BGC0001042: sanglifehrin A biosynthetic gene cluster from Streptomyces flaveolus
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Location: 1 - 118,372 nt. (total: 118,372 nt).
This entry is originally from NCBI GenBank FJ809786.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001042
Short description sanglifehrin A biosynthetic gene cluster from Streptomyces flaveolus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide
Loci NCBI GenBank: FJ809786.1
Compounds
  • sanglifehrin A
Species Streptomyces flaveolus [taxonomy]
References
Chemical products information
sanglifehrin A
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C60H91N5O13
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ACY06266.1
 3 - 1199 (+) cytochrome P450 monooxygenase
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  • ACY06267.1
 1297 - 2505 (+) hypothetical protein
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  • ACY06268.1
 2578 - 2853 (+) acyl carrier protein
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  • ACY06269.1
 2850 - 4502 (+) CoA ligase
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  • ACY06270.1
 4627 - 5496 (+) methyltransferase
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  • ACY06271.1
 5748 - 6896 (+) putative p450 monooxygenase
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  • ACY06272.1
 7389 - 8048 (+) deoxyadenosine kinase
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  • ACY06273.1
 8587 - 9585 (-) dehydrogenase
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  • ACY06274.1
 9708 - 10583 (+) LysR family regulator
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  • ACY06275.1
 10602 - 10940 (+) putative protein kinase
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  • ACY06276.1
 11553 - 12338 (+) hypothetical protein
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  • ACY06277.1
 12370 - 13284 (-) hypothetical protein
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  • ACY06278.1
 13385 - 14017 (+) TetR-like family regulator
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  • ACY06279.1
 14498 - 14764 (+) transglycosylase-associated protein
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  • ACY06280.1
 14973 - 15413 (-) Ser/Arg-related nuclear matrix-like protein
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  • ACY06281.1
 15596 - 16063 (+) chimeric AFGP/trypsinogen-like serine protease precursor
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  • ACY06282.1
  • sfaA
 17024 - 17854 (+) tyrosine 3-monooxygenase
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  • ACY06283.1
  • sfaB
 17851 - 19191 (+) L-lysine 6-monooxygenase
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  • ACY06284.1
  • sfaC
 19193 - 19888 (+) negative transcriptional regulator
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  • ACY06285.1
  • sfaD
 19885 - 30714 (+) non-ribosomal peptide synthetase
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  • ACY06286.1
  • sfaE
 30707 - 37360 (+) polyketide synthase
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  • ACY06287.1
  • sfaF
 37394 - 50014 (+) type I polyketide synthase
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  • ACY06288.1
  • sfaG
 50017 - 60903 (+) type I polyketide synthase
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  • ACY06289.1
  • sfaH
 60918 - 85823 (+) type I polyketide synthase
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  • ACY06290.1
  • sfaI
 85823 - 96040 (+) type I polyketide synthase
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  • ACY06291.1
  • sfaJ
 96225 - 97391 (+) zinc-binding dehydrogenase
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  • ACY06292.1
  • sfaK
 97396 - 101943 (+) modular polyketide synthase
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  • ACY06293.1
  • sfaL
 101936 - 103213 (+) acyltransferase
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  • ACY06294.1
  • sfaM
 103210 - 103929 (+) short-chain dehydrogenase/reductase
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  • ACY06295.1
  • sfaN
 104001 - 105023 (+) 3-oxoacyl-(acyl-carrier-protein) synthase III
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  • ACY06296.1
  • sfaO
 104941 - 105345 (+) acyl carrier protein
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  • ACY06297.1
  • sfaP
 105366 - 107216 (+) asparagine synthase
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  • ACY06298.1
  • sfaQ
 107366 - 108145 (+) thioesterase
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  • ACY06299.1
  • sfaR
 108150 - 109511 (+) crotonyl CoA reductase
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  • ACY06300.1
  • sfaS
 109583 - 109798 (+) putative MbtH family protein
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  • ACY06301.1
  • sfaT
 109776 - 110312 (+) hypothetical protein
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  • ACY06302.1
 111285 - 111743 (-) hypothetical protein
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  • ACY06303.1
 112218 - 112652 (+) hypothetical protein
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  • ACY06304.1
 112763 - 113296 (+) transposase
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  • ACY06305.1
 113783 - 114043 (+) transposase
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  • ACY06307.1
 114808 - 115536 (+) hypothetical protein
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  • ACY06306.1
 115616 - 116281 (-) TetR-family transcriptional regulator
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  • ACY06308.1
 116347 - 117870 (+) FAD-dependent monooxygenase
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  • ACY06309.1
 117873 - >118372 (+) putative endoribonuclease
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
sfaD
Module ?
Specificity: valine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: meta-tyrosine
Evidence for specificity:
  • Feeding study
  • Knock-out studies
  • Structure-based inference
Module ?
Specificity: 3S-carboxypiperazine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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