BGC0001048: tallysomycin A biosynthetic gene cluster from Streptoalloteichus hindustanus
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 80,158 nt. (total: 80,158 nt).
This entry is originally from NCBI GenBank EF032505.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Polyketide
NRP
Saccharide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001048
Short description tallysomycin A biosynthetic gene cluster from Streptoalloteichus hindustanus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP (Glycopeptide)
  • Polyketide (Other)
  • Saccharide (hybrid/tailoring)
Loci NCBI GenBank: EF032505.1
Compounds
  • tallysomycin A
  • tallysomycin B
Species Streptoalloteichus hindustanus [taxonomy]
References
Chemical products information
tallysomycin A
Copy SMILES
C68H110N22O27S2
Chemical database entries
PubCHEM
tallysomycin B
Copy SMILES
C62H98N20O26S2
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ABL74927.1
 1198 - 4902 (+) Orf38
copy AA seq
copy Nt seq
  • ABL74928.1
 4902 - 6473 (+) Orf37
copy AA seq
copy Nt seq
  • ABL74929.1
 6470 - 7135 (+) Orf36
copy AA seq
copy Nt seq
  • ABL74930.1
 7132 - 7875 (+) Orf35
copy AA seq
copy Nt seq
  • ABL74931.1
 7872 - 8438 (+) Orf34
copy AA seq
copy Nt seq
  • ABL74932.1
 8527 - 9582 (+) Orf33
copy AA seq
copy Nt seq
  • ABL74933.1
 9602 - 10963 (-) Orf32
copy AA seq
copy Nt seq
  • ABL74934.1
 11023 - 11865 (-) Orf31
copy AA seq
copy Nt seq
  • ABL74935.1
  • tlmT
 12315 - 14114 (+) ABC multi-drug transport
  • Transport
Sequence-based prediction
copy AA seq
copy Nt seq
  • ABL74936.1
  • tlmX
 16093 - 22491 (+) NRPS
  • Scaffold biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • ABL74937.1
  • tlmIX
 22488 - 25754 (+) NRPS
  • Scaffold biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • ABL74938.1
  • tlmVIII
 25751 - 30352 (+) PKS
  • Scaffold biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • ABL74939.1
  • tlmVII
 30349 - 33774 (+) NRPS
  • Scaffold biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • ABL74940.1
  • tlmVI
 33771 - 41999 (+) NRPS
  • Scaffold biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • ABL74941.1
  • tlmV
 41992 - 43812 (+) NRPS
  • Scaffold biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • ABL74942.1
  • tlmG
 43812 - 44804 (+) NAD-dependent sugar epimerase
  • Tailoring (Epimerization)
Sequence-based prediction
copy AA seq
copy Nt seq
  • ABL74943.1
  • tlmF
 44797 - 46698 (+) alpha ketoglutarate-dependent hydroxylase
  • Tailoring (Glycosylation)
Sequence-based prediction
copy AA seq
copy Nt seq
  • ABL74944.1
 46702 - 48588 (+) Gln-dependent amino transferase
  • Tailoring (Amination)
Sequence-based prediction
copy AA seq
copy Nt seq
  • ABL74945.1
  • tlmIV
 48585 - 56447 (+) NRPS
  • Scaffold biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • ABL74946.1
  • tlmIII
 56552 - 59083 (+) NRPS
  • Scaffold biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • ABL74947.1
  • tlmR3
 59080 - 60126 (+) SyrP-like regulatory protein
  • Regulation
Sequence-based prediction
copy AA seq
copy Nt seq
  • ABL74948.1
  • tlmII
 60123 - 61595 (+) NRPS type II C
copy AA seq
copy Nt seq
  • ABL74949.1
 61599 - 62168 (+) MbtH-like protein
copy AA seq
copy Nt seq
  • ABL74950.1
  • tlmE
 62186 - 63352 (+) glycosyl transferase
  • Tailoring (Glycosylation)
Knock-out
copy AA seq
copy Nt seq
  • ABL74951.1
  • tlmD
 63349 - 64965 (+) carbamoyltransferase
  • Tailoring (Acylation)
Sequence-based prediction
copy AA seq
copy Nt seq
  • ABL74952.1
  • tlmI
