BGC0001042: sanglifehrin A biosynthetic gene cluster from Streptomyces flaveolus
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Location: 1 - 118,372 nt. (total: 118,372 nt).
This entry is originally from NCBI GenBank FJ809786.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001042
Short description sanglifehrin A biosynthetic gene cluster from Streptomyces flaveolus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
FJ809786.1
via
Compounds
  • sanglifehrin A
Species Streptomyces flaveolus [taxonomy]
References
Chemical products information
sanglifehrin A Evidence:
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C60H91N5O13
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ACY06266.1
 3 - 1199 (+) cytochrome P450 monooxygenase
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    • ACY06267.1
    		 1297 - 2505 (+) hypothetical protein
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      • ACY06268.1
      		 2578 - 2853 (+) acyl carrier protein
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        • ACY06269.1
        		 2850 - 4502 (+) CoA ligase
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          • ACY06270.1
          		 4627 - 5496 (+) methyltransferase
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            • ACY06271.1
            		 5748 - 6896 (+) putative p450 monooxygenase
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              • ACY06272.1
              		 7389 - 8048 (+) deoxyadenosine kinase
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                • ACY06273.1
                		 8587 - 9585 (-) dehydrogenase
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                  • ACY06274.1
                  		 9708 - 10583 (+) LysR family regulator
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                    • ACY06275.1
                    		 10602 - 10940 (+) putative protein kinase
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                      • ACY06276.1
                      		 11553 - 12338 (+) hypothetical protein
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                        • ACY06277.1
                        		 12370 - 13284 (-) hypothetical protein
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                          • ACY06278.1
                          		 13385 - 14017 (+) TetR-like family regulator
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                            • ACY06279.1
                            		 14498 - 14764 (+) transglycosylase-associated protein
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                              • ACY06280.1
                              		 14973 - 15413 (-) Ser/Arg-related nuclear matrix-like protein
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                                • ACY06281.1
                                		 15596 - 16063 (+) chimeric AFGP/trypsinogen-like serine protease precursor
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                                  • ACY06282.1
                                  • sfaA
                                  		 17024 - 17854 (+) tyrosine 3-monooxygenase
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                                    • ACY06283.1
                                    • sfaB
                                    		 17851 - 19191 (+) L-lysine 6-monooxygenase
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                                      • ACY06284.1
                                      • sfaC
                                      		 19193 - 19888 (+) negative transcriptional regulator
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                                        • ACY06285.1
                                        • sfaD
                                        		 19885 - 30714 (+) non-ribosomal peptide synthetase
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                                          • ACY06286.1
                                          • sfaE
                                          		 30707 - 37360 (+) polyketide synthase
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                                            • ACY06287.1
                                            • sfaF
                                            		 37394 - 50014 (+) type I polyketide synthase
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                                              • ACY06288.1
                                              • sfaG
                                              		 50017 - 60903 (+) type I polyketide synthase
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                                                • ACY06289.1
                                                • sfaH
                                                		 60918 - 85823 (+) type I polyketide synthase
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                                                  • ACY06290.1
                                                  • sfaI
                                                  		 85823 - 96040 (+) type I polyketide synthase
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                                                    • ACY06291.1
                                                    • sfaJ
                                                    		 96225 - 97391 (+) zinc-binding dehydrogenase
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                                                      • ACY06292.1
                                                      • sfaK
                                                      		 97396 - 101943 (+) modular polyketide synthase
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                                                        • ACY06293.1
                                                        • sfaL
                                                        		 101936 - 103213 (+) acyltransferase
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                                                          • ACY06294.1
                                                          • sfaM
                                                          		 103210 - 103929 (+) short-chain dehydrogenase/reductase
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                                                            • ACY06295.1
                                                            • sfaN
                                                            		 104001 - 105023 (+) 3-oxoacyl-(acyl-carrier-protein) synthase III
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                                                              • ACY06296.1
                                                              • sfaO
                                                              		 104941 - 105345 (+) acyl carrier protein
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                                                                • ACY06297.1
                                                                • sfaP
                                                                		 105366 - 107216 (+) asparagine synthase
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                                                                  • ACY06298.1
                                                                  • sfaQ
                                                                  		 107366 - 108145 (+) thioesterase
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                                                                    • ACY06299.1
                                                                    • sfaR
                                                                    		 108150 - 109511 (+) crotonyl CoA reductase
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                                                                      • ACY06300.1
                                                                      • sfaS
                                                                      		 109583 - 109798 (+) putative MbtH family protein
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                                                                        • ACY06301.1
                                                                        • sfaT
                                                                        		 109776 - 110312 (+) hypothetical protein
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                                                                          • ACY06302.1
                                                                          		 111285 - 111743 (-) hypothetical protein
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                                                                            • ACY06303.1
                                                                            		 112218 - 112652 (+) hypothetical protein
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                                                                              • ACY06304.1
                                                                              		 112763 - 113296 (+) transposase
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                                                                                • ACY06305.1
                                                                                		 113783 - 114043 (+) transposase
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                                                                                  • ACY06307.1
                                                                                  		 114808 - 115536 (+) hypothetical protein
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                                                                                    • ACY06306.1
                                                                                    		 115616 - 116281 (-) TetR-family transcriptional regulator
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                                                                                      • ACY06308.1
                                                                                      		 116347 - 117870 (+) FAD-dependent monooxygenase
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                                                                                        • ACY06309.1
                                                                                        		 117873 - >118372 (+) putative endoribonuclease
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                                                                                          Biosynthesis information

