BGC0001050: thalassospiramide A biosynthetic gene cluster from Tistrella bauzanensis
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Location: 1 - 19,730 nt. (total: 19,730 nt).
This entry is originally from NCBI GenBank KC181865.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001050
Short description thalassospiramide A biosynthetic gene cluster from Tistrella bauzanensis
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "Modules 1 and 5 are missing adenylation domains completely. Module 6 is spread over the two genes, with the condensation domain on ttbA and the remainder of the module on ttbB. The PKS portion is a trans AT system but to date no AT domain has been identified in the rest of the genome."
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Trans-AT type I)
Loci
KC181865.1
via
Compounds
  • thalassospiramide A
Species Tistrella bauzanensis [taxonomy]
References
Chemical products information
thalassospiramide A Evidence:
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C48H75N7O13
Chemical database entries
ChemSpider
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AGC65516.1
  • ttbA
 1 - 16158 (+) NRPS/PKS hybrid
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    • AGC65517.1
    • ttbB
    		 16164 - 19730 (+) NRPS
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      Biosynthesis information

      Biosynthetic modules

      Name
      2
      Type
      nrps-type1
      Genes
      ttbA
      Substrates
      valine (evidence: Sequence-based prediction)
      Integrated Monomers
      Domains
      condensation (LCL), adenylation
      Name
      3
      Type
      nrps-type1
      Genes
      ttbA
      Substrates
      serine (evidence: Sequence-based prediction)
      Integrated Monomers
      Domains
      condensation (LCL), adenylation
      Name
      6
      Type
      nrps-type1
      Genes
      ttbB
      Substrates
      tyrosine (evidence: Sequence-based prediction)
      Integrated Monomers
      Domains
      condensation, adenylation, methyltransferase
      Name
      4
      Type
      pks-trans-at
      Genes
      ttbA
      Substrates
      Integrated Monomers
      Domains
      ketosynthase, ketoreductase, carrier (ACP)
      Annotation changelog

      Entry version: next

      Date
      Changes
      Submitters
      Reviewers
      2024-03-19
      MIBiG v4 annotathon
      • (ID: YMNBNYWEKI2BEKVVGTVE6OUH)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

      Entry version: 4

      Date
      Changes
      Submitters
      Reviewers
      2022-10-07
      Update chemical activity to schema version 2.11
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

      Entry version: 3

      Date
      Changes
      Submitters
      Reviewers
      2022-09-15
      Corrected NRP module activity
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      2022-09-15
      Changed amino acid substrates to lower case
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

      Entry version: 2

      Date
      Changes
      Submitters
      Reviewers
      2019-10-16
      Migrated from v1.4
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      2019-10-16
      Updated compound(s) information (NPAtlas curation)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

      Entry version: 1

      Date
      Changes
      Submitters
      Reviewers
      2015-06-12
      Submitted
      • (ID: CCA4OQJBG74OWG57XELOC2J2)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      Detailed domain annotation
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