BGC0001053: tubulysin A biosynthetic gene cluster from Archangium disciforme
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Location: 1 - 82,868 nt. (total: 82,868 nt).
This entry is originally from NCBI GenBank AJ620477.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001053
Short description tubulysin A biosynthetic gene cluster from Archangium disciforme
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
AJ620477.1
via
Compounds
  • tubulysin A
Species Archangium disciforme [taxonomy]
References
Chemical products information
tubulysin A Evidence:
Copy SMILES
C43H65N5O10S1
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAF05629.1
 1 - 3308 (-) hypothetical protein
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    • CAF05630.1
    		 3453 - 4706 (-) hypothetical protein
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      • CAF05631.1
      		 5719 - 7164 (+) hypothetical protein
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        • CAF05632.1
        		 7317 - 9557 (-) hypothetical protein
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          • CAF05633.1
          		 10550 - 12193 (-) hypothetical protein
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            • CAF05634.1
            		 12841 - 13881 (+) hypothetical protein
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              • CAF05635.1
              		 13835 - 14833 (-) hypothetical protein
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                • CAF05636.1
                		 14942 - 15586 (+) hypothetical protein
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                  • CAF05637.1
                  		 15847 - 16983 (+) hypothetical protein
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                    • CAF05638.1
                    		 18809 - 21154 (-) hypothetical protein
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                      • CAF05639.1
                      		 22366 - 23532 (+) hypothetical protein
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                        • CAF05640.1
                        		 24591 - 26513 (+) hypothetical protein
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                          • CAF05641.1
                          		 26597 - 27517 (+) hypothetical protein
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                            • CAF05642.1
                            		 29858 - 30400 (+) hypothetical protein
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                              • CAF05643.1
                              • tubA
                              		 31220 - 32392 (+) TubA protein
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                                • CAF05644.1
                                		 32397 - 33056 (-) hypothetical protein
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                                  • CAF05645.1
                                  • tubZ
                                  		 33074 - 34195 (-) TubZ protein
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                                    • CAF05646.1
                                    		 34205 - 35422 (-) hypothetical protein
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                                      • CAF05647.1
                                      • tubB
                                      		 35522 - 40147 (+) TubB protein
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                                        • CAF05648.1
                                        • tubC
                                        		 40144 - 48021 (+) TubC protein
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                                          • CAF05649.1
                                          • tubD
                                          		 48011 - 58558 (+) TubD protein
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                                            • CAF05650.1
                                            • tubE
                                            		 58551 - 62096 (+) TubE protein
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                                              • CAF05651.1
                                              • tubF
                                              		 62103 - 70616 (+) TubF protein
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                                                • CAF05652.1
                                                		 70585 - 71640 (-) patatin-like protein
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                                                  • CAF05653.1
                                                  		 71731 - 72786 (-) patatin-like protein
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                                                    • CAF05654.1
                                                    		 74655 - 75359 (-) hypothetical protein
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                                                      • CAF05655.1
                                                      		 75488 - 76645 (+) hypothetical protein
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                                                        • CAF05656.1
                                                        • tubG
                                                        		 76787 - 77545 (+) TubG protein
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                                                          • CAF05657.1
                                                          		 77769 - 78695 (+) hypothetical protein
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                                                            • CAF05658.1
                                                            		 79138 - 80019 (+) hypothetical protein
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                                                              • CAF05659.1
                                                              		 80057 - 81493 (-) hypothetical protein
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                                                                • CAF05660.1
                                                                		 81721 - 82797 (-) pyrroline carboxylate reductase-like protein
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                                                                  Biosynthesis information

                                                                  Biosynthetic modules

                                                                  Name
                                                                  Unk01
                                                                  Type
                                                                  nrps-type1
                                                                  Genes
                                                                  tubB
                                                                  Substrates
                                                                  pipecolic acid (evidence: )
                                                                  Integrated Monomers
                                                                  Domains
                                                                  adenylation
                                                                  Annotation changelog

                                                                  Entry version: 4

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  2022-10-07
                                                                  Update chemical activity to schema version 2.11
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                  Entry version: 3

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  2022-09-15
                                                                  Updated bioactivity data
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  2022-09-15
                                                                  Added NRP substrate specificities
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                  Entry version: 2

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  2019-10-16
                                                                  Migrated from v1.4
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  2019-10-16
                                                                  Updated compound(s) information (NPAtlas curation)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                  Entry version: 1

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  2015-06-12
                                                                  Submitted
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  Detailed domain annotation
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