BGC0001039: pyridomycin biosynthetic gene cluster from Streptomyces pyridomyceticus
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Location: 1 - 42,448 nt. (total: 42,448 nt).
This entry is originally from NCBI GenBank HM436809.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001039
Short description pyridomycin biosynthetic gene cluster from Streptomyces pyridomyceticus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
HM436809.1
via
Compounds
  • pyridomycin
Species Streptomyces pyridomyceticus [taxonomy]
References
Chemical products information
pyridomycin Evidence:
Copy SMILES
C27H32N4O8
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AEF33095.1
  • pyr1
 211 - 360 (+) hypothetical protein
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    • AEF33074.1
    • pyr2
    		 481 - 1221 (+) 3-oxoacyl-[acyl-carrier protein] reductase
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      • AEF33075.1
      • pyr3
      		 1298 - 2302 (-) membrane protein
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        • AEF33094.1
        • pyr4
        		 2290 - 2922 (-) decaheme cytochrome c
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          • AEF33096.1
          • pyr5
          		 3000 - 3218 (-) 4-oxalocrotonate tautomerase
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            • AEF33097.1
            • pyrB
            		 3234 - 4490 (-) L-lysin 2-aminotransferase
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              • AEF33098.1
              • pyrA
              		 4648 - 6279 (-) 3-hydroxypicolinic acid:AMP ligase
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                • AEF33099.1
                • pyrU
                		 6484 - 6738 (+) amino acid adenylation domain-containing protein
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                  • AEF33076.1
                  • pyrC
                  		 6717 - 7871 (+) favin-dependent oxidoreductase
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                    • AEF33077.1
                    • pyrD
                    		 7868 - 9013 (+) sarcosine oxidase
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                      • AEF33078.1
                      • pyrE
                      		 9040 - 15483 (+) dimodular nonribosomal peptide synthetase
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                        • AEF33079.1
                        • pyrF
                        		 15476 - 19711 (+) polyketide synthase
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                          • AEF33080.1
                          • pyrG
                          		 19866 - 27221 (+) putative peptide synthetase
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                            • AEF33081.1
                            • pyrH
                            		 27251 - 27466 (+) putative MbtH-like protein
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                              • AEF33082.1
                              • pyrI
                              		 27463 - 28671 (+) cytochrome P450
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                                • AEF33083.1
                                • pyrJ
                                		 28697 - 29815 (+) putative aminotransferase
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                                  • AEF33084.1
                                  • pyrK
                                  		 29818 - 30339 (+) putative oxidoreductase
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                                    • AEF33085.1
                                    • pyrL
                                    		 30336 - 31544 (+) dehydrogenase
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                                      • AEF33087.1
                                      • pyrM
                                      		 31544 - 33010 (+) putative dehydrogenase
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                                        • AEF33086.1
                                        • pyrN
                                        		 33007 - 33726 (+) esterase
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                                          • AEF33088.1
                                          • pyrO
                                          		 33780 - 34418 (-) TetR family transcriptional regulator
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                                            • AEF33089.1
                                            • pyrP
                                            		 35412 - 36524 (+) 3-dehydroquinate synthase
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                                              • AEF33090.1
                                              • pyrQ
                                              		 36631 - 37995 (+) aspartate kinase
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                                                • AEF33091.1
                                                • pyrR
                                                		 38118 - 39344 (+) cytochrome P450 family protein
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                                                  • AEF33092.1
                                                  • pyrS
                                                  		 39341 - 40882 (+) choline dehydrogenase
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                                                    • AEF33093.1
                                                    • pyrT
                                                    		 40935 - 42428 (+) putative aldehyde dehydrogenase
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                                                      Biosynthesis information

                                                      Biosynthetic modules

                                                      Name
                                                      Unk01
                                                      Type
                                                      nrps-type1
                                                      Genes
                                                      pyrE
                                                      Substrates
                                                      threonine (evidence: )
                                                      Integrated Monomers
                                                      Domains
                                                      adenylation
                                                      Name
                                                      Unk02
                                                      Type
                                                      nrps-type1
                                                      Genes
                                                      pyrE
                                                      Substrates
                                                      3-(3-pyridyl)-alanine (evidence: )
                                                      Integrated Monomers
                                                      Domains
                                                      adenylation
                                                      Annotation changelog

                                                      Entry version: 4

                                                      Date
                                                      Changes
                                                      Submitters
                                                      Reviewers
                                                      2022-10-07
                                                      Update chemical activity to schema version 2.11
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                      Entry version: 3

                                                      Date
                                                      Changes
                                                      Submitters
                                                      Reviewers
                                                      2022-09-15
                                                      Updated bioactivity data
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      2022-09-15
                                                      Added NRP substrate specificities
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                      Entry version: 2

                                                      Date
                                                      Changes
                                                      Submitters
                                                      Reviewers
                                                      2019-10-16
                                                      Migrated from v1.4
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                      Entry version: 1

                                                      Date
                                                      Changes
                                                      Submitters
                                                      Reviewers
                                                      2015-06-12
                                                      Submitted
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      Detailed domain annotation
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