BGC0001051: thuggacin A biosynthetic gene cluster from Sorangium cellulosum
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Location: 17,491 - 76,320 nt. (total: 58,830 nt).
This entry is originally from NCBI GenBank GQ981380.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001051
Short description thuggacin A biosynthetic gene cluster from Sorangium cellulosum
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Type I)
Loci
GQ981380.1
17491 - 76320
via Knock-out studies
Compounds
  • thuggacin A
Species Sorangium cellulosum [taxonomy]
References
Chemical products information
thuggacin A Evidence:
Copy SMILES
C35H53N1O7S1
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ADH04638.1
  • tgaE
 17492 - 18565 (-) monooxygenase
  • Tailoring
  • Knock-out
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  • ADH04639.1
  • tgaA
 18917 - 44572 (+) TgaA
  • Scaffold biosynthesis
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  • ADH04640.1
  • tgaB
 44613 - 54896 (+) TgaB
  • Scaffold biosynthesis
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  • ADH04641.1
  • tgaC
 55016 - 75007 (+) TgaC
  • Scaffold biosynthesis
  • Knock-out
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  • ADH04642.1
  • tgaD
 75157 - 76320 (+) alcohol dehydrogenase
  • Tailoring
  • Knock-out
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Biosynthesis information

Biosynthetic modules

Name
10
Type
nrps-type1
Genes
tgaC
Substrates
cysteine (evidence: Sequence-based prediction)
Integrated Monomers
Domains
condensation (Heterocyclization), adenylation, oxidase
Name
1
Type
pks-modular
Genes
tgaA
Substrates
Integrated Monomers
Domains
acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, enoylreductase, carrier (ACP)
Name
2
Type
pks-modular
Genes
tgaA
Substrates
Integrated Monomers
Domains
acyltransferase, ketosynthase, acyltransferase, dehydratase, carrier (ACP)
Name
3
Type
pks-modular
Genes
tgaA
Substrates
Integrated Monomers
Domains
acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
Name
4
Type
pks-modular
Genes
tgaA
Substrates
Integrated Monomers
Domains
acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
Name
5
Type
pks-modular
Genes
tgaA
Substrates
Integrated Monomers
Domains
acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
Name
6
Type
pks-modular
Genes
tgaB
Substrates
Integrated Monomers
Domains
acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
Name
7
Type
pks-modular
Genes
tgaB
Substrates
Integrated Monomers
Domains
acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
Name
8
Type
pks-modular
Genes
tgaC
Substrates
Integrated Monomers
Domains
acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
Name
9
Type
pks-modular
Genes
tgaC
Substrates
Integrated Monomers
Domains
acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
Name
11
Type
pks-modular
Genes
tgaC
Substrates
Integrated Monomers
Domains
acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
Annotation changelog

Entry version: 4

Date
Changes
Submitters
Reviewers
2022-10-07
Update chemical activity to schema version 2.11
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

Entry version: 3

Date
Changes
Submitters
Reviewers
2022-09-15
Corrected NRP module activity
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
2022-09-15
Remove leading/trailing whitespace in gene identifiers
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2022-09-15
Removed ketoreductase stereochemistry annotation from modules without ketoreductases
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2022-09-15
Refined reference coordinates
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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2022-09-15
Changed amino acid substrates to lower case
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

Entry version: 2

Date
Changes
Submitters
Reviewers
2019-10-16
Migrated from v1.4
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
2019-10-16
Updated compound(s) information (NPAtlas curation)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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Entry version: 1

Date
Changes
Submitters
Reviewers
2015-06-12
Submitted
  • (ID: 7SR74ARK6JXRBGJRGO2LUHE7)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
Detailed domain annotation
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