Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001045.1:
Cluster 1NRP / Polyketide154335

BGC0001045, spiruchostatin biosynthetic gene cluster from Pseudomonas sp. Q71576. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Spiruchostatin A
PubChem ID: 60209141
SMILES string: Copy to clipboard
Molecular formula: C20H31N3O6S2
Average molecular mass: 473.603 Da
Molecular activity: Antifungal, Cytotoxic, Inhibitor
Molecular target: Histone deacetylases

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Cyclic depsipeptide (cyclic)
Thioesterase type:
Type II
Release / cyclization type:
Macrolactamization

Polyketide subclass:
Macrolide (cyclic)
Polyketide synthase subclass:
Modular type I
Starter unit:
Malonyl-CoA
Thioesterase type:
Type II
Release / cyclization type:
Macrolactamization

Gene cluster description

spiruchostatin (BGC0001045). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank JQ045344, positions 4917-45295. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Yi-Qiang (Eric) Cheng (University of North Texas Health Science Center)

Literature references

1. Potharla VY et al. (2014) Identification and characterization of the spiruchostatin biosynthetic gene cluster enable yield improvement by overexpressing a transcriptional activator. J Ind Microbiol Biotechnol 41(9):1457-65. doi: