg acgtgcagat
    40321 cctgccgtcc gcggcggtgc cgaccgccgg actgcccgcc gccttcgtct caccgaccga
    40381 gaaccacccc accggctggg acatggtctt cttcgtctcc tgcgtccagc cccgctcgcg
    40441 gggcagcgtg cggctcgcct cgcgcgaccc cgaggacgcg ccggtcatcg acctcggcct
    40501 gtacacggac gcggacgacg cagaactggt cgcgggcggc gtacgcctgg cccgccggct
    40561 cgcccggacc gagccgctcg ccgacctgct ggtggccgag cgcgtccccg gaccggacgt
    40621 cagcgacgag gacctggcgg aggcgatccg ccgggccccg gcgcactaca accacggcag
    40681 ctccaccatg cgcatgggcg ggcccgacga cccggccgcc gtcgtcgacg ccgacggcgc
    40741 cgtccacggc gtccagggac tgaccgtcgc ggacgcctcg gtgttcccgg cgatgccccg
    40801 ggtggccacc aacgtcccgg ccatcgtcgt cgccgagcgg atcgccggcg tcctgcgcga
    40861 acgactcacg acagacaact gagctccagc atccagcgaa cgccggcgta ccggcgaaca
    40921 gtcaggagga ttccgtgtcc acgaccgagg aaaacgtcga ggtcctgcac accaggtggt
    40981 cgtcgaagga cgacgccgac cggttcaccg tcgagaaccc ggcgaccggc aagcccctgg
    41041 tggtcatcca gggcgccggt gcggaccagg tggaccaggc ggtggaggcc gcctacgacg
    41101 cgcacttcgc gtggaaggcc cgcacgccgc gcgagcgcgg caagtacctg tggaaggtcg
    41161 cccaggtcat ccgggagcac gccgacgaga tcgcggcgct ggagtccagc gacaacggca
    41221 agccggtgac ccaggcccga cagttcgacc tggagggcgc cgccaccgtc ttcgaactgt
    41281 tcgccagcct ctgcgaggtg atgcccggcc aggtccgcga ctccggcagc atgctggacg
    41341 tcacggtgcg cgagccgttc ggcgtcatcg gcgccatcgt gccgttcaac tggccgccgc
    41401 tgcacaccgc cggcaagatc gcccccgcgc tcgccgccgg caacgccgtg gtcatcaagc
    41461 cgccggagca ggccccgctg tcggtgctgc ggacggtcga gctgatccag tccgtgctcc
    41521 cggacgacgt ggtccacgcc gtccccggcc ccggcgccgt cggcgcccgc ctggccgggc
    41581 acaagctggt cggcaaggtc tccttcaccg gcgcgcccac caccggccag gcgatcatcc
    41641 gcaccgcctc ggagaacctg acgccgaccc tgctggagct cggcggcaag aacgccctgg
    41701 tgatcttcga cgacgcggac ctggactcgg cgctgcgctg ggcggtcgag ggcggctact
    41761 tcaaccaggg cgaggcctgc accgcctcct cgcgggtcct ggtccacgcc gacctccacg
    41821 acgaggtggc ccgccgcctg gccgccgccg tctcccgcct gaaggtcggc aacggcgccg
    41881 acgccggcac ccacgtcggt ccgctggtca ccgaggcgca gcgccggcgg gtgctggact
    41941 acctggagat cggcgtcggc gagggcgcca ccatcgcggc gcaggcgccg ctgcccaccg
    42001 acccggagct ggcggacggc tactacgtcc cgccgacgct gttcaccggc gtcaccccgg
    42061 acatgcgcat cgccaaggag gagatcttcg gccccgtcgt ctgcctgatc ccgttccgcg
    42121 acgaggagga ggccgtccgg atcgccaacg gcaccgactt cggcctggtc gccggcgtgt
    42181 tcacccgcga ctccgagcgc gccctgcgct tcagccggga gctgcgcgcg ggcgtcgtct
    42241 tcgtcaacca ctacaaccgc tcgttcacgg gatccccgtt cggcggcgtg ggcgccagcg
    42301 gctacggccg ggaacacgcc ctggagacgc tgcaggagta cagcttcagc cgtaccctgc
    42361 gcctgacctc cggccgcggc gaggtcccgc ggtgggcacc gtcgctggag gtcgtcgacg
    42421 cggagtgatc cggcgtcgtc gtcgaagt
//
