BGC0001066: kendomycin biosynthetic gene cluster from Streptomyces violaceoruber
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Location: 1 - 66,606 nt. (total: 66,606 nt).
This entry is originally from NCBI GenBank AM992894.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001066
Short description kendomycin biosynthetic gene cluster from Streptomyces violaceoruber
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Other)
Loci NCBI GenBank: AM992894.1
Compounds
  • kendomycin
Species Streptomyces violaceoruber [taxonomy]
References
Chemical products information
kendomycin
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C29H42O6
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAQ52612.1
  • ken11
 177 - 617 (-) transcriptional regulator
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  • CAQ52613.1
  • ken10
 746 - 2377 (-) PQQ-dependent enzyme
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  • CAQ52614.1
  • ken9
 2374 - 3933 (-) methyl transferase
  • Precursor biosynthesis
Sequence-based prediction
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  • CAQ52615.1
  • ken7
 4327 - 5124 (-) enoyl-CoA hydratase
  • Precursor biosynthesis
Sequence-based prediction
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  • CAQ52616.1
  • ken6
 5121 - 6590 (-) benzaldehyde degydrogenase
  • Precursor biosynthesis
Sequence-based prediction
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  • CAQ52617.1
  • ken5
 6587 - 8278 (-) benzoyl formate decarboxylase
  • Precursor biosynthesis
Sequence-based prediction
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  • CAQ52618.1
  • ken4
 8275 - 9651 (-) dioxigenase
  • Precursor biosynthesis
Sequence-based prediction
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  • CAQ52619.1
  • ken3
 9713 - 10429 (-) enoyl-CoA hydratase/isomerase
  • Precursor biosynthesis
Sequence-based prediction
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  • CAQ52620.1
  • ken2
 10557 - 11657 (-) type III polyketide synthase
  • Precursor biosynthesis
Sequence-based prediction
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  • CAQ52621.1
  • ken1
 11711 - 12562 (-) type II thioesterase
  • Unknown
Sequence-based prediction
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  • CAQ52622.1
  • ken12
 12831 - 24752 (+) type I polyketide synthase, modules 4-5
  • Scaffold biosynthesis
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  • CAQ52623.1
  • ken13
 24785 - 31303 (+) type I polyketide synthase, module 6
  • Scaffold biosynthesis
Sequence-based prediction
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  • CAQ52624.1
  • ken14
 31342 - 41685 (+) type I polyketide synthase, modules 7-8
  • Scaffold biosynthesis
Sequence-based prediction
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  • CAQ52625.1
  • ken15
 41682 - 42869 (+) FAD-dependent mono oxygenase
  • Tailoring (Monooxygenation)
Sequence-based prediction
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  • CAQ52626.1
  • ken16
 42937 - 61329 (+) type I polyketide synthase, loading module and modules 1-3
  • Scaffold biosynthesis
Sequence-based prediction
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  • CAQ52627.1
  • ken17
 61490 - 62833 (+) putative lipase
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  • CAQ52628.1
  • ken18
 62863 - 63318 (+) hypothetical protein
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  • CAQ52629.1
  • ken19
 63315 - 64868 (+) FAD-dependent oxidoreductase
  • Tailoring (Oxidation)
Sequence-based prediction
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  • CAQ52630.1
  • ken20
 64876 - 65466 (+) putative integral membrane protein
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  • CAQ52631.1
  • ken21
 65944 - 66387 (-) transcriptional regulator
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Polyketide-specific information
Subclass Other
Cyclic? yes
Polyketide-synthases
Genes Properties Modules
ken14
+
ken12 		Synthase subclass: Modular type I
Thioesterases:
  • ken14 (Type I)
Module 1
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: ken12
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 2
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: ken12
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 3
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: ken12
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 4
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: ken12
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Enoylreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 5
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: ken12
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 6
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: ken12
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Enoylreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 7
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: ken12
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Enoylreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 8
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: ken12
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: 7SR74ARK6JXRBGJRGO2LUHE7, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Remove leading/trailing whitespace in gene identifiers
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Sorted modules by module number
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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