BGC0001054: xenocoumacin 1 biosynthetic gene cluster from Xenorhabdus nematophila ATCC 19061
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Location: 1,572,674 - 1,613,982 nt. (total: 41,309 nt).
This entry is originally from NCBI GenBank FN667742.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001054
Short description xenocoumacin 1 biosynthetic gene cluster from Xenorhabdus nematophila ATCC 19061
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Type I)
Loci
FN667742.1
1572674 - 1613982
via Knock-out studies
Compounds
  • xenocoumacin 1
  • xenocoumacin II
Species Xenorhabdus nematophila ATCC 19061 [taxonomy]
References
Chemical products information
xenocoumacin 1 Evidence:
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C22H35N5O6
Chemical database entries
PubCHEM
xenocoumacin II Evidence:
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C21H30N2O6
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • XNC1_1698
  • CBJ89758.1
  • xcnN
 1572674 - 1573756 (-) Fatty acid desaturase involved in xenocoumacin synthesis
  • Activation / processing
  • Knock-out
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  • XNC1_1699
  • CBJ89759.1
  • xcnM
 1574084 - 1575169 (-) Saccharopine dehydrogenase involved in xenocoumacin synthesis
  • Activation / processing
  • Knock-out
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  • XNC1_1700
  • CBJ89760.1
  • xcnL
 1575318 - 1579781 (-) Polyketide synthase involved in xenocoumacin synthesis
  • Scaffold biosynthesis
  • Knock-out
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  • XNC1_1701
  • CBJ89761.1
  • xcnK
 1579884 - 1582457 (-) Non-ribosomal peptide synthase involved in xenocoumacin synthesis
  • Scaffold biosynthesis
  • Knock-out
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  • XNC1_1702
  • CBJ89762.1
  • xcnJ
 1582639 - 1582962 (-) Conserved hypothetical protein involved in xenocoumacin synthesis
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    • XNC1_1703
    • CBJ89763.1
    • xcnI
    		 1582971 - 1583702 (-) Thioesterase involved in xenocoumacin synthesis
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      • XNC1_1704
      • CBJ89764.1
      • xcnH
      		 1583908 - 1589691 (-) Polyketide synthase involved in xenocoumacin synthesis
      • Scaffold biosynthesis
      • Knock-out
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      • XNC1_1705
      • CBJ89765.1
      • xcnG
      		 1589816 - 1591285 (-) Beta-lactamase class C involved in xenocoumacin synthesis
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        • XNC1_1706
        • CBJ89766.1
        • xcnF
        		 1591422 - 1601687 (-) Polyketide synthase involved in xenocoumacin synthesis
        • Scaffold biosynthesis
        • Knock-out
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        • XNC1_1707
        • CBJ89767.1
        • xcnE
        		 1601892 - 1603043 (-) Acyl-CoA dehydrogenase involved in xenocoumacin synthesis
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          • XNC1_1708
          • CBJ89768.1
          • xcnD
          		 1603051 - 1603308 (-) Putative acyl carrier protein potentially involved in xenocoumacin synthesis
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            • XNC1_1709
            • CBJ89769.1
            • xcnC
            		 1603342 - 1604403 (-) Methoxymalonate biosynthesis protein involved in xenocoumacin synthesis
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              • XNC1_1710
              • CBJ89770.1
              • xcnB
              		 1604406 - 1605263 (-) 3-hydroxyacyl-CoA dehydrogenase involved in xenocoumacin synthesis
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                • XNC1_1711
                • CBJ89771.1
                • xcnA
                		 1605964 - 1613982 (-) Non-ribosomal peptide synthase involved in Xenocoumacin synthesis
                • Scaffold biosynthesis
                • Knock-out
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                Biosynthesis information

                Biosynthetic modules

                Name
                2
                Type
                pks-modular
                Genes
                xcnL
                Substrates
                Integrated Monomers
                Domains
                acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                Name
                5
                Type
                pks-modular
                Genes
                xcnF
                Substrates
                Integrated Monomers
                Domains
                acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                Name
                6
                Type
                pks-modular
                Genes
                xcnF
                Substrates
                Integrated Monomers
                Domains
                acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                Name
                7
                Type
                pks-modular
                Genes
                xcnH
                Substrates
                Integrated Monomers
                Domains
                acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                Annotation changelog

                Entry version: 4

                Date
                Changes
                Submitters
                Reviewers
                2022-10-07
                Update chemical activity to schema version 2.11
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 3

                Date
                Changes
                Submitters
                Reviewers
                2022-09-15
                Corrected NRP module activity
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2022-09-15
                Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2022-09-15
                Sorted modules by module number
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 2

                Date
                Changes
                Submitters
                Reviewers
                2019-10-16
                Migrated from v1.4
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2019-10-16
                Updated compound(s) information (NPAtlas curation)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 1

                Date
                Changes
                Submitters
                Reviewers
                2015-06-12
                Submitted
                • (ID: SCFYH7235HZBUM2XBV52IUHT)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                Detailed domain annotation
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