                                                                                          Biosynthetic modules

                                                                                          Name
                                                                                          Unk01
                                                                                          Type
                                                                                          nrps-type1
                                                                                          Genes
                                                                                          sfaD
                                                                                          Substrates
                                                                                          valine (evidence: Structure-based inference, Sequence-based prediction)
                                                                                          Integrated Monomers
                                                                                          Domains
                                                                                          adenylation
                                                                                          Name
                                                                                          Unk02
                                                                                          Type
                                                                                          nrps-type1
                                                                                          Genes
                                                                                          sfaD
                                                                                          Substrates
                                                                                          meta-tyrosine (evidence: Feeding study, Knock-out studies, Structure-based inference)
                                                                                          Integrated Monomers
                                                                                          Domains
                                                                                          adenylation
                                                                                          Name
                                                                                          Unk03
                                                                                          Type
                                                                                          nrps-type1
                                                                                          Genes
                                                                                          sfaD
                                                                                          Substrates
                                                                                          3S-carboxypiperazine (evidence: Structure-based inference, Sequence-based prediction)
                                                                                          Integrated Monomers
                                                                                          Domains
                                                                                          adenylation
                                                                                          Annotation changelog

                                                                                          Entry version: 4

                                                                                          Date
                                                                                          Changes
                                                                                          Submitters
                                                                                          Reviewers
                                                                                          2022-10-07
                                                                                          Update chemical activity to schema version 2.11
                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                          Entry version: 3

                                                                                          Date
                                                                                          Changes
                                                                                          Submitters
                                                                                          Reviewers
                                                                                          2022-09-15
                                                                                          Updated bioactivity data
                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                          2022-09-15
                                                                                          Added NRP substrate specificities
                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                          Entry version: 2

                                                                                          Date
                                                                                          Changes
                                                                                          Submitters
                                                                                          Reviewers
                                                                                          2019-10-16
                                                                                          Migrated from v1.4
                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                          2019-10-16
                                                                                          Updated compound(s) information (NPAtlas curation)
                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                          Entry version: 1

                                                                                          Date
                                                                                          Changes
                                                                                          Submitters
                                                                                          Reviewers
                                                                                          2015-06-12
                                                                                          Submitted
                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                          Detailed domain annotation
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