BGC0001052: tirandamycin biosynthetic gene cluster from Streptomyces sp. 307-9
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Location: 1 - 55,522 nt. (total: 55,522 nt).
This entry is originally from NCBI GenBank GU385216.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001052
Short description tirandamycin biosynthetic gene cluster from Streptomyces sp. 307-9
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Type I)
Loci
GU385216.1
via Enzymatic assays
Compounds
  • tirandamycin
Species Streptomyces sp. 307-9 [taxonomy]
References
Chemical products information
tirandamycin Evidence:
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C22H27N1O7
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ADC79635.1
 1 - 636 (-) TamM
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    • ADC79636.1
    		 770 - 2272 (+) TamL
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      • ADC79637.1
      		 2478 - 19964 (+) TamAI
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        • ADC79638.1
        		 20104 - 30201 (+) TamAII
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          • ADC79639.1
          		 30206 - 38611 (+) TamAIII
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            • ADC79640.1
            		 38608 - 39384 (+) TamB
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              • ADC79641.1
              		 39576 - 40406 (+) TamC
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                • ADC79642.1
                		 40523 - 43678 (+) TamD
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                  • ADC79643.1
                  		 43702 - 44532 (+) TamE
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                    • ADC79644.1
                    		 44529 - 46067 (+) TamF
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                      • ADC79645.1
                      		 46558 - 48651 (+) TamG
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                        • ADC79646.1
                        		 48917 - 51730 (+) TamH
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                          • ADC79647.1
                          		 51684 - 52925 (-) TamI
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                            • ADC79648.1
                            		 53232 - 54728 (-) TamJ
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                              • ADC79649.1
                              		 54890 - 55522 (+) TamK
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                                Biosynthesis information

                                Biosynthetic modules

                                Name
                                8
                                Type
                                nrps-type1
                                Genes
                                ADC79642.1
                                Substrates
                                glycine (evidence: Sequence-based prediction)
                                Integrated Monomers
                                Domains
                                condensation (LCL), adenylation
                                Name
                                0
                                Type
                                pks-modular
                                Genes
                                ADC79637.1
                                Substrates
                                Integrated Monomers
                                Domains
                                acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                                Name
                                1
                                Type
                                pks-modular
                                Genes
                                ADC79637.1
                                Substrates
                                Integrated Monomers
                                Domains
                                acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                Name
                                2
                                Type
                                pks-modular
                                Genes
                                ADC79637.1
                                Substrates
                                Integrated Monomers
                                Domains
                                acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                Name
                                3
                                Type
                                pks-modular
                                Genes
                                ADC79637.1
                                Substrates
                                Integrated Monomers
                                Domains
                                acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                Name
                                4
                                Type
                                pks-modular
                                Genes
                                ADC79638.1
                                Substrates
                                Integrated Monomers
                                Domains
                                acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                Name
                                5
                                Type
                                pks-modular
                                Genes
                                ADC79638.1
                                Substrates
                                Integrated Monomers
                                Domains
                                acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                Name
                                6
                                Type
                                pks-modular
                                Genes
                                ADC79639.1
                                Substrates
                                Integrated Monomers
                                Domains
                                acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                Name
                                7
                                Type
                                pks-modular
                                Genes
                                ADC79639.1
                                Substrates
                                Integrated Monomers
                                Domains
                                acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                                Annotation changelog

                                Entry version: 4

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2022-10-07
                                Update chemical activity to schema version 2.11
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                Entry version: 3

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2022-09-15
                                Linked new NPAtlas id for tirandamycin (npatlas:NPA017695)
                                • (ID: 5UL74VURKJ25VSPPPO3H2NYB)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                2022-09-15
                                Corrected NRP module activity
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                2022-09-15
                                Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                2022-09-15
                                Changed amino acid substrates to lower case
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                Entry version: 2

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2019-10-16
                                Migrated from v1.4
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                Entry version: 1

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2015-06-12
                                Submitted
                                • (ID: RIBLHRV4YSJAGJ5EVZV4GS2Z)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                Detailed domain annotation
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