BGC0001045: spiruchostatin A biosynthetic gene cluster from Pseudomonas sp. Q71576
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 54,335 nt. (total: 54,335 nt).
This entry is originally from NCBI GenBank JQ045344.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001045
Short description spiruchostatin A biosynthetic gene cluster from Pseudomonas sp. Q71576
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Type I)
Loci
JQ045344.1
via
Compounds
  • spiruchostatin A
Species Pseudomonas sp. Q71576 [taxonomy]
References
Chemical products information
spiruchostatin A Evidence:
Copy SMILES
C20H31N3O6S2
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AFR69327.1
 2300 - 3715 (+) putative protease PrtA
    copy AA seq
    copy Nt seq
    • AFR69329.1
    • spiR
    		 4917 - 5789 (+) lysR family transcriptional activator SpiR
      copy AA seq
      copy Nt seq
      • AFR69330.1
      • spiN
      		 6111 - 6359 (+) putative type II peptidyl carrier protein (PCP) SpiN
        copy AA seq
        copy Nt seq
        • AFR69331.1
        • spiA
        		 6631 - 11655 (+) nonribosomal peptide synthetase SpiA
          copy AA seq
          copy Nt seq
          • AFR69332.1
          • spiB
          		 11655 - 16340 (+) polyketide synthase SpiB
            copy AA seq
            copy Nt seq
            • AFR69333.1
            • spiC1
            		 16340 - 19867 (+) polyketide synthase SpiC1
              copy AA seq
              copy Nt seq
              • AFR69334.1
              • spiDE1
              		 19864 - 32109 (+) nonribosomal peptide synthetase SpiDE1
                copy AA seq
                copy Nt seq
                • AFR69335.1
                • spiC2
                		 32106 - 36674 (+) polyketide synthase SpiC2
                  copy AA seq
                  copy Nt seq
                  • AFR69328.1
                  • spiF
                  		 36664 - 37839 (+) acyl CoA dehydrogenase SpiF
                    copy AA seq
                    copy Nt seq
                    • AFR69336.1
                    • spiG
                    		 37836 - 38804 (+) phosphotransfearse SpiG
                      copy AA seq
                      copy Nt seq
                      • AFR69337.1
                      • spiE2
                      		 38801 - 41020 (+) nonribosomal peptide synthetase SpiE2
                        copy AA seq
                        copy Nt seq
                        • AFR69338.1
                        • spiH
                        		 41103 - 42008 (+) FAD-dependent disulfide oxidoreductase SpiH
                          copy AA seq
                          copy Nt seq
                          • AFR69339.1
                          • spiI
                          		 42066 - 42971 (+) esterase/lipase SpiI
                            copy AA seq
                            copy Nt seq
                            • AFR69340.1
                            • spiJ
                            		 43182 - 44033 (+) type II thioesterase SpiJ
                              copy AA seq
                              copy Nt seq
                              • AFR69341.1
                              • spiP
                              		 44153 - 45295 (+) malonyl CoA acyl transferase (MCAT) SpiP
                                copy AA seq
                                copy Nt seq
                                • AFR69342.1
                                		 45705 - 46709 (+) luxR family transcriptional regulator
                                  copy AA seq
                                  copy Nt seq
                                  Biosynthesis information

                                  Biosynthetic modules

                                  Name
                                  Unk01
                                  Type
                                  nrps-type1
                                  Genes
                                  spiDE1
                                  Substrates
                                  alanine (evidence: )
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk02
                                  Type
                                  nrps-type1
                                  Genes
                                  spiDE1
                                  Substrates
                                  cysteine (evidence: )
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk03
                                  Type
                                  nrps-type1
                                  Genes
                                  spiDE1
                                  Substrates
                                  isoleucine, valine (evidence: )
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Annotation changelog

                                  Entry version: 4

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2022-10-07
                                  Update chemical activity to schema version 2.11
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                  Entry version: 3

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2022-09-15
                                  Corrected gene identifiers
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  2022-09-15
                                  Added NRP substrate specificities
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                  Entry version: 2

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2019-10-16
                                  Migrated from v1.4
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  2019-10-16
                                  Updated compound(s) information (NPAtlas curation)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                  Entry version: 1

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2015-06-12
                                  Submitted
                                  • (ID: DUUOEWRWRZA5NTLPQCYGT6Z6)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  Detailed domain annotation
                                  Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                                  A domain glossary is available here, and an explanation of the visualisation is available here.
                                  Selected features only
                                  Show module domains
                                  Similar known gene clusters from MIBiG 4.0
                                  Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                                  Click on reference genes to show details of similarities to genes within the current region.
                                  Click on an accession to open that entry in the MiBIG database.