BGC0001040: rapamycin biosynthetic gene cluster from Streptomyces rapamycinicus NRRL 5491
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Location: 1 - 107,379 nt. (total: 107,379 nt).
This entry is originally from NCBI GenBank X86780.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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resistance
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0001040
Short description rapamycin biosynthetic gene cluster from Streptomyces rapamycinicus NRRL 5491
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
X86780.1
via
Compounds
  • rapamycin
Species Streptomyces rapamycinicus NRRL 5491 [taxonomy]
References
Chemical products information
rapamycin Evidence:
Copy SMILES
C51H79N1O13
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAA60449.1
  • orfZZ
 <1 - 871 (-) monosaccharide transporter
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    • CAA60450.1
    • orfZ
    		 1150 - 2319 (-)
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      • CAA60451.1
      • orfY
      		 2422 - 3036 (+) regulator of antibiotic transport complexes
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        • CAA60452.1
        • orfX
        		 3056 - 3763 (-) ABC-transporter
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          • CAA60453.1
          • orfW
          		 3770 - 5149 (-)
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            • CAA60454.1
            • orfV
            		 5184 - 6497 (-) membrane transport protein
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              • CAA60455.1
              • orfR
              		 6703 - 7365 (+) response regulator
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                • CAA60456.1
                • orfS
                		 7356 - 8555 (+) sensory protein kinase
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                  • CAA60457.1
                  • orfU
                  		 8730 - 9332 (-)
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                    • CAA60458.1
                    • rapT
                    		 9337 - 10131 (-) ketoreductase/dehydrogenase
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                      • CAA60459.1
                      • rapB
                      		 10574 - 41245 (-) polyketide synthase
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                        • CAA60460.1
                        • rapA
                        		 41242 - 66933 (-) polyketide synthase
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                          • CAA60461.1
                          • rapP
                          		 67319 - 71944 (+) pipecolate incorporating enzyme
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                            • CAA60462.1
                            • rapC
                            		 71949 - 90731 (+) polyketide synthase
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                              • CAA60463.1
                              • rapQ
                              		 90798 - 91433 (+) methyltransferase
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                                • CAA60464.1
                                • rapO
                                		 91534 - 91767 (-) ferredoxin
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                                  • CAA60465.1
                                  • rapN
                                  		 91764 - 92978 (-) cytochrome P450
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                                    • CAA60466.1
                                    • rapM
                                    		 92992 - 93945 (-) methyltransferase
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                                      • CAA60467.1
                                      • rapL
                                      		 94047 - 95078 (-) lysine cyclodeaminase
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                                        • CAA60468.1
                                        • rapK
                                        		 95430 - 96434 (+) pteridine-dependent dioxygenase
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                                          • CAA60469.1
                                          • rapJ
                                          		 96465 - 97625 (+) cytochrome P450
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                                            • CAA60470.1
                                            • rapI
                                            		 97622 - 98404 (+) methyltransferase
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                                              • CAA60471.1
                                              • orfH
                                              		 98467 - 101085 (-) regulator of cholesterol oxidase
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                                                • CAA60472.1
                                                • orfG
                                                		 101422 - 102414 (+) helix-turn-helix DNA binding protein
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                                                  • CAA60473.1
                                                  • orfF
                                                  		 102427 - 103788 (-) membrane transport protein
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                                                    • CAA60474.1
                                                    • orfE
                                                    		 103801 - 105198 (-)
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                                                      • CAA60475.1
                                                      • orfD
                                                      		 105445 - 106608 (+)
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                                                        • CAA60476.1
                                                        • orfDD
                                                        		 106758 - >107379 (+) cystathione synthase
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                                                          Biosynthesis information

                                                          Biosynthetic modules

                                                          Name
                                                          Unk01
                                                          Type
                                                          nrps-type1
                                                          Genes
                                                          rapP
                                                          Substrates
                                                          pipecolic acid (evidence: )
                                                          Integrated Monomers
                                                          Domains
                                                          adenylation
                                                          Annotation changelog

                                                          Entry version: 4

                                                          Date
                                                          Changes
                                                          Submitters
                                                          Reviewers
                                                          2022-10-07
                                                          Update chemical activity to schema version 2.11
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                          Entry version: 3

                                                          Date
                                                          Changes
                                                          Submitters
                                                          Reviewers
                                                          2022-09-15
                                                          Updated bioactivity data
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          2022-09-15
                                                          Added NRP substrate specificities
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                          Entry version: 2

                                                          Date
                                                          Changes
                                                          Submitters
                                                          Reviewers
                                                          2019-10-16
                                                          Migrated from v1.4
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          2019-10-16
                                                          Updated compound(s) information (NPAtlas curation)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                          Entry version: 1

                                                          Date
                                                          Changes
                                                          Submitters
                                                          Reviewers
                                                          2015-06-12
                                                          Submitted
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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