BGC0001064: cylindrocyclophane D biosynthetic gene cluster from Cylindrospermum licheniforme UTEX B 2014
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Location: 1 - 26,219 nt. (total: 26,219 nt).
This entry is originally from NCBI GenBank JX477167.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001064
Short description cylindrocyclophane D biosynthetic gene cluster from Cylindrospermum licheniforme UTEX B 2014
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type I)
Loci
JX477167.1
via Knock-out studies
Compounds
  • cylindrocyclophane D
  • cylindrocyclophane E
  • cylindrocyclophane F
Species Cylindrospermum licheniforme UTEX B 2014 [taxonomy]
References
Chemical products information
cylindrocyclophane D Evidence:
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C40H60O8
Chemical database entries
PubCHEM
cylindrocyclophane E Evidence:
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C38H58O6
Chemical database entries
PubCHEM
cylindrocyclophane F Evidence:
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C36H56O4
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AFV96135.1
 1069 - 2886 (+) AMP-dependent synthetase/ligase
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    • AFV96136.1
    		 3419 - 3745 (+) acyl carrier protein
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      • AFV96137.1
      		 4003 - 5418 (+) hypothetical protein
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        • AFV96138.1
        		 5656 - 9342 (+) polyketide synthase
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          • AFV96139.1
          		 9332 - 10573 (+) beta-ketoacyl synthase
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            • AFV96140.1
            		 10578 - 11837 (+) HMG-CoA synthase-like enzyme
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              • AFV96141.1
              		 11840 - 12604 (+) enoyl-CoA hydratase/isomerase
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                • AFV96142.1
                		 12592 - 19266 (+) polyketide synthase
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                  • AFV96143.1
                  		 19362 - 20483 (+) type III polyketide synthase
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                    • AFV96144.1
                    		 20495 - 21094 (+) phospholipid methyltransferase
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                      • AFV96145.1
                      		 21475 - 23430 (+) hemolysin-type calcium-binding region
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                        • AFV96146.1
                        		 23972 - 25579 (+) choline dehydrogenase-like flavoprotein
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                          Biosynthesis information

                          Biosynthetic modules

                          Name
                          0
                          Type
                          pks-trans-at-starter
                          Genes
                          AFV96135.1
                          Substrates
                          Integrated Monomers
                          Domains
                          ligase
                          Name
                          1
                          Type
                          pks-modular
                          Genes
                          AFV96138.1
                          Substrates
                          Integrated Monomers
                          Domains
                          acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                          Name
                          2
                          Type
                          pks-modular
                          Genes
                          AFV96142.1
                          Substrates
                          Integrated Monomers
                          Domains
                          acyltransferase, ketosynthase, acyltransferase, enoylreductase, thioesterase, carrier (ACP)
                          Annotation changelog

                          Entry version: next

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2024-03-19
                          MIBiG v4 annotathon
                          • (ID: 72ZCAUXZQTENCD54K6QM7DQP)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                          Entry version: 4

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2022-10-07
                          Update chemical activity to schema version 2.11
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                          Entry version: 3

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2022-09-15
                          Update compound structure (SMILES) for cylindrocyclophane D
                          • (ID: 5UL74VURKJ25VSPPPO3H2NYB)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2022-09-15
                          Linked new PubChem id for cylindrocyclophane D (pubchem:10258912)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2022-09-15
                          Update compound structure (SMILES) for cylindrocyclophane E
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2022-09-15
                          Linked new PubChem id for cylindrocyclophane E (pubchem:102306484)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2022-09-15
                          Update compound structure (SMILES) for cylindrocyclophane F
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2022-09-15
                          Linked new PubChem id for cylindrocyclophane F (pubchem:11757351)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2022-09-15
                          Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2022-09-15
                          Corrected gene identifiers
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                          Entry version: 2

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2019-10-16
                          Migrated from v1.4
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                          Entry version: 1

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2015-06-12
                          Submitted
                          • (ID: AK6U5FV25F7Z3GQ43DVTSAVK)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          Detailed domain annotation
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