BGC0001061: polyketomycin biosynthetic gene cluster from Streptomyces diastatochromogenes
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Location: 1 - 52,164 nt. (total: 52,164 nt).
This entry is originally from NCBI GenBank FJ483966.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
Saccharide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001061
Short description polyketomycin biosynthetic gene cluster from Streptomyces diastatochromogenes
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Other)
  • Saccharide (hybrid/tailoring)
Loci NCBI GenBank: FJ483966.1
Compounds
  • polyketomycin
Species Streptomyces diastatochromogenes [taxonomy]
References
Chemical products information
polyketomycin
Copy SMILES
C44H48O18
Chemical database entries
NPAtlas
ChEBI
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ACN64816.1
  • pokSAMS
 2 - 358 (+) PokSAMS
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  • ACN64817.1
  • pokR3
 395 - 1375 (+) PokR3
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  • ACN64818.1
  • pokS8
 1372 - 2619 (+) PokS8
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  • ACN64819.1
  • pokR1
 2700 - 5897 (+) PokR1
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  • ACN64820.1
  • pokGT2
 5940 - 7088 (-) PokGT2
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  • ACN64821.1
  • pokABC2
 7101 - 7910 (-) PokABC2
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  • ACN64822.1
  • pokABC1
 7907 - 8839 (-) PokABC1
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  • ACN64823.1
  • pokGT1
 9073 - 10266 (+) PokGT1
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  • ACN64824.1
  • pokS6
 10263 - 11291 (+) PokS6
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  • ACN64825.1
  • pokS5
 11296 - 12594 (+) PokS5
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  • ACN64826.1
  • pokU2
 12678 - 13832 (-) PokU2
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  • ACN64827.1
  • pokU1
 13829 - 14350 (-) PokU2
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  • ACN64828.1
  • pokS4
 14347 - 15348 (-) PokS4
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  • ACN64829.1
  • pokS3
 15342 - 16772 (-) PokS3
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  • ACN64830.1
  • pokM3
 16769 - 18424 (-) PokM3
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  • ACN64831.1
  • pokM1
 18421 - 23640 (-) PokM1
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  • ACN64832.1
  • pokM2
 23637 - 24665 (-) PokM2
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  • ACN64833.1
  • pokMT1
 24720 - 25763 (-) PokMT1
  • Tailoring (Methylation)
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  • ACN64834.1
  • pokP1
 25972 - 27240 (+) PokP1
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  • ACN64835.1
  • pokP2
 27237 - 28460 (+) PokP2
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  • ACN64836.1
  • pokP3
 28501 - 28758 (+) PokP3
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  • ACN64837.1
  • pokAC1
 28755 - 30494 (+) PokAC1
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  • ACN64838.1
  • pokAC3
 30499 - 31035 (+) PokAC3
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  • ACN64839.1
  • pokAC2
 31042 - 32454 (+) PokAC2
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  • ACN64840.1
  • pokS1
 32469 - 33533 (+) PokS1
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  • ACN64841.1
  • pokS2
 33530 - 34519 (+) PokS2
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  • ACN64842.1
  • pokR2
 34713 - 35525 (+) PokR2
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  • ACN64843.1
  • pokMT2
 35677 - 36714 (-) PokMT2
  • Tailoring (Methylation)
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  • ACN64844.1
  • pokT1
 37159 - 37938 (+) PokT1
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  • ACN64845.1
  • pokO1
 37950 - 39179 (+) PokO1
  • Tailoring (Hydroxylation)
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  • ACN64846.1
  • pokC2
 39186 - 39971 (+) PokC2
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  • ACN64847.1
  • pokMT3
 39977 - 41092 (+) PokMT3
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  • ACN64848.1
  • pokC1
 41211 - 41663 (+) PokC1
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  • ACN64849.1
  • pokO3
 41747 - 42076 (-) PokO3
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  • ACN64850.1
  • pokL
 42073 - 43560 (-) PokL
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  • ACN64851.1
  • pokC3
 43553 - 44497 (-) PokC3
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  • ACN64852.1
  • pokT2
 44547 - 45302 (-) PokT2
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  • ACN64853.1
  • pokO2
 45312 - 46937 (-) PokO2
  • Tailoring (Hydroxylation)
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  • ACN64854.1
  • pokO4
 47306 - 48826 (+) PokO4
  • Scaffold biosynthesis
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  • ACN64855.1
  • pokS7
 48823 - 49437 (+) PokS7
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  • ACN64856.1
  • pokS9
 49434 - 50393 (+) PokS9
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  • ACN64857.1
  • pokU3
 50634 - 51608 (+) PokU3
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  • ACN64858.1
  • pokX1
 51876 - >52164 (+) PokX1
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Polyketide-specific information
Subclass Other
Starter unit Malonyl-CoA
Ketide length 10
Cyclic? yes
Polyketide-synthases
Genes Properties Modules
pokM1
+
pokC1
+
pokC3
+
pokP1
+
pokC2
+
pokP3 		Synthase subclass: Iterative type I/Type II
Iterative PKS type: Partially reducing, Unknown
Iteration counts: 9
Module 1
Specificity: Methylmalonyl-CoA
Genes: pokM1
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Saccharide-specific information
Subclass hybrid/tailoring
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: LPHAMZXQ3BT6INJWOLKUYGWU, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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