BGC0001067: Fumagillin biosynthetic gene cluster from Aspergillus fumigatus Af293
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Location: 79,285 - 114,438 nt. (total: 35,154 nt).
This entry is originally from NCBI GenBank CM000176.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001067
Short description Fumagillin biosynthetic gene cluster from Aspergillus fumigatus Af293
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Iterative type I)
  • terpene (Sesquiterpene)
Loci
CM000176.1
79285 - 114438
via Knock-out studies, Enzymatic assays, Heterologous expression
Compounds
  • Fumagillin
Species Aspergillus fumigatus Af293 [taxonomy]
References
Chemical products information
Fumagillin Evidence: Mass spectrometry [1]
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C26H34O7
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AFUA_8G00370
  • EAL85129.1
 79285 - 86887 (-) polyketide synthase
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    • AFUA_8G00380
    • EAL85128.1
    		 87370 - 88295 (+) acyltransferase
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      • AFUA_8G00390
      • EAL85127.1
      		 88492 - 89296 (-) O-methyltransferase
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        • AFUA_8G00400
        • EAL85126.1
        		 89383 - 89870 (-) conserved hypothetical protein
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          • AFUA_8G00410
          • EAL85125.1
          		 90299 - 92235 (-) methionine aminopeptidase, type II, putative
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            • AFUA_8G00420
            • EAL85124.1
            		 93113 - 95101 (+) C6 finger transcription factor
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              • AFUA_8G00430
              • EAL85123.1
              		 95277 - 95807 (-) conserved hypothetical protein
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                • AFUA_8G00440
                • EAL85122.1
                		 96252 - 98969 (-) steroid monooxygenase, putative
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                  • AFUA_8G00460
                  • EAL85121.1
                  		 100917 - 102341 (+) methionine aminopeptidase, type I, putative
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                    • AFUA_8G00470
                    • EAL85120.1
                    		 102474 - 103368 (-) ABM superfamily monooxygenase
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                      • AFUA_8G00480
                      • EAL85119.2
                      		 103765 - 104694 (+) hydroxylase
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                        • AFUA_8G00490
                        • EAL85118.1
                        		 105095 - 108249 (+) PKS-like enzyme, ketoreductase
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                          • AFUA_8G00500
                          • EAL85117.1
                          		 108297 - 110523 (-) acetate-CoA ligase, putative
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                            • AFUA_8G00510
                            • EAL85116.1
                            		 110932 - 112596 (-) cytochrome P450 oxidoreductase
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                              • AFUA_8G00520
                              • EAL85115.1
                              		 113744 - 114438 (+) terpene cycase
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                                Biosynthesis information

                                Biosynthetic modules

                                Name
                                1
                                Type
                                pks-modular
                                Genes
                                AFUA_8G00370
                                Substrates
                                Integrated Monomers
                                Domains
                                acyltransferase, ketosynthase, acyltransferase, dehydratase, enoylreductase, ketoreductase, carrier (ACP)
                                Annotation changelog

                                Entry version: next

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2024-06-04
                                MIBiG v4 annotathon
                                • (ID: MHEG72J5P6EVQJZ6TDG3KBTM)
                                • (ID: D44UGPXERIZAXNCG2VXZP5I3)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                Entry version: 4

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2022-10-07
                                Update chemical activity to schema version 2.11
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                Entry version: 3

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2022-09-15
                                Add additional publications
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                2022-09-15
                                Removed gene names of 'No gene ID'
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                2022-09-15
                                Trimmed gene names containing multiple alternatives
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                2022-09-15
                                Cleaned up synonym list
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                Entry version: 2

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2019-10-16
                                Migrated from v1.4
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                2019-10-16
                                Updated compound(s) information (NPAtlas curation)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                Entry version: 1

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2015-06-12
                                Submitted
                                • (ID: BMUFDHMMOLZWQLUNJMQED2GP)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                Detailed domain annotation
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