Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001041.1:
Cluster 1NRP / Polyketide142010

BGC0001041, salinosporamide biosynthetic gene cluster from Salinispora tropica. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: salinosporamide
PubChem ID: 11695330
SMILES string: Copy to clipboard
Molecular formula: C15H20ClNO4
Average molecular mass: 313.778 Da
Molecular activity: Cytotoxic
Molecular target: 20S proteasome

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Other (cyclic)
Thioesterase type:
None
Release / cyclization type:
Unknown

Polyketide subclass:
Other (cyclic)
Polyketide synthase subclass:
Other
Starter unit:
Acetyl-CoA
Polyketide synthase / ketosynthase-encoding genes:

Gene cluster description

salinosporamide (BGC0001041). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank CP000667, positions 1140547-1182556. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Enzymatic assays, Heterologous expression, Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Bradley S. Moore (University of California, San Diego)

Literature references

1. Eustaquio AS et al. (2009) Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine. Proc Natl Acad Sci U S A 106(30):12295-300. doi: