Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001066.1:
Cluster 1Polyketide166606

BGC0001066, kendomycin biosynthetic gene cluster from Streptomyces violaceoruber. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Kendomycin
SMILES string: Copy to clipboard
Molecular formula: C29H42O6
Average molecular mass: 486.2981 Da
Molecular activity: Antibacterial, Cytotoxic

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Other (cyclic)
Polyketide synthase subclass:
Modular type I
Starter unit:
Other
Thioesterase type:
Type I
Release / cyclization type:
Unknown

Modular polyketide synthases:
ken12 (CAQ52622.1)
Module 4
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: B-group
Module 5
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: B-group
Module 6
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: B-group
Module 7
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: B-group
Module 8
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Module 1
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: B-group
Module 2
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: B-group
Module 3
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: A-group

Gene cluster description

kendomycin (BGC0001066). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank AM992894, positions 1-66606. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
MIxS-compliance:No
Contact for this cluster:Daniel Krug (HIPS)

Literature references

1. Wenzel SC et al. (2008) A type I/type III polyketide synthase hybrid biosynthetic pathway for the structurally unique ansa compound kendomycin. Chembiochem 9(16):2711-21. doi: 10.1002/cbic.200800456.