Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001051.1:
Cluster 1NRP / Polyketide182258

BGC0001051, thuggacin biosynthetic gene cluster from Sorangium cellulosum. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Thuggacin A
SMILES string: Copy to clipboard
Molecular formula: C35H53N1O7S1
Exact molecular mass: 632.3615 Da ([M+H]+)
Molecular activity: Antibacterial

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Other (linear)
Thioesterase type:
None
Release / cyclization type:
Macrolactonization

Nonribosomal peptide synthetases:
tgaC (ADH04641.1)
Module 10
A specificity: Cysteine
Evidence for specificity: Sequence-based prediction
C domain subtype: Heterocyclization
Scaffold-modifying domain: Oxidation
Polyketide subclass:
Other (cyclic)
Polyketide synthase subclass:
Modular type I
Starter unit:
Acetyl-CoA
Thioesterase type:
Type I
Release / cyclization type:
Macrolactonization

Modular polyketide synthases:
tgaA (ADH04639.1)
Module 1
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: B-group
Module 2
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Module 3
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: B-group
Module 4
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: B-group
Module 5
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: B-group

tgaB (ADH04640.1)
Module 6
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: A-group
Module 7
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: B-group

tgaC (ADH04641.1)
Module 8
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: A-group
Module 9
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: A-group
Module 11
AT specificity: Other
Evidence for specificity: Structure-based inference
KR stereochemistry: B-group

Gene cluster description

thuggacin (BGC0001051). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank GQ981380, positions 1-82258. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
MIxS-compliance:No
Contact for this cluster:Daniel Krug (HIPS)

Literature references

1. Buntin K et al. (2010) Biosynthesis of thuggacins in myxobacteria: comparative cluster analysis reveals basis for natural product structural diversity. Chem Biol 17(4):342-56. doi: 10.1016/j.chembiol.2010.02.013.