BGC0001049: tenellin biosynthetic gene cluster from Beauveria bassiana
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Location: 1,717 - 20,893 nt. (total: 19,177 nt).
This entry is originally from NCBI GenBank AM409327.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001049
Short description tenellin biosynthetic gene cluster from Beauveria bassiana
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Other)
Loci NCBI GenBank: AM409327.1
Compounds
  • tenellin
Species Beauveria bassiana [taxonomy]
References
Chemical products information
tenellin
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C21H23N1O5
Chemical database entries
NPAtlas
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAL69594.1
  • tens1
 1717 - 3369 (+) hypothetical protein
  • Tailoring (Oxidation)
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  • CAL69595.1
  • tens2
 3777 - 5453 (-) hypothetical protein
  • Tailoring (Oxidation)
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  • CAL69596.1
  • tens3
 6093 - 7259 (-) hypothetical protein
  • Scaffold biosynthesis
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  • CAL69597.1
  • tens
 7941 - 20892 (+) PKS-NRPS
  • Scaffold biosynthesis
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Polyketide-specific information
Subclass Other
Starter unit Acetyl-CoA
Cyclic? no
Polyketide-synthases
Genes Properties Modules
tens Synthase subclass: Iterative type I
Iterative PKS type: Highly reducing, Unknown
Iteration counts: 4
Module 1
Specificity: Acetyl-CoA
Evidence for specificity: Structure-based inference
Genes: tens
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: Unknown
Non-canonical activity:
  • Iterated
Evidence for non-canonical activity:
  • Activity assay
NRP-specific information
Subclass N/A
Cyclic? yes
NRP-synthases
Gene Modules
tens
Module 2 [inactive]
Specificity: tyrosine
Evidence for specificity:
  • Structure-based inference
  • Heterologous expression
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: 3XTF2R3BHL5LPPSMGJ2QHJQC, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
  • Updated loci information
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Fixed gene accessions
  • Corrected NRP module activity
  • Updated NRP substrate specificities
Detailed domain annotation
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