BGC0001048: tallysomycin A biosynthetic gene cluster from Streptoalloteichus hindustanus
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Location: 1 - 80,158 nt. (total: 80,158 nt).
This entry is originally from NCBI GenBank EF032505.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001048
Short description tallysomycin A biosynthetic gene cluster from Streptoalloteichus hindustanus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Type I)
  • saccharide (hybrid/tailoring)
Loci
EF032505.1
via Knock-out studies
Compounds
  • tallysomycin A
  • tallysomycin B
Species Streptoalloteichus hindustanus [taxonomy]
References
Chemical products information
tallysomycin A Evidence:
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C68H110N22O27S2
Chemical database entries
PubCHEM
tallysomycin B Evidence:
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C62H98N20O26S2
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ABL74927.1
 1198 - 4902 (+) Orf38
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    • ABL74928.1
    		 4902 - 6473 (+) Orf37
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      • ABL74929.1
      		 6470 - 7135 (+) Orf36
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        • ABL74930.1
        		 7132 - 7875 (+) Orf35
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          • ABL74931.1
          		 7872 - 8438 (+) Orf34
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            • ABL74932.1
            		 8527 - 9582 (+) Orf33
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              • ABL74933.1
              		 9602 - 10963 (-) Orf32
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                • ABL74934.1
                		 11023 - 11865 (-) Orf31
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                  • ABL74935.1
                  • tlmT
                  		 12315 - 14114 (+) ABC multi-drug transport
                  • Transport
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                  • ABL74936.1
                  • tlmX
                  		 16093 - 22491 (+) NRPS
                  • Scaffold biosynthesis
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                  • ABL74937.1
                  • tlmIX
                  		 22488 - 25754 (+) NRPS
                  • Scaffold biosynthesis
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                  • ABL74938.1
                  • tlmVIII
                  		 25751 - 30352 (+) PKS
                  • Scaffold biosynthesis
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                  • ABL74939.1
                  • tlmVII
                  		 30349 - 33774 (+) NRPS
                  • Scaffold biosynthesis
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                  • ABL74940.1
                  • tlmVI
                  		 33771 - 41999 (+) NRPS
                  • Scaffold biosynthesis
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                  • ABL74941.1
                  • tlmV
                  		 41992 - 43812 (+) NRPS
                  • Scaffold biosynthesis
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                  • ABL74942.1
                  • tlmG
                  		 43812 - 44804 (+) NAD-dependent sugar epimerase
                  • Tailoring
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                  • ABL74943.1
                  • tlmF
                  		 44797 - 46698 (+) alpha ketoglutarate-dependent hydroxylase
                  • Tailoring
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                  • ABL74944.1
                  		 46702 - 48588 (+) Gln-dependent amino transferase
                  • Tailoring
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                  • ABL74945.1
                  • tlmIV
                  		 48585 - 56447 (+) NRPS
                  • Scaffold biosynthesis
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                  • ABL74946.1
                  • tlmIII
                  		 56552 - 59083 (+) NRPS
                  • Scaffold biosynthesis
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                  • ABL74947.1
                  • tlmR3
                  		 59080 - 60126 (+) SyrP-like regulatory protein
                  • Regulation
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                  • ABL74948.1
                  • tlmII
                  		 60123 - 61595 (+) NRPS type II C
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                    • ABL74949.1
                    		 61599 - 62168 (+) MbtH-like protein
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                      • ABL74950.1
                      • tlmE
                      		 62186 - 63352 (+) glycosyl transferase
                      • Tailoring
                      • Knock-out
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                      • ABL74951.1
                      • tlmD
                      		 63349 - 64965 (+) carbamoyltransferase
                      • Tailoring
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                      • ABL74952.1
                      • tlmI
                      		 64965 - 65234 (+) type II PCP
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                        • ABL74953.1
                        • tlmC
                        		 65231 - 66727 (+) NTP sugar synthase
                        • Activation / processing
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                        • ABL74954.1
                        		 66724 - 67998 (+) SAM-dependent oxidase or methyl transferase
                        • Tailoring
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                        • ABL74955.1
                        		 68022 - 68948 (+) alpha ketoglutarate-dependent hydroxylase
                        • Tailoring
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                        • ABL74956.1
                        • tlmA
                        		 69009 - 69383 (+) Sh Ble binding protein
                        • Resistance/immunity
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                        • ABL74957.1
                        		 69452 - 70045 (+) ankyrin-like protein
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                          • ABL74958.1
                          		 70042 - 70431 (+) peptide deformylase
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                            • ABL74959.1
                            • tlmH
                            		 70887 - 71861 (+) alpha ketoglutarate-dependent hydroxylas
                            • Tailoring
                            • Knock-out
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                            • ABL74960.1
                            • tlmJ
                            		 71889 - 73088 (+) aminotransferase
                            • Tailoring
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                            • ABL74961.1
                            • tlmK
                            		 73120 - 74682 (+) glycosyl transferase
                            • Tailoring
                            • Knock-out
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                            • ABL74962.1
                            • tlmB
                            		 74732 - 75610 (+) N-acetyl transferase
                            • Resistance/immunity
                            • Other in vivo study
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                            • ABL74963.1
                            • tlmR2
                            		 75700 - 76899 (-) putative transcription regulator
                            • Regulation
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                            • ABL74964.1
                            • tlmR1
                            		 77602 - 77964 (+) putative transcription regulator
                            • Regulation
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                            • ABL74965.1
                            		 77961 - 78443 (+) Orf (-)1
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                              • ABL74966.1
                              		 78810 - 80111 (+) Orf (-)2
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                                Biosynthesis information

