BGC0001065 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001065 (Streptomyces chromofuscus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	53,036	herboxidiene	PKS	100%

BGC0001065 - Region 1 - T1PKS

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Location: 1 - 53,036 nt. (total: 53,036 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 53,037
Label		BGC0001065

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001065	1.00	Polyketide	herboxidiene	Streptomyces chromofuscus
BGC0002631	0.33	RiPP	myxarylin	Pyxidicoccus fallax
BGC0000067	0.30	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001276	0.29	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275	0.29	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0000041	0.29	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0002229	0.28	Polyketide	6-MSA, aculin A	Aspergillus aculeatus ATCC 16872
BGC0001068	0.27	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0000996	0.27	NRP, Polyketide	frontalamide B, frontalamide A	Streptomyces sp. SPB78
BGC0001544	0.27	NRP, Polyketide	chlorflavonin	Aspergillus campestris IBT 28561

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001065	1.00	Polyketide	herboxidiene	Streptomyces chromofuscus
BGC0002631	0.66	RiPP	myxarylin	Pyxidicoccus fallax
BGC0000067	0.64	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001276	0.63	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275	0.63	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0000041	0.62	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0002229	0.62	Polyketide	6-MSA, aculin A	Aspergillus aculeatus ATCC 16872
BGC0001068	0.61	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0000996	0.60	NRP, Polyketide	frontalamide B, frontalamide A	Streptomyces sp. SPB78
BGC0001544	0.60	NRP, Polyketide	chlorflavonin	Aspergillus campestris IBT 28561

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 53036:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-mal - pk - pk - pk) + (ccmal - Me-ccmal - pk - redmal) + (ccmal)
Non-colinear ordering:: herB + herC + herD

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

herB

PKS_AT (514..802): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 214.4
Ethylmalonyl-CoA: 208.8
Methoxymalonyl-CoA: 171.7
2-Methylbutyryl-CoA: 154.4
trans-1,2-CPDA: 151.8
Propionyl-CoA: 120.5
CHC-CoA: 119.7
Malonyl-CoA: 99.7
Isobutyryl-CoA: 76.5
Benzoyl-CoA: 57.1
Acetyl-CoA: 46.4
3-Methylbutyryl-CoA: 39.5
fatty_acid: 34.5
inactive: 27.9

PKS_AT (1531..1838): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 212.4
Methylmalonyl-CoA: 206.9
Methoxymalonyl-CoA: 166.1
2-Methylbutyryl-CoA: 144.1
Propionyl-CoA: 119.2
trans-1,2-CPDA: 118.0
CHC-CoA: 107.1
Malonyl-CoA: 95.0
Isobutyryl-CoA: 82.7
Benzoyl-CoA: 76.9
Acetyl-CoA: 57.3
3-Methylbutyryl-CoA: 52.4
fatty_acid: 40.2
inactive: 19.9

PKS_AT (3017..3310): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 214.9
Methylmalonyl-CoA: 213.7
Methoxymalonyl-CoA: 169.9
2-Methylbutyryl-CoA: 149.6
trans-1,2-CPDA: 120.1
CHC-CoA: 101.0
Malonyl-CoA: 97.4
Propionyl-CoA: 94.1
Benzoyl-CoA: 67.4
Isobutyryl-CoA: 59.1
Acetyl-CoA: 46.2
fatty_acid: 39.8
3-Methylbutyryl-CoA: 32.3
inactive: 20.0

PKS_AT (4804..5090): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 221.2
Methylmalonyl-CoA: 214.6
Methoxymalonyl-CoA: 178.8
2-Methylbutyryl-CoA: 171.0
trans-1,2-CPDA: 121.3
Propionyl-CoA: 117.4
CHC-CoA: 109.9
Malonyl-CoA: 102.2
Isobutyryl-CoA: 87.6
Benzoyl-CoA: 71.7
Acetyl-CoA: 48.0
3-Methylbutyryl-CoA: 41.7
fatty_acid: 30.4
inactive: 26.9

herC

PKS_AT (528..812): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%; Propionyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 190.6
inactive: 79.7
Methoxymalonyl-CoA: 77.0
Methylmalonyl-CoA: 76.6
Ethylmalonyl-CoA: 50.7
Isobutyryl-CoA: 36.5
Propionyl-CoA: 26.6
Acetyl-CoA: 22.4
trans-1,2-CPDA: 21.0
CHC-CoA: 20.7
Benzoyl-CoA: 14.9
fatty_acid: 12.3
2-Methylbutyryl-CoA: 9.9
3-Methylbutyryl-CoA: 0.0

PKS_AT (2268..2560): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 202.5
Ethylmalonyl-CoA: 202.0
Methoxymalonyl-CoA: 169.0
2-Methylbutyryl-CoA: 147.9
Propionyl-CoA: 121.3
trans-1,2-CPDA: 118.3
Malonyl-CoA: 112.9
CHC-CoA: 103.1
Isobutyryl-CoA: 92.5
Benzoyl-CoA: 64.7
fatty_acid: 43.3
Acetyl-CoA: 40.5
inactive: 34.4
3-Methylbutyryl-CoA: 21.1

PKS_AT (4005..4300): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 214.9
Methylmalonyl-CoA: 214.4
Methoxymalonyl-CoA: 178.2
2-Methylbutyryl-CoA: 146.3
trans-1,2-CPDA: 130.4
Propionyl-CoA: 119.3
CHC-CoA: 100.1
Malonyl-CoA: 87.7
Isobutyryl-CoA: 81.2
Benzoyl-CoA: 62.4
Acetyl-CoA: 56.2
3-Methylbutyryl-CoA: 42.0
fatty_acid: 35.7
inactive: 26.3

PKS_AT (5541..5839): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 200.9
inactive: 92.6
Methoxymalonyl-CoA: 65.4
Methylmalonyl-CoA: 60.7
Propionyl-CoA: 46.0
Isobutyryl-CoA: 29.5
Acetyl-CoA: 26.8
2-Methylbutyryl-CoA: 26.8
Ethylmalonyl-CoA: 24.0
Benzoyl-CoA: 20.4
CHC-CoA: 17.0
trans-1,2-CPDA: 11.6
fatty_acid: 10.2
3-Methylbutyryl-CoA: 0.0

herD

PKS_AT (568..862): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 70.8%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 219.1
Methoxymalonyl-CoA: 91.3
inactive: 86.3
Methylmalonyl-CoA: 79.1
Isobutyryl-CoA: 48.1
Ethylmalonyl-CoA: 42.9
Propionyl-CoA: 38.6
2-Methylbutyryl-CoA: 30.4
Benzoyl-CoA: 26.3
Acetyl-CoA: 23.0
CHC-CoA: 22.1
fatty_acid: 12.5
trans-1,2-CPDA: 6.1
3-Methylbutyryl-CoA: 0.0