 64965 - 65234 (+) type II PCP
  • Unknown
Sequence-based prediction
copy AA seq
copy Nt seq
  • ABL74953.1
  • tlmC
 65231 - 66727 (+) NTP sugar synthase
  • Activation / processing
Sequence-based prediction
copy AA seq
copy Nt seq
  • ABL74954.1
 66724 - 67998 (+) SAM-dependent oxidase or methyl transferase
  • Tailoring (Methylation)
Sequence-based prediction
copy AA seq
copy Nt seq
  • ABL74955.1
 68022 - 68948 (+) alpha ketoglutarate-dependent hydroxylase
  • Tailoring (Hydroxylation)
Sequence-based prediction
copy AA seq
copy Nt seq
  • ABL74956.1
  • tlmA
 69009 - 69383 (+) Sh Ble binding protein
  • Resistance/immunity
Sequence-based prediction
copy AA seq
copy Nt seq
  • ABL74957.1
 69452 - 70045 (+) ankyrin-like protein
copy AA seq
copy Nt seq
  • ABL74958.1
 70042 - 70431 (+) peptide deformylase
copy AA seq
copy Nt seq
  • ABL74959.1
  • tlmH
 70887 - 71861 (+) alpha ketoglutarate-dependent hydroxylas
  • Tailoring (Hydroxylation)
Knock-out
copy AA seq
copy Nt seq
  • ABL74960.1
  • tlmJ
 71889 - 73088 (+) aminotransferase
  • Tailoring (Amination)
Sequence-based prediction
copy AA seq
copy Nt seq
  • ABL74961.1
  • tlmK
 73120 - 74682 (+) glycosyl transferase
  • Tailoring (Glycosylation)
Knock-out
copy AA seq
copy Nt seq
  • ABL74962.1
  • tlmB
 74732 - 75610 (+) N-acetyl transferase
  • Resistance/immunity
Other in vivo study
copy AA seq
copy Nt seq
  • ABL74963.1
  • tlmR2
 75700 - 76899 (-) putative transcription regulator
  • Regulation
Sequence-based prediction
copy AA seq
copy Nt seq
  • ABL74964.1
  • tlmR1
 77602 - 77964 (+) putative transcription regulator
  • Regulation
Sequence-based prediction
copy AA seq
copy Nt seq
  • ABL74965.1
 77961 - 78443 (+) Orf (-)1
copy AA seq
copy Nt seq
  • ABL74966.1
 78810 - 80111 (+) Orf (-)2
copy AA seq
copy Nt seq
Polyketide-specific information
Subclass Other
Cyclic? no
Polyketide-synthases
Genes Properties Modules
tlmVIII Synthase subclass: Modular type I
Module 7
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: tlmVIII
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
NRP-specific information
Subclass Glycopeptide
Cyclic? no
NRP-synthases
Gene Modules
tlmX
Module 4
Specificity: asparagine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
Module 5
Specificity: histidine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: DCL
tlmIX
Module 6
Specificity: alanine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
tlmVII
Module 8
Specificity: threonine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
tlmVI
Module 1
Condensation domain type: Starter
Module 2
Specificity: serine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
Module 3
Specificity: asparagine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: DCL
tlmV
Module 3
Condensation domain type: DCL
tlmIV
Module 10
Specificity: cysteine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: Heterocyclization
Modification domains: Unknown
Module 11
Condensation domain type: Heterocyclization
Module 9
Specificity: beta-alanine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
tlmIII
Module 11
Modification domains: Oxidation
Saccharide-specific information
Subclass hybrid/tailoring
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: E2T2HCM4X7QXVS4LL4JVBPPK, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: 5UL74VURKJ25VSPPPO3H2NYB, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Add new compound: tallysomycin B
  • Corrected NRP module activity
  • Updated bioactivity data
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.