BGC0001061: polyketomycin biosynthetic gene cluster from Streptomyces diastatochromogenes
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Location: 1 - 52,164 nt. (total: 52,164 nt).
This entry is originally from NCBI GenBank FJ483966.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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resistance
TTA codons
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Gene details
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General
Compounds
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Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001061
Short description polyketomycin biosynthetic gene cluster from Streptomyces diastatochromogenes
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type II aromatic)
Loci
FJ483966.1
via Knock-out studies
Compounds
  • polyketomycin
Species Streptomyces diastatochromogenes [taxonomy]
References
Chemical products information
polyketomycin Evidence: NMR [1]
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C44H48O18
Chemical database entries
ChEBI
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ACN64816.1
  • pokSAMS
 2 - 358 (+) PokSAMS
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    • ACN64817.1
    • pokR3
    		 395 - 1375 (+) PokR3
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      • ACN64818.1
      • pokS8
      		 1372 - 2619 (+) PokS8
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        • ACN64819.1
        • pokR1
        		 2700 - 5897 (+) PokR1
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          • ACN64820.1
          • pokGT2
          		 5940 - 7088 (-) PokGT2
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            • ACN64821.1
            • pokABC2
            		 7101 - 7910 (-) PokABC2
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              • ACN64822.1
              • pokABC1
              		 7907 - 8839 (-) PokABC1
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                • ACN64823.1
                • pokGT1
                		 9073 - 10266 (+) PokGT1
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                  • ACN64824.1
                  • pokS6
                  		 10263 - 11291 (+) PokS6
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                    • ACN64825.1
                    • pokS5
                    		 11296 - 12594 (+) PokS5
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                      • ACN64826.1
                      • pokU2
                      		 12678 - 13832 (-) PokU2
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                        • ACN64827.1
                        • pokU1
                        		 13829 - 14350 (-) PokU2
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                          • ACN64828.1
                          • pokS4
                          		 14347 - 15348 (-) PokS4
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                            • ACN64829.1
                            • pokS3
                            		 15342 - 16772 (-) PokS3
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                              • ACN64830.1
                              • pokM3
                              		 16769 - 18424 (-) PokM3
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                                • ACN64831.1
                                • pokM1
                                		 18421 - 23640 (-) PokM1
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                                  • ACN64832.1
                                  • pokM2
                                  		 23637 - 24665 (-) PokM2
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                                    • ACN64833.1
                                    • pokMT1
                                    		 24720 - 25763 (-) PokMT1
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                                      • ACN64834.1
                                      • pokP1
                                      		 25972 - 27240 (+) PokP1
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                                        • ACN64835.1
                                        • pokP2
                                        		 27237 - 28460 (+) PokP2
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                                          • ACN64836.1
                                          • pokP3
                                          		 28501 - 28758 (+) PokP3
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                                            • ACN64837.1
                                            • pokAC1
                                            		 28755 - 30494 (+) PokAC1
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                                              • ACN64838.1
                                              • pokAC3
                                              		 30499 - 31035 (+) PokAC3
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                                                • ACN64839.1
                                                • pokAC2
                                                		 31042 - 32454 (+) PokAC2
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                                                  • ACN64840.1
                                                  • pokS1
                                                  		 32469 - 33533 (+) PokS1
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                                                    • ACN64841.1
                                                    • pokS2
                                                    		 33530 - 34519 (+) PokS2
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                                                      • ACN64842.1
                                                      • pokR2
                                                      		 34713 - 35525 (+) PokR2
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                                                        • ACN64843.1
                                                        • pokMT2
                                                        		 35677 - 36714 (-) PokMT2
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                                                          • ACN64844.1
                                                          • pokT1
                                                          		 37159 - 37938 (+) PokT1
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                                                            • ACN64845.1
                                                            • pokO1
                                                            		 37950 - 39179 (+) PokO1
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                                                              • ACN64846.1
                                                              • pokC2
                                                              		 39186 - 39971 (+) PokC2
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                                                                • ACN64847.1
                                                                • pokMT3
                                                                		 39977 - 41092 (+) PokMT3
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                                                                  • ACN64848.1
                                                                  • pokC1
                                                                  		 41211 - 41663 (+) PokC1
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                                                                    • ACN64849.1
                                                                    • pokO3
                                                                    		 41747 - 42076 (-) PokO3
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                                                                      • ACN64850.1
                                                                      • pokL
                                                                      		 42073 - 43560 (-) PokL
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                                                                        • ACN64851.1
                                                                        • pokC3
                                                                        		 43553 - 44497 (-) PokC3
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                                                                          • ACN64852.1
                                                                          • pokT2
                                                                          		 44547 - 45302 (-) PokT2
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                                                                            • ACN64853.1
                                                                            • pokO2
                                                                            		 45312 - 46937 (-) PokO2
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                                                                              • ACN64854.1
                                                                              • pokO4
                                                                              		 47306 - 48826 (+) PokO4
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                                                                                • ACN64855.1
                                                                                • pokS7
                                                                                		 48823 - 49437 (+) PokS7
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                                                                                  • ACN64856.1
                                                                                  • pokS9
                                                                                  		 49434 - 50393 (+) PokS9
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                                                                                    • ACN64857.1
                                                                                    • pokU3
                                                                                    		 50634 - 51608 (+) PokU3
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                                                                                      • ACN64858.1
                                                                                      • pokX1
                                                                                      		 51876 - >52164 (+) PokX1
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                                                                                        Biosynthesis information
                                                                                        Annotation changelog

                                                                                        Entry version: next

                                                                                        Date
                                                                                        Changes
                                                                                        Submitters
                                                                                        Reviewers
                                                                                        2024-05-14
                                                                                        MIBiG v4 annotathon
                                                                                        • (ID: P75FRHHCFPTCPYSP65VDVPHW)
                                                                                        • (ID: HSOJFFPY5IUT4HBQLSN7DGJX)
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                        Entry version: 3

                                                                                        Date
                                                                                        Changes
                                                                                        Submitters
                                                                                        Reviewers
                                                                                        2022-10-07
                                                                                        Update chemical activity to schema version 2.11
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                        Entry version: 2

                                                                                        Date
                                                                                        Changes
                                                                                        Submitters
                                                                                        Reviewers
                                                                                        2019-10-16
                                                                                        Migrated from v1.4
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                        2019-10-16
                                                                                        Updated compound(s) information (NPAtlas curation)
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                        Entry version: 1

                                                                                        Date
                                                                                        Changes
                                                                                        Submitters
                                                                                        Reviewers
                                                                                        2015-06-12
                                                                                        Submitted
                                                                                        • (ID: LPHAMZXQ3BT6INJWOLKUYGWU)
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                        Detailed domain annotation
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