Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001040.1:
Cluster 1NRP / Polyketide1107379

BGC0001040, rapamycin biosynthetic gene cluster from Streptomyces rapamycinicus. Locus 1. Partial MIBiG entry.

Chemical compounds

Compound: rapamycin
PubChem ID: 5284616
SMILES string: Copy to clipboard
Molecular formula: C51H79NO13
Average molecular mass: 914.187 Da

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Polyketide synthase subclass:
Type I

Gene cluster description

rapamycin (BGC0001040). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank X86780. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

Literature references

1. Schwecke T et al. (1995) The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin. Proc Natl Acad Sci U S A 92(17):7839-43.
2. Molnar I et al. (1996) Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of genes flanking the polyketide synthase. Gene 169(1):1-7.
3. Aparicio JF et al. (1996) Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of the enzymatic domains in the modular polyketide synthase. Gene 169(1):9-16.