BGC0001043 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001043 (Streptomyces griseus subsp. griseus NBRC 13350)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS,NRPS	1	16,183	SGR PTMs/SGR PTM Compound b/SGR PTM Compound c/SGR PTM Compound d	NRPS:Type I+PKS	100%

BGC0001043 - Region 1 - NRPS,T1PKS

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Location: 1 - 16,183 nt. (total: 16,183 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 16,184
Label		BGC0001043

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001043	2.00	NRP, Polyketide	SGR PTMs, SGR PTM Compound b, SGR PTM Compound c, SGR PTM Compound d	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002365	1.29	Other, Polyketide	10-epi-HSAF, 10-epi-3-deOH-HSAF, 10-epi-maltophilin, 10-epi-xanthobaccin C, 10-epi-hydroxymaltophilin, 10-epi-FI-2	Streptomyces sp.
BGC0000996	1.02	NRP, Polyketide	frontalamide B, frontalamide A	Streptomyces sp. SPB78
BGC0001726	0.92	NRP, Polyketide	pactamides	Streptomyces pactum
BGC0002509	0.77	NRP	montamide A, capsimycin, clifednamide A, frontalamide A, combamide A	Streptomyces sp.
BGC0001556	0.75	NRP, Polyketide	combamide	Streptomyces sp.
BGC0000999	0.74	NRP, Polyketide	heat-stable antifungal factor	Lysobacter enzymogenes
BGC0001273	0.68	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001553	0.67	NRP, Polyketide	clifednamide A	Streptomyces sp. JV178
BGC0001244	0.67	Polyketide	(-)-Mellein	Parastagonospora nodorum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001043	1.00	NRP, Polyketide	SGR PTMs, SGR PTM Compound b, SGR PTM Compound c, SGR PTM Compound d	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002365	0.86	Other, Polyketide	10-epi-HSAF, 10-epi-3-deOH-HSAF, 10-epi-maltophilin, 10-epi-xanthobaccin C, 10-epi-hydroxymaltophilin, 10-epi-FI-2	Streptomyces sp.
BGC0000996	0.79	NRP, Polyketide	frontalamide B, frontalamide A	Streptomyces sp. SPB78
BGC0001726	0.76	NRP, Polyketide	pactamides	Streptomyces pactum
BGC0002509	0.71	NRP	montamide A, capsimycin, clifednamide A, frontalamide A, combamide A	Streptomyces sp.
BGC0001556	0.70	NRP, Polyketide	combamide	Streptomyces sp.
BGC0000999	0.70	NRP, Polyketide	heat-stable antifungal factor	Lysobacter enzymogenes
BGC0001273	0.67	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001553	0.67	NRP, Polyketide	clifednamide A	Streptomyces sp. JV178
BGC0001244	0.66	Polyketide	(-)-Mellein	Parastagonospora nodorum

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 16183:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk - Orn)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

SGR_814

Search NORINE for peptide: strict or relaxed

PKS_AT (551..847): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; CE-Malonyl-CoA: 58.3%; Methylmalonyl-CoA: 54.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 127.2
Methoxymalonyl-CoA: 118.1
Malonyl-CoA: 112.8
Ethylmalonyl-CoA: 101.8
Isobutyryl-CoA: 93.9
Acetyl-CoA: 72.5
trans-1,2-CPDA: 69.5
Propionyl-CoA: 69.1
2-Methylbutyryl-CoA: 68.4
Benzoyl-CoA: 53.0
CHC-CoA: 51.1
fatty_acid: 43.4
3-Methylbutyryl-CoA: 37.4
inactive: 27.4

AMP-binding (2331..2743): Orn

nrpys: Orn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:: Orn and hydroxy-Orn specific (Orn, OH-Orn)
Single AA prediction:: orn (Orn)

Stachelhaus prediction details:

Stachelhaus sequence:: DVGEVGSIDK
Nearest Stachelhaus code(s):: Orn DVGEVGSIDK (88% 8Å match)
Stachelhaus code match:: 100% (strong)