BGC0001067 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001067 (Aspergillus fumigatus Af293)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	35,154	Fumagillin	PKS:Iterative type I+terpene:Sesquiterpene	100%

BGC0001067 - Region 1 - T1PKS

Download region GenBank file

Download region SVG

Location: 1 - 35,154 nt. (total: 35,154 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 35,155
Label		BGC0001067

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001067	0.80	Polyketide, Terpene	fumagillin, β-trans-bergamotene, fumagillol	Aspergillus fumigatus Af293
BGC0002228	0.29	NRP	CIML B, CIML A, CIML D, CIML C	Colletotrichum incanum
BGC0002729	0.29	Polyketide	sordarial	Neurospora crassa OR74A
BGC0001749	0.28	Polyketide	epipyriculol	Pyricularia oryzae 70-15
BGC0002227	0.27	NRP	AKML B, AKML D, AKML A, AKML C	Aspergillus luchuensis IFO 4308
BGC0001124	0.26	Polyketide	pyranonigrin E	Aspergillus niger ATCC 1015
BGC0000046	0.26	Polyketide	depudecin	Alternaria brassicicola
BGC0002211	0.26	Polyketide	HEx-pks1 polyketide	Paraphaeosphaeria sporulosa
BGC0001264	0.26	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0002180	0.25	Polyketide	(+)-asperlin, (2Z,4Z,6E)-octa-2,4,6-trienoic acid	Aspergillus nidulans FGSC A4

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001067	1.00	Polyketide, Terpene	fumagillin, β-trans-bergamotene, fumagillol	Aspergillus fumigatus Af293
BGC0002228	0.64	NRP	CIML B, CIML A, CIML D, CIML C	Colletotrichum incanum
BGC0001749	0.63	Polyketide	epipyriculol	Pyricularia oryzae 70-15
BGC0002233	0.63	Polyketide	trichoxide	Trichoderma virens Gv29-8
BGC0002729	0.63	Polyketide	sordarial	Neurospora crassa OR74A
BGC0001264	0.63	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0001124	0.62	Polyketide	pyranonigrin E	Aspergillus niger ATCC 1015
BGC0002227	0.61	NRP	AKML B, AKML D, AKML A, AKML C	Aspergillus luchuensis IFO 4308
BGC0002211	0.60	Polyketide	HEx-pks1 polyketide	Paraphaeosphaeria sporulosa
BGC0001205	0.60	Polyketide	communesin A, communesin B, communesin C, communesin D, communesin E, communesin G, communesin H	Penicillium expansum

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 27603:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-redmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

AFUA_8G00370

PKS_AT (597..911): mmal

ATSignature: Malonyl-CoA, Methylmalonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; Methylmalonyl-CoA: 75.0%; Ethylmalonyl-CoA: 66.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 86.5
Methoxymalonyl-CoA: 83.2
Malonyl-CoA: 72.0
Isobutyryl-CoA: 59.0
Propionyl-CoA: 44.6
Ethylmalonyl-CoA: 33.8
2-Methylbutyryl-CoA: 29.2
3-Methylbutyryl-CoA: 28.9
Benzoyl-CoA: 18.7
Acetyl-CoA: 16.0
trans-1,2-CPDA: 15.1
fatty_acid: 15.1
inactive: 13.2
CHC-CoA: 10.8

AFUA_8G00500

Search NORINE for peptide: strict or relaxed

AMP-binding (74..567): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: ala (Ala)

Stachelhaus prediction details:

Stachelhaus sequence:: DIYFFANSPK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)