BGC0001045: spiruchostatin A biosynthetic gene cluster from Pseudomonas sp. Q71576
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Location: 1 - 54,335 nt. (total: 54,335 nt).
This entry is originally from NCBI GenBank JQ045344.1.

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core biosynthetic genes
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001045
Short description spiruchostatin A biosynthetic gene cluster from Pseudomonas sp. Q71576
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP (Cyclic depsipeptide)
  • Polyketide (Macrolide)
Loci NCBI GenBank: JQ045344.1
Compounds
  • spiruchostatin A
Species Pseudomonas sp. Q71576 [taxonomy]
References
Chemical products information
spiruchostatin A
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C20H31N3O6S2
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AFR69327.1
 2300 - 3715 (+) putative protease PrtA
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  • AFR69329.1
  • spiR
 4917 - 5789 (+) lysR family transcriptional activator SpiR
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  • AFR69330.1
  • spiN
 6111 - 6359 (+) putative type II peptidyl carrier protein (PCP) SpiN
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  • AFR69331.1
  • spiA
 6631 - 11655 (+) nonribosomal peptide synthetase SpiA
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  • AFR69332.1
  • spiB
 11655 - 16340 (+) polyketide synthase SpiB
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  • AFR69333.1
  • spiC1
 16340 - 19867 (+) polyketide synthase SpiC1
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  • AFR69334.1
  • spiDE1
 19864 - 32109 (+) nonribosomal peptide synthetase SpiDE1
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  • AFR69335.1
  • spiC2
 32106 - 36674 (+) polyketide synthase SpiC2
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  • AFR69328.1
  • spiF
 36664 - 37839 (+) acyl CoA dehydrogenase SpiF
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  • AFR69336.1
  • spiG
 37836 - 38804 (+) phosphotransfearse SpiG
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  • AFR69337.1
  • spiE2
 38801 - 41020 (+) nonribosomal peptide synthetase SpiE2
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  • AFR69338.1
  • spiH
 41103 - 42008 (+) FAD-dependent disulfide oxidoreductase SpiH
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  • AFR69339.1
  • spiI
 42066 - 42971 (+) esterase/lipase SpiI
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  • AFR69340.1
  • spiJ
 43182 - 44033 (+) type II thioesterase SpiJ
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  • AFR69341.1
  • spiP
 44153 - 45295 (+) malonyl CoA acyl transferase (MCAT) SpiP
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  • AFR69342.1
 45705 - 46709 (+) luxR family transcriptional regulator
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Polyketide-specific information
Subclass Macrolide
Starter unit Malonyl-CoA
Cyclic? yes
Release type
  • Macrolactamization
Polyketide-synthases
Genes Properties Modules
spiJ Synthase subclass: Modular type I
Thioesterases:
  • spiJ (Type II)
NRP-specific information
Subclass Cyclic depsipeptide
Cyclic? yes
Release type
  • Macrolactamization
NRP-synthases
Gene Modules
spiDE1
Module ?
Specificity: alanine
Evidence for specificity:
Module ?
Specificity: cysteine
Evidence for specificity:
Module ?
Specificity: isoleucine / valine
Evidence for specificity:
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: DUUOEWRWRZA5NTLPQCYGT6Z6, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected gene identifiers
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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