BGC0001046: streptolydigin biosynthetic gene cluster from Streptomyces lydicus
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Location: 1 - 80,894 nt. (total: 80,894 nt).
This entry is originally from NCBI GenBank FN433113.1.

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core biosynthetic genes
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transport-related genes
regulatory genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
Saccharide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001046
Short description streptolydigin biosynthetic gene cluster from Streptomyces lydicus
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Other)
  • Saccharide (hybrid/tailoring)
Loci NCBI GenBank: FN433113.1
Compounds
  • streptolydigin
Species Streptomyces lydicus [taxonomy]
References
Chemical products information
streptolydigin
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C32H44N2O9
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CBA11554.1
 1 - 438 (+) putative glycerophosphoryl diester phosphodiesterase
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  • CBA11555.1
 808 - 1194 (+) hypothetical protein
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  • CBA11556.1
  • slgR2
 1429 - 4260 (+) LuxR-family transcriptional regulator
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  • CBA11557.1
  • slgN2
 4318 - 6441 (-) non-ribosomal peptide synthetase
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  • CBA11558.1
  • slgL
 6495 - 7337 (-) hypothetical protein
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  • CBA11559.1
  • slgM
 7392 - 8672 (-) methyltransferase
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  • CBA11560.1
  • slgS7
 8767 - 9423 (-) NDP-hexose-3,5-epimerase
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  • CBA11561.1
  • slgS6
 9405 - 10709 (-) NDP-hexose-3,4-dehydratase
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  • CBA11562.1
  • slgS5
 10720 - 11742 (-) NDP-4-keto-6-deoxyhexose reductase
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  • CBA11563.1
  • slgS4
 11739 - 12755 (-) NDP-hexose-3-ketoreductase
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  • CBA11564.1
  • slgS3
 12752 - 14104 (-) NDP-hexose-2,3-dehydratase
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  • CBA11565.1
  • slgO2
 14101 - 15342 (-) cytochrome P450
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  • CBA11566.1
  • slgC2
 15339 - 16193 (-) putative secreted hydrolase
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  • CBA11567.1
  • slgG
 16402 - 17577 (+) glycosyltransferase
  • Tailoring (Glycosylation)
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  • CBA11568.1
  • slgZ
 18302 - 19282 (+) asparaginyl-tRNA synthetase-like
  • Scaffold biosynthesis
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  • CBA11569.1
  • slgE3
 19279 - 20601 (+) ferredoxin-dependent glutamate synthase
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  • CBA11570.1
  • slgN1
 20598 - 22301 (+) non-ribosomal peptide synthetase
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  • CBA11571.1
  • slgS2
 22449 - 23435 (-) NDP-glucose-4,6-dehydratase
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  • CBA11572.1
  • slgS1
 23432 - 24499 (-) NDP-glucose synthase
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  • CBA11573.1
  • slgE2
 24496 - 25845 (-) glutamate mutase-E chain
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  • CBA11574.1
  • slgE1
 25842 - 26303 (-) glutamate mutase subunit
  • Precursor biosynthesis
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  • CBA11575.1
  • slgY
 26650 - 28749 (+) putative ATP/GTP binding-protein
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  • CBA11576.1
  • slgR1
 28862 - 29524 (-) TetR-family transcriptional regulator
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  • CBA11577.1
  • slgT
 29625 - 31172 (+) putative transport integral membrain protein
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  • CBA11578.1
  • slgO1
 31294 - 32538 (+) cytochrome P450
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  • CBA11579.1
  • slgX
 32589 - 34136 (-) putative ent-copalyl diphosphate synthase
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  • CBA11580.1
  • slgC1
 34133 - 35035 (-) putative secreted hydrolase
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  • CBA11581.1
  • slgB
 35032 - 35814 (-) thioesterase type II
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  • CBA11582.1
  • slgA3
 35811 - 46154 (-) polyketide synthase type I
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  • CBA11583.1
  • slgA2
 46319 - 56758 (-) polyketide synthase type I
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  • CBA11584.1
  • slgA1
 56865 - 75380 (-) polyketide synthase type I
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  • CBA11585.1
 75897 - 76637 (+) putative integral membrane protein
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  • CBA11586.1
 76841 - 77776 (+) putative integral membrane protein
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  • CBA11587.1
 77818 - 78480 (+) putative integral membrane protein
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  • CBA11588.1
 78477 - 79205 (+) putative hydrolase
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  • CBA11589.1
 79234 - 79632 (-) hypothetical protein
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  • CBA11590.1
 79840 - 80457 (+) putative TetR-family transcriptional regulator
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  • CBA11591.1
 80468 - >80893 (+) hypothetical protein
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Polyketide-specific information
Subclass Other
Starter unit Acetyl-CoA
Cyclic? yes
Polyketide-synthases
Genes Properties Modules
slgB
+
slgA3
+
slgA1
+
slgA2 		Synthase subclass: Modular type I
Thioesterases:
  • slgB (Type II)
Module 0
Specificity: Malonyl-CoA
Genes: slgA1
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
Module 1
Specificity: Methylmalonyl-CoA
Genes: slgA1
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 2
Specificity: Malonyl-CoA
Genes: slgA1
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 3
Specificity: Methylmalonyl-CoA
Genes: slgA1
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 4
Specificity: Methylmalonyl-CoA
Genes: slgA2
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 5
Specificity: Methylmalonyl-CoA
Genes: slgA2
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 6
Specificity: Malonyl-CoA
Genes: slgA3
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 7
Specificity: Malonyl-CoA
Genes: slgA3
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Saccharide-specific information
Subclass hybrid/tailoring
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: IROSGRAECON7XFWB774QFHDN, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: 5UL74VURKJ25VSPPPO3H2NYB, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update compound structure (SMILES) for streptolydigin
  • Linked new PubChem id for streptolydigin (pubchem:54708748)
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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