Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001052.1:
Cluster 1NRP / Polyketide155522

BGC0001052, tirandamycin biosynthetic gene cluster from Streptomyces sp. 307-9. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: tirandamycin
SMILES string: Copy to clipboard
Molecular formula: C22H27NO7
Exact molecular mass: 417.1787 Da ([M+H]+)
Molecular activity: Antibacterial

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Other (linear)
Thioesterase type:
Type II
Release / cyclization type:
Unknown

Nonribosomal peptide synthetases:
ADC79642.1
Module 8
A specificity: Glycine
Evidence for specificity: Sequence-based prediction
C domain subtype: LCL
Polyketide subclass:
Ansamycin (cyclic)
Polyketide synthase subclass:
Modular type I
Starter unit:
Malonyl-CoA
Thioesterase type:
Type II
Release / cyclization type:
Unknown

Modular polyketide synthases:
ADC79637.1
Module 0
AT specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Scaffold-modifying domain: None
Module 1
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Sequence-based prediction
KR stereochemistry: Inactive
Scaffold-modifying domain: None
Module 2
AT specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
KR stereochemistry: B-group
Scaffold-modifying domain: None
Module 3
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Sequence-based prediction
KR stereochemistry: B-group
Scaffold-modifying domain: None

ADC79638.1
Module 4
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Sequence-based prediction
KR stereochemistry: A-group
Scaffold-modifying domain: None
Module 5
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Sequence-based prediction
KR stereochemistry: B-group
Scaffold-modifying domain: None

ADC79639.1
Module 6
AT specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
KR stereochemistry: B-group
Scaffold-modifying domain: None
Module 7
AT specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Scaffold-modifying domain: None

Gene cluster description

tirandamycin (BGC0001052). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank GU385216, positions 1-55522. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Enzymatic assays
MIxS-compliance:Unknown
Contact for this cluster:Fengan Yu (University of Michigan)

Literature references

1. Carlson JC et al. (2010) Identification of the tirandamycin biosynthetic gene cluster from Streptomyces sp. 307-9. Chembiochem 11(4):564-72. doi: 10.1002/cbic.200900658.