Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001064.1:
Cluster 1Polyketide126219

BGC0001064, cylindrocyclophane biosynthetic gene cluster from Cylindrospermum licheniforme. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Cylindrocyclophane D
SMILES string: Copy to clipboard
Molecular formula: C40H60O8
Exact molecular mass: 668.43 Da (None)
Molecular activity: Cytotoxic

Class-specific details

Biosynthetic class(es):
Polyketide subclass:
Other (cyclic)
Polyketide synthase subclass:
Modular type I / Type III
Starter unit:
Thioesterase type:
Release / cyclization type:

Modular polyketide synthases:
cylA (AFV96135.1)
Module 0
AT specificity: Decanoyl-CoA
Evidence for specificity: Activity assay
Scaffold-modifying domain: None

cylD (AFV96138.1)
Module 1
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Scaffold-modifying domain: None

cylH (AFV96142.1)
Module 2
AT specificity: Malonyl-CoA
Evidence for specificity: Activity assay
Scaffold-modifying domain: None

Gene cluster description

cylindrocyclophane (BGC0001064). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank JX477167. Click on genes for more information.


biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?unknown
Evidence for cluster-compound connection:Knock-out studies, Sequence-based prediction
Contact for this cluster:Emily Balskus (Harvard University)

Literature references

1. Nakamura H et al. (2012) Cylindrocyclophane biosynthesis involves functionalization of an unactivated carbon center. J Am Chem Soc 134(45):18518-21. doi: 10.1021/ja308318p. Epub 2012