                                Biosynthetic modules

                                Name
                                4
                                Type
                                nrps-type1
                                Genes
                                tlmX
                                Substrates
                                asparagine (evidence: Sequence-based prediction)
                                Integrated Monomers
                                Domains
                                condensation (LCL), adenylation
                                Name
                                5
                                Type
                                nrps-type1
                                Genes
                                tlmX
                                Substrates
                                histidine (evidence: Sequence-based prediction)
                                Integrated Monomers
                                Domains
                                condensation (DCL), adenylation
                                Name
                                6
                                Type
                                nrps-type1
                                Genes
                                tlmIX
                                Substrates
                                alanine (evidence: Sequence-based prediction)
                                Integrated Monomers
                                Domains
                                condensation (LCL), adenylation
                                Name
                                8
                                Type
                                nrps-type1
                                Genes
                                tlmVII
                                Substrates
                                threonine (evidence: Sequence-based prediction)
                                Integrated Monomers
                                Domains
                                condensation (LCL), adenylation
                                Name
                                2
                                Type
                                nrps-type1
                                Genes
                                tlmVI
                                Substrates
                                serine (evidence: Sequence-based prediction)
                                Integrated Monomers
                                Domains
                                condensation (LCL), adenylation
                                Name
                                3
                                Type
                                nrps-type1
                                Genes
                                tlmVI tlmV
                                Substrates
                                asparagine (evidence: Sequence-based prediction)
                                Integrated Monomers
                                Domains
                                condensation (DCL), adenylation
                                Name
                                10
                                Type
                                nrps-type1
                                Genes
                                tlmIV
                                Substrates
                                cysteine (evidence: Sequence-based prediction)
                                Integrated Monomers
                                Domains
                                condensation (Heterocyclization), adenylation
                                Name
                                9
                                Type
                                nrps-type1
                                Genes
                                tlmIV
                                Substrates
                                beta-alanine (evidence: Sequence-based prediction)
                                Integrated Monomers
                                Domains
                                condensation (LCL), adenylation
                                Name
                                7
                                Type
                                pks-modular
                                Genes
                                tlmVIII
                                Substrates
                                Integrated Monomers
                                Domains
                                acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                Annotation changelog

                                Entry version: 4

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2022-10-07
                                Update chemical activity to schema version 2.11
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                Entry version: 3

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2022-09-15
                                Add new compound: tallysomycin B
                                • (ID: 5UL74VURKJ25VSPPPO3H2NYB)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                2022-09-15
                                Corrected NRP module activity
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                2022-09-15
                                Updated bioactivity data
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                2022-09-15
                                Updated NRP substrate specificities
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                Entry version: 2

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2019-10-16
                                Migrated from v1.4
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                Entry version: 1

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2015-06-12
                                Submitted
                                • (ID: E2T2HCM4X7QXVS4LL4JVBPPK)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                Detailed domain annotation
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