BGC0001054: xenocoumacin 1 biosynthetic gene cluster from Xenorhabdus nematophila ATCC 19061
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Location: 1,572,674 - 1,613,982 nt. (total: 41,309 nt).
This entry is originally from NCBI GenBank FN667742.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001054
Short description xenocoumacin 1 biosynthetic gene cluster from Xenorhabdus nematophila ATCC 19061
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Other)
Loci NCBI GenBank: FN667742.1
Compounds
  • xenocoumacin 1
  • xenocoumacin II
Species Xenorhabdus nematophila ATCC 19061 [taxonomy]
References
Chemical products information
xenocoumacin 1
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C22H35N5O6
Chemical database entries
PubCHEM
xenocoumacin II
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C21H30N2O6
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • XNC1_1698
  • CBJ89758.1
  • xcnN
 1572674 - 1573756 (-) Fatty acid desaturase involved in xenocoumacin synthesis
  • Activation / processing
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  • XNC1_1699
  • CBJ89759.1
  • xcnM
 1574084 - 1575169 (-) Saccharopine dehydrogenase involved in xenocoumacin synthesis
  • Activation / processing
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  • XNC1_1700
  • CBJ89760.1
  • xcnL
 1575318 - 1579781 (-) Polyketide synthase involved in xenocoumacin synthesis
  • Scaffold biosynthesis
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  • XNC1_1701
  • CBJ89761.1
  • xcnK
 1579884 - 1582457 (-) Non-ribosomal peptide synthase involved in xenocoumacin synthesis
  • Scaffold biosynthesis
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  • XNC1_1702
  • CBJ89762.1
  • xcnJ
 1582639 - 1582962 (-) Conserved hypothetical protein involved in xenocoumacin synthesis
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  • XNC1_1703
  • CBJ89763.1
  • xcnI
 1582971 - 1583702 (-) Thioesterase involved in xenocoumacin synthesis
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  • XNC1_1704
  • CBJ89764.1
  • xcnH
 1583908 - 1589691 (-) Polyketide synthase involved in xenocoumacin synthesis
  • Scaffold biosynthesis
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  • XNC1_1705
  • CBJ89765.1
  • xcnG
 1589816 - 1591285 (-) Beta-lactamase class C involved in xenocoumacin synthesis
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  • XNC1_1706
  • CBJ89766.1
  • xcnF
 1591422 - 1601687 (-) Polyketide synthase involved in xenocoumacin synthesis
  • Scaffold biosynthesis
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  • XNC1_1707
  • CBJ89767.1
  • xcnE
 1601892 - 1603043 (-) Acyl-CoA dehydrogenase involved in xenocoumacin synthesis
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  • XNC1_1708
  • CBJ89768.1
  • xcnD
 1603051 - 1603308 (-) Putative acyl carrier protein potentially involved in xenocoumacin synthesis
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  • XNC1_1709
  • CBJ89769.1
  • xcnC
 1603342 - 1604403 (-) Methoxymalonate biosynthesis protein involved in xenocoumacin synthesis
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  • XNC1_1710
  • CBJ89770.1
  • xcnB
 1604406 - 1605263 (-) 3-hydroxyacyl-CoA dehydrogenase involved in xenocoumacin synthesis
  • Unknown
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  • XNC1_1711
  • CBJ89771.1
  • xcnA
 1605964 - 1613982 (-) Non-ribosomal peptide synthase involved in Xenocoumacin synthesis
  • Scaffold biosynthesis
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Polyketide-specific information
Subclass Other
Cyclic? no
Polyketide-synthases
Genes Properties Modules
xcnL
+
xcnF
+
xcnH
+
xcnI 		Synthase subclass: Modular type I
Thioesterases:
  • xcnI (Type II)
Module 2
Genes: xcnL
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 5
Genes: xcnF
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 6
Genes: xcnF
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
Module 7
Genes: xcnH
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
xcnA
Module 3
Condensation domain type: Unknown
Module 4
Condensation domain type: Unknown
xcnK
Module 1
Condensation domain type: Unknown
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: SCFYH7235HZBUM2XBV52IUHT, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Sorted modules by module number
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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