BGC0001056: zeamine biosynthetic gene cluster from Serratia plymuthica RVH1
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Location: 1 - 55,138 nt. (total: 55,138 nt).
This entry is originally from NCBI GenBank HE995400.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001056
Short description zeamine biosynthetic gene cluster from Serratia plymuthica RVH1
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Type I)
Loci
HE995400.1
via Knock-out studies, Enzymatic assays
Compounds
  • zeamine
  • zeamine I
  • zeamine II
  • prezeamine
  • prezeamine I
Species Serratia plymuthica RVH1 [taxonomy]
References
Chemical products information
zeamine Evidence:
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C49H104N6O4
Chemical database entries
NPAtlas
zeamine I Evidence:
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C47H100N6O3
zeamine II Evidence:
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C40H87N5O1
prezeamine Evidence:
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C71H133N15O13
prezeamine I Evidence:
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C69H129N15O12
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CCM44321.1
  • zmn1
 1 - 426 (+) hypothetical protein
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    • CCM44322.1
    • zmn2
    		 423 - 935 (+) hypothetical protein
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      • CCM44323.1
      • zmn3
      		 952 - 2325 (+) putative pyridoxal-dependent decarboxylase
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        • CCM44324.1
        • zmn4
        		 2373 - 3026 (+) hypothetical protein
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          • CCM44325.1
          • zmn5
          		 3096 - 3824 (-) Phosphopantetheinyl transferase
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            • CCM44326.1
            • zmn6
            		 3895 - 4815 (-) putative HlyD family secretion protein
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              • CCM44327.1
              • zmn7
              		 4812 - 5531 (-) putative ABC transporter ATP-binding protein
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                • CCM44328.1
                • zmn8
                		 5540 - 6706 (-) putative ABC transporter membrane protein
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                  • CCM44329.1
                  • zmn9
                  		 7316 - 8311 (+) hypothetical protein
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                    • CCM44330.1
                    • zmn10
                    		 8448 - 15194 (+) Polyketide synthase
                    • Scaffold biosynthesis
                    • Knock-out Other in vivo study
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                    • CCM44331.1
                    • zmn11
                    		 15277 - 19527 (+) Mixed fatty acid synthase-polyketide synthase
                    • Scaffold biosynthesis
                    • Knock-out Other in vivo study
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                    • CCM44332.1
                    • zmn12
                    		 19524 - 22556 (+) PfaD family protein
                    • Scaffold biosynthesis
                    • Knock-out Other in vivo study
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                    • CCM44333.1
                    • zmn13
                    		 22553 - 23320 (+) 3-oxoacyl-ACP reductase
                    • Scaffold biosynthesis
                    • Knock-out
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                    • CCM44334.1
                    • zmn14
                    		 23366 - 24598 (+) Thioester reductase
                    • Scaffold biosynthesis
                    • Knock-out Activity assay
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                    • CCM44335.1
                    • zmn15
                    		 24632 - 25411 (+) putative carbon-nitrogen hydrolase
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                      • CCM44336.1
                      • zmn16
                      		 25460 - 37969 (+) Nonribosomal peptide synthetase
                      • Scaffold biosynthesis
                      • Knock-out
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                      • CCM44337.1
                      • zmn17
                      		 37969 - 44511 (+) Nonribosomal peptide synthetase
                      • Scaffold biosynthesis
                      • Knock-out
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                      • CCM44338.1
                      • zmn18
                      		 44508 - 49103 (+) Polyketide synthase
                      • Scaffold biosynthesis
                      • Knock-out
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                      • CCM44339.1
                      • zmn19
                      		 49100 - 50419 (+) Condensation domain-containing protein
                      • Scaffold biosynthesis
                      • Knock-out
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                      • CCM44340.1
                      • zmn20
                      		 50657 - 51601 (+) ABC transporter ATP-binding protein
                      • Transport
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                      • CCM44341.1
                      • zmn21
                      		 51594 - 52709 (+) ABC transporter permease
                      • Transport
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                      • CCM44342.1
                      • zmn22
                      		 52752 - 53789 (-) Acylpeptide hydrolase
                      • Activation / processing
                      • Knock-out
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                      • CCM44343.1
                      • zmn23
                      		 54818 - 55138 (+) putative NifA subfamily transcriptional regulator
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                        Biosynthesis information

                        Biosynthetic modules

                        Name
                        B0
                        Type
                        nrps-type1
                        Genes
                        zmn16
                        Substrates
                        aspartic acid (evidence: Structure-based inference)
                        Integrated Monomers
                        Domains
                        condensation, adenylation
                        Name
                        B1
                        Type
                        nrps-type1
                        Genes
                        zmn16
                        Substrates
                        histidine (evidence: Structure-based inference [2])
                        Integrated Monomers
                        Domains
                        condensation, adenylation
                        Name
                        B2
                        Type
                        nrps-type1
                        Genes
                        zmn16
                        Substrates
                        asparagine (evidence: Structure-based inference)
                        Integrated Monomers
                        Domains
                        condensation, adenylation, epimerase
                        Name
                        B3
                        Type
                        nrps-type1
                        Genes
                        zmn16
                        Substrates
                        asparagine (evidence: Structure-based inference)
                        Integrated Monomers
                        Domains
                        condensation, adenylation
                        Name
                        B4
                        Type
                        nrps-type1
                        Genes
                        zmn17
                        Substrates
                        threonine (evidence: Structure-based inference)
                        Integrated Monomers
                        Domains
                        condensation, adenylation
                        Name
                        B5
                        Type
                        nrps-type1
                        Genes
                        zmn17
                        Substrates
                        valine (evidence: Structure-based inference)
                        Integrated Monomers
                        Domains
                        condensation, adenylation
                        Name
                        B6
                        Type
                        pks-modular
                        Genes
                        zmn18
                        Substrates
                        Integrated Monomers
                        Domains
                        acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                        Annotation changelog

                        Entry version: 4

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2022-10-07
                        Update chemical activity to schema version 2.11
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                        Entry version: 3

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2022-09-15
                        Corrected NRP module activity
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        2022-09-15
                        Updated bioactivity data
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        2022-09-15
                        Updated NRP substrate specificities
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                        Entry version: 2

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2019-10-16
                        Migrated from v1.4
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        2019-10-16
                        Updated compound(s) information (NPAtlas curation)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                        Entry version: 1

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2015-06-12
                        Submitted
                        • (ID: LBLIPTLAGFUPCXL63ODXWSCG)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        Detailed domain annotation
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